| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heba M Mansour, Aiman S El-Khati. Exploring Parkinson-associated Kinases for CRISPR/Cas9-Based Gene Editing: Beyond Alpha-Synuclein. Ageing research reviews. 2023-11-04. PMID:37924981. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substania nigra (sn) and is associated with progressive motor impairment. |
2023-11-04 |
2023-11-08 |
Not clear |
| Isaac Colvett, Anah Gilmore, Samuel Guzman, Aurélie Ledreux, Jorge E Quintero, Dhanunjaya Rao Ginjupally, Julie A Gurwell, John T Slevin, Zain Guduru, Greg A Gerhardt, Craig G van Horne, Ann-Charlotte Granhol. Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain. Journal of clinical medicine. vol 12. issue 19. 2023-10-14. PMID:37834764. |
dopaminergic neurites showed active growth in the graft area and into the graft in the sn graft, and cholinergic neurites were abundant near the graft in the nbm. |
2023-10-14 |
2023-10-15 |
human |
| Tuo Liang, Sheng-Xi Yang, Christopher Qian, Li-Da Du, Zhong-Ming Qian, Wing-Ho Yung, Ya K. HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism. Molecular neurobiology. 2023-10-13. PMID:37833459. |
hmgb1 neutralizing antibody suppressed inflammation in the sn, dmt1+ elevation in dopaminergic neurons, and dopaminergic neuronal loss in both lps and 6-ohda administration- induced pd models. |
2023-10-13 |
2023-10-15 |
rat |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-10-11. PMID:37820786. |
parkinson's disease (pd) is characterized by motor impairments and progressive dopaminergic neuronal death in the substantia nigra (sn). |
2023-10-11 |
2023-10-15 |
rat |
| Xv-Shen Ding, Li Gao, Zheng Han, Simona Eleuteri, Wei Shi, Yun Shen, Zi-Yao Song, Mingming Su, Qian Yang, Yan Qu, David K Simon, Xue-Lian Wang, Bao Wan. Ferroptosis in Parkinson's Disease: Molecular Mechanisms and Therapeutic Potential. Ageing research reviews. 2023-09-24. PMID:37742785. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn), leading to motor and non-motor symptoms. |
2023-09-24 |
2023-10-07 |
Not clear |
| Amin A Hafi. The neuroprotective effect of vitamin D in Parkinson's disease: association or causation. Nutritional neuroscience. 2023-09-21. PMID:37731327. |
parkinson's disease (pd) is a chronic neurodegenerative disease (ndd) due to the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-09-21 |
2023-10-07 |
Not clear |
| Lei Liu, Yange Cui, Yan-Zhong Chang, Peng Y. Ferroptosis-related factors in the substantia nigra are associated with Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-09-16. PMID:37717088. |
despite this superficial connection, the possible role(s) of ferroptosis-related (fr) proteins in dopaminergic neurons and/or glial cells in the substantia nigra (sn) in pd have not been examined in depth. |
2023-09-16 |
2023-10-07 |
human |
| Lei Liu, Yange Cui, Yan-Zhong Chang, Peng Y. Ferroptosis-related factors in the substantia nigra are associated with Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-09-16. PMID:37717088. |
to explore the correlations between the different sn cell types and ferroptosis at the single-cell level in pd patients, and to explore genes that may affect the sensitivity of dopaminergic neurons to ferroptosis, we performed in silico analysis of a single cell rna sequence (rna-seq) set (gse178265) from the gene expression omnibus (geo) database. |
2023-09-16 |
2023-10-07 |
human |
| Lei Liu, Yange Cui, Yan-Zhong Chang, Peng Y. Ferroptosis-related factors in the substantia nigra are associated with Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-09-16. PMID:37717088. |
we identified differentially expressed genes (degs) in the different cell types in the human sn, and proceeded to perform enrichment analysis, constructing a protein-protein interaction network from the degs of dopaminergic neurons with the metascape database. |
2023-09-16 |
2023-10-07 |
human |
| Lei Liu, Yange Cui, Yan-Zhong Chang, Peng Y. Ferroptosis-related factors in the substantia nigra are associated with Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-09-16. PMID:37717088. |
the number of dopaminergic neurons decreased in the sn of pd patients. |
2023-09-16 |
2023-10-07 |
human |
| Dong Yeol Kim, Jin Young Shin, Ji Eun Lee, Ha Na Kim, Seok Jong Chung, Han Soo Yoo, Sang Jin Kim, Hwa Jin Cho, Eun-Jae Lee, Soo Jeong Nam, Seong Heon Kim, Jaewon Jang, Seung Eun Lee, Phil Hyu Le. A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 37. 2023-09-05. PMID:37669380. |
overexpression of α-synuclein in the er of the substantia nigra (sn) resulted in marked loss of dopaminergic neurons and motor deficits, mimicking pd characteristics. |
2023-09-05 |
2023-10-07 |
Not clear |
| Dong Yeol Kim, Jin Young Shin, Ji Eun Lee, Ha Na Kim, Seok Jong Chung, Han Soo Yoo, Sang Jin Kim, Hwa Jin Cho, Eun-Jae Lee, Soo Jeong Nam, Seong Heon Kim, Jaewon Jang, Seung Eun Lee, Phil Hyu Le. A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 37. 2023-09-05. PMID:37669380. |
however, enhancement of er-phagy using fam134b overexpression in the sn exerted neuroprotective effects on dopaminergic neurons and recovered motor performance. |
2023-09-05 |
2023-10-07 |
Not clear |
| Saud A Alnaaim, Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of Brain Liver X Receptor in Parkinson's Disease: Hidden Treasure and Emerging Opportunities. Molecular neurobiology. 2023-08-22. PMID:37606719. |
parkinson's disease (pd) is a neurodegenerative disease due to the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-08-22 |
2023-09-07 |
Not clear |
| Mengdi Wang, Fengjiao Sun, Xiaofeng Han, Nan Wang, Yalan Liu, Jinfeng Cai, Shanshan Tong, Rui Wang, Hongcai Wan. Astragaloside IV Inhibits Rotenone-Induced α-syn Presentation and the CD4 T-Cell Immune Response. Molecular neurobiology. 2023-08-21. PMID:37603153. |
the increased α-synuclein (α-syn)-dependent activation of cd4 t cells leads to the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2023-08-21 |
2023-09-07 |
rat |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hend Mostafa Selim, Athanasios Alexiou, Marios Papadakis, Walaa A Negm, Gaber El-Saber Batih. Does vitamin D protect or treat Parkinson's disease? A narrative review. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-09. PMID:37555855. |
vdrs are highly expressed in the sn that regulates the activity of dopaminergic neurons and synaptic plasticity. |
2023-08-09 |
2023-08-16 |
human |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hend Mostafa Selim, Athanasios Alexiou, Marios Papadakis, Walaa A Negm, Gaber El-Saber Batih. Does vitamin D protect or treat Parkinson's disease? A narrative review. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-09. PMID:37555855. |
vd exerts protective and therapeutic effects against the development of pd by modulating dopaminergic neurons of sn. |
2023-08-09 |
2023-08-16 |
human |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
the higher expression of clec7a was observed in the substantia nigra (sn) and striatum of pd rats with dopaminergic neurons damage and was mainly localized in the microglial. |
2023-07-26 |
2023-08-14 |
rat |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
adeno-associated virus (aav)-mediated specific knockdown of clec7a in microglial alleviated 6-ohda induced motor deficits and nigrostriatal dopaminergic neuron damage of rats, as evidenced by the increase of tyrosine hydroxylase (th) -positive neurons in sn, as well as dopaminergic nerve fibers in the striatum. |
2023-07-26 |
2023-08-14 |
rat |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Abdul-Karim Abd Ali Al-Mahammadawy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. The potential role of cholesterol in Parkinson's disease neuropathology: perpetrator or victim. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-07-10. PMID:37428278. |
additionally, cholesterol increases aggregation of α-synuclein and induces degeneration of dopaminergic neurons (dn) in the substantia nigra (sn). |
2023-07-10 |
2023-08-14 |
Not clear |
| Carmela Conte, Angela Ingrassia, John Breve, John J Bol, Evelien Timmermans-Huisman, Anne-Marie van Dam, Tommaso Beccari, Wilma D J van de Ber. Toll-like Receptor 4 Is Upregulated in Parkinson's Disease Patients and Co-Localizes with pSer129αSyn: A Possible Link with the Pathology. Cells. vol 12. issue 10. 2023-07-06. PMID:37408202. |
using qpcr, we observed an upregulation of tlr4 expression in the sn and gtm in pd patients compared to controls, which was accompanied by a reduction in αsyn expression likely due to the depletion of dopaminergic (da) cells. |
2023-07-06 |
2023-08-14 |
Not clear |