| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gang Li, Shenggang Sun, Xuebing Cao, Jiangxin Zhong, E'tang Ton. LPS-induced degeneration of dopaminergic neurons of substantia nigra in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 1. 2004-12-10. PMID:15165124. |
the results suggested that lps could induce the degeneration of dopaminergic neurons in the sn in a dose- and time-dependent manner. |
2004-12-10 |
2023-08-12 |
rat |
| Adam Przybyłkowski, Iwona Kurkowska-Jastrzebska, Ilona Joniec, Agnieszka Ciesielska, Anna Członkowska, Andrzej Członkowsk. Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306248. |
mptp causes an acute damage of dopaminergic neurons especially in the nigrostriatal dopaminergic system, thus diminishing dopamine (da) content in striatum and decreasing the number of dopaminergic cells in the pars compacta of the substantia nigra (sn). |
2004-11-04 |
2023-08-12 |
mouse |
| Judit Soós, József I Engelhardt, László Siklós, László Havas, Katalin Majtény. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257133. |
immunohistochemical techniques revealed a significant increase of poly(adp-ribose) polymerase (parp)-containing nuclei in the dopaminergic neurons of the substantia nigra (sn) in parkinson disease and in diffuse lewy body disease as compared with a group of patients with other neurodegenerative diseases and normal controls. |
2004-10-21 |
2023-08-12 |
Not clear |
| Judit Soós, József I Engelhardt, László Siklós, László Havas, Katalin Majtény. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257133. |
however, in another subgroup of dopaminergic cells of the sn an increased parvalbumin content was detected reflecting a natural protective mechanism against the putative increase of intracellular calcium caused by excitotoxic injury and oxidative stress. |
2004-10-21 |
2023-08-12 |
Not clear |
| Lidia I Serova, Shreekrishna Maharjan, An Huang, Dong Sun, Gabor Kaley, Esther L Sabba. Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. Brain research. vol 1015. issue 1-2. 2004-10-15. PMID:15223360. |
short-term administration of estradiol benzoate (eb) by five injections of 15 or 40 microg/kg 12 h apart led to increase in th and gtpch mrna levels in dopaminergic and noradrenergic cell bodies of the ventral tegmental area (vta), substantia nigra (sn), locus coeruleus (lc) and the nucleus of solitary tract (nts) depending on dose of administration. |
2004-10-15 |
2023-08-12 |
rat |
| Zhaoliang Hu, Margaret Cooper, David P Crockett, Renping Zho. Differentiation of the midbrain dopaminergic pathways during mouse development. The Journal of comparative neurology. vol 476. issue 3. 2004-10-07. PMID:15269972. |
dopaminergic (da) neurons in the substantia nigra (sn) and ventral tegmental area (vta) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus accumbens, respectively, establishing the mesostriatal and the mesolimbic pathways. |
2004-10-07 |
2023-08-12 |
mouse |
| Beth-Anne Sieber, Alexander Kuzmin, Josep M Canals, Anne Danielsson, Gustavo Paratcha, Ernest Arenas, Jordi Alberch, Sven Ove Ogren, Carlos F Ibáñe. Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Molecular and cellular neurosciences. vol 26. issue 3. 2004-09-17. PMID:15234346. |
adult transgenic mice showed a 30-40% reduction in the total volume of the substantia nigra (sn) without detectable differences in the number of dopaminergic neurons. |
2004-09-17 |
2023-08-12 |
mouse |
| Tatiana M Korotkova, Alexei A Ponomarenko, Ritchie E Brown, Helmut L Haa. Functional diversity of ventral midbrain dopamine and GABAergic neurons. Molecular neurobiology. vol 29. issue 3. 2004-09-16. PMID:15181237. |
recent findings indicate that vta and sn dopaminergic (da) and gabaergic neurons form subpopulations that are divergent in their electrophysiological features, vulnerability to neurodegeneration, and regulation by neuropeptides. |
2004-09-16 |
2023-08-12 |
Not clear |
| David A Ballok, Aoife M Earls, Catherine Krasnik, Steven A Hoffman, Boris Saki. Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. Journal of neuroimmunology. vol 152. issue 1-2. 2004-09-16. PMID:15223241. |
supportive of the notion that dying neurons were dopaminergic, the sn of autoimmune mice showed approximately a 35% reduction in the number of th-positive cells. |
2004-09-16 |
2023-08-12 |
mouse |
| Jesus Landeira-Fernandez, Carlos V Grijalv. Participation of the substantia nigra dopaminergic neurons in the occurrence of gastric mucosal erosions. Physiology & behavior. vol 81. issue 1. 2004-08-09. PMID:15059688. |
taken together, these results suggest that modulation of dopaminergic levels by neurons located within the sn may play an important role for the development of gastric erosions. |
2004-08-09 |
2023-08-12 |
Not clear |
| Sophie Sarre, Hong Yuan, Nadine Jonkers, An Van Hemelrijck, Guy Ebinger, Yvette Michott. In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198664. |
we investigated the effect of an injection of 6-hydroxydopamine (6-ohda) into the rat medial forebrain bundle (mfb) on the degeneration and the function of the dopaminergic cell bodies in the substantia nigra (sn) 3 and 5 weeks after lesioning. |
2004-08-06 |
2023-08-12 |
rat |
| Yan Xu, Shenggang Sun, Xuebing Cao, Etang Ton. Protective effect of GSH on PD model induced by 6-OHDA in vitro. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 22. issue 4. 2004-07-20. PMID:12674779. |
to study the effects of 6-hydroxydopamine (6-ohda) and reduced glutathione (gsh) on the nigral dopaminergic neurons in brain slices in vitro, immolunohistochemical technique was used to observe the changes of th-stained neurons, including cell bodies and the dendrites, in the substantia nigra (sn) of midbrain slices of rats after incubation for 1 h in the presence of gsh 15 min before and during the period of incubation with 6-ohda. |
2004-07-20 |
2023-08-12 |
rat |
| Jean-Charles Paterna, Joram Feldon, Hansruedi Büele. Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats. Journal of virology. vol 78. issue 13. 2004-07-15. PMID:15194756. |
we also compared the potentials of the two vectors for retrograde transduction and found that striatal delivery of raav-5 resulted in significantly more transduced dopaminergic cell bodies within the sn pars compacta and ventral tegmental area. |
2004-07-15 |
2023-08-12 |
rat |
| Hideto Miwa, Tomomi Kubo, Shuhei Morita, Ichiro Nakanishi, Tomoyoshi Kond. Oxidative stress and microglial activation in substantia nigra following striatal MPP+. Neuroreport. vol 15. issue 6. 2004-06-29. PMID:15076730. |
the present study aims to study sequential alterations occurring in both dopaminergic neurons and microglia in substantia nigra (sn) following intrastriatal injection of 1-methyl-4-phenylpridium ion (mpp+) in rats. |
2004-06-29 |
2023-08-12 |
rat |
| Hideto Miwa, Tomomi Kubo, Shuhei Morita, Ichiro Nakanishi, Tomoyoshi Kond. Oxidative stress and microglial activation in substantia nigra following striatal MPP+. Neuroreport. vol 15. issue 6. 2004-06-29. PMID:15076730. |
heme oxygenase-1 (ho-1), a marker of oxidative stress, first appeared in dopaminergic neurons in sn at 1 day post-lesion. |
2004-06-29 |
2023-08-12 |
rat |
| D Makarovsky, Y Kalechman, T Sonino, I Freidkin, S Teitz, M Albeck, M Weil, R Geffen-Aricha, G Yadid, B Sredn. Tellurium compound AS101 induces PC12 differentiation and rescues the neurons from apoptotic death. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033807. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2004-06-15 |
2023-08-12 |
Not clear |
| Bhisham Chera, Kurt E Schaecher, Anne Rocchini, Syed Z Imam, Eric A Sribnick, Swapan K Ray, Syed F Ali, Naren L Bani. Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Brain research. vol 1006. issue 2. 2004-06-07. PMID:15051518. |
parkinson's disease (pd) is a movement disorder characterized by rigidity, tremor, and bradykinesia, originating from degeneration of dopaminergic neurons in the substantia nigra (sn), retrorubral area, and locus ceoruleus (lc). |
2004-06-07 |
2023-08-12 |
mouse |
| Chang-Lin Liang, Omar Nelson, Umar Yazdani, Parichehr Pasbakhsh, Dwight C Germa. Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. The Journal of comparative neurology. vol 473. issue 1. 2004-05-24. PMID:15067721. |
the dopaminergic neurons in the ventral substantia nigra (sn) are significantly more vulnerable to degeneration in parkinson's disease (pd) than the dopaminergic neurons in the ventral tegmental area (vta). |
2004-05-24 |
2023-08-12 |
human |
| Chang-Lin Liang, Omar Nelson, Umar Yazdani, Parichehr Pasbakhsh, Dwight C Germa. Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. The Journal of comparative neurology. vol 473. issue 1. 2004-05-24. PMID:15067721. |
the ventral sn neurons also contain significantly more neuromelanin pigment than the dopaminergic neurons in the vta. |
2004-05-24 |
2023-08-12 |
human |
| Chang-Lin Liang, Omar Nelson, Umar Yazdani, Parichehr Pasbakhsh, Dwight C Germa. Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. The Journal of comparative neurology. vol 473. issue 1. 2004-05-24. PMID:15067721. |
these data support the hypothesis that midbrain dopaminergic neurons that synthesize greater amounts of dopamine have more vesicular storage capacity for action potential-induced release of transmitter and that the ventral sn neurons accumulate the most neuromelanin pigment, in part because they have the least vmat2 protein. |
2004-05-24 |
2023-08-12 |
human |