| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiuyu Lv, Xuanyi Wang, Pan Lin, Xiang Wan. Neuromelanin-sensitive magnetic resonance imaging in the study of mental disorder: A systematic review. Psychiatry research. Neuroimaging. vol 339. 2024-02-07. PMID:38325165. |
recent research suggests that neuromelanin-sensitive magnetic resonance imaging (nm-mri) techniques may overcome this limitation by enabling the non-invasive imaging of the substantia nigra (sn)/ ventral tegmental area (vta) dopaminergic and locus coeruleus (lc) noradrenergic systems. |
2024-02-07 |
2024-02-10 |
Not clear |
| Rongsha Chen, Ke Li, Yinying Wang, Liyun Song, Ruohua Wang, Wenhui Fan, Ninghui Zhao, Wei Zou, Zhongshan Yang, Jinyuan Ya. Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model. Journal of drug targeting. 2024-02-05. PMID:38315456. |
the present study demonstrated that cos increased dopaminergic neurons in the substantia nigra (sn) and ameliorated dyskinesia in a pd mouse model. |
2024-02-05 |
2024-02-09 |
mouse |
| Karen Manoutcharian, Goar Gevorkia. Recombinant Antibody Fragments for Immunotherapy of Parkinson's Disease. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2024-01-27. PMID:38280078. |
multiple genetic and environmental factors leading to progressive loss of dopaminergic neurons in the substantia nigra pars compacta (sn) and consequent depletion of dopamine were described. |
2024-01-27 |
2024-01-30 |
Not clear |
| Junming Huang, Bowen Li, Huangwei Wei, Chengxin Li, Chao Liu, Hua Mi, Shaohua Che. Integrative analysis of gene expression profiles of substantia nigra identifies potential diagnosis biomarkers in Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-01-25. PMID:38272954. |
parkinson's disease (pd) is a progressive neurodegenerative disease whose etiology is attributed to development of lewy bodies and degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-01-25 |
2024-01-28 |
human |
| Ramasamy Thangavel, Harleen Kaur, Iuliia Dubova, Govindhasamy Pushphavathi Selvakumar, Mohammad Ejaz Ahmed, Sudhanshu P Raikwar, Raghav Govindarajan, Duraisamy Kempura. Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256254. |
we detected a large number of gmf-positive glial fibrillary acidic protein (gfap) reactive astrocytes, especially abundant in areas with degenerating dopaminergic neurons within the sn and striatum in pdd. |
2024-01-23 |
2024-01-25 |
human |
| Danlei Wang, Hongling Gao, Qixiong Qin, Jingyi Li, Jingwei Zhao, Yi Qu, Jiangting Li, Yongjie Xiong, Zhe Min, Zhijuan Mao, Zheng Xu. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson's disease. Journal of translational medicine. vol 22. issue 1. 2024-01-16. PMID:38229084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-01-16 |
2024-01-19 |
mouse |
| Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Lap Ho, Kurt Farrell, Kristin G Beaumont, Robert Sebra, Claudia De Sanctis, John F Crary, Tim Ahfeldt, Joel Blanchard, Drew Neavin, Joseph Powell, David A Davis, Xiaoyan Sun, Bin Zhang, Zhenyu Yu. Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease. Science advances. vol 10. issue 2. 2024-01-10. PMID:38198537. |
parkinson's disease (pd) is characterized pathologically by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-01-10 |
2024-01-13 |
human |
| Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wan. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson's disease mice model. Folia neuropathologica. 2024-01-04. PMID:38174686. |
using open field, rotarod, and pole climbing tests, we have found that b-ecd alleviates motor disorder in mptp/pro-induced mice and ultimately reduces the impairment of tyrosine hydroxylase (th)-positive dopaminergic neurons in the substantia nigra (sn). |
2024-01-04 |
2024-01-06 |
mouse |
| Sora Kang, Youngjin Noh, Seung Jun Oh, Hye Ji Yoon, Suyeol Im, Hung Taeck Kwon, Youngmi Kim Pa. Neuroprotective Effects of Aldehyde-Reducing Composition in an LPS-Induced Neuroinflammation Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 28. issue 24. 2023-12-23. PMID:38138478. |
oral administration of arc at 10 or 20 units/kg/day for 3 days prior to intraperitoneal injection of lps (10 mg/kg) effectively preserved dopaminergic neurons in the substantia nigra (sn) and striatum by preventing lps-induced cell death. |
2023-12-23 |
2023-12-25 |
Not clear |
| Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi L. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-12-02. PMID:38041169. |
parkinson's disease (pd), one of the most devastating neurodegenerative brain disorders, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) and deposits of α-synuclein aggregates. |
2023-12-02 |
2023-12-10 |
mouse |
| Javiera Arcos, Felipe Grunenwald, Denisse Sepulveda, Carolina Jerez, Valentina Urbina, Tomas Huerta, Paulina Troncoso-Escudero, Daniel Tirado, Angela Perez, Rodrigo Diaz-Espinoza, Esteban Nova, Ulrich Kubitscheck, Juan Eduardo Rodriguez-Gatica, Claudio Hetz, Jorge Toledo, Pablo Ahumada, Diego Rojas-Rivera, Elisa Martín-Montañez, María Garcia-Fernandez, René L Vida. IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models. Cell death discovery. vol 9. issue 1. 2023-12-02. PMID:38042807. |
moreover, igf2 expression prevents dopaminergic neuronal loss in the sn together with a decrease in α-syn accumulation (phospho-α-syn levels) in the striatum and sn brain region. |
2023-12-02 |
2023-12-10 |
Not clear |
| Rupert D Smit, Biswarup Ghosh, Thomas J Campion, Rachel Stingel, Emily Lavell, Robert Hooper, Xiaoxuan Fan, Jonathan Soboloff, George M Smit. STAT3 protects dopaminergic neurons against degeneration in animal model of Parkinson's disease. Brain research. vol 1824. 2023-12-01. PMID:38030102. |
parkinson's disease (pd) is the most prevalent disorder of the basal ganglia, propagated by the degeneration of axon terminals within the striatum and subsequent loss of dopaminergic neurons in the substantia nigra (sn). |
2023-12-01 |
2023-12-10 |
Not clear |
| Zhixin Xiao, Xiaoya Wang, Xuening Pan, Junxia Xie, Huamin X. Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease. Experimental neurology. 2023-11-25. PMID:38007207. |
understanding how iron damages dopaminergic neurons in the substantia nigra (sn) of pd is particularly important for developing targeted neurotherapeutic strategies for the disease. |
2023-11-25 |
2023-11-28 |
Not clear |
| De-Wen Kong, Li-da Du, Run-Zhe Liu, Tian-Yi Yuan, Shou-Bao Wang, Yue-Hua Wang, Yang Lu, Lian-Hua Fang, Guan-Hua D. Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels. Acta pharmacologica Sinica. 2023-11-22. PMID:37993535. |
dopaminergic neurons in the substantia nigra (sn) expressing sur1/kir6.2 type atp-sensitive potassium channels (k-atp) are more vulnerable to rotenone or metabolic stress, which may be an important reason for the selective degeneration of neurons in parkinson's disease (pd). |
2023-11-22 |
2023-11-29 |
Not clear |
| Andréia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Júnio Araújo de Castro, Anamélia Lorenzetti Bocca, Márcia Renata Mortar. New fraternine analogues: Evaluation of the antiparkinsonian effect in the model of Parkinson's disease. Neuropeptides. vol 103. 2023-11-20. PMID:37984248. |
overall, only the peptide fra-24 presented a neuroprotection effect on dopaminergic neurons of sn and a reduction of cytokine tnf-α levels, making it worthy of consideration for the treatment of pd. |
2023-11-20 |
2023-11-29 |
mouse |
| Qiong Liu, Juan Chen, Jin Xue, Xun Zhou, Yun Tian, Qiao Xiao, Wen Huang, Yongcheng Pan, Xiaoxia Zhou, Jian Li, Yuwen Zhao, Hongxu Pan, Yige Wang, Runcheng He, Yaqin Xiang, Tian Tu, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jifeng Guo, Lu Shen, Ranhui Duan, Beisha Tang, Zhenhua Li. GGC expansions in NOTCH2NLC contribute to Parkinson disease and dopaminergic neuron degeneration. European journal of neurology. 2023-11-17. PMID:37975799. |
we also investigate the role of ggc repeat expansions within notch2nlc in the dopaminergic neurodegeneration of sn. |
2023-11-17 |
2023-11-20 |
Not clear |
| Tracy-Shi Zhang Fang, Yu Sun, Andrew C Pearce, Simona Eleuteri, Mark Kemp, Christopher A Luckhurst, Rachel Williams, Ross Mills, Sarah Almond, Laura Burzynski, Nóra M Márkus, Christopher J Lelliott, Natasha A Karp, David J Adams, Stephen P Jackson, Jin-Feng Zhao, Ian G Ganley, Paul W Thompson, Gabriel Balmus, David K Simo. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nature communications. vol 14. issue 1. 2023-11-13. PMID:37957154. |
here we show that loss of usp30 in usp30 knockout mice protects against behavioral deficits and leads to increased mitophagy, decreased phospho-s129 αsyn, and attenuation of sn dopaminergic neuronal loss induced by αsyn. |
2023-11-13 |
2023-11-20 |
mouse |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
these results have important implications, as dat is crucial for dopamine signalling, and is commonly used as a marker for dopaminergic sn neurons. |
2023-11-10 |
2023-11-20 |
mouse |
| Julia J Meerman, Juliette Legler, Aldert H Piersma, Remco H S Westerink, Harm J Heusinkvel. An Adverse Outcome Pathway for Chemical-induced Parkinson's disease: Calcium is Key. Neurotoxicology. 2023-11-05. PMID:37926220. |
pd symptoms are caused by loss of function and ultimately death of dopaminergic neurons in the substantia nigra (sn). |
2023-11-05 |
2023-11-08 |
human |
| Julia J Meerman, Juliette Legler, Aldert H Piersma, Remco H S Westerink, Harm J Heusinkvel. An Adverse Outcome Pathway for Chemical-induced Parkinson's disease: Calcium is Key. Neurotoxicology. 2023-11-05. PMID:37926220. |
this ke can lead to death of dopaminergic neurons of the sn, and eventually parkinsonian motor symptoms, via four distinct pathways: 1) activation of calpains, 2) endoplasmic reticulum stress, 3) impairment of protein degradation, and 4) oxidative damage. |
2023-11-05 |
2023-11-08 |
human |