| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH. vol 65. issue s1. 2021-09-23. PMID:34468106. |
it was shown that dopaminergic neurons in sn pars compacta differ in the amount of neuromelanin and the intensity of th-immunoreactivity. |
2021-09-23 |
2023-08-13 |
human |
| Taewoo Kim, Jeha Jeon, Jin-Sun Park, Yeongwon Park, Jooeui Kim, Haneul Noh, Hee-Sun Kim, Hyemyung Se. Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice. Biomolecules & therapeutics. vol 29. issue 5. 2021-09-14. PMID:34045367. |
parkinson's disease (pd) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-09-14 |
2023-08-13 |
mouse |
| Maike Hartlage-Rübsamen, Alexandra Bluhm, Sandra Moceri, Lisa Machner, Janett Köppen, Mathias Schenk, Isabel Hilbrich, Max Holzer, Martin Weidenfeller, Franziska Richter, Roland Coras, Geidy E Serrano, Thomas G Beach, Stephan Schilling, Stephan von Hörsten, Wei Xiang, Anja Schulze, Steffen Roßne. A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies. Acta neuropathologica. vol 142. issue 3. 2021-09-09. PMID:34309760. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that is neuropathologically characterized by degeneration of dopaminergic neurons of the substantia nigra (sn) and formation of lewy bodies and lewy neurites composed of aggregated α-synuclein. |
2021-09-09 |
2023-08-13 |
mouse |
| Maike Hartlage-Rübsamen, Alexandra Bluhm, Sandra Moceri, Lisa Machner, Janett Köppen, Mathias Schenk, Isabel Hilbrich, Max Holzer, Martin Weidenfeller, Franziska Richter, Roland Coras, Geidy E Serrano, Thomas G Beach, Stephan Schilling, Stephan von Hörsten, Wei Xiang, Anja Schulze, Steffen Roßne. A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies. Acta neuropathologica. vol 142. issue 3. 2021-09-09. PMID:34309760. |
in brains of wild-type mice, qc and α-synuclein were co-expressed by dopaminergic sn neurons. |
2021-09-09 |
2023-08-13 |
mouse |
| Vaibhavi Peshattiwar, Suraj Muke, Aakruti Kaikini, Sneha Bagle, Vikas Dighe, Sadhana Sathay. Mechanistic evaluation of Ursolic acid against rotenone induced Parkinson's disease- emphasizing the role of mitochondrial biogenesis. Brain research bulletin. vol 160. 2021-08-31. PMID:32147532. |
it is caused due to degeneration of dopaminergic neurons in substantia nigra (sn). |
2021-08-31 |
2023-08-13 |
rat |
| Linlin Zhang, Yanan Zheng, Junxia Xie, Limin Sh. Potassium channels and their emerging role in parkinson's disease. Brain research bulletin. vol 160. 2021-08-31. PMID:32305406. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, which is associated with a selective loss of dopaminergic neurons in the substantia nigra (sn) and a reduction of dopamine in the striatum. |
2021-08-31 |
2023-08-13 |
Not clear |
| Rasem Mustafa, Chahinaz Rawas, Nadja Mannal, Grzegorz Kreiner, Björn Spittau, Katarzyna Kamińska, Rüstem Yilmaz, Christina Pötschke, Joachim Kirsch, Birgit Liss, Kerry L Tucker, Rosanna Parlat. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants (Basel, Switzerland). vol 10. issue 8. 2021-08-30. PMID:34439532. |
here, we report that pc are required for maintenance of substantia nigra (sn) dopaminergic (da) neurons highly vulnerable in parkinson's disease (pd). |
2021-08-30 |
2023-08-13 |
mouse |
| Guoxue Zhu, Wang Wang, Chang Chen, Lili Tang, Yan Liang, Zhennian Zhang, Yan Lu, Yang Zha. UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson's disease mice after oral administration of Wen-Shen-Yang-Gan decoction. Aging. vol 13. issue 15. 2021-08-28. PMID:34339394. |
parkinson's disease (pd), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2021-08-28 |
2023-08-13 |
mouse |
| Blake L Elliott, Kimberlee D'Ardenne, Prerona Mukherjee, Julie B Schweitzer, Samuel M McClur. Limbic and Executive Meso- and Nigrostriatal Tracts Predict Impulsivity Differences in Attention-Deficit/Hyperactivity Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-08-26. PMID:34051394. |
we tested whether human midbrain pathways (where dopaminergic cell bodies originate) between the substantia nigra (sn) and ventral tegmental area (vta) and the striatum differed between participants with adhd and typically developing adolescent and young adult participants. |
2021-08-26 |
2023-08-13 |
human |
| Tz-Yun Jan, Lee-Chin Wong, Ming-Tao Yang, Chien-Feng Judith Huang, Chia-Jui Hsu, Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Le. Correlation of dystonia severity and iron accumulation in Rett syndrome. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33436916. |
the dystonia scales were correlated with the average contrast ratio of sn, putamen and gp, indicating iron accumulation in dopaminergic system and related grey matter. |
2021-08-25 |
2023-08-13 |
human |
| Osman Sinen, Ayşe Özkan, Aysel Ağar, Mehmet Bülbü. Neuropeptide-S prevents 6-OHDA-induced gastric dysmotility in rats. Brain research. vol 1762. 2021-08-11. PMID:33753063. |
chronic nps treatment reversed 6-ohda-induced impairment of the motor performance, and ge, while preventing the loss of dopaminergic and cholinergic neurons in sn and dmv, respectively. |
2021-08-11 |
2023-08-13 |
rat |
| Xiaoyi Xu, Xin He, Shanshan Ma, Mingtao Li, Qiaoying Huan. Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model. Neuroscience letters. vol 759. 2021-08-06. PMID:34119603. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-08-06 |
2023-08-13 |
mouse |
| Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zen. Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33261640. |
subsequently, dab staining analysis of substantia nigra (sn) dopaminergic neurons with the marker for tyrosine hydroxylase (th) was performed. |
2021-08-05 |
2023-08-13 |
mouse |
| Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang, Degui Wan. Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33230666. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-07-28 |
2023-08-13 |
mouse |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (sn) in the midbrain due to loss of dopaminergic neurons. |
2021-07-26 |
2023-08-13 |
rat |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
the findings from this study revealed that supplementation of α- and γ-t3 was able to ameliorate the motor deficits induced by 6-ohda and improve the neuronal functions by reducing inflammation, reversing the neuronal degradation, and preventing further reduction of dopaminergic neurons in the sn and striatum (str) fibre density. |
2021-07-26 |
2023-08-13 |
rat |
| Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garrau. Parkinson's disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI. NPJ Parkinson's disease. vol 7. issue 1. 2021-07-24. PMID:34238927. |
parkinson's disease (pd) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (nm)-containing dopaminergic neurons and deposition of iron in the substantia nigra (sn). |
2021-07-24 |
2023-08-13 |
Not clear |
| Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Cho. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson's Disease. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-20. PMID:34206041. |
parkinson's disease (pd) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (sn) mediated via oxidative stress. |
2021-07-20 |
2023-08-13 |
Not clear |
| Su Bin Cho, Won Sik Eum, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Duk-Soo Kim, Dae Won Kim, Soo Young Cho. Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416093. |
immunohistochemical analysis revealed that when tat‑ar protein was transduced into the substantia nigra (sn) of mice with pd, it markedly inhibited dopaminergic neuronal cell death. |
2021-07-12 |
2023-08-13 |
mouse |
| Yasuhiro Nakata, Atsuko Sakamoto, Akihiro Kawat. Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease. Neuroradiology. vol 62. issue 11. 2021-07-07. PMID:32556403. |
pathological studies revealed less melanin-containing dopaminergic neurons in the substantia nigra (sn) pars compacta in mjd/sca3 patients. |
2021-07-07 |
2023-08-13 |
Not clear |