| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seunghwan Shim, Da Un Jeong, Hyemi Kim, Chae Yun Kim, Hyejun Park, Yinglan Jin, Kyung Min Kim, Hwa Jeong Lee, Dong Hwan Kim, Yun Soo Bae, Yongseok Cho. Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease. European journal of medicinal chemistry. vol 244. 2022-10-24. PMID:36274279. |
oral administration of compound 11 (30 mg/kg/daily, 4 weeks) into the mice resulted in suppression of dopaminergic neuronal death in substantia nigra (sn) and in striatum as well as inhibition of microglial migration into sn. |
2022-10-24 |
2023-08-14 |
mouse |
| Qing Guan, Wei Liu, Ketao Mu, Qi Hu, Jiazhao Xie, Liming Cheng, Xiong Wan. Single-cell RNA sequencing of CSF reveals neuroprotective RAC1 Frontiers in immunology. vol 13. 2022-10-10. PMID:36211372. |
results showed that nk cells infiltrate the substantia nigra (sn) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd model mice and colocalize with dopaminergic neurons and α-syn. |
2022-10-10 |
2023-08-14 |
mouse |
| Sushmaa Chandralekha Selvakumar, K Auxzilia Preethi, Deusdedit Tusubira, Durairaj Seka. MicroRNAs in the epigenetic regulation of disease progression in Parkinson's disease. Frontiers in cellular neuroscience. vol 16. 2022-10-03. PMID:36187290. |
the loss of dopaminergic neurons in the substantia nigra (sn) is thought to be the primary cause of pd disease progression. |
2022-10-03 |
2023-08-14 |
Not clear |
| Marieke van der Pluijm, Elon D Wallert, Bram F Coolen, Kaithlyn T Tjong Tjin Joe, Lieuwe de Haan, Jan Booij, Elsmarieke van de Giesse. Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options. Neuroradiology. 2022-09-28. PMID:36169662. |
neuromelanin mri (nm-mri) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (sn). |
2022-09-28 |
2023-08-14 |
Not clear |
| Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Le. Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142491. |
we found that dietary morin prevented mptp-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (str) and substantia nigra (sn) in our mouse model. |
2022-09-23 |
2023-08-14 |
mouse |
| Xin Li, Xiao-Wen Jiang, Hai-Xiao Chu, Qing-Chun Zhao, Huai-Wei Ding, Chao-Hong Ca. Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition. Chinese herbal medicines. vol 13. issue 1. 2022-09-19. PMID:36117765. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in substantia nigra (sn). |
2022-09-19 |
2023-08-14 |
Not clear |
| Daniela Elgueta, Ornella Chovar, Valentina Ugalde, Vanesa Sánchez-Guajardo, Alejandra Catenaccio, Felipe Court, Rodrigo Pachec. Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein. Journal of visualized experiments : JoVE. issue 185. 2022-08-15. PMID:35969046. |
this work analyzes a mouse model of parkinson's disease that recapitulates microglial activation, t-cell infiltration into the sn, the neurodegeneration of nigral dopaminergic neurons, and motor impairment. |
2022-08-15 |
2023-08-14 |
mouse |
| Daniela Elgueta, Ornella Chovar, Valentina Ugalde, Vanesa Sánchez-Guajardo, Alejandra Catenaccio, Felipe Court, Rodrigo Pachec. Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein. Journal of visualized experiments : JoVE. issue 185. 2022-08-15. PMID:35969046. |
afterward, how the dose of aav-hαsyn administered in the sn affected the extent of hαsyn expression, the loss of nigral dopaminergic neurons, and motor impairment were evaluated. |
2022-08-15 |
2023-08-14 |
mouse |
| Min Kyung Song, Levi Adams, Joo Hee Lee, Yoon-Seong Ki. NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease. PloS one. vol 17. issue 7. 2022-07-28. PMID:35901090. |
we found that oral administration of nxp031 ameliorated motor deficits measured by the rotarod test and prevented the loss of nigral dopaminergic neurons caused by wt-α-syn overexpression in the sn. |
2022-07-28 |
2023-08-14 |
mouse |
| Sage S Frehner, Kip T Dooley, Michelle C Palumbo, Aaron L Smith, Mark M Goodman, Karen L Bales, Sara M Freema. Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 377. issue 1858. 2022-07-20. PMID:35858098. |
here, we explore whether differences in oxtr can be identified in the dopaminergic sn pars compacta of individuals with autism. |
2022-07-20 |
2023-08-14 |
human |
| Maximilian Wulf, Katalin Barkovits, Karin Schork, Martin Eisenacher, Peter Riederer, Manfred Gerlach, Britta Eggers, Katrin Marcu. Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes. Journal of neural transmission (Vienna, Austria : 1996). 2022-07-19. PMID:35852604. |
neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (nmgs) in the cell bodies of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-07-19 |
2023-08-14 |
Not clear |
| Anita Siller, Nadja T Hofer, Giulia Tomagra, Nicole Wiederspohn, Simon Hess, Julia Benkert, Aisylu Gaifullina, Desiree Spaich, Johanna Duda, Christina Poetschke, Kristina Vilusic, Eva Maria Fritz, Toni Schneider, Peter Kloppenburg, Birgit Liss, Valentina Carabelli, Emilio Carbone, Nadine Jasmin Ortner, Jörg Striessni. rβ2-subunit alternative splicing stabilizes Cav2.3 Ca eLife. vol 11. 2022-07-06. PMID:35792082. |
rβ2-subunit alternative splicing stabilizes cav2.3 ca in dopaminergic (da) substantia nigra (sn) neurons cav2.3 r-type ca |
2022-07-06 |
2023-08-14 |
Not clear |
| Lei Wang, Xinghong Wu, Ge Yang, Nan Hu, Zijian Zhao, Lei Zhao, Shengyu L. Cannabidiol alleviates the damage to dopaminergic neurons in MPTP-induced Parkinson's disease mice via regulating neuronal apoptosis and neuroinflammation. Neuroscience. 2022-07-06. PMID:35792194. |
the main pathological feature of pd is the loss or apoptosis of dopaminergic neurons in the substantia nigra (sn). |
2022-07-06 |
2023-08-14 |
mouse |
| Amnon A Berger, Ariel Winnick, Jonathan Izygon, Binil M Jacob, Jessica S Kaye, Rachel J Kaye, Elisa E Neuchat, Adam M Kaye, Edward S Alpaugh, Elyse M Cornett, Andrew H Han, Alan D Kay. Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson's Disease "Off" Episodes. Health psychology research. vol 10. issue 3. 2022-07-01. PMID:35774903. |
the traditional pathogenesis theory of pd involves the loss of dopaminergic neurons in the substantia nigra (sn). |
2022-07-01 |
2023-08-14 |
Not clear |
| Thomas Musacchio, Jing Yin, Fabian Kremer, James B Koprich, Jonathan M Brotchie, Jens Volkmann, Chi Wang I. Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease. Behavioural brain research. 2022-06-23. PMID:35738338. |
a differential intraneuronal vulnerability of dopaminergic neurons within the substantia nigra (sn) has been suggested, starting as an axonopathy followed by neuronal cell loss that is accompanied with motor deficits. |
2022-06-23 |
2023-08-14 |
human |
| Thomas Musacchio, Jing Yin, Fabian Kremer, James B Koprich, Jonathan M Brotchie, Jens Volkmann, Chi Wang I. Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease. Behavioural brain research. 2022-06-23. PMID:35738338. |
we here aimed to analyze the time course of dopaminergic neurodegeneration in an aav pd rat model overexpressing human mutated a53t α-synuclein (hasyn), differentially correlate striatal terminal and sn perikarya loss with behavioral deficits and investigate if nucleo-cytoplasmic nrf2 and hdac1 expression are altered in dopaminergic perikarya of the hasyn pd rat model. |
2022-06-23 |
2023-08-14 |
human |
| Binlin Xu, Xiaoquan Wang, Zhengshuang Xu, Qinkai Li, Junmin Qua. N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson's disease. Neuroscience letters. 2022-06-23. PMID:35738458. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn), which is highly associated with oxidative stress. |
2022-06-23 |
2023-08-14 |
mouse |
| Isaac Deng, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson's Disease. Frontiers in bioscience (Scholar edition). vol 14. issue 2. 2022-06-22. PMID:35730438. |
the major hallmark of parkinson's disease (pd) is the degeneration of dopaminergic neurons in the substantia nigra (sn), which is responsible for the core motor symptoms of pd. |
2022-06-22 |
2023-08-14 |
mouse |
| Minghao Yan, Haibo Jin, Chun Pan, Hexing Hang, Dongmei Li, Xiaodong Ha. Movement Disorder and Neurotoxicity Induced by Chronic Exposure to Microcystin-LR in Mice. Molecular neurobiology. 2022-06-22. PMID:35732866. |
and 15 μg/l mc-lr also caused hypokinesia in mice and induced the loss and apoptosis of sn dopaminergic neurons (da neurons). |
2022-06-22 |
2023-08-14 |
mouse |
| Zhenhua Liu, Nannan Yang, Jie Dong, Wotu Tian, Lisa Chang, Jinghong Ma, Jifeng Guo, Jieqiong Tan, Ao Dong, Kaikai He, Jingheng Zhou, Resat Cinar, Junbing Wu, Armando G Salinas, Lixin Sun, Mantosh Kumar, Breanna T Sullivan, Braden B Oldham, Vanessa Pitz, Mary B Makarious, Jinhui Ding, Justin Kung, Chengsong Xie, Sarah L Hawes, Lupeng Wang, Tao Wang, Piu Chan, Zhuohua Zhang, Weidong Le, Shengdi Chen, David M Lovinger, Cornelis Blauwendraat, Andrew B Singleton, Guohong Cui, Yulong Li, Huaibin Cai, Beisha Tan. Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction. Nature communications. vol 13. issue 1. 2022-06-17. PMID:35715418. |
daglb is the main 2-ag synthase in human and mouse substantia nigra (sn) dopaminergic neurons (dans). |
2022-06-17 |
2023-08-14 |
mouse |