| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hashem Haghdoost-Yazdi, Mohammad Sarookhani, Ayda Faraj, Negin Fraidouni, Tahereh Dargahi, Mohammad Hosein Yaghoubidoust, Hassan Azhdari-Zarmehr. Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24992727. |
considering the direct correlation between the severity of rotational behavior and the degree of lesion in the substantia nigra (sn), our data indicate that higher thcy values can predict higher sn dopaminergic neurodegeneration. |
2015-05-19 |
2023-08-13 |
rat |
| Sujung Yeo, Keon Sang An, Yeon-Mi Hong, Yeong-Gon Choi, Bruce Rosen, Sung-Hoon Kim, Sabina Li. Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. Genetics and molecular biology. vol 38. issue 1. 2015-05-18. PMID:25983633. |
acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the sn in parkinsonism animal models. |
2015-05-18 |
2023-08-13 |
mouse |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
until now there is lack of animal experimental data on the supportive effect of estrogen on function of dopaminergic neurons in substantia nigra (sn) in physiological state. |
2015-05-16 |
2023-08-12 |
human |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
p50 induced by two brief acoustic stimuli were recorded in the right sn and the number of th(+) dopaminergic neurons in the sn stained by immunohistochemistry was calculated after the determination of p50. |
2015-05-16 |
2023-08-12 |
human |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
these results indicate that the mechanism of protection of dopaminergic neurons in the sn provided by physiological level of estrogen is by promoting the resistibility of the neurons to harmful stimulation. |
2015-05-16 |
2023-08-12 |
human |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
if the gonads are resected resulting in a lack of estrogen, the degree of injury to the function and morphology of dopaminergic neurons in sn induced by 6-ohda increases. |
2015-05-16 |
2023-08-12 |
human |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
sensory gating p50 in sn may reflect dynamically the protection of estrogen against dopaminergic neurons depletion in vivo. |
2015-05-16 |
2023-08-12 |
human |
| Vishnu P Murty, Maheen Shermohammed, David V Smith, R McKell Carter, Scott A Huettel, R Alison Adcoc. Resting state networks distinguish human ventral tegmental area from substantia nigra. NeuroImage. vol 100. 2015-05-12. PMID:24979343. |
next, we constructed a probabilistic atlas of the vta, sn, and the dopaminergic midbrain region (comprised of sn plus vta) from individual hand-drawn rois. |
2015-05-12 |
2023-08-13 |
human |
| Kuldip D Dave, Shehan De Silva, Niketa P Sheth, Sylvie Ramboz, Melissa J Beck, Changyu Quang, Robert C Switzer, Syed O Ahmad, Susan M Sunkin, Dan Walker, Xiaoxia Cui, Daniel A Fisher, Aaron M McCoy, Kevin Gamber, Xiaodong Ding, Matthew S Goldberg, Stanley A Benkovic, Meredith Haupt, Marco A S Baptista, Brian K Fiske, Todd B Sherer, Mark A Frasie. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiology of disease. vol 70. 2015-04-21. PMID:24969022. |
these results demonstrate that inactivation of the pink1 or dj-1 genes in the rat produces progressive neurodegeneration and early behavioral deficits, suggesting that these recessive genes may be essential for the survival of dopaminergic neurons in the substantia nigra (sn). |
2015-04-21 |
2023-08-13 |
rat |
| Jie Li, Terence Duarte, Arif Kocabas, Melissa Works, Susan K McConnell, Mary A Hyne. Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24867253. |
there are two main subgroups of midbrain dopaminergic (da) neurons: the more medially located ventral tegmental area (vta) da neurons, which have axons that innervate the ventral-lateral (vl) striatum, and the more laterally located substantia nigra (sn) da neurons, which preferentially degenerate in parkinson's disease (pd) and have axons that project to the dorsal-medial (dm) striatum. |
2015-04-15 |
2023-08-13 |
mouse |
| Sandra A Acosta, Naoki Tajiri, Ike de la Pena, Marina Bastawrous, Paul R Sanberg, Yuji Kaneko, Cesar V Borlonga. Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease. Journal of cellular physiology. vol 230. issue 5. 2015-04-10. PMID:25251017. |
unbiased stereology analyses revealed significant decrease of th-positive expression in the surviving dopaminergic neurons of the sn pars compacta (snpc) relative to sham control. |
2015-04-10 |
2023-08-13 |
rat |
| Qing He, Wenbo Yu, Jianjun Wu, Chan Chen, Zhiyin Lou, Qiong Zhang, Jian Zhao, Jian Wang, Baoguo Xia. Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins. PloS one. vol 8. issue 11. 2015-03-30. PMID:24250796. |
these mice display a progressive hypokinesia, selective loss of dopaminergic neurons, and reduction in striatal dopamine (da) content, as well as α-synuclein aggregation in the sn, without systemic inflammatory and immune responses. |
2015-03-30 |
2023-08-12 |
mouse |
| Olalekan Michael Ogundele, Adetokunbo Adedotun Okunnuga, Temitope Deborah Fabiyi, Olayemi Joseph Olajide, Ibukun Dorcas Akinrinade, Philip Adeyemi Adeniyi, Abiodun Ayodele Oj. NMDA-R inhibition affects cellular process formation in Tilapia melanocytes; a model for pigmented adrenergic neurons in process formation and retraction. Metabolic brain disease. vol 29. issue 2. 2015-03-05. PMID:24242214. |
although most studies have focused on dopaminergic neurons, it is important to consider the role of pigment cells in the etiology of the disease and to create an in vitro live cell model for studies involving pigmented adrenergic cells of the sn in parkinsonism. |
2015-03-05 |
2023-08-12 |
Not clear |
| Li Zhou, Zhi-Yong Wang, Hui Lian, Hai-Yan Song, Yi-Min Zhang, Xiao-Li Zhang, Rui-Fang Fan, Li-Fei Zheng, Jin-Xia Zh. Altered expression of dopamine receptors in cholinergic motoneurons of the hypoglossal nucleus in a 6-OHDA-induced Parkinson's disease rat model. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25172664. |
however, the link between the degenerated dopaminergic neurons in the substantia nigra (sn) and lingual dysfunction remains unclear. |
2015-02-25 |
2023-08-13 |
rat |
| Chen Qi, Mingxin Xu, Jing Gan, Xinxin Yang, Na Wu, Lu Song, Weien Yuan, Zhenguo Li. Erythropoietin improves neurobehavior by reducing dopaminergic neuron loss in a 6‑hydroxydopamine‑induced rat model. International journal of molecular medicine. vol 34. issue 2. 2015-02-12. PMID:24939444. |
the dopaminergic neurons in the 6‑ohda‑lesioned sn were also increased in the epo‑pretreated rats when compared with control rats (p<0.01). |
2015-02-12 |
2023-08-13 |
rat |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song L. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental neurology. vol 263. 2015-02-09. PMID:25263579. |
application of a potent activator of aldh2, alda-1, was effective in protecting against rotenone-induced apoptotic cell death in both sh-sy5y cells and primary cultured substantia nigra (sn) dopaminergic neurons. |
2015-02-09 |
2023-08-13 |
Not clear |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song L. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental neurology. vol 263. 2015-02-09. PMID:25263579. |
in addition, intraperitoneal administration of alda-1 significantly reduced rotenone- or mptp-induced death of sn tyrosine hydroxylase (th)-positive dopaminergic neurons. |
2015-02-09 |
2023-08-13 |
Not clear |
| Wei Zhang, Zhao-fen Yan, Jun-hua Gao, Li Sun, Xi-yan Huang, Zhuo Liu, Shu-yang Yu, Chen-Jie Cao, Li-jun Zuo, Ze-Jie Chen, Yang Hu, Fang Wang, Jau-shyong Hong, Xiao-min Wan. Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration. Molecular neurobiology. vol 49. issue 3. 2015-01-26. PMID:24277523. |
however, the role and mechanism of microglial activation in iron-induced dopaminergic neurodegeneration in sn remain unclear yet. |
2015-01-26 |
2023-08-12 |
mouse |
| Shinji Oikawa, Hatasu Kobayashi, Yuki Kitamura, Hong Zhu, Kumi Obata, Yoshio Minabe, Maryia Dazortsava, Kyoko Ohashi, Saeko Tada-Oikawa, Hitoshi Takahashi, Kenichiro Yata, Mariko Murata, Tetsumori Yamashim. Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion. Free radical research. vol 48. issue 6. 2015-01-10. PMID:24697733. |
in parkinson's disease (pd), oxidative stresses cause cell death of dopaminergic neurons of the substantia nigra (sn), but its molecular mechanism still remains unclarified. |
2015-01-10 |
2023-08-13 |
monkey |
| Sinem Aras, Gamze Tanriover, Mutay Aslan, Piraye Yargicoglu, Aysel Aga. The role of nitric oxide on visual-evoked potentials in MPTP-induced Parkinsonism in mice. Neurochemistry international. vol 72. 2015-01-09. PMID:24795109. |
dopaminergic cell death at pars compacta of sn (snpc) was significantly increased in mptp treated group compared to control. |
2015-01-09 |
2023-08-13 |
mouse |