| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Hua Li, Qing He, Jie-zhong Yu, Chun-yun Liu, Ling Feng, Zhi Chai, Qing Wang, Hong-zhen Zhang, Guang-Xian Zhang, Bao-guo Xiao, Cun-gen M. Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model. Metabolic brain disease. vol 30. issue 5. 2016-06-24. PMID:26084861. |
our results for the first time showed that la administration improved motor dysfunction, protected dopaminergic neurons loss, and decreased α-synuclein accumulation in the substantia nigra (sn) area of brain. |
2016-06-24 |
2023-08-13 |
Not clear |
| Supriti Samantaray, Varduhi H Knaryan, Donald C Shields, April A Cox, Azizul Haque, Naren L Bani. Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice. Molecular neurobiology. vol 52. issue 2. 2016-06-21. PMID:26108182. |
attenuated glial activation, t cell infiltration, nigral dopaminergic degeneration in sn, and neuronal death in spinal cord. |
2016-06-21 |
2023-08-13 |
mouse |
| Yukiko Ogura, Takeshi Izumi, Mitsuhiro Yoshioka, Toshiya Matsushim. Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick. Behavioural brain research. vol 294. 2016-06-14. PMID:26235329. |
as the ascending dopaminergic projections include the mesolimbic and nigrostriatal pathways, we targeted our lesions at the medial striatum (mst) and substantia nigra (sn). |
2016-06-14 |
2023-08-13 |
chicken |
| Jun-yu Li, Shan-shan Ma, Qiao-ying Huang, Ming-tao L. [The Function of Neuroinflammation in Parkinson Disease]. Sheng li ke xue jin zhan [Progress in physiology]. vol 46. issue 3. 2016-06-10. PMID:26521481. |
parkinson disease (pd) is the second most common neurodegenerative disorder, characterized by a progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2016-06-10 |
2023-08-13 |
Not clear |
| Jonathan Murray Lovell, Judith Mylius, Henning Scheich, Michael Brosc. Stimulation of the Dopaminergic Midbrain as a Behavioral Reward in Instrumentally Conditioned Monkeys. Brain stimulation. vol 8. issue 5. 2016-06-09. PMID:26070295. |
since the mesocortical dopaminergic system of rodents has several differences to that found in primate species, including humans, there is the need for more exhaustively studying causative relationships between activation/stimulation of the ventral tegmental area (vta) and substantia nigra (sn) and behavior in monkeys. |
2016-06-09 |
2023-08-13 |
monkey |
| Neha Sharma, Bimla Nehr. Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation. Neurochemistry international. vol 87. 2016-05-24. PMID:26055970. |
primary pathology underlying parkinson's disease (pd) is the loss of dopaminergic neurons in the substantia nigra (sn). |
2016-05-24 |
2023-08-13 |
Not clear |
| Wenda Jiang, Zhejian Wang, Yiyang Jiang, Meili Lu, Xin L. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. vol 96. issue 1-2. 2016-05-23. PMID:26065578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine levels in the striatum. |
2016-05-23 |
2023-08-13 |
rat |
| Xian-Chang Sun, Xiao-Fan Ren, Lei Chen, Xian-Qi Gao, Jun-Xia Xie, Wen-Fang Che. Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt A. 2016-05-03. PMID:26455404. |
the present study aimed to evaluate the protective effects of ginsenoside rg1 on lipopolysaccharide (lps)-induced microglia activation and dopaminergic neuronal degeneration in rat substantia nigra (sn) and its potential mechanisms. |
2016-05-03 |
2023-08-13 |
rat |
| Yi-Hsin Weng, Chu-Yu Chen, Kun-Jun Lin, Ying-Ling Chen, Tu-Hsueh Yeh, Ing-Tsung Hsiao, Ing-Jou Chen, Chin-Song Lu, Hung-Li Wan. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26363496. |
(r1441c) lrrk2 induces the degeneration of sn dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. |
2016-04-29 |
2023-08-13 |
mouse |
| Yi-Hsin Weng, Chu-Yu Chen, Kun-Jun Lin, Ying-Ling Chen, Tu-Hsueh Yeh, Ing-Tsung Hsiao, Ing-Jou Chen, Chin-Song Lu, Hung-Li Wan. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26363496. |
compared with wild-type mice, 16-month-old (r1441c) lrrk2 mice exhibited a significant reduction in the number of substantia nigra (sn) dopaminergic neurons. |
2016-04-29 |
2023-08-13 |
mouse |
| Yi-Hsin Weng, Chu-Yu Chen, Kun-Jun Lin, Ying-Ling Chen, Tu-Hsueh Yeh, Ing-Tsung Hsiao, Ing-Jou Chen, Chin-Song Lu, Hung-Li Wan. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26363496. |
to elucidate molecular pathogenic pathways involved in (r1441c) lrrk2-induced death of sn dopaminergic neurons, we performed microarray analysis to visualize altered mrna expressions in the sn of (r1441c) lrrk2 mouse. |
2016-04-29 |
2023-08-13 |
mouse |
| Seon Ae Eom, Dae Won Kim, Min Jea Shin, Eun Hee Ahn, Seok Young Chung, Eun Jeong Sohn, Hyo Sang Jo, Su-Jeong Jeon, Duk-Soo Kim, Hyeok Yil Kwon, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Cho. Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease. BMB reports. vol 48. issue 7. 2016-04-25. PMID:25322954. |
parkinson's disease (pd) is a neurodegenerative disability caused by a decrease of dopaminergic neurons in the substantia nigra (sn). |
2016-04-25 |
2023-08-13 |
Not clear |
| Bo Zhang, Kun Ma, Baixiang L. Inflammatory reaction regulated by microglia plays a role in atrazine-induced dopaminergic neuron degeneration in the substantia nigra. The Journal of toxicological sciences. vol 40. issue 4. 2016-04-19. PMID:26165640. |
increasing evidence indicates that atr plays a critical role in inducing physiological changes to the endocrine and reproductive systems, and further may affect the nigrostriatal dopaminergic system in the diencephalon, resulting in altered dopamine (da) levels in the striatum, transport and storage-related protein abnormalities in the synaptic terminals, motor function deficits, and degeneration of da neurons in the substantia nigra (sn). |
2016-04-19 |
2023-08-13 |
rat |
| Nancy G Hernandez-Chan, Michael J Bannon, Carlos E Orozco-Barrios, Lourdes Escobedo, Sergio Zamudio, Fidel De la Cruz, Jose L Gongora-Alfaro, Juan Armendáriz-Borunda, David Reyes-Corona, Armando J Espadas-Alvarez, Yazmin M Flores-Martínez, Jose Ayala-Davila, Maria E Hernandez-Gutierrez, Lenin Pavón, Refugio García-Villegas, Rasajna Nadella, Daniel Martinez-Fon. Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease. Journal of biomedical science. vol 22. 2016-04-18. PMID:26198255. |
the reduction of bdnf expression in parkinson's disease substantia nigra (sn) might contribute to the death of dopaminergic neurons because inhibiting bdnf expression in the sn causes parkinsonism in the rat. |
2016-04-18 |
2023-08-13 |
rat |
| Jia-Jia Xiao, Ming Yin, Ze-Jian Wang, Xiao-Ping Wan. Transplanted Neural Stem Cells: Playing a Neuroprotective Role by Ceruloplasmin in the Substantia Nigra of PD Model Rats? Oxidative medicine and cellular longevity. vol 2015. 2016-04-08. PMID:26146528. |
although mounting evidence suggests that ceruloplasmin (cp) deficiency and iron deposition are pivotal factors responsible for exacerbating demise of dopaminergic neurons in the substantia nigra (sn) of the parkinsonism and neural stem cells (nscs) are believed to be excellent candidates for compensating the lost dopaminergic neurons, there are few researches to explore the change of cp expression and of iron deposition in the pathological microenvironment of sn after nscs transplantation and the ability of grafted nscs to differentiate directionally into dopaminergic neurons under the changed homeostasis. |
2016-04-08 |
2023-08-13 |
rat |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
as expected, pd patients demonstrated a severe loss of all dopaminergic markers, including dopamine (p < 0.0001) and the dopamine transporter (p < 0.0001) in the striatum, and dopaminergic neurons (p < 0.001) in the sn, compared with controls. |
2016-04-07 |
2023-08-13 |
Not clear |
| Mohammad Moshahid Khan, Smita Zaheer, Ramasamy Thangavel, Margi Patel, Duraisamy Kempuraj, Asgar Zahee. Absence of glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of parkinsonism. Neurochemical research. vol 40. issue 5. 2016-04-01. PMID:25754447. |
in the present study, we demonstrate that absence of gmf suppresses dopaminergic (da) neuron loss, glial activation, and expression of proinflammatory mediators in the substantia nigra pars compacta (sn) and striatum (str) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treated mice. |
2016-04-01 |
2023-08-13 |
mouse |
| K Hikishima, K Ando, Y Komaki, K Kawai, R Yano, T Inoue, T Itoh, M Yamada, S Momoshima, H J Okano, H Okan. Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model. Neuroscience. vol 300. 2016-03-29. PMID:26012491. |
movement dysfunction in parkinson's disease (pd) is caused by the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-03-29 |
2023-08-13 |
monkey |
| Jun Wang, Mingxia Bi, Junxia Xi. Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats. Cellular and molecular neurobiology. vol 35. issue 5. 2016-03-28. PMID:25656940. |
in these pd models, almost no dopaminergic neurons can be detected in the lesioned sn and nigral iron level was further increased. |
2016-03-28 |
2023-08-13 |
rat |