| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanna A Korecka, Elizabeth B Moloney, Ruben Eggers, Barbara Hobo, Sanny Scheffer, Nienke Ras-Verloop, R Jeroen Pasterkamp, Dick F Swaab, August B Smit, Ronald E van Kesteren, Koen Bossers, Joost Verhaage. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 39. 2017-10-10. PMID:28842419. |
in line with this, rgma induced selective degeneration of dopaminergic neurons in the substantia nigra (sn) and affected the integrity of the nigrostriatal system. |
2017-10-10 |
2023-08-13 |
mouse |
| Shida Zhou, Xinxing Du, Junxia Xie, Jun Wan. Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. PloS one. vol 12. issue 7. 2017-10-06. PMID:28672025. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and subsequent da depletion in the striatum. |
2017-10-06 |
2023-08-13 |
Not clear |
| Ana Tereza Di Lorenzo Alho, Claudia Kimie Suemoto, Lívia Polichiso, Edilaine Tampellini, Kátia Cristina de Oliveira, Mariana Molina, Glaucia Aparecida Bento Santos, Camila Nascimento, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferreti-Rebustini, Alexandre Valotta da Silva, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Helmut Heinsen, Lea Tenenholz Grinber. Three-dimensional and stereological characterization of the human substantia nigra during aging. Brain structure & function. vol 221. issue 7. 2017-09-29. PMID:26386691. |
the substantia nigra (sn), the source of major dopaminergic pathways in the brain, is particularly vulnerable to changes in the progression of several age-related neurodegenerative diseases. |
2017-09-29 |
2023-08-13 |
human |
| Konstantinos Botsakis, Theodora Mourtzi, Vasiliki Panagiotakopoulou, Malamati Vreka, Georgios T Stathopoulos, Iosif Pediaditakis, Ioannis Charalampopoulos, Achilleas Gravanis, Foteini Delis, Katerina Antoniou, Dimitrios Zisimopoulos, Christos D Georgiou, Nikolaos T Panagopoulos, Nikolaos Matsokis, Fevronia Angelato. BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor. Neuropharmacology. vol 121. 2017-09-05. PMID:28461162. |
using the "weaver" mouse, a genetic model of pd, which exhibits progressive dopaminergic neurodegeneration in the substantia nigra (sn), we have shown that long-term administration (p1-p21) of bnn-20 almost fully protected the dopaminergic neurons and their terminals, via i) a strong anti-apoptotic effect, probably mediated through the tropomyosin receptor kinase b (trkb) neurotrophin receptor's pi3k-akt-nf-κb signaling pathway, ii) by exerting an efficient antioxidant effect, iii) by inducing significant anti-inflammatory activity and iv) by restoring brain-derived neurotrophic factor (bdnf) levels. |
2017-09-05 |
2023-08-13 |
mouse |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
altered antioxidant homeostasis and mitochondrial functions are the key mechanisms in loss of dopaminergic neurons in the substantia nigra (sn) region of the midbrain in pd. |
2017-08-25 |
2023-08-13 |
mouse |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
moreover, in the mptp model of pd, hypercholesterolemia exacerbated mptp-induced reduction of striatal dopamine as well as dopaminergic neurons in sn with motor behavioral depreciation. |
2017-08-25 |
2023-08-13 |
mouse |
| Ajit Ray, Maltesh Kambali, Vijayalakshmi Ravindranat. Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease. Antioxidants & redox signaling. vol 25. issue 5. 2017-08-10. PMID:27121974. |
a single unilateral administration of the thiol oxidant, diamide (1.45 μmol) into substantia nigra (sn) of mice leads to locomotor deficits and degeneration of dopaminergic (da) neurons in sn pars compacta (snpc). |
2017-08-10 |
2023-08-13 |
mouse |
| Jiawen Yuan, Jinpeng Ren, Ying Wang, Xiao He, Yuwu Zha. Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease. PloS one. vol 11. issue 9. 2017-08-08. PMID:27632381. |
parkinson's disease (pd) is characterized by the progressive degeneration of the dopaminergic neurons in the substantia nigra (sn) region. |
2017-08-08 |
2023-08-13 |
rat |
| Seyedeh Shohreh Ebrahimi, Shahrbanoo Oryan, Esmael Izadpanah, Kambiz Hassanzade. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicology letters. vol 276. 2017-08-08. PMID:28526446. |
dopamine levels of dopaminergic areas in the substantia nigra (sn) and striatum (st) measured using high-performance liquid chromatography. |
2017-08-08 |
2023-08-13 |
rat |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
thus, the objective of this study was to evaluate (1) the validity of mre to detect viscoelastic changes in small and specific brain regions: the substantia nigra (sn), midbrain and hippocampus in a mouse model of pd, and (2) if the induced dopaminergic neurodegeneration and inflammation in the sn is reflected by local changes in viscoelasticity. |
2017-07-31 |
2023-08-13 |
mouse |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
therefore, mre measurements of the sn, midbrain and hippocampus were performed in adult female mice before and at five time points after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin hydrochloride (mptp) treatment specifically lesioning dopaminergic neurons in the sn. |
2017-07-31 |
2023-08-13 |
mouse |
| Dandan Luo, Ying Shi, Jun Wang, Qing Lin, Yi Sun, Keqiang Ye, Qiao Yan, Hai Zhan. 7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents. Neuroscience letters. vol 620. 2017-07-24. PMID:27019033. |
the results demonstrated that treatment with 7,8-dhf in drinking water for four weeks (two weeks before 6-ohda+two weeks after 6-ohda lesion) significantly improved dopamine-mediated behaviors in 6-ohda rat model, and prevented the loss of dopaminergic neurons in the substantia nigra (sn). |
2017-07-24 |
2023-08-13 |
mouse |
| Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A Goldber. Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053029. |
α-synuclein overexpression (asox) drives the formation of toxic aggregates in neurons vulnerable in parkinson's disease (pd), including dopaminergic neurons of the substantia nigra (sn) and cholinergic neurons of the dorsal motor nucleus of the vagus (dmv). |
2017-07-24 |
2023-08-13 |
mouse |
| Shih-Ying Wu, Yun-Wen Chen, Sheng-Feng Tsai, Sheng-Nan Wu, Yao-Hsiang Shih, Ya-Fen Jiang-Shieh, Ting-Ting Yang, Yu-Min Ku. Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K(+) channel. Scientific reports. vol 6. 2017-07-19. PMID:26960267. |
by comparing microglia and dopaminergic (da) neurons in the substantia nigra (sn) of male and female mice of different ages, we found that the degrees of microglial activation and da neuron loss increased with age in both genders, but were more pronounced in males, as were peripheral lipopolysaccharide (lps)-induced microglial activation and da neuron loss. |
2017-07-19 |
2023-08-13 |
mouse |
| Johanna Duda, Christina Pötschke, Birgit Lis. Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:26865375. |
dopamine-releasing neurons within the substantia nigra (sn da) are particularly vulnerable to degeneration compared to other dopaminergic neurons. |
2017-07-14 |
2023-08-13 |
Not clear |
| Hong Jiang, Jun Wang, Jack Rogers, Junxia Xi. Brain Iron Metabolism Dysfunction in Parkinson's Disease. Molecular neurobiology. vol 54. issue 4. 2017-07-07. PMID:27039308. |
understanding how iron accumulates in the substantia nigra (sn) and why it specifically targets dopaminergic (daergic) neurons is particularly warranted for pd, as this knowledge may provide new therapeutic avenues for a more targeted neurotherapeutic strategy for this disease. |
2017-07-07 |
2023-08-13 |
Not clear |
| Federica Marcuzzi, Silvia Zucchelli, Maria Bertuzzi, Claudio Santoro, Gianluca Tell, Piero Carninci, Stefano Gustincic. Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra. Journal of neurochemistry. vol 139. issue 4. 2017-06-15. PMID:27488413. |
in the brain, epor has been shown to protect several neuronal cell types from cell death, including the a9 dopaminergic neurons (da) of the substantia nigra (sn). |
2017-06-15 |
2023-08-13 |
mouse |
| Nivedita Bhattacharjee, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Sabanum Choudhury, Anupom Bora. L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra. Neuroscience letters. vol 628. 2017-06-13. PMID:27283777. |
in rodent, elevated level of hcy in brain or infusion of the same directly into the substantia nigra (sn) potentiates dopaminergic neurodegeneration. |
2017-06-13 |
2023-08-13 |
mouse |
| Nivedita Bhattacharjee, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Sabanum Choudhury, Anupom Bora. L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra. Neuroscience letters. vol 628. 2017-06-13. PMID:27283777. |
however, there is no significant decrease in the number of dopaminergic neurons in sn region in the parkinsonian mice given l-dopa treatment. |
2017-06-13 |
2023-08-13 |
mouse |
| Yuta Masaki, Yasuhiko Izumi, Atsuko Matsumura, Akinori Akaike, Toshiaki Kum. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. European journal of pharmacology. vol 798. 2017-05-15. PMID:28167258. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn), and oxidative stress is thought to contribute to the pathogenesis. |
2017-05-15 |
2023-08-13 |
mouse |