| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazumasa Wakamatsu, Kenta Nakao, Hitomi Tanaka, Yuki Kitahori, Yui Tanaka, Makoto Ojika, Shosuke It. The Oxidative Pathway to Dopamine-Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson's Disease. International journal of molecular sciences. vol 20. issue 10. 2019-11-14. PMID:31130632. |
neuromelanin (nm) is a dark brown pigment found in dopaminergic neurons of the substantia nigra (sn) and in norepinephrinergic neurons of the locus coeruleus (lc). |
2019-11-14 |
2023-08-13 |
Not clear |
| Courtney K Walker, Joy K Roche, Vidushi Sinha, Rosalinda C Robert. Substantia nigra ultrastructural pathology in schizophrenia. Schizophrenia research. vol 197. 2019-11-08. PMID:29274737. |
dopamine is thought to play a role in schizophrenia pathology, yet the substantia nigra (sn), the origin of dopaminergic pathways, has not been studied extensively in schizophrenia. |
2019-11-08 |
2023-08-13 |
human |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczn. Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30295916. |
prolonged impairment of astrocytic functions could increase the vulnerability of dopaminergic neurons in the substantia nigra (sn), accelerate their degeneration and affect ability to compensate for partial degeneration at the presymptomatic stages of the disease. |
2019-10-28 |
2023-08-13 |
Not clear |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczn. Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30295916. |
the aim of this study was to investigate the astrocyte depletion in the sn, its impact on the dopaminergic system functioning and multiple markers of energy metabolism during the early stages of neurodegeneration and compensation. |
2019-10-28 |
2023-08-13 |
Not clear |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczn. Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30295916. |
we induced death of 30% of astrocytes by chronic infusion of fluorocitrate (fc) into the sn, simultaneously activating microglia response but sparing the dopaminergic neurons. |
2019-10-28 |
2023-08-13 |
Not clear |
| Xiang-Xing Zhu, Yi-Zhi Zhong, Yao-Wen Ge, Ke-Huan Lu, Sheng-Sheng L. CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127453. |
parkinson's disease (pd) is a common, progressive neurodegenerative disorder characterized by classical motor dysfunction and is associated with α-synuclein-immunopositive pathology and the loss of dopaminergic neurons in the substantia nigra (sn). |
2019-10-24 |
2023-08-13 |
Not clear |
| Xiang-Xing Zhu, Yi-Zhi Zhong, Yao-Wen Ge, Ke-Huan Lu, Sheng-Sheng L. CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127453. |
however, immunohistochemical analysis was not able to detect pd-specific pathological changes such as α-synuclein-immunopositive pathology and loss of sn dopaminergic neurons in the gene-edited minipigs at 3 months of age. |
2019-10-24 |
2023-08-13 |
Not clear |
| Sujung Yeo, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model. The American journal of Chinese medicine. vol 47. issue 3. 2019-10-17. PMID:30966771. |
parkinson's disease (pd), a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2019-10-17 |
2023-08-13 |
mouse |
| Bingxu Huang, Juxiong Liu, Tianyu Meng, Yuhang Li, Dewei He, Xin Ran, Guangxin Chen, Wenjin Guo, Xingchi Kan, Shoupeng Fu, Wei Wang, Dianfeng Li. Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis. Frontiers in immunology. vol 9. 2019-09-26. PMID:30455692. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra (sn). |
2019-09-26 |
2023-08-13 |
rat |
| Thea Pinholt Lillethorup, Andreas Nørgaard Glud, Natalie Landeck, Aage Kristian Olsen Alstrup, Steen Jakobsen, Kim Vang, Doris J Doudet, David J Brooks, Deniz Kirik, Rainer Hinz, Jens Christian Sørensen, Anne M Landa. In vivo quantification of glial activation in minipigs overexpressing human α-synuclein. Synapse (New York, N.Y.). vol 72. issue 12. 2019-09-10. PMID:30009467. |
parkinson's disease is characterized by a progressive loss of substantia nigra (sn) dopaminergic neurons and the formation of lewy bodies containing accumulated alpha-synuclein (α-syn). |
2019-09-10 |
2023-08-13 |
human |
| Juciano Gasparotto, Camila Tiefensee Ribeiro, Helen Tais da Rosa-Silva, Rafael Calixto Bortolin, Thallita Kelly Rabelo, Daniel Oppermann Peixoto, José Claudio Fonseca Moreira, Daniel Pens Gelai. Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30094805. |
immunofluorescence analysis in sn confirmed that rage expression was mainly co-localized in endothelial cells (rage/pecam-1 co-staining) in untreated animals, while lps-treated animals had rage expression predominantly in dopaminergic neurons (rage/th co-staining). |
2019-08-20 |
2023-08-13 |
rat |
| Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research. vol 83. issue 6. 2019-08-12. PMID:29741516. |
the effect of propofol and isoflurane on the dopaminergic neurotransmitter phenotype in the substantia nigra (sn) was studied using tyrosine hydroxylase immunohistochemistry. |
2019-08-12 |
2023-08-13 |
Not clear |
| Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research. vol 83. issue 6. 2019-08-12. PMID:29741516. |
propofol could potentially protect the dopaminergic neurotransmitter phenotype within the sn at the cost of a widespread increase in tau phosphorylation. |
2019-08-12 |
2023-08-13 |
Not clear |
| Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook O. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice. Journal of the neurological sciences. vol 392. 2019-07-18. PMID:30031172. |
parkinson's disease (pd) is a progressive neurodegenerative disorder accompanied by movement deficits with selective degeneration of dopaminergic neurons in the substantia nigra (sn). |
2019-07-18 |
2023-08-13 |
mouse |
| Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook O. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice. Journal of the neurological sciences. vol 392. 2019-07-18. PMID:30031172. |
we also found the reduction of dopaminergic neuronal cell numbers in the sn and striatal dopamine transporter levels starting from the asymptomatic stage. |
2019-07-18 |
2023-08-13 |
mouse |
| Cong Zhang, Liyan Hou, Jie Yang, Yuning Che, Fuqiang Sun, Huihua Li, Qingshan Wan. 2,5-Hexanedione induces dopaminergic neurodegeneration through integrin α Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352205. |
2,5-hexanedione induces dopaminergic neurodegeneration through integrin α recent study demonstrated that chronic exposure to solvents increases the risk of parkinson's disease (pd), the second most common neurodegenerative disorder characterized by progressive dopaminergic neurodegeneration in the substantia nigra (sn). |
2019-06-10 |
2023-08-13 |
rat |
| José Vicente Lafuente, Catalina Requejo, Luisa Uged. Nanodelivery of therapeutic agents in Parkinson's disease. Progress in brain research. vol 245. 2019-06-05. PMID:30961870. |
however, motor signs are detectable when the loss of dopaminergic striatal terminals exceeds to the dopaminergic neuronal degeneration in sn. |
2019-06-05 |
2023-08-13 |
Not clear |
| Ying Chen, Qianhang Shao, Yu-He Yuan, Nai-Hong Che. Prion-like propagation of α-synuclein in the gut-brain axis. Brain research bulletin. vol 140. 2019-05-30. PMID:29894766. |
the progression of pd includes the degenerative loss of dopaminergic (da) neurons and aggregation of α-synuclein in the substantia nigra (sn). |
2019-05-30 |
2023-08-13 |
Not clear |
| Wei-Zhong Zhao, Hsiang-Tsui Wang, Hui-Ju Huang, Yu-Li Lo, Anya Maan-Yuh Li. Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28866823. |
in the present study, the neuroprotective effect of baicalein (a phenolic flavonoid in the dried root of scutellaria baicalensis georgi) on acrolein-induced neurodegeneration of nigrostriatal dopaminergic system was investigated using local infusion of acrolein in the substantia nigra (sn) of rat brain. |
2019-05-08 |
2023-08-13 |
rat |
| Eric Wildon Kostuk, Jingli Cai, Lorraine Iacovitt. Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-15. PMID:29751760. |
parkinson's disease (pd) is characterized by selective degeneration of dopaminergic (da) neurons of the substantia nigra pars compacta (sn) while neighboring ventral tegmental area (vta) da neurons are relatively spared. |
2019-04-15 |
2023-08-13 |
Not clear |