| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayuka Ehara, Nozomi Ito, Kazuhiko Nakadate, Nobuko Tokud. Localization of Melanocortin 1 Receptor in the Substantia Nigra. International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39796093. |
recent findings have revealed that melanocortin 1 receptor (mc1r) deficiency leads to parkinson's disease-like dopaminergic neurodegeneration in the substantia nigra (sn). |
2025-01-11 |
2025-01-14 |
Not clear |
| Ayuka Ehara, Nozomi Ito, Kazuhiko Nakadate, Nobuko Tokud. Localization of Melanocortin 1 Receptor in the Substantia Nigra. International journal of molecular sciences. vol 26. issue 1. 2025-01-11. PMID:39796093. |
our findings reveal that mc1r was slightly present in dopaminergic neurons in the ventral tier of sn pars compacta dorsal (vsncd), a region particularly vulnerable to pd-related neurodegeneration. |
2025-01-11 |
2025-01-14 |
Not clear |
| Nehal Shawky Nagy, Mohamed Helal, Eman Sheta Alsawy, Mohamad Moustafa Ali, Soheir Salem Al-Sherif, Amina Essawy Essaw. Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson's disease. PloS one. vol 19. issue 12. 2024-12-18. PMID:39693313. |
parkinson's disease, characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn), is exacerbated by oxidative stress and neuroinflammation. |
2024-12-18 |
2024-12-21 |
rat |
| Hiroshi Sakiyama, Kousuke Baba, Yasuyoshi Kimura, Kotaro Ogawa, Ujiakira Nishiike, Hideki Hayakawa, Miki Yoshida, Cesar Aguirre, Kensuke Ikenaka, Seiichi Nagano, Hideki Mochizuk. Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation. Neurochemistry international. 2024-11-25. PMID:39586378. |
at 24 weeks after injection of saline or pff, we found that samp8 mice injected with pff exhibited robust lewy pathology and exacerbated degeneration of dopaminergic neurons in the sn compared to pff-injected samr1 mice. |
2024-11-25 |
2024-11-28 |
mouse |
| Luiz Fernando A T Pedrão, Pamela O S Medeiros, Estela C Leandro, Barbara Falquett. Parkinson's disease models and death signaling: what do we know until now? Frontiers in neuroanatomy. vol 18. 2024-11-14. PMID:39533977. |
parkinson's disease (pd) is the second neurodegenerative disorder most prevalent in the world, characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2024-11-14 |
2024-11-17 |
Not clear |
| Jin-Sun Park, Yea-Hyun Leem, Do-Yeon Kim, Jae-Min Park, Seong-Eun Kim, Hee-Sun Ki. Neuroprotective and anti-inflammatory effects of the RIPK3 inhibitor GSK872 in an MPTP-induced mouse model of Parkinson's disease. Neurochemistry international. 2024-11-04. PMID:39491747. |
parkinson's disease (pd) is a neurodegenerative disorder triggered by the loss of dopaminergic neurons in the substantia nigra (sn). |
2024-11-04 |
2024-11-06 |
mouse |
| Jin-Sun Park, Yea-Hyun Leem, Do-Yeon Kim, Jae-Min Park, Seong-Eun Kim, Hee-Sun Ki. Neuroprotective and anti-inflammatory effects of the RIPK3 inhibitor GSK872 in an MPTP-induced mouse model of Parkinson's disease. Neurochemistry international. 2024-11-04. PMID:39491747. |
gsk872 rescued mptp-induced motor impairment and inhibited tyrosine hydroxylase-positive dopaminergic cell death in the sn and striatum. |
2024-11-04 |
2024-11-06 |
mouse |
| Hyun Jung Kwon, Hyo Young Jung, Soo Young Choi, In Koo Hwang, Dae Won Kim, Min Jea Shi. TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons. Molecular and cellular neurosciences. 2024-11-02. PMID:39488259. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain, resulting in severe motor impairments. |
2024-11-02 |
2024-11-05 |
Not clear |
| Xiangbo Zhang, Haiyang Yu, Juan Fen. Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson's disease. Frontiers in aging neuroscience. vol 16. 2024-10-24. PMID:39444806. |
the main pathological characteristics of pd are the loss of dopaminergic neurons in the substantia nigra (sn) as well as abnormal aggregation of α-synuclein (α-syn) monomers and oligomers, which results in formation of lewy bodies (lbs). |
2024-10-24 |
2024-10-26 |
Not clear |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
dopamine is synthesized in the dopaminergic neurons of the sn by the actions of tyrosine hydroxylase (th) and dihydroxyphenylalanine decarboxylase (ddc). |
2024-10-16 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
in this study, we found that mc-lr could enter dopaminergic neurons in the sn and directly bound to extracellular signal-regulated kinase 2 (erk2), enhancing erk2 stability. |
2024-10-16 |
2024-10-19 |
mouse |
| Wen Cheng, Kexin Fang, Xiaorong Ouyang, Lingjing Jin, Yunping Song, Bin Y. Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease. Neurochemistry international. vol 180. 2024-10-04. PMID:39362497. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-10-04 |
2024-10-07 |
mouse |
| Wen Cheng, Kexin Fang, Xiaorong Ouyang, Lingjing Jin, Yunping Song, Bin Y. Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease. Neurochemistry international. vol 180. 2024-10-04. PMID:39362497. |
our results suggest that vns improved behavioral performance in rod rotation, open field tests and pole-climbing tests in pd mice, accompanied by a decrease in the loss of dopaminergic neurons in the sn and increased th expression in the striatum. |
2024-10-04 |
2024-10-07 |
mouse |
| Tae-Young Ha, Jae-Bong Kim, Yeji Kim, Sang Myun Park, Keun-A Chan. GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models. Pharmacological research. 2024-09-23. PMID:39313081. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracellular α-synuclein (ɑ-syn) aggregates known as lewy bodies and lewy neurites. |
2024-09-23 |
2024-09-26 |
mouse |
| Tae-Young Ha, Jae-Bong Kim, Yeji Kim, Sang Myun Park, Keun-A Chan. GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models. Pharmacological research. 2024-09-23. PMID:39313081. |
in 6-ohda-induced pd model mice, tug469 treatment improved motor impairment, preserved dopaminergic fibers and cell bodies in the striatum (st) or sn, and attenuated 6-ohda-induced microgliosis and astrogliosis in the brain. |
2024-09-23 |
2024-09-26 |
mouse |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. Brain : a journal of neurology. 2024-09-16. PMID:39282945. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-09-16 |
2024-09-19 |
Not clear |
| Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong B. Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. EJNMMI research. vol 14. issue 1. 2024-09-03. PMID:39225971. |
neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (sn) pars compacta, and can be detected by magnetic resonance imaging (mri). |
2024-09-03 |
2024-09-05 |
Not clear |
| Zahra Baridjavadi, Mahmoud Mahmoudi, Narges Abdollahi, Negar Ebadpour, Samaneh Mollazadeh, Dariush Haghmorad, Seyed-Alireza Esmaeil. The humoral immune landscape in Parkinson's disease: Unraveling antibody and B cell changes. Cell biochemistry and function. vol 42. issue 7. 2024-08-27. PMID:39189398. |
parkinson's disease (pd) is a complex neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) in the brain and progressive loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2024-08-27 |
2024-08-30 |
Not clear |
| Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chushen Huang, Zhongquan Q. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model. IUBMB life. 2024-07-31. PMID:39082886. |
parkinson's disease (pd) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (sn) and striatum, resulting in impaired motor functions. |
2024-07-31 |
2024-08-02 |
mouse |
| Divya Bharathi Selvaraj, Anusiya Panneerselvam, Jemi Feiona Vergil Andrews, Mahesh Kandasam. Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson's Disease. Brain sciences. vol 14. issue 7. 2024-07-27. PMID:39061373. |
furthermore, we investigated the effect of cys-hcl on the number of dopaminergic tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and olfactory bulb (ob) of the experimental mice using immunohistochemistry. |
2024-07-27 |
2024-07-29 |
mouse |