| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanying Song, Gino Cortopass. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain research. vol 1594. 2015-08-04. PMID:25446449. |
parkinson׳s disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) of midbrain. |
2015-08-04 |
2023-08-13 |
mouse |
| J A D Dela Cruz, R Schmidt-Kastner, J A A Stevens, H W M Steinbusch, B P F Rutte. Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area. Journal of chemical neuroanatomy. vol 61-62. 2015-07-31. PMID:25017895. |
stereological analysis showed that arnt was preferentially expressed in dopaminergic neurons in sn compacta and vta. |
2015-07-31 |
2023-08-13 |
mouse |
| Kim-Ann Saal, Jan C Koch, Lars Tatenhorst, Eva M Szegő, Vinicius Toledo Ribas, Uwe Michel, Mathias Bähr, Lars Tönges, Paul Lingo. AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo. Neurobiology of disease. vol 73. 2015-07-29. PMID:25283984. |
downregulation of rock2 protected dopaminergic neurons in the sn from 6-ohda-induced degeneration and resulted in significantly increased th-positive neuron numbers. |
2015-07-29 |
2023-08-13 |
rat |
| Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaj. MRI can detect nigral volume loss in patients with Parkinson's disease: evidence from a meta-analysis. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24577503. |
parkinson's disease (pd) involves the degeneration of dopaminergic neurons in substantia nigra (sn) compacta. |
2015-07-27 |
2023-08-12 |
Not clear |
| Zhi-Yong Wang, Hui Lian, Qing-Qing Cai, Hai-Yan Song, Xiao-Li Zhang, Li Zhou, Yi-Min Zhang, Li-Fei Zheng, Jin-Xia Zh. No direct projection is observed from the substantia nigra to the dorsal vagus complex in the rat. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24613863. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons in the substantia nigra (sn). |
2015-07-27 |
2023-08-12 |
rat |
| Mahmoud M Iravani, Mona Sadeghian, Sarah Rose, Peter Jenne. Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 12. 2015-07-07. PMID:24781752. |
we examine if destruction of the locus coeruleus with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4) alters dopaminergic cell loss in substantia nigra (sn) initiated by lipopolysaccharide (lps) in the rat through an effect on glial cell activation. |
2015-07-07 |
2023-08-13 |
rat |
| Mahmoud M Iravani, Mona Sadeghian, Sarah Rose, Peter Jenne. Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 12. 2015-07-07. PMID:24781752. |
in rats, a single intraperitoneal dose of dsp-4 administered 8 days previously, caused a marked loss of tyrosine hydroxylase positive neurons in lc but no change in dopaminergic cell number in sn. |
2015-07-07 |
2023-08-13 |
rat |
| Xiqi Liu, Rushing Shao, Meng Li, Guofeng Yan. Edaravone protects neurons in the rat substantia nigra against 6-hydroxydopamine-induced oxidative stress damage. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24948472. |
edaravone prevented 6-ohda-induced behavioral changes and de-pigmentation of sn that results from the loss of dopaminergic neurons. |
2015-07-02 |
2023-08-13 |
rat |
| Hongcai Wang, Yan Chen, Jinbo Chen, Zhentao Zhang, Wansheng Lao, Xizhi Li, Jinsha Huang, Tao Wan. Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. PloS one. vol 9. issue 10. 2015-06-23. PMID:25303312. |
the cell cycle was reactivated in cyclin d-expressing dopaminergic neurons from the substantia nigra (sn) of rats following stereotactic (st) infusion of rotenone. |
2015-06-23 |
2023-08-13 |
rat |
| Anuradha Yadav, Swati Agarwal, Shashi Kant Tiwari, Rajnish K Chaturved. Mitochondria: prospective targets for neuroprotection in Parkinson's disease. Current pharmaceutical design. vol 20. issue 35. 2015-06-22. PMID:24606805. |
parkinson's disease is the second most common neurodegenerative disorder characterized by persistent loss of dopaminergic neurons in the sn and clinically associated with cognitive, behavioral and motor deficits. |
2015-06-22 |
2023-08-12 |
Not clear |
| Stéphane Lehéricy, Eric Bardinet, Cyril Poupon, Marie Vidailhet, Chantal Françoi. 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 13. 2015-06-22. PMID:25308960. |
histologically, the sn is subdivided into the ventral pars reticulata and the dorsal pars compacta, which is composed of dopaminergic neurons. |
2015-06-22 |
2023-08-13 |
human |
| Stéphane Lehéricy, Eric Bardinet, Cyril Poupon, Marie Vidailhet, Chantal Françoi. 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 13. 2015-06-22. PMID:25308960. |
in humans, dopaminergic neurons, which are known to accumulate neuromelanin, form clusters of cells (nigrosomes) that penetrate deep into the sn pars reticulata (snr). |
2015-06-22 |
2023-08-13 |
human |
| L P Voitenko, A G Nikonenk. [Modification of experimental rotenone model of Parkinson's disease]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 61. issue 1. 2015-06-11. PMID:26040040. |
it was shown that 10 days after infusion of the neurotoxin the density of dopaminergic (da) neurons in the infusion area drops nearly six-fold, to 20.2±3.2 neurons/mm2, with respect to the corresponding value in non-affected controlateral sn, 119.0±3.3 neurons/mm2. |
2015-06-11 |
2023-08-13 |
rat |
| S P Patil, P D Jain, P J Ghumatkar, R Tambe, S Sathay. Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience. vol 277. 2015-06-08. PMID:25108167. |
dopaminergic degeneration was evaluated by analyzing the tyrosine hydroxylase (th) by immunostaining and nissl staining of the substantia nigra (sn) region of the brain. |
2015-06-08 |
2023-08-13 |
mouse |
| Ye Lee Jun, Chang-Hwan Bae, Dongsoo Kim, Sungtae Koo, Seungtae Ki. Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model. Journal of ginseng research. vol 39. issue 2. 2015-06-05. PMID:26045688. |
the present study investigated a possible role of korean red ginseng (krg) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in the substantia nigra (sn) and striatum (st) using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinson's disease mouse model. |
2015-06-05 |
2023-08-13 |
mouse |
| Annamaria Lanzillotta, Vanessa Porrini, Arianna Bellucci, Marina Benarese, Caterina Branca, Edoardo Parrella, Pier Franco Spano, Marina Pizz. NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases. Frontiers in neurology. vol 6. 2015-06-04. PMID:26042083. |
constitutive knockout of c-rel shatters the resilience of substantia nigra (sn) dopaminergic (da) neurons to aging and induces a parkinsonian like pathology in mice. |
2015-06-04 |
2023-08-13 |
mouse |
| Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasaga. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. vol 1585. 2015-06-02. PMID:24657313. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that results mainly due to the death of dopaminergic neurons in the substantia nigra (sn), and subsequently has an effect on one's motor function and coordination. |
2015-06-02 |
2023-08-12 |
mouse |
| Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasaga. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. vol 1585. 2015-06-02. PMID:24657313. |
oral treatment of escin significantly attenuated mptp/p induced dopaminergic markers depletion, physiological abnormalities, oxidative stress and inhibit neuroinflammatory cytokine expressions in sn. |
2015-06-02 |
2023-08-12 |
mouse |
| Alice Grison, Silvia Zucchelli, Alice Urzì, Ilaria Zamparo, Dejan Lazarevic, Giovanni Pascarella, Paola Roncaglia, Alejandro Giorgetti, Paula Garcia-Esparcia, Christina Vlachouli, Roberto Simone, Francesca Persichetti, Alistair R R Forrest, Yoshihide Hayashizaki, Paolo Carloni, Isidro Ferrer, Claudia Lodovichi, Charles Plessy, Piero Carninci, Stefano Gustincic. Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC genomics. vol 15. 2015-05-28. PMID:25164183. |
the mesencephalic dopaminergic (mda) cell system is composed of two major groups of projecting cells in the substantia nigra (sn) (a9 neurons) and the ventral tegmental area (vta) (a10 cells). |
2015-05-28 |
2023-08-13 |
Not clear |
| Nina Daschil, Christian Humpe. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain research. vol 1581. 2015-05-21. PMID:25038562. |
however, nimodipine and nifedipine significantly enhanced the survival of dopaminergic substantia nigra (sn) but not ventral tegmental area (vta) neurons, while nicardipine, isradipine and verapamil had no effect. |
2015-05-21 |
2023-08-13 |
rat |