| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyunjung Baek, Hyun Il Jang, Hat Nim Jeon, Hyunsu Ba. Comparison of Administration Routes on the Protective Effects of Bee Venom Phospholipase A2 in a Mouse Model of Parkinson's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-29. PMID:29942256. |
progressive loss of dopaminergic neurons in the substantia nigra (sn) and their synaptic terminal connections in the striatum are main characterizations of pd. |
2020-09-29 |
2023-08-13 |
mouse |
| Yu Pei, Robert W Maitt. Alpha synuclein in hematopoiesis and immunity. Heliyon. vol 5. issue 10. 2020-09-29. PMID:31692680. |
parkinson's disease (pd) is the second most common neurodegenerative condition and intracellular deposition of lewy bodies in the substantia nigra (sn), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. |
2020-09-29 |
2023-08-13 |
Not clear |
| Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Adrianna Wysocka, Anna Stepniewska, Grazyna Niewiadomsk. Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease. Frontiers in neurology. vol 10. 2020-09-29. PMID:31736859. |
a current hypothesis assumes a central role of neurotrophic factors in the neuroprotection of dopaminergic neurons, even though it is still not clear whether increased da level in the nigrostriatal axis results from neurogenesis of dopaminergic neurons in the sn, recovery of the phenotype of dopaminergic neurons, increased sprouting of the residual dopaminergic axons in the striatum, or generation of local striatal neurons from inhibitory interneurons. |
2020-09-29 |
2023-08-13 |
human |
| Xiaoli Wang, Xiaoxuan Sun, Mengyue Niu, Xiaona Zhang, Jing Wang, Chang Zhou, Anmu Xi. RAGE Silencing Ameliorates Neuroinflammation by Inhibition of p38-NF-κB Signaling Pathway in Mouse Model of Parkinson's Disease. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32410941. |
further experiments showed that rage ablation inhibited phosphorylation of iκb and p38 and protected nigral dopaminergic neurons against cell death in the substantia nigra (sn). |
2020-09-28 |
2023-08-13 |
mouse |
| Rafael Gonzalo-Gobernado, Diana Reimers, María José Casarejos, Lucía Calatrava Ferreras, Manuela Vallejo-Muñoz, Adriano Jiménez-Escrig, Juan José Diaz-Gil, Gonzalo M Ulzurrun de Asanza, Eulalia Bazá. Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease. Brain sciences. vol 10. issue 5. 2020-09-28. PMID:32455921. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive death of dopaminergic (da) neurons in the substantia nigra (sn), which leads to a loss of the neurotransmitter dopamine in the basal ganglia. |
2020-09-28 |
2023-08-13 |
rat |
| Kuo-Hsuan Chang, Chiung-Mei Che. The Role of Oxidative Stress in Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 9. issue 7. 2020-09-28. PMID:32650609. |
parkinson's disease (pd) is caused by progressive neurodegeneration of dopaminergic (daergic) neurons with abnormal accumulation of α-synuclein in substantia nigra (sn). |
2020-09-28 |
2023-08-13 |
Not clear |
| Bin Xiao, Naying He, Qian Wang, Zenghui Cheng, Yining Jiao, E Mark Haacke, Fuhua Yan, Feng Sh. Quantitative susceptibility mapping based hybrid feature extraction for diagnosis of Parkinson's disease. NeuroImage. Clinical. vol 24. 2020-09-21. PMID:31734535. |
the aetiology and pathogenesis of parkinson's disease (pd) are still unclear, but the loss of dopaminergic cells and the excessive iron deposition in the substantia nigra (sn) are associated with the pathophysiology. |
2020-09-21 |
2023-08-13 |
Not clear |
| Diego Perez-Rodriguez, Maria Kalyva, Melissa Leija-Salazar, Tammaryn Lashley, Maxime Tarabichi, Viorica Chelban, Steve Gentleman, Lucia Schottlaender, Hannah Franklin, George Vasmatzis, Henry Houlden, Anthony H V Schapira, Thomas T Warner, Janice L Holton, Zane Jaunmuktane, Christos Proukaki. Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing. Acta neuropathologica communications. vol 7. issue 1. 2020-09-11. PMID:31870437. |
in msa substantia nigra (sn), we noted snca gains in > 3% of dopaminergic (da) neurons (identified by neuromelanin) and neuromelanin-negative cells, including olig2-positive oligodendroglia. |
2020-09-11 |
2023-08-13 |
Not clear |
| b' Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A F Nicolaes, Jos C S Kleinjans, Jacco J Bried\\xc3\\xa. Acetaminophen Overdose as a Potential Risk Factor for Parkinson\'s Disease. Clinical and translational science. vol 12. issue 6. 2020-08-31. PMID:31305025.' |
thus, it is plausible that acetaminophen is taken up by the dopaminergic transport system into the substantia nigra (sn). |
2020-08-31 |
2023-08-13 |
human |
| Pedro A Dionísio, Sara R Oliveira, Maria M Gaspar, Maria J Gama, Margarida Castro-Caldas, Joana D Amaral, Cecilia M P Rodrigue. Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease. Cell death & disease. vol 10. issue 11. 2020-08-26. PMID:31690718. |
parkinson's disease (pd) is driven by dopaminergic neurodegeneration in the substantia nigra pars compacta (sn) and striatum. |
2020-08-26 |
2023-08-13 |
mouse |
| Pedro A Dionísio, Sara R Oliveira, Maria M Gaspar, Maria J Gama, Margarida Castro-Caldas, Joana D Amaral, Cecilia M P Rodrigue. Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease. Cell death & disease. vol 10. issue 11. 2020-08-26. PMID:31690718. |
rip3ko protected from dopaminergic neurodegeneration in the sn of mptp-injected mice, but this effect was independent of necroptosis. |
2020-08-26 |
2023-08-13 |
mouse |
| Yu Zhang, Qimei Wu, Lei Zhang, Qing Wang, Zexian Yang, Jia Liu, Linyin Fen. Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease. Pharmacological research. vol 150. 2020-08-24. PMID:31707034. |
in a53t tg mice, ca improved behavioural impairments, attenuated loss of dopaminergic neurons, enhanced autophagy and reduced α-synuclein in the sn. |
2020-08-24 |
2023-08-13 |
mouse |
| Zhan Liu, Ao-Wang Qiu, Yan Huang, Ya Yang, Jin-Na Chen, Ting-Ting Gu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Pen. IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31351185. |
neuroinflammation has been involved in pathogenesis of parkinson's disease (pd), a chronic neurodegenerative disease characterized neuropathologically by progressive dopaminergic neuronal loss in the substantia nigra (sn). |
2020-08-14 |
2023-08-13 |
mouse |
| Eoin O'Neill, Rosa Chiara Goisis, Ruth Haverty, Andrew Harki. L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats. Journal of neuroscience research. vol 97. issue 7. 2020-08-13. PMID:30924171. |
neuroinflammation is a contributory factor underlying the progressive nature of dopaminergic neuronal loss within the substantia nigra (sn) of parkinson's disease (pd) patients, albeit the role of astrocytes in this process has been relatively unexplored to date. |
2020-08-13 |
2023-08-13 |
rat |
| Miquel Vila, Ariadna Laguna, Iria Carballo-Carbaja. Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology. Autophagy. vol 15. issue 11. 2020-08-06. PMID:31480882. |
in parkinson disease (pd), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (sn), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal pathological diagnostic criterion for pd. |
2020-08-06 |
2023-08-13 |
Not clear |
| Buket Ucar, Christian Humpe. Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models. Brain research bulletin. vol 149. 2020-07-20. PMID:31004735. |
glial cell line-derived neurotrophic factor (gdnf) is a potent trophic factor that supports the survival of dopaminergic neurons of the substantia nigra (sn), which degenerate in parkinson's disease (pd). |
2020-07-20 |
2023-08-13 |
mouse |
| Buket Ucar, Christian Humpe. Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models. Brain research bulletin. vol 149. 2020-07-20. PMID:31004735. |
gdnf released from collagen scaffolds significantly protected dopaminergic sn neurons against axotomy and rotenone (50 nm, 14 days) induced cell death and showed a tendency of neuroprotection in 6-ohda (5 mm, 10 min) lesions. |
2020-07-20 |
2023-08-13 |
mouse |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
olfactory dysfunction is a major non-motor symptom that appears during the early stages of parkinson's disease (pd), a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn). |
2020-07-06 |
2023-08-13 |
mouse |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
depletion of sn dopaminergic neurons by 6-hydroxydopamine (6-ohda) is widely used as a model for pd and ultimately results in motor deficits. |
2020-07-06 |
2023-08-13 |
mouse |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
we partially depleted the sn dopaminergic population in mice by injection of 6-ohda. |
2020-07-06 |
2023-08-13 |
mouse |