| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dario Domenico Lofrumento, Concetta Saponaro, Antonia Cianciulli, Francesco De Nuccio, Vincenzo Mitolo, Giuseppe Nicolardi, Maria Antonietta Panar. MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain. Neuroimmunomodulation. vol 18. issue 2. 2011-04-06. PMID:20938211. |
parkinson's disease (pd) is a common neurodegenerative disease characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2011-04-06 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the change of dopamine was very similar to dopaminergic neurons in the sn. |
2011-04-04 |
2023-08-12 |
mouse |
| Hey-Kyeong Jeong, Ilo Jou, Eun-hye Jo. Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Experimental & molecular medicine. vol 42. issue 12. 2011-03-23. PMID:20962566. |
interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mrna/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (sn), where dopaminergic neurons are located. |
2011-03-23 |
2023-08-12 |
rat |
| Shih-Ying Wu, Tzu-Feng Wang, Lung Yu, Chauying J Jen, Jih-Ing Chuang, Fong-Sen Wu, Chih-Wei Wu, Yu-Min Ku. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain, behavior, and immunity. vol 25. issue 1. 2011-03-10. PMID:20851176. |
parkinson's disease (pd) is characterized by a progressive and selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2011-03-10 |
2023-08-12 |
Not clear |
| Rodrigo Somoza, Carlos Juri, Mauricio Baes, Ursula Wyneken, Francisco Javier Rubi. Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson's disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 16. issue 11. 2011-03-04. PMID:20542127. |
one week after transplantation into the sn, the human cells integrated into the surrounding tissue, and some showed a dopaminergic phenotype. |
2011-03-04 |
2023-08-12 |
human |
| O-B Tysnes, B Müller, J P Larse. Are dysautonomic and sensory symptoms present in early Parkinson's disease? Acta neurologica Scandinavica. Supplementum. issue 190. 2011-02-25. PMID:20586740. |
the motor symptoms in pd are related to the degeneration of dopaminergic cells in the substantia nigra (sn). |
2011-02-25 |
2023-08-12 |
Not clear |
| Jun Ping Cao, Fu Zhen Li, Yuan Yuan Zhu, Hong Hua Yuan, Zheng Quan Yu, Dian Shuai Ga. Expressions and possible roles of GDNF receptors in the developing dopaminergic neurons. Brain research bulletin. vol 83. issue 6. 2011-02-24. PMID:20884338. |
glial cell line-derived neurotrophic factor (gdnf) has an essential role in the survival and maturation of the dopaminergic (da) neurons in the substantia nigra (sn) of mammalian embryonic brain. |
2011-02-24 |
2023-08-12 |
human |
| Carsten Nicolas Boehler, Nico Bunzeck, Ruth M Krebs, Toemme Noesselt, Mircea A Schoenfeld, Hans-Jochen Heinze, Thomas F Münte, Marty G Woldorff, Jens-Max Hop. Substantia nigra activity level predicts trial-to-trial adjustments in cognitive control. Journal of cognitive neuroscience. vol 23. issue 2. 2011-02-11. PMID:20465358. |
in particular, dopaminergic projections from the midbrain (i.e., from the substantia nigra [sn] and the ventral tegmental area) have been proposed to play a pivotal role in modulating the activity in these areas for cognitive control purposes. |
2011-02-11 |
2023-08-12 |
Not clear |
| Carsten Nicolas Boehler, Nico Bunzeck, Ruth M Krebs, Toemme Noesselt, Mircea A Schoenfeld, Hans-Jochen Heinze, Thomas F Münte, Marty G Woldorff, Jens-Max Hop. Substantia nigra activity level predicts trial-to-trial adjustments in cognitive control. Journal of cognitive neuroscience. vol 23. issue 2. 2011-02-11. PMID:20465358. |
this link between sn activity and subsequent behavioral adjustments lends support to theoretical accounts that propose dopaminergic control signals that shape behavior both in the presence and in the absence of direct reward. |
2011-02-11 |
2023-08-12 |
Not clear |
| Christopher J Barnum, Malú G Tanse. Modeling neuroinflammatory pathogenesis of Parkinson's disease. Progress in brain research. vol 184. 2011-01-21. PMID:20887872. |
the molecular mechanisms underlying the pathogenesis of idiopathic parkinson's disease (pd) have not been completely elucidated; however, some progress has been made in identifying factors that compromise survival of the dopaminergic neurons in the substantia nigra (sn) the death of which give rise to the motor symptoms that enable clinicians to diagnose the disease in its mid- to late stages. |
2011-01-21 |
2023-08-12 |
Not clear |
| Almas Siddiqui, Jyothi K Mallajosyula, Anand Rane, Julie K Anderse. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20655384. |
these include a specific, selective and progressive loss of dopaminergic neurons of the substantia nigra (sn), selective decreases in mitochondrial complex i (ci) activity and increased oxidative stress. |
2011-01-12 |
2023-08-12 |
mouse |
| Michela Deleidi, Penelope J Hallett, James B Koprich, Chee-Yeun Chung, Ole Isacso. The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 48. 2011-01-06. PMID:21123556. |
in parkinson's disease (pd), loss of striatal dopaminergic (da) terminals and degeneration of da neurons in the substantia nigra (sn) are associated with glial reactions. |
2011-01-06 |
2023-08-12 |
rat |
| Yoshihisa Kitamur. [Dopaminergic neuroprotection and reconstruction of neural network tiara]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 130. issue 10. 2010-12-30. PMID:20930477. |
parkinson's disease (pd) is an age-related neurodegenerative disorder in whose brain massive loss of dopaminergic neurons and formation of lewy bodies occur in the substantia nigra (sn). |
2010-12-30 |
2023-08-12 |
mouse |
| Bonnie G Garcia, M Diana Neely, Ariel Y Deutc. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 10. 2010-12-28. PMID:20118184. |
striatal medium spiny neurons (msns) receive glutamatergic afferents from the cerebral cortex and dopaminergic inputs from the substantia nigra (sn). |
2010-12-28 |
2023-08-12 |
Not clear |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Ning Song, Jun Wang, Hong Jiang, Junxia Xi. Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells. Journal of cellular biochemistry. vol 110. issue 5. 2010-11-15. PMID:20564203. |
our previous in vivo experiments suggested that decreased ferroportin1 (fpn1) and hephaestin (hp) expression might account for the cellular iron accumulation and resulting dopaminergic neurons loss in the sn of pd animal models. |
2010-11-15 |
2023-08-12 |
Not clear |
| Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R Kramer, Wolfgang Wurst, Rüdiger Klei. Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS biology. vol 8. issue 4. 2010-09-01. PMID:20386724. |
while inactivation of dj-1, an oxidative stress suppressor, causes pd, animal models lacking dj-1 show no overt dopaminergic (da) neuron degeneration in the sn. |
2010-09-01 |
2023-08-12 |
mouse |
| Li Lu, Fengqiao Li, Xiaomin Wan. Novel anti-inflammatory and neuroprotective agents for Parkinson's disease. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20015029. |
parkinson's disease (pd) is a type of motor system disorder that results from the progressive loss of dopaminergic (daergic) neurons in the substantia nigra (sn) of the midbrain. |
2010-07-12 |
2023-08-12 |
Not clear |
| Hong-Ning Zhang, Chun-Na An, Hui-Nan Zhang, Xiao-Ping P. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227465. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-07-08 |
2023-08-12 |
mouse |