| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eung Seok Oh, Chaejeong Heo, Ji Seon Kim, Minah Suh, Young Hee Lee, Jong-Min Ki. Hyperspectral fluorescence imaging for cellular iron mapping in the in vitro model of Parkinson's disease. Journal of biomedical optics. vol 19. issue 5. 2014-08-04. PMID:24297062. |
parkinson's disease (pd) is characterized by progressive dopaminergic cell loss in the substantia nigra (sn) and elevated iron levels demonstrated by autopsy. |
2014-08-04 |
2023-08-12 |
Not clear |
| Anna Czarnecka, Tomasz Lenda, Helena Domin, Jolanta Konieczny, Maria Smiałowska, Elżbieta Lorenc-Koc. Alterations in the expression of nNOS in the substantia nigra and subthalamic nucleus of 6-OHDA-lesioned rats: the effects of chronic treatment with l-DOPA and the nitric oxide donor, molsidomine. Brain research. vol 1541. 2014-07-28. PMID:24129225. |
degeneration of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease leads to disturbances in the nitrergic transmission in the basal ganglia. |
2014-07-28 |
2023-08-12 |
rat |
| Anna Czarnecka, Tomasz Lenda, Helena Domin, Jolanta Konieczny, Maria Smiałowska, Elżbieta Lorenc-Koc. Alterations in the expression of nNOS in the substantia nigra and subthalamic nucleus of 6-OHDA-lesioned rats: the effects of chronic treatment with l-DOPA and the nitric oxide donor, molsidomine. Brain research. vol 1541. 2014-07-28. PMID:24129225. |
our results showed that degeneration of dopaminergic neurons in the ipsilateral sn resulted in a 25% decrease in the number of nnos-immunoreactive neurons in that structure and in nnos protein level determined by western blot. |
2014-07-28 |
2023-08-12 |
rat |
| Miklos Antal, Brandon M Beneduce, Wade G Regeh. The substantia nigra conveys target-dependent excitatory and inhibitory outputs from the basal ganglia to the thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 23. 2014-07-25. PMID:24899724. |
the substantia nigra (sn) consists of gabaergic neurons of the pars reticulata that inhibit thalamic neurons and provide the primary output of the bg, and dopaminergic neurons of the pars compacta that modulate thalamic excitability. |
2014-07-25 |
2023-08-13 |
mouse |
| Miklos Antal, Brandon M Beneduce, Wade G Regeh. The substantia nigra conveys target-dependent excitatory and inhibitory outputs from the basal ganglia to the thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 23. 2014-07-25. PMID:24899724. |
glutamatergic sn neurons express the vesicular glutamate receptor transporter vglut2 and receive inhibitory synapses from striatal neurons, and many also express tyrosine hydroxylase, a marker of dopaminergic neurons. |
2014-07-25 |
2023-08-13 |
mouse |
| Esperanza García, Ricardo Santana-Martínez, Carlos A Silva-Islas, Ana Laura Colín-González, Sonia Galván-Arzate, Yessica Heras, Perla D Maldonado, Julio Sotelo, Abel Santamarí. S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free radical research. vol 48. issue 2. 2014-07-24. PMID:24147739. |
our findings suggest that sac can exert neuroprotection since the origin of the dopaminergic lesion-at the substantia nigra (sn)-not only by means of direct antioxidant actions, but also through nrf2 nuclear transactivation and phase 2 enzymes upregulation. |
2014-07-24 |
2023-08-12 |
mouse |
| Marina S Hernandes, Graziella D R Santos, Cecília C Café-Mendes, Larissa S Lima, Cristoforo Scavone, Carolina D Munhoz, Luiz R G Britt. Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration. PloS one. vol 8. issue 9. 2014-07-14. PMID:24086556. |
immunolabeling assays indicated that striatal 6-ohda injections reduced the number of dopaminergic (da) neurons in the sn of wt mice. |
2014-07-14 |
2023-08-12 |
mouse |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
at 7 d after the 6-ohda injection, 6-ohda led to a severe loss of tyrosine hydroxylase (th)-positive dopaminergic neurons in the striatum and substantia nigra (sn). |
2014-07-14 |
2023-08-12 |
mouse |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
on the other hand, tca dramatically maintained the number of th-positive dopaminergic neurons in the striatum and sn regions of the 6-ohda-treated mice, which indicates that tca is able to inhibit the 6-ohda-induced reduction of th expression in the dopaminergic neurons in the striatum and sn regions. |
2014-07-14 |
2023-08-12 |
mouse |
| Ashwin G Ramayya, Amrit Misra, Gordon H Baltuch, Michael J Kahan. Microstimulation of the human substantia nigra alters reinforcement learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 20. 2014-07-10. PMID:24828643. |
animal studies have shown that substantia nigra (sn) dopaminergic (da) neurons strengthen action-reward associations during reinforcement learning, but their role in human learning is not known. |
2014-07-10 |
2023-08-13 |
human |
| Henriqueta Dias Cardoso, Eraldo Fonseca dos Santos Junior, David Filipe de Santana, Catarina Gonçalves-Pimentel, Monara Kaélle Angelim, Alinny R Isaac, Cláudia Jacques Lagranha, Rubem Carlos Araújo Guedes, Eduardo Isidoro Beltrão, Edgar Morya, Marcelo Cairrão Araújo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression. Biochimica et biophysica acta. vol 1840. issue 6. 2014-07-03. PMID:24361617. |
our previous study demonstrated that essential fatty acid (efa) dietary restriction over two generations induced midbrain dopaminergic cell loss and oxidative stress in the substantia nigra (sn) but not in the striatum of young rats. |
2014-07-03 |
2023-08-12 |
rat |
| Simone A van den Berge, Miriam E van Strien, Elly M Ho. Resident adult neural stem cells in Parkinson's disease--the brain's own repair system? European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872414. |
furthermore, we will summarise the reports that describe efforts to stimulate nscs to replace dopaminergic cells in the sn and restore striatal dopamine levels. |
2014-07-02 |
2023-08-12 |
human |
| Vanessa Stuckenholz, Michael Bacher, Monika Balzer-Geldsetzer, Daniel Alvarez-Fischer, Wolfgang H Oertel, Richard C Dodel, Carmen Noelke. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. Journal of Parkinson's disease. vol 3. issue 2. 2014-06-25. PMID:23938346. |
parkinson's disease (pd) is associated with neurodegeneration of dopaminergic neurons and an accompanying neuroinflammatory process in the substantia nigra (sn). |
2014-06-25 |
2023-08-12 |
mouse |
| Sachiko Tanaka, Atsuko Ishii, Hirokazu Ohtaki, Seiji Shioda, Takemi Yoshida, Satoshi Numazaw. Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24289537. |
parkinson's disease (pd) is an age-related progressive neurodegenerative disorder caused by selective loss of dopaminergic neurons from the substantia nigra (sn) to the striatum. |
2014-06-25 |
2023-08-12 |
mouse |
| Xian-Ming Luo, Hai Lin, Wei Wang, Marilyn S Geaney, Lee Law, Shaun Wynyard, Shamim B Shaikh, Henry Waldvogel, Richard L M Faull, Robert B Elliott, Stephen J M Skinner, Jacqueline E Lee, Paul L-J Ta. Recovery of neurological functions in non-human primate model of Parkinson's disease by transplantation of encapsulated neonatal porcine choroid plexus cells. Journal of Parkinson's disease. vol 3. issue 3. 2014-06-17. PMID:24002224. |
parkinson's disease (pd) is a neurodegenerative disease that is primarily characterized by degeneration of dopaminergic (da) neurons in the substantia nigra (sn) and a loss of their fibre projections in the striatum. |
2014-06-17 |
2023-08-12 |
monkey |
| Gabriela Oana Bodea, Jan-Hendrik Spille, Philipp Abe, Aycan Senturk Andersson, Amparo Acker-Palmer, Ralf Stumm, Ulrich Kubitscheck, Sandra Blaes. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449842. |
the proper functioning of the dopaminergic system requires the coordinated formation of projections extending from dopaminergic neurons in the substantia nigra (sn), ventral tegmental area (vta) and retrorubral field to a wide array of forebrain targets including the striatum, nucleus accumbens and prefrontal cortex. |
2014-03-20 |
2023-08-12 |
mouse |
| Gabriela Oana Bodea, Jan-Hendrik Spille, Philipp Abe, Aycan Senturk Andersson, Amparo Acker-Palmer, Ralf Stumm, Ulrich Kubitscheck, Sandra Blaes. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449842. |
here, we have investigated in detail the migratory behavior of dopaminergic neurons giving rise to either the sn or the medial vta using genetic inducible fate mapping, ultramicroscopy, time-lapse imaging, slice culture and analysis of mouse mutants. |
2014-03-20 |
2023-08-12 |
mouse |
| Gabriela Oana Bodea, Jan-Hendrik Spille, Philipp Abe, Aycan Senturk Andersson, Amparo Acker-Palmer, Ralf Stumm, Ulrich Kubitscheck, Sandra Blaes. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449842. |
perturbation of reelin signaling interferes with the speed and orientation of tangentially, but not radially, migrating dopaminergic neurons and results in severe defects in the formation of the sn. |
2014-03-20 |
2023-08-12 |
mouse |
| Gabriela Oana Bodea, Jan-Hendrik Spille, Philipp Abe, Aycan Senturk Andersson, Amparo Acker-Palmer, Ralf Stumm, Ulrich Kubitscheck, Sandra Blaes. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449842. |
with this study, we provide the first molecular and functional characterization of the distinct migratory pathways taken by dopaminergic neurons destined for sn and vta, and uncover mechanisms that regulate different migratory behaviors of dopaminergic neurons. |
2014-03-20 |
2023-08-12 |
mouse |
| N Emmanuel Díaz-Martínez, Elisa Tamariz, N Fabián Díaz, Claudia M García-Peña, Alfredo Varela-Echavarría, Iván Velasc. Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 8. 2014-03-06. PMID:23732989. |
one strategy to promote axonal growth of dopaminergic neurons from the substantia nigra (sn) to the striatum is degradation of inhibitory components such as chondroitin sulphate proteoglycans (cspg). |
2014-03-06 |
2023-08-12 |
rat |