| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Salma Bukhatwa, Bai-Yun Zeng, Sarah Rose, Peter Jenne. A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. Brain research. vol 1326. 2010-06-25. PMID:20176003. |
dysfunction of the ubiquitin-proteasome system (ups) occurs in dopaminergic neurones in the sn in pd and it is associated with lewy body formation. |
2010-06-25 |
2023-08-12 |
Not clear |
| G Todd, J L Taylor, D Baumann, J E Butler, S R Duma, M Hayes, F Carew-Jones, O Piguet, S Behnke, M C Ridding, D Berg, K L Doubl. Substantia nigra echomorphology and motor cortex excitability. NeuroImage. vol 50. issue 4. 2010-06-23. PMID:20117219. |
this study provides further evidence that sn hyperechogenicity in healthy individuals is associated with changes characteristic of pd supporting a role for this feature as a vulnerability marker or state marker for subtle nigral dopaminergic dysfunction. |
2010-06-23 |
2023-08-12 |
human |
| L Hunter Randy, Bing Guoyin. Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease. Current neuropharmacology. vol 5. issue 1. 2010-06-11. PMID:18615152. |
evidence suggests inflammation, mitochondria dysfunction, and oxidative stress play major roles in parkinson's disease (pd), where the primary pathology is the significant loss of dopaminergic neurons in the substantia nigra (sn). |
2010-06-11 |
2023-08-12 |
Not clear |
| Li-Fang Hu, Ming Lu, Chi Xin Tiong, Gavin S Dawe, Gang Hu, Jin-Song Bia. Neuroprotective effects of hydrogen sulfide on Parkinson's disease rat models. Aging cell. vol 9. issue 2. 2010-06-10. PMID:20041858. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2010-06-10 |
2023-08-12 |
rat |
| Yong-Sheng Wang, Jian-Ping Zhou, Zi-Feng Wei, Qing-You Tian, Hong-Xia Zhou, Yu-Xin Zhan. [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 8. 2010-06-09. PMID:17715026. |
to investigate the effect of phophorylated c-jun (p-c-jun) expression on the expression of cox-2 in the substantia nigra (sn) of the mptp mouse model of subacute parkinson disease (pd) and explore the possible mechanism of the dopaminergic (da) neuron death in pd. |
2010-06-09 |
2023-08-12 |
mouse |
| Fabio Coppedè, Roberto Ceravolo, Francesca Migheli, Francesca Fanucchi, Daniela Frosini, Gabriele Siciliano, Ubaldo Bonuccelli, Lucia Miglior. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. Neuroscience letters. vol 473. issue 3. 2010-05-17. PMID:20193742. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders characterized by progressive and profound loss of dopaminergic neurons in the substantia nigra (sn) resulting in resting tremor, rigidity, bradykinesia, and postural instability. |
2010-05-17 |
2023-08-12 |
mouse |
| Chong Shi, Yu-xin Zhang, Zuo-feng Zhan. [Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP-induced Parkinson disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 1. 2010-04-29. PMID:19218114. |
to investigate the effect of phosphorylated-erk1/2 (p-erk1/2) on inducible nitric oxide synthase (inos) expression in the substantia nigra (sn) of a mouse model of parkinson's disease (pd), and explore the possible mechanism of dopaminergic (da) neuron loss in the sn of the midbrain in pd. |
2010-04-29 |
2023-08-12 |
mouse |
| Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdi. Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082978. |
large-scale transcriptomics analysis of gene expression profile of sporadic parkinson's disease (pd) substantia nigra (sn) has identified a number of differentially expressed genes participating in the neurotoxic cascade of da neurons death, in particular those related to handling of proteins, dopaminergic transmission and iron metabolism. |
2010-03-31 |
2023-08-12 |
human |
| E C Hirsc. Iron transport in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082992. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd) but the neurodegenerative mechanisms have not been completely elucidated. |
2010-03-31 |
2023-08-12 |
mouse |
| E C Hirsc. Iron transport in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082992. |
iron accumulation in dopaminergic neurons and glial cells in the sn of pd patients may contribute to the generation of oxidative stress, protein aggregation and neuronal death. |
2010-03-31 |
2023-08-12 |
mouse |
| June-Hee Park, Grigori Enikolopo. Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079351. |
the dentate gyrus (dg), a site of continuous production of new neurons in the adult hippocampus, receives dopaminergic inputs from the neurons of the substantia nigra (sn). |
2010-03-26 |
2023-08-12 |
mouse |
| Y-Q Xue, B-F Ma, L-R Zhao, J B Tatom, B Li, L-X Jiang, R L Klein, W-M Dua. AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease. Gene therapy. vol 17. issue 1. 2010-03-08. PMID:19727138. |
we have recently shown that intrastriatal injection of recombinant human erythropoietin (epo) protects dopaminergic (da) neurons in the substantia nigra (sn) from 6-hydroxydopamine (6-ohda) toxicity in a rat model of parkinson's disease. |
2010-03-08 |
2023-08-12 |
human |
| Joanne Clark, David K Simo. Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease. Antioxidants & redox signaling. vol 11. issue 3. 2010-03-01. PMID:18717631. |
parkinson's disease (pd) is a progressive, primarily motor disorder that is characterized by loss of dopaminergic (da) neurons within the substantia nigra (sn). |
2010-03-01 |
2023-08-12 |
mouse |
| Yu Luo, Sara Arezou Sarabi, Cristina Backman, Lufei Shan, Barry Hoffer, Howard Federof. Expression pattern of NuIP gene in adult mouse brain. Brain research. vol 1302. 2010-02-23. PMID:19765553. |
interestingly, nuip is expressed in high levels in midbrain dopaminergic neurons including ventral tegmental area (vta) and substantia nigra (sn) dopaminergic neurons but is not expressed or expressed in low levels in other dopaminergic neurons such as olfactory bulb and hypothalamus. |
2010-02-23 |
2023-08-12 |
mouse |
| Hong-Ning Zhang, Chun-Na An, Man Xu, De-An Guo, Min Li, Xiao-Ping P. Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin. Biological & pharmaceutical bulletin. vol 32. issue 11. 2010-02-17. PMID:19881299. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) with the presence of alpha-synuclein inclusions termed lewy bodies. |
2010-02-17 |
2023-08-12 |
rat |
| Chee Yeun Chung, James B Koprich, Penelope J Hallett, Ole Isacso. Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 52. 2010-02-17. PMID:20007772. |
in parkinson's disease (pd), dopaminergic (da) neurons in the substantia nigra (sn, a9) are particularly vulnerable, compared to adjacent da neurons within the ventral tegmental area (vta, a10). |
2010-02-17 |
2023-08-12 |
human |
| Lokesh Agrawal, Jean-Pierre Louboutin, Elena Marusich, Beverley A S Reyes, Elisabeth J Van Bockstaele, David S Straye. Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates. Brain research. vol 1306. 2010-02-03. PMID:19815008. |
we examined the role of reactive oxygen species (ros) in loss of dopaminergic neurons (dns) from the substantia nigra (sn) in neuroaids. |
2010-02-03 |
2023-08-12 |
rat |
| Rachel Hammond, Sandra Blaess, Asa Abeliovic. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PloS one. vol 4. issue 9. 2010-02-01. PMID:19774071. |
midbrain dopaminergic axons project from the substantia nigra (sn) and the ventral tegmental area (vta) to rostral target tissues, including the striatum, pallidum, and hypothalamus. |
2010-02-01 |
2023-08-12 |
mouse |
| Carles Gaig, Eduardo Tolos. When does Parkinson's disease begin? Movement disorders : official journal of the Movement Disorder Society. vol 24 Suppl 2. 2010-01-26. PMID:19877243. |
pathological and neuroimaging studies have shown that in parkinson's disease (pd) there is a "subclinical" or "premotor" period during which dopaminergic neurons in the substantia nigra (sn) degenerate but typical motor symptoms have not yet developed. |
2010-01-26 |
2023-08-12 |
Not clear |
| Mika Shimoji, Fernando Pagan, Edward B Healton, Italo Mocchett. CXCR4 and CXCL12 expression is increased in the nigro-striatal system of Parkinson's disease. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19551455. |
in the human substantia nigra (sn), cxcr4 immunoreactivity was high in dopaminergic neurons. |
2010-01-25 |
2023-08-12 |
mouse |