| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oeystein Roed Brekk, Jonathan R Honey, Seungil Lee, Penelope J Hallett, Ole Isacso. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 44. 2021-01-07. PMID:33060302. |
this study aimed to determine human pd sn neutral lipid content and distribution in dopaminergic neurons, astrocytes, and microglia relative to age-matched healthy subject controls. |
2021-01-07 |
2023-08-13 |
mouse |
| Oeystein Roed Brekk, Jonathan R Honey, Seungil Lee, Penelope J Hallett, Ole Isacso. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 44. 2021-01-07. PMID:33060302. |
histological localization of neutral lipids using a fluorescent probe (bodipy) revealed that dopaminergic neurons and midbrain microglia significantly accumulated intracellular lipids in pd sn, while adjacent astrocytes had a reduced lipid load overall. |
2021-01-07 |
2023-08-13 |
mouse |
| Qi-Wen Han, Yu-He Yuan, Nai-Hong Che. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31442553. |
parkinson's disease (pd) is a neurodegenerative disease and its characteristic is the progressive degeneration of dopaminergic neurons within the substantia nigra (sn) of the midbrain. |
2021-01-04 |
2023-08-13 |
Not clear |
| Yu Tian, Yuwen Cao, Rong Chen, Yufeng Jing, Lin Xia, Shiqing Zhang, Huaxi Xu, Zhaoliang S. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson's disease model. Clinical science (London, England : 1979). vol 134. issue 15. 2020-12-29. PMID:32706028. |
in the subacute parkinson's disease (pd) mice model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), injection of hmgb1 competitive inhibitor protein hmgb1 a box and the ethyl pyruvate (ep) that inhibit the release of hmgb1 from cells restored the number of dopaminergic neurons and th+ fibers in the sn and striatum. |
2020-12-29 |
2023-08-13 |
mouse |
| Jiangnan Ma, Jinzhao Gao, Mengyue Niu, Xiaona Zhang, Jing Wang, Anmu Xi. P2X4R Overexpression Upregulates Interleukin-6 and Exacerbates 6-OHDA-Induced Dopaminergic Degeneration in a Rat Model of PD. Frontiers in aging neuroscience. vol 12. 2020-12-18. PMID:33328961. |
and p2x4r overexpression could upregulate the expression of il-6, reduce the amount of dopaminergic (da) neurons in the sn of pd rats, suggesting that p2x4r may mediate the production of il-6 to damage da neurons in the sn. |
2020-12-18 |
2023-08-13 |
rat |
| E V Novosadova, V V Nenasheva, I V Makarova, O V Dolotov, L S Inozemtseva, E L Arsenyeva, S V Chernyshenko, R I Sultanov, S N Illarioshkin, I A Grivennikov, V Z Tarantu. Parkinson's Disease-Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-12-04. PMID:31820346. |
parkinson's disease (pd) is a neurodegenerative pathology resulting from the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2020-12-04 |
2023-08-13 |
human |
| Carmen Diaz-Ruiz, Begoña Villar-Cheda, Antonio Dominguez-Meijide, Pablo Garrido-Gil, Maria J Guerra, Jose L Labandeira-Garci. Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 3. 2020-11-20. PMID:30412227. |
treatment with the specific sirt3 inhibitor agk7 induced overexpression of at1 and at2 in substantia nigra (sn) of rats, and in dopaminergic neuronal mes23.5 and microglial n9 cell lines. |
2020-11-20 |
2023-08-13 |
mouse |
| Benedetta Conio, Matteo Martino, Paola Magioncalda, Andrea Escelsior, Matilde Inglese, Mario Amore, Georg Northof. Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders. Molecular psychiatry. vol 25. issue 1. 2020-11-17. PMID:30953003. |
in particular, the dopaminergic substantia nigra (snc)-related nigrostriatal pathway is structurally and functionally connected with core regions of the smn, whereas the ventral tegmental area (vta)-related mesocorticolimbic pathway with core regions of the sn. |
2020-11-17 |
2023-08-13 |
Not clear |
| b' Slobodan Kapor, Milan Aksi\\xc4\\x87, Laslo Pu\\xc5\\xa1ka\\xc5\\xa1, Marin Juki\\xc4\\x87, Joko Poleksi\\xc4\\x87, Filip Milosavljevi\\xc4\\x87, Suncica Bjelica, Branislav Filipovi\\xc4\\x8. Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats. Frontiers in neuroanatomy. vol 14. 2020-11-17. PMID:33192342.' |
the volume of dopaminergic nuclei and the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta) were analyzed in three representative coordinates. |
2020-11-17 |
2023-08-13 |
rat |
| Paulina Troncoso-Escudero, Denisse Sepulveda, Rodrigo Pérez-Arancibia, Alejandra V Parra, Javiera Arcos, Felipe Grunenwald, Rene L Vida. On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101007. |
these symptoms are due to the loss principally of dopaminergic neurons of the substantia nigra (sn) par compacta and the gabaergic neurons of the striatum in pd and hd, respectively. |
2020-10-28 |
2023-08-13 |
Not clear |
| Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalep. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Scientific reports. vol 9. issue 1. 2020-10-05. PMID:30918302. |
postmortem studies of brains from pd patients have revealed the degeneration of noradrenergic neurons in the locus coeruleus (lc) to the same or even greater extent than that observed in the dopaminergic neurons of substantia nigra (sn) and ventral tegmental area (vta). |
2020-10-05 |
2023-08-13 |
mouse |
| Sarah K Peters, Katharine Dunlop, Jonathan Downa. Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment. Frontiers in systems neuroscience. vol 10. 2020-10-01. PMID:28082874. |
in addition to cortical nodes of the sn, the network's associated subcortical structures, including the dorsal striatum, mediodorsal thalamus and dopaminergic brainstem nuclei, comprise a discrete regulatory loop circuit. |
2020-10-01 |
2023-08-13 |
Not clear |
| Evgeny A Budygin, Erik B Oleson, Yun Beom Lee, Lawrence C Blume, Michael J Bruno, Allyn C Howlett, Alexis C Thompson, Caroline E Bas. Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Frontiers in behavioral neuroscience. vol 10. 2020-10-01. PMID:28154530. |
the present study takes a different approach using rna interference (rnai) to knockdown the expression of the d2 receptors (d2r) in the substantia nigra (sn), including dopaminergic neurons, which project primarily to the dorsal striatum (dstr) in adult rats. |
2020-10-01 |
2023-08-13 |
mouse |
| Yunseon Jang, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Ilhwan Ryu, Xianshu Ju, Min Jeong Ryu, Woosuk Chung, Eungseok Oh, Gi Ryang Kweon, Jun Young He. A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities. Experimental neurobiology. vol 26. issue 2. 2020-10-01. PMID:28442947. |
a dopaminergic neuronal pathway from the substantia nigra (sn) to the striatum is responsible for regulating grip strength and motor initiation through tyrosine hydroxylase (th) activity-dependent dopamine release. |
2020-10-01 |
2023-08-13 |
mouse |
| Shuifen Ye, Ho Kee Koon, Wen Fan, Yihui Xu, Wei Wei, Chuanshan Xu, Jing Ca. Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP Parkinson's disease. vol 2017. 2020-10-01. PMID:28607800. |
effect of a traditional chinese herbal medicine formulation on cell survival and apoptosis of mpp progressive degeneration of dopaminergic neurons in the substantia nigra (sn) is implicated in parkinson's disease (pd). |
2020-10-01 |
2023-08-13 |
Not clear |
| Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storc. Early Postnatal but Not Late Adult Neurogenesis Is Impaired in the Pitx3-Mutant Animal Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28883785. |
as dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (sn) in pd may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (svz) and dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
mouse |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
after the last pole test, dopaminergic neuronal survival in the striatum and the substantia nigra (sn), cell proliferation in the svz and mrna expression of neurotrophic factors and dopamine receptors in the striatum were evaluated. |
2020-10-01 |
2023-08-13 |
mouse |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
krg administration suppressed dopaminergic neuronal death induced by mptp in the striatum as well as the sn, augmented the number of brdu- and brdu/doublecortin (dcx)-positive cells in the svz and enhanced the expression of proliferation cell nuclear antigen, brain derived neurotrophic factor (bdnf), glial cell derived neurotrophic factor (gdnf), cerebral dopamine neurotrophic factor (cdnf), ciliary neurotrophic factor (cntf), dopamine receptor d3 (drd3) and d5 mrnas. |
2020-10-01 |
2023-08-13 |
mouse |
| Yan-Li Yang, Xue-Rui Ran, Yong Li, Li Zhou, Li-Fei Zheng, Yu Han, Qing-Qing Cai, Zhi-Yong Wang, Jin-Xia Zh. Expression of Dopamine Receptors in the Lateral Hypothalamic Nucleus and Their Potential Regulation of Gastric Motility in Rats With Lesions of Bilateral Substantia Nigra. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30923496. |
in the present study, using a double-labeling immunofluorescence technique combined with confocal microscopy, we significantly extend our understanding of the sn-lh-dmv pathway by showing that (1) a considerable quantity of dopamine receptor 1 and 2 (d1 and d2) was expressed in the lh as well as the ox1r was expressed in the dmv; (2) nearly all of the d1-immuoreactve (ir) neurons were also oxa-positive while only a few neurons express both d2 and oxa in the lh, and the dr-positive neurons were surrounded by the dopaminergic neural fibers; in the dmv, ox1r were colocalized with choline acetyltransferase (chat)-labeled motor neurons; (3) when the gastroparesis was induced by the destruction of dopaminergic neurons in the sn, the decreased expression of d1 and oxa was observed in the lh as well as the reduced ox1r and chat expression in the dmv. |
2020-10-01 |
2023-08-13 |
rat |
| Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Ca. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson's disease. vol 2019. 2020-10-01. PMID:30944722. |
th immunostaining was performed to evaluate rotenone-induced neurotoxicity on substantia nigra (sn) dopaminergic neurons and the da terminals in the striatum. |
2020-10-01 |
2023-08-13 |
rat |