Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Chee Yeun Chung, James B Koprich, Shogo Endo, Ole Isacso. An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 31. 2007-08-28. PMID:17670978. |
in parkinson's disease, dopaminergic (da) neurons in the substantia nigra (sn) (a9) are particularly vulnerable, whereas adjacent da neurons within the ventral tegmental area (a10) are essentially spared. |
2007-08-28 |
2023-08-12 |
human |
Michael D Boska, Khader M Hasan, Danette Kibuule, Rebecca Banerjee, Erin McIntyre, Jay A Nelson, Theresa Hahn, Howard E Gendelman, R Lee Mosle. Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiology of disease. vol 26. issue 3. 2007-08-24. PMID:17428671. |
transverse diffusivity demonstrated the most significant differences (p < or = 0.002) and correlated with the numbers of sn dopaminergic neurons (r=-0.75, p=0.012). |
2007-08-24 |
2023-08-12 |
Not clear |
Andreas Hald, Johan Van Beek, Julie Lothariu. Inflammation in Parkinson's disease: causative or epiphenomenal? Sub-cellular biochemistry. vol 42. 2007-08-06. PMID:17612055. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra (sn). |
2007-08-06 |
2023-08-12 |
human |
Uwe Walter, Jacqueline Hoeppner, Lara Prudente-Morrissey, Sebastian Horowski, Sabine C Herpertz, Reiner Beneck. Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disorders. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17329323. |
sn hyperechogenicity, found also in approximately 10% of healthy adults, was related to a subclinical malfunction of the nigrostriatal dopaminergic system on pet studies and is, therefore, thought to represent a risk marker for parkinson's disease. |
2007-07-24 |
2023-08-12 |
human |
Vittorio Calabrese, Cesare Mancuso, Agrippino Ravagna, Marzia Perluigi, Chiara Cini, Carlo De Marco, D Allan Butterfield, Anna Maria Giuffrida Stell. In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. Journal of neurochemistry. vol 101. issue 3. 2007-07-18. PMID:17241115. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a severe depletion in number of dopaminergic cells of the substantia nigra (sn). |
2007-07-18 |
2023-08-12 |
rat |
Benjamin Sredni, Revital Geffen-Aricha, Wenzhen Duan, Michael Albeck, Frances Shalit, Harry M Lander, Noa Kinor, Ortal Sagi, Amnon Albeck, Sigal Yosef, Miri Brodsky, Dvora Sredni-Kenigsbuch, Tali Sonino, Dan L Longo, Mark P Mattson, Gal Yadi. Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 8. 2007-07-03. PMID:17314138. |
in parkinson's disease (pd) dopaminergic neurons in the substantia nigra (sn) become dysfunctional and many ultimately die. |
2007-07-03 |
2023-08-12 |
Not clear |
N A Do Thi, P Saillour, L Ferrero, T Paunio, J Malle. Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease? Gene therapy. vol 14. issue 5. 2007-06-29. PMID:17093508. |
we found that (i) the nse promoter can restrict transgene expression in neurons; (ii) ad-nse-gdnf significantly protected dopaminergic (da) neurons in the substantia nigra (sn) but did not reverse the impairments of amphetamine-induced rotational behavior in lesioned rats. |
2007-06-29 |
2023-08-12 |
rat |
Uwe Walter, Stefanie Behnke, Jens Eyding, Ludwig Niehaus, Thomas Postert, Günter Seidel, Daniela Ber. Transcranial brain parenchyma sonography in movement disorders: state of the art. Ultrasound in medicine & biology. vol 33. issue 1. 2007-06-28. PMID:17189043. |
in healthy adults, the tcs finding of marked sn hyperechogenicity indicates a subclinical functional impairment of the nigrostriatal dopaminergic system. |
2007-06-28 |
2023-08-12 |
Not clear |
A Lessard, E F Grady, N W Bunnett, V M Picke. Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17197098. |
to determine the relevant sites for activation of these receptors, we examined the electron microscopic localization of nk(3) receptors and tyrosine hydroxylase (th), the catecholamine synthesizing enzyme in dopaminergic neurons in the sn and vta of rat brain. |
2007-05-21 |
2023-08-12 |
rat |
A Lessard, E F Grady, N W Bunnett, V M Picke. Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17197098. |
these results provide the first ultrastructural evidence indicating that nk(3) receptors are available in cytoplasmic reserve in dopaminergic neurons, but more immediately accessible at the plasmalemmal surface of non-dopaminergic dendrites in both the sn and vta. |
2007-05-21 |
2023-08-12 |
rat |
Walter Maetzler, Daniela Berg, Natalie Schalamberidze, Arthur Melms, Klaus Schott, Jakob C Mueller, Lucy Liaw, Thomas Gasser, Cordula Nitsc. Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17188882. |
loss of tyrosine-hydroxylase-positive cells in the sn and of dopaminergic fibers in the striatum was reduced 3 weeks after mptp intoxication in opn-null mice. |
2007-05-17 |
2023-08-12 |
mouse |
J Salazar, N Mena, M T Núñe. Iron dyshomeostasis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447431. |
the work of youdim and collaborators has been fundamental in describing the accumulation of iron confined to the substantia nigra (sn) in parkinson's disease (pd) and to clarify iron toxicity pathways and oxidative damage in dopaminergic neurons. |
2007-05-17 |
2023-08-12 |
Not clear |
Wei-Guo Liu, Guo-Qiang Lu, Biao Li, Sheng-Di Che. Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease. Parkinsonism & related disorders. vol 13. issue 2. 2007-05-15. PMID:16963309. |
in addition, inverse transfer of ntn protein into the substantia nigra (sn) was able to protect dopaminergic neurons from 6-ohda toxicity. |
2007-05-15 |
2023-08-12 |
rat |
S Urakawa, H Hida, T Masuda, S Misumi, T-S Kim, H Nishin. Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17161913. |
striatal damage was induced at an age of 8 weeks by injection of the neuro-toxins 6-hydroxydopamine (6-ohda) or quinolinic acid (qa) into the striatum, or by injection of 6-ohda into the substantia nigra (sn), which depleted nigrostriatal dopaminergic innervation. |
2007-04-11 |
2023-08-12 |
rat |
T M Korotkova, B P Klyuch, A A Ponomarenko, J S Lin, H L Haas, O A Sergeev. Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors. Neuropharmacology. vol 52. issue 2. 2007-04-10. PMID:17070873. |
we investigated the modafinil action on identified dopaminergic and gabaergic neurons in the ventral tegmental area (vta) and substantia nigra (sn) of rat brain slices. |
2007-04-10 |
2023-08-12 |
rat |
Laure Sonnier, Gwenaëlle Le Pen, Andreas Hartmann, Jean-Charles Bizot, Fabrice Trovero, Marie-Odile Krebs, Alain Prochiant. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267560. |
en1 and, to a lesser degree, en2 also are expressed in the adult substantia nigra (sn) and ventral tegmental area (vta), two dopaminergic (da) nuclei of the ventral midbrain. |
2007-03-16 |
2023-08-12 |
mouse |
Hee Soon Choi, Jae Jin An, So Young Kim, Sun Hwa Lee, Dae Won Kim, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung-Woo Cho, Oh-Shin Kwon, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962931. |
parkinson disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2007-02-16 |
2023-08-12 |
mouse |
Hee Soon Choi, Jae Jin An, So Young Kim, Sun Hwa Lee, Dae Won Kim, Ki-Yeon Yoo, Moo Ho Won, Tae-Cheon Kang, Hyung Joo Kwon, Jung Hoon Kang, Sung-Woo Cho, Oh-Shin Kwon, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model. Free radical biology & medicine. vol 41. issue 7. 2007-02-16. PMID:16962931. |
when the pep-1-sod fusion protein was injected intraperitoneally into mice, a completely protective effect against dopaminergic neuronal cell death in the sn was observed. |
2007-02-16 |
2023-08-12 |
mouse |
Javorina Milosevic, Martina Maisel, Florian Wegner, Julia Leuchtenberger, Roland H Wenger, Manfred Gerlach, Alexander Storch, Johannes Schwar. Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215402. |
in substantia nigra (sn) of adult hif-1alpha cko mice, protein levels of dopaminergic marker molecules such as tyrosine hydroxylase (th) and aldehyde dehydrogenase were reduced by 41 and 61%, respectively. |
2007-02-02 |
2023-08-12 |
mouse |
James E Galvi. Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16791599. |
major disease symptoms are due to the loss of dopaminergic (da) neurons in substantia nigra (sn). |
2007-02-01 |
2023-08-12 |
mouse |