| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maibam R Singh, Jozsef Vigh, Gregory C Amber. Angiotensin-II Modulates GABAergic Neurotransmission in the Mouse Substantia Nigra. eNeuro. vol 8. issue 2. 2021-07-02. PMID:33771900. |
given the complex relationship between sn dopaminergic and gabaergic neurons, we hypothesized that ang-ii could regulate snc dopaminergic neuronal activity directly and indirectly by modulating snr gabaergic neurotransmission. |
2021-07-02 |
2023-08-13 |
mouse |
| Elinor Tzvi, Richard Bey, Matthias Nitschke, Norbert Brüggemann, Joseph Classen, Thomas F Münte, Ulrike M Krämer, Jost-Julian Rump. Motor Sequence Learning Deficits in Idiopathic Parkinson's Disease Are Associated With Increased Substantia Nigra Activity. Frontiers in aging neuroscience. vol 13. 2021-07-02. PMID:34194317. |
as increased sn activity was also associated (on trend) with higher doses of dopaminergic medication as well as disease duration, the results suggest that learning deficits in pd are associated with disease progression, indexing an increased drive to recruit dopaminergic neurons in the sn, however, unsuccessfully. |
2021-07-02 |
2023-08-13 |
human |
| Sara R Oliveira, Pedro A Dionísio, Maria M Gaspar, Maria B T Ferreira, Catarina A B Rodrigues, Rita G Pereira, Mónica S Estevão, Maria J Perry, Rui Moreira, Carlos A M Afonso, Joana D Amaral, Cecília M P Rodrigue. Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice. International journal of molecular sciences. vol 22. issue 10. 2021-06-23. PMID:34069782. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (sn). |
2021-06-23 |
2023-08-13 |
mouse |
| Sara R Oliveira, Pedro A Dionísio, Maria M Gaspar, Maria B T Ferreira, Catarina A B Rodrigues, Rita G Pereira, Mónica S Estevão, Maria J Perry, Rui Moreira, Carlos A M Afonso, Joana D Amaral, Cecília M P Rodrigue. Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice. International journal of molecular sciences. vol 22. issue 10. 2021-06-23. PMID:34069782. |
more importantly, mice exposed to mptp and further treated with oxa12 showed protection against mptp-induced dopaminergic neuronal loss in the sn and striatum. |
2021-06-23 |
2023-08-13 |
mouse |
| Vandana Zaman, Donald C Shields, Ramsha Shams, Kelsey P Drasites, Denise Matzelle, Azizul Haque, Narendra L Bani. Cellular and molecular pathophysiology in the progression of Parkinson's disease. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33599945. |
parkinson's disease (pd) is a neurodegenerative disorder etiologically linked to the loss of substantia nigra (sn) dopaminergic neurons in the mid-brain. |
2021-06-22 |
2023-08-13 |
human |
| Elena Ferrari, Antonella Cardinale, Barbara Picconi, Fabrizio Gardon. From cell lines to pluripotent stem cells for modelling Parkinson's Disease. Journal of neuroscience methods. vol 340. 2021-06-21. PMID:32311374. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by loss of dopaminergic (daergic) neurons in the substantia nigra (sn) that contributes to the main motor symptoms of the disease. |
2021-06-21 |
2023-08-13 |
mouse |
| Danielle Walu Kasongo, Gioacchino de Leo, Nunzio Vicario, Giampiero Leanza, Giuseppe Legnam. Chronic α-Synuclein Accumulation in Rat Hippocampus Induces Lewy Bodies Formation and Specific Cognitive Impairments. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393581. |
no pathologic α-syn deposits were found within the substantia nigra (sn), the ventral tegmental area (vta), or the striatum, nor was any loss of dopaminergic, noradrenergic, or cholinergic neurons detected in α-syn-injected animals, compared with controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao, Yan-Zhong Chan. Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33248265. |
in contrast to the predicted neuroprotective role of nrf2 in oxidative stress-related diseases, we found that nrf2 ko remarkably improved the motor coordination of aged mice, which was associated with the reduced ros level and decreased apoptosis of dopaminergic neurons in substantia nigra (sn) of 18-month-old nrf2 ko mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Hyongjun Jeon, Chang-Hwan Bae, Yukyoung Lee, Hee-Young Kim, Seungtae Ki. Korean red ginseng suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced inflammation in the substantia nigra and colon. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33662500. |
parkinson's disease (pd) is a neurodegenerative disease involving dopaminergic neuronal death in the substantia nigra (sn); recent studies have shown that interactions between gut and brain play a critical role in the pathogenesis of pd. |
2021-05-28 |
2023-08-13 |
mouse |
| Hyongjun Jeon, Chang-Hwan Bae, Yukyoung Lee, Hee-Young Kim, Seungtae Ki. Korean red ginseng suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced inflammation in the substantia nigra and colon. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33662500. |
these findings suggest that krg prevents mptp-induced dopaminergic neuronal death, activation of microglia and astrocytes, and accumulation of α-synuclein in the sn, and the regulation of inflammation-related factors in the colon may influence the effect. |
2021-05-28 |
2023-08-13 |
mouse |
| Julian Rössler, Wulf Rössler, Erich Seifritz, Lui Unterrassner, Thomas Wyss, Helene Haker, Diana Wotrub. Dopamine-Induced Dysconnectivity Between Salience Network and Auditory Cortex in Subjects With Psychotic-like Experiences: A Randomized Double-Blind Placebo-Controlled Study. Schizophrenia bulletin. vol 46. issue 3. 2021-05-14. PMID:31751466. |
however, dopaminergic influence on the sn and its presumed influence on psychotic and subpsychotic symptoms or psychotic-like experiences in healthy individuals remain unclear. |
2021-05-14 |
2023-08-13 |
human |
| Li Liu, Mingchao Li, Mingze Xu, Zhen Wang, Zhi Zeng, Yunqing Li, Yi Zhang, Rong You, Chu-Hua Li, Yan-Qing Gua. Actively targeted gold nanoparticle composites improve behavior and cognitive impairment in Parkinson's disease mice. Materials science & engineering. C, Materials for biological applications. vol 114. 2021-05-14. PMID:32994016. |
parkinson's disease (pd) is characterized by motor and non-motor symptoms, primarily affecting dopaminergic neurons (daergic neurons) in substantia nigra (sn). |
2021-05-14 |
2023-08-13 |
mouse |
| Mustafa Makav, Hüseyin Avni Eroğl. Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats. Environmental science and pollution research international. vol 28. issue 17. 2021-05-12. PMID:33410082. |
parkinson's disease (pd) is described as the loss of dopaminergic neurons located in the substantia nigra (sn) region of the brain and a progressive motor failure. |
2021-05-12 |
2023-08-13 |
rat |
| Min Kyung Song, Joo Hee Lee, Jinil Kim, Ji Hyun Kim, Soonhye Hwang, Yoon-Seong Kim, Youn-Jung Ki. Neuroprotective effect of NXP031 in the MPTP-induced Parkinson's disease model. Neuroscience letters. vol 740. 2021-05-07. PMID:33075422. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2021-05-07 |
2023-08-13 |
mouse |
| Min Kyung Song, Joo Hee Lee, Jinil Kim, Ji Hyun Kim, Soonhye Hwang, Yoon-Seong Kim, Youn-Jung Ki. Neuroprotective effect of NXP031 in the MPTP-induced Parkinson's disease model. Neuroscience letters. vol 740. 2021-05-07. PMID:33075422. |
we observed that the administration of nxp031 ameliorated mptp-induced loss of dopaminergic neurons in the sn and exhibited improvement of mptp-mediated motor impairment. |
2021-05-07 |
2023-08-13 |
mouse |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33911050. |
these pathological and inflammatory changes, including microglial activation and dopaminergic cell loss in the substantia nigra (sn) area were reversed by papaverine (pap) administration. |
2021-05-07 |
2023-08-13 |
mouse |
| Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang, Degui Wan. Protective effect of thioredoxin reductase 1 in Parkinson's disease. Neuroscience letters. vol 741. 2021-05-04. PMID:33171211. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-05-04 |
2023-08-13 |
mouse |
| Mark F McCarty, Aaron Lerne. Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin. Advances in nutrition (Bethesda, Md.). vol 12. issue 2. 2021-05-03. PMID:32945884. |
mitochondrial dysfunction in dopaminergic neurons of the substantia nigra (sn) appears to be a key mediating feature of parkinson's disease (pd), a complex neurodegenerative disorder of still unknown etiology. |
2021-05-03 |
2023-08-13 |
Not clear |
| Ricardo Leitão, Carla Guerreiro, Rita G Nunes, Nilza Gonçalves, Giulia Galati, Madalena Rosário, Leonor Correia Guedes, Joaquim J Ferreira, Sofia Reimã. Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in Huntington's Disease. Journal of Huntington's disease. vol 9. issue 2. 2021-04-27. PMID:32065802. |
neuromelanin (nm)-sensitive magnetic resonance imaging (nm-mri) is an innovative technique that was recently developed allowing the in vivo study of pathological changes in the dopaminergic neurons of the sn. |
2021-04-27 |
2023-08-13 |
Not clear |
| Yingchuan Chen, Guanyu Zhu, Defeng Liu, Xin Zhang, Yuye Liu, Tianshuo Yuan, Tingting Du, Jianguo Zhan. Subthalamic nucleus deep brain stimulation suppresses neuroinflammation by Fractalkine pathway in Parkinson's disease rat model. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32726685. |
we found that motor deficits were alleviated by stn-dbs, with increased survival of dopaminergic neurons in the substantia nigra (sn). |
2021-04-27 |
2023-08-13 |
rat |