| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun-Jung Park, Jin Young Shin, Bo Ra Lee, Hyun Ok Kim, Phil Hyu Le. Mesenchymal stem cells augment neurogenesis in the subventricular zone and enhance differentiation of neural precursor cells into dopaminergic neurons in the substantia nigra of a parkinsonian model. Cell transplantation. vol 21. issue 8. 2013-04-01. PMID:22546197. |
the present study demonstrated that hmsc administration significantly augmented neurogenesis in both the svz and sn of pd animal models, which led to increased differentiation of npcs into dopaminergic neurons in the sn. |
2013-04-01 |
2023-08-12 |
human |
| F L Campos, A C Cristovão, S M Rocha, C P Fonseca, G Baltaza. GDNF contributes to oestrogen-mediated protection of midbrain dopaminergic neurones. Journal of neuroendocrinology. vol 24. issue 11. 2013-03-28. PMID:22672424. |
parkinson's disease (pd) is characterised by the preferential loss of dopaminergic neurones from the substantia nigra (sn) that leads to the hallmark motor disturbances. |
2013-03-28 |
2023-08-12 |
human |
| Gulay Hacioglu, Yasemin Seval-Celik, Gamze Tanriover, Ozlem Ozsoy, Esen Saka-Topcuoglu, Sevin Balkan, Aysel Aga. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. Folia histochemica et cytobiologica. vol 50. issue 2. 2013-03-26. PMID:22763967. |
the dopaminergic lesion was determined by immunohistochemical analysis for tyrosine hydroxylase (th)-immunopositive cells in substantia nigra (sn). |
2013-03-26 |
2023-08-12 |
rat |
| Mi Jin Kim, Dae Won Kim, Hoon Jae Jeong, Eun Jeong Sohn, Min Jea Shin, Eun Hee Ahn, Soon Won Kwon, Young Nam Kim, Duk-Soo Kim, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease. Biochimie. vol 94. issue 11. 2013-03-05. PMID:22809528. |
parkinson's disease (pd) is caused by various factors such as reactive oxygen species (ros), dysfunction of mitochondria, and aggregation of misfolded proteins, thereby leading to loss of dopaminergic (da) neurons in the substantia nigra (sn) of the brain. |
2013-03-05 |
2023-08-12 |
mouse |
| Franz Marxreiter, Martin Regensburger, Jürgen Winkle. Adult neurogenesis in Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 70. issue 3. 2013-03-04. PMID:22766974. |
the diagnosis of pd is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (sn). |
2013-03-04 |
2023-08-12 |
Not clear |
| Eun S Park, Sang R Kim, Byung K Ji. Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress. Brain research bulletin. vol 89. issue 3-4. 2013-02-27. PMID:22796104. |
the present study examined whether capsaicin (cap), an agonist of transient receptor potential vanilloid subtype 1 (trpv1) can prevent 1-methyl-4-phenylpyridinium (mpp(+))-induced dopaminergic (da) neuronal death in the substantia nigra (sn). |
2013-02-27 |
2023-08-12 |
rat |
| Mohammad Hossein Esmaeili, Mohadeseh Movahedi, Ayda Faraji, Hashem Haghdoost-Yazd. Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicology and teratology. vol 34. issue 5. 2013-02-25. PMID:22789434. |
considering that the rotational test is only valid in animals with severe parkinsonism, but time spent on the rotating rod correlates inversely with severity of parkinsonism, our results indicate that a single exposure to low amounts of nh is effective in producing moderate parkinsonism-like behavioral symptoms, possibly through a neurotoxic effect of this agent on the sn dopaminergic neurons. |
2013-02-25 |
2023-08-12 |
rat |
| Olivier Pauly, Seyed-Ahmad Ahmadi, Annika Plate, Kai Boetzel, Nassir Nava. Detection of substantia nigra echogenicities in 3D transcranial ultrasound for early diagnosis of Parkinson disease. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286161. |
parkinson's disease (pd) is a neurodegenerative movement disorder caused by decay of dopaminergic cells in the substantia nigra (sn), which are basal ganglia residing within the midbrain area. |
2013-01-29 |
2023-08-12 |
Not clear |
| Candan Depboylu, Sarah Stricker, Jean-Pierre Ghobril, Wolfgang H Oertel, Josef Priller, Günter U Höglinge. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22964486. |
parkinson disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2013-01-21 |
2023-08-12 |
mouse |
| Candan Depboylu, Sarah Stricker, Jean-Pierre Ghobril, Wolfgang H Oertel, Josef Priller, Günter U Höglinge. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22964486. |
we found that half of both endogenous (gfp-) and exogenous (gfp+) microglia (iba1+) in the sn incorporated the tracer from degenerating dopaminergic neurons 1d after mptp intoxication. |
2013-01-21 |
2023-08-12 |
mouse |
| Candan Depboylu, Sarah Stricker, Jean-Pierre Ghobril, Wolfgang H Oertel, Josef Priller, Günter U Höglinge. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22964486. |
our data suggest that brain-resident microglia are predominantly implicated in the removal of dopaminergic cell debris and the cross-talk with infiltrating t-lymphocytes in the sn in the mptp mouse model of pd. |
2013-01-21 |
2023-08-12 |
mouse |
| C-Y Chen, Y-H Weng, K-Y Chien, K-J Lin, T-H Yeh, Y-P Cheng, C-S Lu, H-L Wan. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell death and differentiation. vol 19. issue 10. 2013-01-14. PMID:22539006. |
(g2019s) lrrk2 activates mkk4-jnk pathway and causes degeneration of sn dopaminergic neurons in a transgenic mouse model of pd. |
2013-01-14 |
2023-08-12 |
mouse |
| C-Y Chen, Y-H Weng, K-Y Chien, K-J Lin, T-H Yeh, Y-P Cheng, C-S Lu, H-L Wan. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell death and differentiation. vol 19. issue 10. 2013-01-14. PMID:22539006. |
our results suggest that mutant (g2019s) lrrk2 activates mkk4-jnk-c-jun pathway in the sn and causes the resulting degeneration of snpc dopaminergic neurons in pd transgenic mice. |
2013-01-14 |
2023-08-12 |
mouse |
| Yan Zhou, Yanxin Zhang, Junquan Li, Fengyue Lv, Yongmei Zhao, Deyi Duan, Qunyuan X. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957701. |
parkinson's disease (pd) is characterized by selective and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-01-10 |
2023-08-12 |
rat |
| Yan Zhou, Yanxin Zhang, Junquan Li, Fengyue Lv, Yongmei Zhao, Deyi Duan, Qunyuan X. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957701. |
these results indicate that microglia are activated for several months after a single, low dose injection of lps, which eventually results in progressive and selective damage to dopaminergic neurons in the sn. |
2013-01-10 |
2023-08-12 |
rat |
| Philip Long, Parwez Samnakay, Peter Jenner, Sarah Ros. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22779921. |
osteopontin (opn) expression is reduced in surviving dopaminergic neurones in the substantia nigra (sn) in parkinson's disease (pd), and protects against mpp(+) -induced cell death in primary mesencephalic cultures and 6-ohda-induced cell loss in the rat, while inactivation of opn aggravates cell death. |
2013-01-09 |
2023-08-12 |
human |
| Hoon Jae Jeong, Dae Won Kim, Su Jung Woo, Hye Ri Kim, So Mi Kim, Hyo Sang Jo, Meeyoung Park, Duk-Soo Kim, Oh-Shin Kwon, In Koo Hwang, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Cho. Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model. Molecules and cells. vol 33. issue 5. 2012-12-07. PMID:22526393. |
parkinson's disease (pd) is a well known neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compact (sn). |
2012-12-07 |
2023-08-12 |
mouse |
| Virginie Licker, Mélanie Côte, Johannes Alexander Lobrinus, Neftali Rodrigo, Enikö Kövari, Denis F Hochstrasser, Natacha Turck, Jean-Charles Sanchez, Pierre R Burkhar. Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease. Journal of proteomics. vol 75. issue 15. 2012-12-04. PMID:22410244. |
immunohistochemical analyses demonstrated the presence of cndp2 within the cytoplasm of sn dopaminergic neurons. |
2012-12-04 |
2023-08-12 |
human |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| Melanie B Watson, Franziska Richter, Soo Kyung Lee, Lauryn Gabby, Jennifer Wu, Eliezer Masliah, Rita B Effros, Marie-Françoise Chessele. Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22750327. |
our results suggest that specific factors, possibly involving a regionally and temporally selective increase in tlrs, mediate alpha-synuclein-induced inflammatory responses in the sn, and may play a role in the selective vulnerability of nigrostriatal dopaminergic neurons in pd. |
2012-11-13 |
2023-08-12 |
mouse |