| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsin-Yi Huang, Shinn-Zong Lin, Wu-Fu Chen, Kuo-Wei Li, Jon-Son Kuo, Mei-Jen Wan. Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase. Neurobiology of aging. vol 32. issue 9. 2012-05-17. PMID:19875195. |
although ucn is principally expressed in dopaminergic neurons in rat substantia nigra (sn), the function of ucn in modulating dopaminergic neuronal survival remains unclear. |
2012-05-17 |
2023-08-12 |
rat |
| Almas Siddiqui, Jyothi K Mallajosyula, Anand Rane, Julie K Anderse. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21809503. |
we previously demonstrated that elevation of astrocytic monoamine oxidase b (mao-b) levels in adoxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to those observed in the parkinsonian midbrain (mallajosyula et al., 2008).these include a specific, selective and progressive loss of dopaminergic neurons of the substantia nigra (sn),selective decreases in mitochondrial complex i (ci) activity and increased oxidative stress. |
2012-05-07 |
2023-08-12 |
mouse |
| Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capel. Dopamine and α-synuclein dysfunction in Smad3 null mice. Molecular neurodegeneration. vol 6. 2012-04-24. PMID:21995845. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2012-04-24 |
2023-08-12 |
mouse |
| Tae Woo Kim, Younghye Moon, Kyungjin Kim, Jeong Eun Lee, Hyun Chul Koh, Im Joo Rhyu, Hyun Kim, Woong Su. Dissociation of progressive dopaminergic neuronal death and behavioral impairments by Bax deletion in a mouse model of Parkinson's diseases. PloS one. vol 6. issue 10. 2012-04-06. PMID:22043283. |
parkinson's disease (pd) is a common, late-onset movement disorder with selective degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2012-04-06 |
2023-08-12 |
mouse |
| Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyungjin Bae, Younbyoung Chae, Insop Shim, Hyangsook Lee, Woongjoon Moon, Hyejung Lee, Hi-Joon Par. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132113. |
parkinson's disease (pd) is caused by the selective loss of dopaminergic neurons in the substantia nigra (sn) and the depletion of striatal dopamine (da). |
2012-04-02 |
2023-08-12 |
mouse |
| Ye-Ming J Sun, Theresa Hoang, Judith A Neubauer, Arthur S Walter. Opioids protect against substantia nigra cell degeneration under conditions of iron deprivation: a mechanism of possible relevance to the Restless Legs Syndrome (RLS) and Parkinson's disease. Journal of the neurological sciences. vol 304. issue 1-2. 2012-03-06. PMID:21376342. |
cell cultures of the substantia nigra (sn) of sprague-dawley rats were established and the cells were determined to be primarily dopaminergic. |
2012-03-06 |
2023-08-12 |
rat |
| Alicia M Pickrell, Milena Pinto, Aline Hida, Carlos T Morae. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 48. 2012-02-09. PMID:22131425. |
these mice recapitulate most of the major features of pd: they have a motor phenotype that is reversible with l-dopa treatment, a progressive neurodegeneration of the sn dopaminergic population, and striatal da depletion. |
2012-02-09 |
2023-08-12 |
mouse |
| Takashi Tateno, Hugh P C Robinso. The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I(h) and GABAergic synaptic integration. Journal of neurophysiology. vol 106. issue 4. 2012-02-08. PMID:21697445. |
hyperpolarization-activated and cyclic nucleotide-gated (hcn) channels are expressed in dopaminergic (da) neurons of the ventral tegmental area (vta) as well as in da and gabaergic neurons of the substantia nigra (sn). |
2012-02-08 |
2023-08-12 |
rat |
| b' A Anastas\\xc3\\xada, J Wojnacki, G A de Erausquin, D H Masc\\xc3\\xb. Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson\'s disease. Neuroscience. vol 195. 2012-02-06. PMID:21871541.' |
we previously reported that ecs protects the integrity of the rat nigrostriatal dopaminergic system against 6-hydroxydopamine (6-ohda)-induced toxicity; in order to shed light into its neuroprotective mechanism, we studied glial cell-line derived neurotrophic factor (gdnf) levels (the most efficient tf for dopaminergic neurons) in the substantia nigra (sn) and striatum of 6-ohda-injected animals with or without ecs treatment. |
2012-02-06 |
2023-08-12 |
human |
| Rajeswara Babu Mythri, C Venkateshappa, G Harish, Anita Mahadevan, Uday B Muthane, T C Yasha, M M Srinivas Bharath, S K Shanka. Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson's disease brains. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21484266. |
dopaminergic neurons die in parkinson's disease (pd) due to oxidative stress and mitochondrial dysfunction in the substantia nigra (sn). |
2012-02-01 |
2023-08-12 |
human |
| Yanxia Yang, Jiaze An, Yayun Wang, Wenjing Luo, Wei Wang, Xiaopeng Mei, Shengxi Wu, Jingyuan Che. Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neurons. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787683. |
our previous studies showed chronic exposure to manganese chloride (mn) causes locomotor impairment and lesion of dopaminergic neurons in substantia nigra (sn). |
2012-01-23 |
2023-08-12 |
mouse |
| Yanxia Yang, Jiaze An, Yayun Wang, Wenjing Luo, Wei Wang, Xiaopeng Mei, Shengxi Wu, Jingyuan Che. Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neurons. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787683. |
but effects of acute mn exposure on locomotor ability, sn dopaminergic and gabaergic neurons were not clear. |
2012-01-23 |
2023-08-12 |
mouse |
| Yanxia Yang, Jiaze An, Yayun Wang, Wenjing Luo, Wei Wang, Xiaopeng Mei, Shengxi Wu, Jingyuan Che. Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neurons. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787683. |
the numbers of sn dopaminergic and gabaergic neurons were not altered significantly 24h after mn injection; however, some of sn gabaergic neurons were activated and dopaminergic neurons were left inactivated. |
2012-01-23 |
2023-08-12 |
mouse |
| Yanxia Yang, Jiaze An, Yayun Wang, Wenjing Luo, Wei Wang, Xiaopeng Mei, Shengxi Wu, Jingyuan Che. Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neurons. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787683. |
our data suggested that activation of sn gabaergic neurons but not lesion of dopaminergic neurons, which was found to play an important role in the mn-induced chronic neurotoxicity in our previous studies, contributed partially to mn-induced acute locomotor impairment. |
2012-01-23 |
2023-08-12 |
mouse |
| Hiroyasu Sato, Shigeki Arawaka, Susumu Hara, Shingo Fukushima, Kaori Koga, Shingo Koyama, Takeo Kat. Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 46. 2012-01-12. PMID:22090514. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the appearance of fibrillar aggregates of insoluble α-synuclein (α-syn) called lewy bodies (lbs). |
2012-01-12 |
2023-08-12 |
rat |
| Raymond T Bartus, Lamar Brown, Alistair Wilson, Brian Kruegel, Joao Siffert, Eugene M Johnson, Jeffrey H Kordower, Christopher D Herzo. Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease. Neurobiology of disease. vol 44. issue 1. 2011-12-01. PMID:21704161. |
we also showed that prior destruction of the dopaminergic sn neurons via 6-ohda had no impact on the weight loss phenomenon, further dissociating neurotrophic exposure to the sn as the culprit for weight changes. |
2011-12-01 |
2023-08-12 |
human |
| Sandra Blaess, Gabriela O Bodea, Anna Kabanova, Soline Chanet, Emilie Mugniery, Amin Derouiche, Daniel Stephen, Alexandra L Joyne. Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural development. vol 6. 2011-11-15. PMID:21689430. |
the ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (vta) and substantia nigra (sn) and neurons of the red nucleus (rn). |
2011-11-15 |
2023-08-12 |
Not clear |
| Wei Zhang, Kester Phillips, Albert R Wielgus, Jie Liu, Alberto Albertini, Fabio A Zucca, Rudolph Faust, Steven Y Qian, David S Miller, Colin F Chignell, Belinda Wilson, Vernice Jackson-Lewis, Serge Przedborski, Danielle Joset, John Loike, Jau-Shyong Hong, David Sulzer, Luigi Zecc. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:19957214. |
herein, we have investigated the interplay between microglia and human nm on the degeneration of sn dopaminergic neurons. |
2011-11-08 |
2023-08-12 |
mouse |
| Jeswinder Sian-Hülsmann, Silvia Mandel, Moussa B H Youdim, Peter Riedere. The relevance of iron in the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21138437. |
however, intensive investigations have provided a host of putative mechanisms that might contribute to the pathogenesis underlying the characteristic degeneration of the dopaminergic neurons in the substantia nigra (sn). |
2011-11-01 |
2023-08-12 |
Not clear |
| Gregory P Mark, Shkelzen Shabani, Lauren K Dobbs, Stephen T Hanse. Cholinergic modulation of mesolimbic dopamine function and reward. Physiology & behavior. vol 104. issue 1. 2011-10-14. PMID:21549724. |
cholinergic cells in the pons project to da-rich cell body regions in the ventral tegmental area (vta) and substantial nigra (sn) where they modulate the activity of dopaminergic neurons and reward processing. |
2011-10-14 |
2023-08-12 |
Not clear |