| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowsk. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Neuroscience. vol 314. 2016-10-13. PMID:26628402. |
intrastriatal 6-ohda injections decreased the number of dopaminergic, but not serotonergic neurons in the dr. 6-ohda reduced the dat binding in the cp, and sert binding in the nigrostriatal system (cp, substantia nigra (sn)), limbic system (ventral tegmental area (vta), nucleus accumbens (nac), amygdala, prefrontal cortex (pfcx), habenula, hippocampus) and dr. a significant positive correlation was found between dat and sert binding in the cp. |
2016-10-13 |
2023-08-13 |
rat |
| Weibo Shi, Chunling Ma, Qian Qi, Lizhe Liu, Haitao Bi, Bin Cong, Yingmin L. The effect of different durations of morphine exposure on mesencephalic dopaminergic neurons in morphine dependent rats. Neurotoxicology. vol 51. 2016-10-12. PMID:26386147. |
therefore, this study investigated th changes in dopaminergic neurons of the ventral tegmental area (vta) and substantia nigra (sn), as well as the morphine effects on dopaminergic neurons induced by different durations of morphine dependence. |
2016-10-12 |
2023-08-13 |
rat |
| Weibo Shi, Chunling Ma, Qian Qi, Lizhe Liu, Haitao Bi, Bin Cong, Yingmin L. The effect of different durations of morphine exposure on mesencephalic dopaminergic neurons in morphine dependent rats. Neurotoxicology. vol 51. 2016-10-12. PMID:26386147. |
with prolonged morphine exposure, the dopaminergic nerve cells in the vta and sn showed degeneration and necrosis, while apoptotic cells were not observed. |
2016-10-12 |
2023-08-13 |
rat |
| Weibo Shi, Chunling Ma, Qian Qi, Lizhe Liu, Haitao Bi, Bin Cong, Yingmin L. The effect of different durations of morphine exposure on mesencephalic dopaminergic neurons in morphine dependent rats. Neurotoxicology. vol 51. 2016-10-12. PMID:26386147. |
the number of vta and sn dopaminergic nerve cells decreased with increasing periods of morphine dependence, which was most likely attributable to the degeneration and necrosis of nerve cells induced by morphine toxicity. |
2016-10-12 |
2023-08-13 |
rat |
| Sarah J Stednitz, Briana Freshner, Samantha Shelton, Tori Shen, Donovan Black, Ethan Gahta. Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae. Neurotoxicology and teratology. vol 52. issue Pt A. 2016-10-12. PMID:26546233. |
the primary neuropathology in pd involves the death of dopaminergic cells in the substantia nigra (sn), an anatomical region of the brain implicated in dopamine production and voluntary motor control. |
2016-10-12 |
2023-08-13 |
zebrafish |
| Paula Trujillo, Alex K Smith, Paul E Summers, Luca M Mainardi, Sergio Cerutti, Seth A Smith, Antonella Cost. High-resolution quantitative imaging of the substantia nigra. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2015. 2016-09-26. PMID:26737519. |
there is a growing interest in identifying neuroimaging-based biomarkers for parkinson's disease (pd), a progressive neurodegenerative disorder in which the major pathologic substrate is the loss of pigmented dopaminergic neurons in the substantia nigra (sn). |
2016-09-26 |
2023-08-13 |
human |
| Qinqin Wang, Qinbo Zhou, Shuzhen Zhang, Wei Shao, Yanqing Yin, Yandong Li, Jincan Hou, Xinhua Zhang, Yongshun Guo, Xiaomin Wang, Xiaosong Gu, Jiawei Zho. Elevated Hapln2 Expression Contributes to Protein Aggregation and Neurodegeneration in an Animal Model of Parkinson's Disease. Frontiers in aging neuroscience. vol 8. 2016-09-07. PMID:27601993. |
parkinson's disease (pd), the second most common age-associated progressive neurodegenerative disorder, is characterized by the loss of dopaminergic (da) neurons in the substantia nigra pars compacta (sn). |
2016-09-07 |
2023-08-13 |
human |
| Sachchida Nand Rai, Satyndra Kumar Yadav, Divakar Singh, Surya Pratap Sing. Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model. Journal of chemical neuroanatomy. vol 71. 2016-09-01. PMID:26686287. |
tyrosine hydroxylase (th) immunostaining of sn dopaminergic neurons as well as hplc quantification of dopamine and its metabolites 3,4-dihydroxyphenylacetic acid (dopac) and homovanilic acid (hva) were also performed. |
2016-09-01 |
2023-08-13 |
mouse |
| Shuke Nie, Yan Xu, Guiqin Chen, Kai Ma, Chao Han, Zhenli Guo, Zhentao Zhang, Keqiang Ye, Xuebing Ca. Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. Neuropharmacology. vol 99. 2016-08-30. PMID:26282118. |
dopaminergic neurons loss in the substantia nigra (sn) and dopamine (da) content loss in the striatum correlate well with disease severity in parkinson's disease (pd). |
2016-08-30 |
2023-08-13 |
mouse |
| Shuke Nie, Yan Xu, Guiqin Chen, Kai Ma, Chao Han, Zhenli Guo, Zhentao Zhang, Keqiang Ye, Xuebing Ca. Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. Neuropharmacology. vol 99. 2016-08-30. PMID:26282118. |
the results revealed that pretreatment with deoxygedunin improved pd models' behavioral performance and reduced dopaminergic neurons loss in sn, associated with the activation of trkb receptors and its two major signaling cascades involving mitogen-activated protein kinase (mapk) and phosphatidylinositol 3-kinase (pi3k). |
2016-08-30 |
2023-08-13 |
mouse |
| Patricia Tagliaferro, Tatyana Kareva, Tinmarla F Oo, Olga Yarygina, Nikolai Kholodilov, Robert E Burk. An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. Neurobiology of disease. vol 82. 2016-08-24. PMID:26192625. |
we have shown that as human bac transgenic hlrrk2(r1441g) mice age, they exhibit two abnormalities in the nigrostriatal dopaminergic system: an axonopathy and a diminished number of dendrites in the substantia nigra (sn). |
2016-08-24 |
2023-08-13 |
mouse |
| Ning Yao, Yanhong Wu, Yan Zhou, Lili Ju, Yujun Liu, Rongkai Ju, Deyi Duan, Qunyuan X. Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease. Brain research. vol 1625. 2016-08-15. PMID:26342895. |
the degeneration of noradrenergic neurons in the locus coeruleus (lc) commonly occurs in patients with parkinson's disease (pd), which is characterized by a selective injury of dopaminergic neurons in the substantia nigra (sn). |
2016-08-15 |
2023-08-13 |
mouse |
| Ning Yao, Yanhong Wu, Yan Zhou, Lili Ju, Yujun Liu, Rongkai Ju, Deyi Duan, Qunyuan X. Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease. Brain research. vol 1625. 2016-08-15. PMID:26342895. |
in the present study, we used a noradrenergic toxin, n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp4), to deplete noradrenaline (na) derived from the lc to explore its influence on degeneration or injury of dopaminergic neurons in the sn in mouse model produced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) or lipopolysaccharide (lps). |
2016-08-15 |
2023-08-13 |
mouse |
| Sarah Y Branch, Cang Chen, Ramaswamy Sharma, James D Lechleiter, Senlin Li, Michael J Beckstea. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053209. |
dopaminergic neurons of the substantia nigra (sn) play a vital role in everyday tasks, such as reward-related behavior and voluntary movement, and excessive loss of these neurons is a primary hallmark of parkinson's disease (pd). |
2016-08-15 |
2023-08-13 |
mouse |
| Sarah Y Branch, Cang Chen, Ramaswamy Sharma, James D Lechleiter, Senlin Li, Michael J Beckstea. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053209. |
here, we used brain slice electrophysiology to construct a timeline of functional decline in sn dopaminergic neurons from mitopark mice. |
2016-08-15 |
2023-08-13 |
mouse |
| Hiroshi Kawaguchi, Hitoshi Shimada, Fumitoshi Kodaka, Masayuki Suzuki, Hitoshi Shinotoh, Shigeki Hirano, Jeff Kershaw, Yuichi Inoue, Masaki Nakamura, Taeko Sasai, Mina Kobayashi, Tetsuya Suhara, Hiroshi It. Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density. PloS one. vol 11. issue 3. 2016-08-03. PMID:26954690. |
the loss of dopaminergic (da) neurons in the substantia nigra (sn) is a major pathophysiological feature of patients with parkinson's disease (pd). |
2016-08-03 |
2023-08-13 |
human |
| Jui-Chih Chang, Shey-Lin Wu, Ko-Hung Liu, Ya-Hui Chen, Chieh-Sen Chuang, Fu-Chou Cheng, Hong-Lin Su, Yau-Huei Wei, Shou-Jen Kuo, Chin-San Li. Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Translational research : the journal of laboratory and clinical medicine. vol 170. 2016-08-02. PMID:26730494. |
moreover, we determined signal translocation of graft allogeneic mitochondria from the mfb to the calbindin-positive sn neuron, which demonstrated the regulatory role of mitochondrial transport in alleviating 6-ohda-induced degeneration of dopaminergic neurons. |
2016-08-02 |
2023-08-13 |
rat |
| Joshua E Albright, Iva Stojkovska, Abir A Rahman, Connor J Brown, Brad E Morriso. Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice. Neuroscience letters. vol 615. 2016-07-14. PMID:26806039. |
the primary clinical motor symptoms of parkinson's disease (pd) result from loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-07-14 |
2023-08-13 |
mouse |
| Marcio S Medeiros, Arthur Schumacher-Schuh, Andreia Machado Cardoso, Guilherme Vargas Bochi, Jucimara Baldissarelli, Aline Kegler, Daniel Santana, Carolina Maria Martins Behle Soares Chaves, Maria Rosa Chitolina Schetinger, Rafael Noal Moresco, Carlos R M Rieder, Michele Rechia Figher. Iron and Oxidative Stress in Parkinson's Disease: An Observational Study of Injury Biomarkers. PloS one. vol 11. issue 1. 2016-06-30. PMID:26751079. |
parkinson's disease (pd) is characterized by progressive motor impairment attributed to progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2016-06-30 |
2023-08-13 |
cat |
| Ji Zhang, Beibei Yang, Hongbin Sun, Yan Zhou, Mengdi Liu, Jianhua Ding, Feng Fang, Yi Fan, Gang H. Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson's disease. Neuroscience letters. vol 614. 2016-06-29. PMID:26748031. |
parkinson's disease (pd) is primarily due to the progressive, selective and irreversible loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-06-29 |
2023-08-13 |
mouse |