| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Grotemeyer, Judith F Fischer, James B Koprich, Jonathan M Brotchie, Robert Blum, Jens Volkmann, Chi Wang I. Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-03-22. PMID:36945016. |
we have used a human α-synuclein mouse model of progressive pd to examine the anti-inflammatory and neuroprotective effects of inflammasome inhibition on dopaminergic (da) neurons in the substantia nigra (sn). |
2023-03-22 |
2023-08-14 |
mouse |
| Yu-Hsuan Chen, Yi-Ying Kuo, Yi-Qian You, Ya-Tin Lin, Pei-Chun Che. Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease. Journal of neurochemistry. 2023-02-25. PMID:36840377. |
parkinson's disease (pd) is a common movement disorder caused by a characteristic loss of dopaminergic neurons in the substantia nigra (sn) and degeneration of dopamine terminals in the dorsal striatum. |
2023-02-25 |
2023-08-14 |
mouse |
| Anna Kolacheva, Ekaterina Pavlova, Alyona Bannikova, Vsevolod Bogdanov, Dmitry Troshev, Michael Ugrumo. The Gene Expression of Proteins Involved in Intercellular Signaling and Neurodegeneration in the Substantia Nigra in a Mouse Subchronic Model of Parkinson's Disease. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769355. |
further analysis of the gene expression in the sn of mice has shown that the expression of some genes also changes in the model of the preclinical stage, when dopaminergic neurons have not yet died. |
2023-02-11 |
2023-08-14 |
mouse |
| Waijiao Cai, Kazumasa Wakamatsu, Fabio A Zucca, Qing Wang, Kai Yang, Niyaz Mohamadzadehonarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella, Shosuke Ito, Luigi Zecca, Xiqun Che. DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease. Progress in neurobiology. 2023-02-06. PMID:36746222. |
neuromelanin (nm) in dopaminergic neurons of human substantia nigra (sn) has a melanic component that consists of pheomelanin and eumelanin moieties and has been proposed as a key factor contributing to dopaminergic neuron vulnerability in parkinson's disease (pd). |
2023-02-06 |
2023-08-14 |
human |
| Marco Travaglio, Filippos Michopoulos, Yizhou Yu, Rebeka Popovic, Edmund Foster, Muireann Coen, L Miguel Martin. Increased cysteine metabolism in PINK1 models of Parkinson's disease. Disease models & mechanisms. vol 16. issue 1. 2023-01-25. PMID:36695500. |
parkinson's disease (pd), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2023-01-25 |
2023-08-14 |
human |
| Qionghui Cai, Na Xu, Yan He, Jiamin Zhu, Fenfen Ye, Zhi Luo, Ruojun Lu, Linshan Huang, Feiyang Zhang, Jiang-Fan Chen, Yan L. α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine A International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674880. |
here, we coupled two unique behavioral paradigms with two pd models to reveal the following: (i) focally injecting α-syn fibrils into the dorsolateral striatum (dls) and the transgenic expression of a53t-α-syn in the dopaminergic neurons in the substantia nigra (sn, pitx3-ires2-tta/teto-a53t mice) selectively impaired forelimb fine movements induced by the single-pellet reaching task. |
2023-01-21 |
2023-08-14 |
mouse |
| Jin Yi Han, Eun-Hye Lee, Sang-Mi Kim, Chang-Hwan Par. Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes. Biomolecules & therapeutics. 2023-01-15. PMID:36642416. |
pd is caused by loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn) and therefore, replenishment of da neurons via stem cell-based therapy is a potential treatment option. |
2023-01-15 |
2023-08-14 |
mouse |
| Carmen F M van Hooijdonk, Marieke van der Pluijm, Iris Bosch, Therese A M J van Amelsvoort, Jan Booij, Lieuwe de Haan, Jean-Paul Selten, Elsmarieke van de Giesse. The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 68. 2023-01-14. PMID:36640734. |
despite being one of the main origins of dopaminergic input to the striatum, the (dys)functioning of the substantia nigra (sn) has been relatively understudied in schizophrenia. |
2023-01-14 |
2023-08-14 |
Not clear |
| Shu-Yi Huang, Zong-Ying Su, Yuan-Yuan Han, Li Liu, Ying-Jie Shang, Zi-Fan Mai, Zhi-Wei Zeng, Chu-Hua L. Cordycepin improved the cognitive function through regulating adenosine A Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 110. 2023-01-12. PMID:36634379. |
cordycepin improved the cognitive function through regulating adenosine a parkinson's disease (pd), the most common neurodegenerative disorder, primarily affects dopaminergic neurons in the substantia nigra (sn). |
2023-01-12 |
2023-08-14 |
Not clear |
| Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumo. Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. Frontiers in molecular neuroscience. vol 15. 2022-12-26. PMID:36568278. |
we have developed a method for selecting a population of dns from the sn of mice, as evidenced by: (i) immunopositivity of 95% of the sorted cells for tyrosine hydroxylase, the first enzyme of dopamine synthesis; (ii) the sorted cells expressing the genes for specific proteins of the dopaminergic phenotype, tyrosine hydroxylase, the dopamine transporter, and vesicular monoamine transporter 2 and non-specific proteins, such as aromatic l-amino acid decarboxylase, non-specific enzyme of dopamine synthesis. |
2022-12-26 |
2023-08-14 |
mouse |
| Hong-Yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Еlena Kaznacheyeva, Xiao-Jun Lu, Hai-Gang Ren, Guang-Hui Wan. Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway. Acta pharmacologica Sinica. 2022-12-19. PMID:36536076. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic (da) neurons and the accumulation of lewy bodies (lb) in the substantia nigra (sn). |
2022-12-19 |
2023-08-14 |
mouse |
| Shuanglong Yi, Linfang Wang, Honglei Wang, Margaret S Ho, Shiping Zhan. Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499080. |
pathologically, the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn) and the accumulation of α-synuclein (α-syn)-composed lewy bodies (lbs) and lewy neurites (lns) are key hallmarks. |
2022-12-11 |
2023-08-14 |
Not clear |
| Xue Gan, Jiahan Ren, Tianzhuang Huang, Kunhua Wu, Shulin Li, Yanchao Duan, Zhengbo Wang, Wei Si, Jingkuan We. Pathological α-Synuclein Accumulation, CSF Metabolites Changes and Brain Microstructures in Cynomolgus Monkeys Treated with 6-hydroxydopamine. Neurotoxicology. 2022-12-08. PMID:36476940. |
we found the dopaminergic neurons were significantly reduced and had fragmented morphology in substantia nigra (sn). |
2022-12-08 |
2023-08-14 |
monkey |
| Qinyu Peng, Guoxin Zhang, Xiaodi Guo, Lijun Dai, Min Xiong, Zhaohui Zhang, Liam Chen, Zhentao Zhan. Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-12-08. PMID:36479526. |
microglial activation and neuroinflammation play a key role in the degeneration of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2022-12-08 |
2023-08-14 |
mouse |
| Wei Liang, Lulu Yao, Jiahao Chen, Zhiying Chen, Xiling Wu, Xiaobo Huan. Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-11-28. PMID:36437828. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-11-28 |
2023-08-14 |
rat |
| Hanna Kim, Ji-Yeong Lee, Soo Jeong Park, Eunsang Kwag, Jihye Kim, Joo-Ho Shi. S-nitrosylated PARIS Leads to the Sequestration of PGC-1α into Insoluble Deposits in Parkinson's Disease Model. Cells. vol 11. issue 22. 2022-11-26. PMID:36429110. |
to assess the dopaminergic (da) neuronal toxicity by sno-paris, lentiviral paris wt, c265s, and s-nitrosylation mimic c265w was injected into the sn of either pbs- or α-syn pffs-injected mice. |
2022-11-26 |
2023-08-14 |
mouse |
| Vandana Zaman, Kelsey P Drasites, Ali Myatich, Ramsha Shams, Donald C Shields, Denise Matzelle, Azizul Haque, Narendra L Bani. Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430329. |
calpain, a calcium-dependent neutral protease, is widely expressed in the brain, including substantia nigra (sn) dopaminergic (da) neurons. |
2022-11-26 |
2023-08-14 |
human |
| Yura Jang, Olga Pletnikova, Juan C Troncoso, Alexander Y Pantelyat, Ted M Dawson, Liana S Rosenthal, Chan Hyun N. Mass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease. Molecular & cellular proteomics : MCP. 2022-11-24. PMID:36423813. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) of the brain. |
2022-11-24 |
2023-08-14 |
human |
| Min Hyung Seo, Sujung Ye. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Molecular neurobiology. 2022-11-12. PMID:36369636. |
parkinson's disease (pd) is the second most common neurodegenerative disorder and is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2022-11-12 |
2023-08-14 |
mouse |
| Min Hyung Seo, Sujung Ye. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Molecular neurobiology. 2022-11-12. PMID:36369636. |
our results provide an avenue for understanding the role of srpk3 in dopaminergic cell loss and α-syn upregulation in sn. |
2022-11-12 |
2023-08-14 |
mouse |