| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emilce Carrasco, Peter Werner, Diana Caspe. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597941. |
finally, we show that melanized dopaminergic neurons in the human sn express ep2. |
2008-11-05 |
2023-08-12 |
human |
| Supriti Samantaray, Swapan K Ray, Naren L Bani. Calpain as a potential therapeutic target in Parkinson's disease. CNS & neurological disorders drug targets. vol 7. issue 3. 2008-11-05. PMID:18673214. |
pathophysiology of idiopathic parkinson's disease (pd) is associated with degeneration of dopaminergic neurons and inflammatory responses in the mid-brain substantia nigra (sn). |
2008-11-05 |
2023-08-12 |
Not clear |
| Supriti Samantaray, Swapan K Ray, Naren L Bani. Calpain as a potential therapeutic target in Parkinson's disease. CNS & neurological disorders drug targets. vol 7. issue 3. 2008-11-05. PMID:18673214. |
however, central dopaminergic replenishment therapeutic strategy with l-3,4-dihydroxyphenylalanine (l-dopa), the precursor for dopamine synthesis, does not fully rescue these cells in sn or improve motor function. |
2008-11-05 |
2023-08-12 |
Not clear |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2008-10-14 |
2023-08-12 |
human |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
after different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (sn, 1 week) were stained with iba-1 and/or gfap antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (th) to monitor dopaminergic cell survival (sn group only). |
2008-10-14 |
2023-08-12 |
human |
| Luigi Zecca, Henrik Wilms, Sebastian Geick, Jan-Hendrik Claasen, Lars-Ove Brandenburg, Christian Holzknecht, Michele L Panizza, Fabio A Zucca, Günther Deuschl, Jobst Sievers, Ralph Luciu. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. vol 116. issue 1. 2008-10-14. PMID:18343932. |
in the sn group, there was, apart from strong microglia activation, a significant dopaminergic cell loss after 1 week of survival time. |
2008-10-14 |
2023-08-12 |
human |
| Shankar J Chinta, Julie K Anderse. Redox imbalance in Parkinson's disease. Biochimica et biophysica acta. vol 1780. issue 11. 2008-10-08. PMID:18358848. |
parkinson's disease (pd) is an adult-onset neurodegenerative disorder characterized by preferential loss of dopaminergic neurons in an area of the midbrain called the substantia nigra (sn) along with occurrence of intraneuronal inclusions called lewy bodies. |
2008-10-08 |
2023-08-12 |
Not clear |
| Shankar J Chinta, Julie K Anderse. Redox imbalance in Parkinson's disease. Biochimica et biophysica acta. vol 1780. issue 11. 2008-10-08. PMID:18358848. |
dopaminergic neurons (da) are particularly prone to oxidative stress due to da metabolism and auto-oxidation combined with increased iron, decreased total glutathione levels and mitochondrial complex i inhibition-induced ros production in the sn which can lead to cell death by exceeding the oxidative capacity of da-containing cells in the region. |
2008-10-08 |
2023-08-12 |
Not clear |
| Steven R Danielson, Julie K Anderse. Oxidative and nitrative protein modifications in Parkinson's disease. Free radical biology & medicine. vol 44. issue 10. 2008-09-22. PMID:18395015. |
increased oxidative stress appears to be a common causative aspect involved in the preferential loss of dopaminergic neurons in a region of the brain prominently affected by the disorder, the substantia nigra (sn). |
2008-09-22 |
2023-08-12 |
Not clear |
| Steven R Danielson, Julie K Anderse. Oxidative and nitrative protein modifications in Parkinson's disease. Free radical biology & medicine. vol 44. issue 10. 2008-09-22. PMID:18395015. |
loss of dopaminergic sn neurons is responsible for the classic clinical motor symptoms associated with pd. |
2008-09-22 |
2023-08-12 |
Not clear |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
the current transplantation paradigm for parkinson's disease that places foetal dopaminergic cells in the striatum neither normalizes neuronal activity in basal ganglia structures such as the substantia nigra (sn) and subthalamic nucleus (stn) nor leads to complete functional recovery. |
2008-09-15 |
2023-08-12 |
human |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
it was hypothesized that restoration of parkinsonian deficits requires inhibition of the pathological overactivity of the stn and sn in addition to restoration of dopaminergic activity in the striatum. |
2008-09-15 |
2023-08-12 |
human |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
in hemiparkinsonian rats, transplantation of foetal rat dopaminergic cells in the striatum in conjunction with gabaergic grafts in the stn and/or sn promoted significant improvement in forelimb akinesia and motor function compared to transplantation of intrastriatal dopaminergic grafts alone or in conjunction with undifferentiated hnpcs. |
2008-09-15 |
2023-08-12 |
human |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
thus, restoration of dopaminergic activity to the striatum in concert with inhibition of the stn and sn by gabaergic grafts may be beneficial for improving clinical outcomes in patients with parkinson's disease and potential clinical application of this strategy may be enhanced by the use of differentiated hnpcs. |
2008-09-15 |
2023-08-12 |
human |
| Xi Jun He, Hirofumi Yamauchi, Koji Uetsuka, Hiroyuki Nakayam. Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease. Neurotoxicology. vol 29. issue 3. 2008-08-25. PMID:18387672. |
in recent years, the notion that the neurotoxicity of mptp is restricted to dopaminergic neurons in the substantia nigra (sn) has been challenged. |
2008-08-25 |
2023-08-12 |
mouse |
| Xi Jun He, Hirofumi Yamauchi, Koji Uetsuka, Hiroyuki Nakayam. Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease. Neurotoxicology. vol 29. issue 3. 2008-08-25. PMID:18387672. |
the results raise the possibility that migrating neuroblasts in the svz and rms may be more vulnerable to mptp than nigrostriatal dopaminergic neurons in the sn, and the death of migrating neuroblasts may be a primary event in the mouse model of pd. |
2008-08-25 |
2023-08-12 |
mouse |
| J T García Navia, M A Burguillos, A Ramón-Cueto, A Machado, J Cano, J L Vener. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18338800. |
time-course changes of trkb mrna expression demonstrated a robust increase in an area projecting from the rostral tip of the sn to the glial scar, which coincided with evidence of nigral dopaminergic sprouting. |
2008-08-20 |
2023-08-12 |
Not clear |
| Kristi L Haik, Deborah A Shear, Chad Hargrove, Jared Patton, Michelle Mazei-Robison, Michael I Sandstrom, Gary L Dunba. 7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Experimental and clinical psychopharmacology. vol 16. issue 2. 2008-08-13. PMID:18489022. |
parkinson's disease (pd) is a neurodegenerative disorder in which loss of dopaminergic (da) neurons (>50%) in the substantia nigra (sn) precedes most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. |
2008-08-13 |
2023-08-12 |
rat |
| Cheng-Fang Huang, Gang Li, Rong Ma, Sheng-Gang Sun, Jian-Guo Che. Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo. Neuroscience bulletin. vol 24. issue 2. 2008-08-11. PMID:18369384. |
to evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2008-08-11 |
2023-08-12 |
rat |
| Margarete Zanardo Gomes, Rita Raisman-Vozari, Elaine A Del Be. A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain research. vol 1203. 2008-08-01. PMID:18313645. |
these results suggest that nitric oxide synthase inhibition may decrease the toxic effects of 6-ohda on dopaminergic terminals and on dopamine cell bodies in sub-regions of the sn and on neuronal nitric oxide synthase cell density in the rat brain. |
2008-08-01 |
2023-08-12 |
rat |