| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
iron accumulated in the sn of patients with pd can cause dopaminergic neuronal degeneration by enhancing oxidative stress. |
2006-02-07 |
2023-08-12 |
human |
| Birgit Liss, Olga Haeckel, Johannes Wildmann, Takashi Miki, Susumu Seino, Jochen Roepe. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16299504. |
the selective degeneration of dopaminergic (da) midbrain neurons in the substantia nigra (sn) is a hallmark of parkinson disease. |
2006-01-24 |
2023-08-12 |
mouse |
| Birgit Liss, Olga Haeckel, Johannes Wildmann, Takashi Miki, Susumu Seino, Jochen Roepe. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16299504. |
genetic inactivation of the k-atp channel pore-forming subunit kir6.2 resulted in a selective rescue of sn but not vta da neurons in two mechanistically distinct mouse models of dopaminergic degeneration, the neurotoxicological 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) model and the mutant weaver mouse. |
2006-01-24 |
2023-08-12 |
mouse |
| Sang H Choi, Da Y Lee, Eun S Chung, Young B Hong, Seung U Kim, Byung K Ji. Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16219027. |
seven days after thrombin injection in the rat substantia nigra (sn), tyrosine hydroxylase immunocytochemistry showed a significant loss of nigral dopaminergic neurons. |
2006-01-20 |
2023-08-12 |
rat |
| Thomas D Corso, German Torres, Christopher Goulah, Indrajit Roy, Angelo S Gambino, John Nayda, Timothy Buckley, Ewa K Stachowiak, Earl J Bergey, Haridas Pudavar, Purnendu Dutta, David C Bloom, William J Bowers, Michal K Stachowia. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16039006. |
thus, we conclude that reduced fgf signaling in the sn of parkinsonian patients could play a role in the impaired dopaminergic transmission associated with the degenerative disease. |
2006-01-17 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
we report pitx3 expression in almost all dopaminergic substantia nigra (sn) and ventral tegmental area (vta) neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
it is coexpressed with the neuroprotective marker calbindin (cb) in a larger population of vta (43%) than sn (16%) dopaminergic neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
a higher pitx3 expression level and higher coexpression of pitx3 and cb in vta than in sn neurons may contribute to the different vulnerability of these dopaminergic nuclei to neurodegeneration. |
2006-01-10 |
2023-08-12 |
rat |
| Angela De Iuliis, Jessica Grigoletto, Alessandra Recchia, Pietro Giusti, Paola Arsla. A proteomic approach in the study of an animal model of Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 357. issue 2. 2005-11-01. PMID:15946658. |
the aetiology of parkinson's disease (pd), an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of the substantia nigra (sn) pars compacta, remains unclear. |
2005-11-01 |
2023-08-12 |
rat |
| Angela De Iuliis, Jessica Grigoletto, Alessandra Recchia, Pietro Giusti, Paola Arsla. A proteomic approach in the study of an animal model of Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 357. issue 2. 2005-11-01. PMID:15946658. |
in an animal model of pd, termed 'the hemiparkinsonian rat', unilateral injection of 6-ohda into the nigrostriatal pathway results in extensive loss of dopaminergic cells in the ipsolateral sn. |
2005-11-01 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Kochupurackal P Mohanakuma. Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease. Brain research. vol 1049. issue 2. 2005-10-19. PMID:15936733. |
a dose of rotenone (6 microg in 1 microl) that caused 55% striatal dopamine depletion when infused into the sn failed to affect serotonin levels in the terminal regions when infused into the nucleus raphe dorsalis, indicating rotenone's specificity of action towards dopaminergic neurons. |
2005-10-19 |
2023-08-12 |
rat |
| Jin H Son, Hibiki Kawamata, Myung S Yoo, Dae J Kim, Young K Lee, Sooyoul Kim, Ted M Dawson, Hui Zhang, David Sulzer, Lichuan Yang, M Flint Beal, Lorraine A Degiorgio, Hong S Chun, Harriet Baker, Chu Pen. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of neurochemistry. vol 94. issue 4. 2005-09-27. PMID:16092945. |
the regulatory function of septin 5 in dopaminergic (daergic) neurons of substantia nigra (sn), maintained at relatively low levels, has not yet been delineated. |
2005-09-27 |
2023-08-12 |
mouse |
| Xiong Zhang, Wenjie Xie, Shen Qu, Tianhong Pan, Xiaotong Wang, Weidong L. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochemical and biophysical research communications. vol 333. issue 2. 2005-09-07. PMID:15950935. |
our present studies have shown that micro-injection of the proteasome inhibitor lactacystin into the substantia nigra (sn) of c57bl/6 mice causes significant loss of dopaminergic cells and induces intracellular inclusion body formation. |
2005-09-07 |
2023-08-12 |
mouse |
| L E Bartlett, I Mende. Dopaminergic reinnervation of the globus pallidus by fetal nigral grafts in the rodent model of Parkinson's disease. Cell transplantation. vol 14. issue 2-3. 2005-08-19. PMID:15881421. |
this limitation may be due to an incomplete restoration of the dopaminergic input to other basal ganglia structures such as the external segment of the globus pallidus (gpe, homologue of the rodent gp), which normally receives dopaminergic input from the substantia nigra (sn). |
2005-08-19 |
2023-08-12 |
rat |
| S J López-Pérez, P Vergara, J P Ventura-Valenzuela, M E Ureña-Guerrero, J Segovia, C Beas-Zárat. Modification of dopaminergic markers expression in the striatum by neonatal exposure to glutamate during development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 4. 2005-08-01. PMID:15927757. |
results indicate that an over-stimulation of the glutamatergic system by neonatal exposure to a high glutamate concentration induces a partial loss in th-positive neurons in the sn and an important reduction in dopaminergic markers expression in the striatum, suggesting that early excitotoxicity could contribute to developmental alterations in the nigrostriatal pathway, which may be associated with various disorders of the basal ganglia. |
2005-08-01 |
2023-08-12 |
rat |
| Hideto Miwa, Tomomi Kubo, Ai Suzuki, Katsunori Nishi, Tomoyoshi Kond. Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition. Neuroscience letters. vol 380. issue 1-2. 2005-07-28. PMID:15854758. |
these results reveal that intrastriatal proteasome inhibition sufficiently induces retrograde dopaminergic neuronal degeneration with abundant accumulation of alpha-synuclein in the sn. |
2005-07-28 |
2023-08-12 |
Not clear |
| Etienne C Hirsch, Stéphane Hunot, Andreas Hartman. Neuroinflammatory processes in Parkinson's disease. Parkinsonism & related disorders. vol 11 Suppl 1. 2005-07-25. PMID:15885630. |
in parkinson's disease (pd), post-mortem examination reveals a loss of dopaminergic (da) neurons in the substantia nigra (sn) associated with a massive astrogliosis and the presence of activated microglial cells. |
2005-07-25 |
2023-08-12 |
Not clear |
| Yasuhiko Izumi, Hideyuki Sawada, Noriko Sakka, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15712215. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2005-07-15 |
2023-08-12 |
human |
| Yasuhiko Izumi, Hideyuki Sawada, Noriko Sakka, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15712215. |
although iron accumulated in the sn of patients with pd can cause dopaminergic neuronal degeneration by enhancing oxidative stress, we found that extracellular ferrous iron promoted the formation of melanin and reduced the amount of p-quinone. |
2005-07-15 |
2023-08-12 |
human |
| Andreas Hald, Julie Lothariu. Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869932. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra (sn). |
2005-07-15 |
2023-08-12 |
human |