| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Candan Depboylu, Kathrin Schorlemmer, Martin Klietz, Wolfgang H Oertel, Eberhard Weihe, Günter U Höglinger, Martin K-H Schäfe. Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease. Journal of neuroimmunology. vol 236. issue 1-2. 2011-09-13. PMID:21640391. |
c1q-positive microglia exhibited morphological characteristics of activated macrophage-type of cells, co-stained for mhcii, proliferated and were in close contact with degenerating dopaminergic neurons and fibers in the mptp-lesioned sn. |
2011-09-13 |
2023-08-12 |
mouse |
| Evangelos Sotiriou, Demetrios K Vassilatis, Miquel Vila, Leonidas Stefani. Selective noradrenergic vulnerability in α-synuclein transgenic mice. Neurobiology of aging. vol 31. issue 12. 2011-08-29. PMID:19152986. |
classical pathological signs of parkinson's disease (pd) include loss of dopaminergic neurons in substantia nigra (sn) and noradrenergic neurons in locus coeruleus (lc), and deposition of lewy bodies rich in the presynaptic protein alpha-synuclein (asyn). |
2011-08-29 |
2023-08-12 |
mouse |
| A Van der Perren, J Toelen, M Carlon, C Van den Haute, F Coun, B Heeman, V Reumers, L H Vandenberghe, J M Wilson, Z Debyser, V Baekeland. Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. Gene therapy. vol 18. issue 5. 2011-08-22. PMID:21326331. |
in light of the further development of a viral vector-mediated rat model for pd, we performed a comprehensive comparison of the transduction and tropism for dopaminergic neurons (dns) in the adult wistar rat substantia nigra (sn) of seven raav vector serotypes (raav 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9). |
2011-08-22 |
2023-08-12 |
rat |
| Jun Hu, Chenlei Zhu, Yuan Liu, Fang Wang, Zuhu Huang, Weimin Fan, Jie W. Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model. Neuroscience letters. vol 494. issue 3. 2011-08-17. PMID:21406211. |
(4) stereological data showed that after administration of mptp for 24h, there was a robust astrogliosis in the sn associated with significant dopaminergic neurodegeneration. |
2011-08-17 |
2023-08-12 |
mouse |
| Zhanyun Lv, Hong Jiang, Huamin Xu, Ning Song, Junxia Xi. Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 3. 2011-08-16. PMID:20556443. |
moreover, the lipofuscin granular aggregations and upregulation of α-synuclein were also involved in the selective degeneration of dopaminergic neurons in the sn. |
2011-08-16 |
2023-08-12 |
mouse |
| Zang-Hee Cho, Se-Hong Oh, Jong-Min Kim, Sung-Yeon Park, Dae-Hyuk Kwon, Hye-Jin Jeong, Young-Bo Kim, Je-Geun Chi, Chan-Woong Park, John Huston, Kendall H Lee, Beom S Jeo. Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 4. 2011-08-15. PMID:21506148. |
parkinson's disease (pd) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2011-08-15 |
2023-08-12 |
human |
| Sun Shan, Tang Hong-Min, Feng Yi, Gao Jun-Peng, Fan Yue, Tang Yan-Hong, Yang Yun-Ke, Li Wen-Wei, Wang Xiang-Yu, Ma Jun, Wang Guo-Hua, Huang Ya-Ling, Li Hua-Wei, Cai Ding-Fan. New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:19368990. |
to further investigate the role of fractalkine in pd, we injected exogenous fractalkine in unilateral sn, and observed microglial activation, dopaminergic cell depletion, and motor dysfunction. |
2011-07-19 |
2023-08-12 |
rat |
| E Kirche. Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson's Disease? Current genomics. vol 10. issue 8. 2011-07-14. PMID:20514220. |
it became necessary to exploit pcr techniques, which were able to detect any deletion in a few microdissected dopaminergic neurons of the sn. |
2011-07-14 |
2023-08-12 |
Not clear |
| E Kirche. Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson's Disease? Current genomics. vol 10. issue 8. 2011-07-14. PMID:20514220. |
they seem to accumulate to relevant levels in the sn dopaminergic neurons of aged individuals in general, but faster in those developing pd. |
2011-07-14 |
2023-08-12 |
Not clear |
| James B Koprich, Tom H Johnston, M Gabriela Reyes, Xuan Sun, Jonathan M Brotchi. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:21029459. |
the pathological hallmarks of parkinson's disease (pd) include the presence of alpha-synuclein (α-syn) rich lewy bodies and neurites and the loss of dopaminergic (da) neurons of the substantia nigra (sn). |
2011-07-14 |
2023-08-12 |
human |
| Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malle. 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21211034. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), resulting in tremor, rigidity, and bradykinesia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Anna R Carta, Augusta Pisanu, Ezio Carbon. Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? Parkinson's disease. vol 2011. 2011-07-14. PMID:21603186. |
moreover, after the discovery of infiltrating activated limphocytes in the substantia nigra (sn) of pd patients, most recent research supports a role of immune-mediated mechanisms in the pathological process leading to chronic neuroinflammation and dopaminergic degeneration. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
pink1 is believed to exert neuroprotective effect on sn dopaminergic cells by acting as a mitochondrial ser/thr protein kinase. |
2011-06-09 |
2023-08-12 |
mouse |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
in the present study, confocal imaging of cultured sn dopaminergic neurons prepared from pink1 knockout mice was performed to investigate physiological importance of pink1 in maintaining mitochondrial membrane potential (ΔΨ(m)) and mitochondrial morphology and test the hypothesis that park6 mutations cause the loss of pink1 function. |
2011-06-09 |
2023-08-12 |
mouse |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
pink1-deficient sn dopaminergic neurons exhibited a depolarized ΔΨ(m). |
2011-06-09 |
2023-08-12 |
mouse |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
in contrast to long thread-like mitochondria of wild-type neurons, fragmented mitochondria were observed from pink1-null sn dopaminergic cells. |
2011-06-09 |
2023-08-12 |
mouse |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
mitochondrial toxin rotenone-induced cell death of dopaminergic neurons was augmented in pink1-null sn neuronal culture. |
2011-06-09 |
2023-08-12 |
mouse |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
these results indicate that pink1 is required for maintaining normal ΔΨ(m) and mitochondrial morphology of cultured sn dopaminergic neurons and exerts its neuroprotective effect by inhibiting ros formation. |
2011-06-09 |
2023-08-12 |
mouse |
| Hung-Li Wang, An-Hsun Chou, Ai-Shun Wu, Si-Ying Chen, Yi-Hsin Weng, Yu-Cheng Kao, Tu-Hsueh Yeh, Po-Ju Chu, Chin-Song L. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et biophysica acta. vol 1812. issue 6. 2011-06-09. PMID:21421046. |
our study also provides the evidence that park6 mutant (g309d), (e417g) or (cΔ145) pink1 is defective in regulating mitochondrial functions and attenuating ros production of sn dopaminergic cells. |
2011-06-09 |
2023-08-12 |
mouse |
| Pamela J McMillan, Sylvia S White, Allyn Franklin, J Lynne Greenup, James B Leverenz, Murray A Raskind, Patricia Szo. Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease. Brain research. vol 1373. 2011-05-03. PMID:21147074. |
in parkinson's disease (pd), there is a significant loss of noradrenergic neurons in the locus coeruleus (lc) in addition to the loss of dopaminergic neurons in the substantia nigra (sn). |
2011-05-03 |
2023-08-12 |
human |