| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Anderse. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286173. |
elevated astrocytic mao-b mimicking age related increase resulted in specific, selective and progressive loss of dopaminergic neurons in the substantia nigra (sn), the same subset of neurons primarily impacted in the human condition. |
2008-07-15 |
2023-08-12 |
mouse |
| Balusamy Jagatha, Rajeswara Babu Mythri, Shireen Vali, M M Srinivas Bharat. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free radical biology & medicine. vol 44. issue 5. 2008-04-24. PMID:18166164. |
oxidative stress has been implicated in the degeneration of dopaminergic neurons in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2008-04-24 |
2023-08-12 |
mouse |
| H J Waldvogel, K Baer, W-P Gai, R T Gilbert, M I Rees, H Mohler, R L M Faul. Differential localization of GABAA receptor subunits within the substantia nigra of the human brain: an immunohistochemical study. The Journal of comparative neurology. vol 506. issue 6. 2008-04-04. PMID:18085588. |
the sn comprises two major regions, the sn pars compacta (snc) consisting of dopaminergic projection neurons, and the sn pars reticulata (snr) consisting of gabaergic parvalbumin-positive projection neurons. |
2008-04-04 |
2023-08-12 |
human |
| Koji Aoyama, Nobuko Matsumura, Masahiko Watabe, Toshio Nakak. Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction. The European journal of neuroscience. vol 27. issue 1. 2008-03-18. PMID:18093171. |
studies with chloromethylfluorescein diacetate, a gsh marker, demonstrated dopaminergic neurons in the sn to have increased gsh levels after nac treatment. |
2008-03-18 |
2023-08-12 |
mouse |
| Dae Y Song, Young C Yang, Dong H Shin, Shuei Sugama, Yoon S Kim, Bong H Lee, Tong H Joh, Byung P Ch. Axotomy-induced dopaminergic neurodegeneration is accompanied with c-Jun phosphorylation and activation transcription factor 3 expression. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:18036593. |
to elucidate the significance and functional role of these immediate-early genes during neuronal damage in the central nervous system, we examined temporal and spatial profiles of pc-jun and atf3 in dopaminergic neurons of the substantia nigra (sn) following transection of the medial forebrain bundle (mfb) in adult rats. |
2008-03-05 |
2023-08-12 |
rat |
| Emilce Carrasco, Diana Casper, Peter Werne. PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. Journal of neuroscience research. vol 85. issue 14. 2008-02-14. PMID:17868147. |
oxidative stress and increased cyclooxygenase-2 (cox-2) activity are both implicated in the loss of dopaminergic neurons from the substantia nigra (sn) in idiopathic parkinson's disease (pd). |
2008-02-14 |
2023-08-12 |
rat |
| Emilce Carrasco, Diana Casper, Peter Werne. PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. Journal of neuroscience research. vol 85. issue 14. 2008-02-14. PMID:17868147. |
using double-label immunohistochemistry for specific ep receptors and tyrosine hydroxylase (th), we identified ep1 and ep2 receptors on dopaminergic neurons in rat sn. |
2008-02-14 |
2023-08-12 |
rat |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (sn). |
2008-01-14 |
2023-08-12 |
mouse |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
one of the earliest detectable biochemical alterations that occurs in the parkinsonian brain is a marked reduction in sn levels of total glutathione (glutathione plus glutathione disulfide), occurring before losses in mitochondrial complex i (ci) activity, striatal dopamine levels, or midbrain dopaminergic neurodegeneration associated with the disease. |
2008-01-14 |
2023-08-12 |
mouse |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
to address the effects of depletion in dopaminergic glutathione levels in vivo on the nigrostriatal system, we created genetically engineered transgenic mouse lines in which expression of gamma-glutamyl cysteine ligase, the rate-limiting enzyme in de novo glutathione synthesis, can be inducibly downregulated in catecholaminergic neurons, including those of the sn. |
2008-01-14 |
2023-08-12 |
mouse |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
this suggests that depletion in glutathione within dopaminergic sn neurons has a direct impact on mitochondrial complex i activity via increased nitric oxide-related thiol oxidation and age-related dopaminergic sn cell loss. |
2008-01-14 |
2023-08-12 |
mouse |
| Dekel Segev, Alon Korngree. Kinetics of two voltage-gated K+ conductances in substantia nigra dopaminergic neurons. Brain research. vol 1173. 2008-01-09. PMID:17826751. |
aiming at describing the mechanism of action potential firing in these cells, the current research examined the biophysical characteristics of voltage-gated k+ conductances in the dopaminergic neurons of the sn. |
2008-01-09 |
2023-08-12 |
Not clear |
| Dekel Segev, Alon Korngree. Kinetics of two voltage-gated K+ conductances in substantia nigra dopaminergic neurons. Brain research. vol 1173. 2008-01-09. PMID:17826751. |
this mechanism may indicate that sn dopaminergic neurons may perform analog coding by modulation of action potential shape. |
2008-01-09 |
2023-08-12 |
Not clear |
| Donald R Staine. Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides? Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17562359. |
parkinson's disease (pd) is a motor disease including disorders of mobility, fine tremor, rigidity and posture caused by a relentless deterioration of dopaminergic cells in the substantia nigra (sn). |
2008-01-03 |
2023-08-12 |
Not clear |
| Donald R Staine. Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides? Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17562359. |
involvement of the th1 directed cytokine interferon-gamma has been demonstrated and th2 directed cytokines such as il-10 protect against inflammation-mediated degeneration of dopaminergic neurons in the sn. |
2008-01-03 |
2023-08-12 |
Not clear |
| Jahn N O'Neil, Peter R Mouton, Yousef Tizabi, Mary Ann Ottinger, De-Liang Lei, Donald K Ingram, Kebreten F Manay. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. Journal of chemical neuroanatomy. vol 34. issue 3-4. 2007-11-21. PMID:17658239. |
blocks of brain tissue containing the noradrenergic lc nucleus and two nuclei of dopaminergic neurons, the sn and vta, were sectioned and sampled in a systematic-random manner and immunostained for tyrosine hydroxylase (th), a specific marker for catecholaminergic neurons. |
2007-11-21 |
2023-08-12 |
mouse |
| Risa Sakai, Yoshifumi Irie, Takeshi Murata, Atsushi Ishige, Naoko Anjiki, Kenji Watanab. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Phytotherapy research : PTR. vol 21. issue 9. 2007-10-29. PMID:17486689. |
parkinson's disease (pd) is a neurodegenerative disease of the brain characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-10-29 |
2023-08-12 |
mouse |
| Hong Jiang, Ning Song, Jun Wang, Li-Ying Ren, Jun-Xia Xi. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochemistry international. vol 51. issue 1. 2007-10-17. PMID:17490790. |
to demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (sn), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (th) immunohistochemistry, perls' iron staining, and high performance liquid chromatography-electrochemical detection to study the degeneration of dopaminergic neurons and increased iron content in the sn of iron dextran overloaded animals. |
2007-10-17 |
2023-08-12 |
rat |
| Hong Jiang, Ning Song, Jun Wang, Li-Ying Ren, Jun-Xia Xi. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochemistry international. vol 51. issue 1. 2007-10-17. PMID:17490790. |
these results suggest that peripheral iron dextran can increase the iron level in the sn, where excessive iron causes the degeneration of dopaminergic neurons. |
2007-10-17 |
2023-08-12 |
rat |
| Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, Helen Chapman, Menelas N Pangalos, Neil Upton, David J Virle. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498809. |
in addition, mptp-treated mice were detected to have a marked depletion in striatal dopamine levels and a concomitant reduction in substantia nigra (sn) tyrosine hydroxylase (th) immunoreactivity, at 7 days post-mptp administration, indicative of dopaminergic neuronal loss. |
2007-09-27 |
2023-08-12 |
mouse |