| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aideen M Sullivan, Gerard W O'Keeff. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment. Journal of anatomy. vol 207. issue 3. 2006-08-21. PMID:16185246. |
gdf5 is under investigation as a potential therapeutic agent for parkinson's disease (pd), which is caused by the progressive degeneration of dopaminergic neurones projecting from the substantia nigra (sn) to the striatum. |
2006-08-21 |
2023-08-12 |
rat |
| Aideen M Sullivan, Gerard W O'Keeff. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment. Journal of anatomy. vol 207. issue 3. 2006-08-21. PMID:16185246. |
in the rat ventral mesencephalon (vm; the developing sn), gdf5 expression peaks at embryonic day 14, the time at which dopaminergic neurones undergo terminal differentiation. |
2006-08-21 |
2023-08-12 |
rat |
| Jackalina M Van Kampen, Christopher B Eckma. Dopamine D3 receptor agonist delivery to a model of Parkinson's disease restores the nigrostriatal pathway and improves locomotor behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 27. 2006-07-25. PMID:16822985. |
consistent with previous findings, we observed a significant induction of cell proliferation in the substantia nigra pars compacta (sn(c)) with a time-dependent adoption of a neuronal dopaminergic phenotype in many of these cells. |
2006-07-25 |
2023-08-12 |
rat |
| Jackalina M Van Kampen, Christopher B Eckma. Dopamine D3 receptor agonist delivery to a model of Parkinson's disease restores the nigrostriatal pathway and improves locomotor behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 27. 2006-07-25. PMID:16822985. |
dopaminergic cell counts in the lesioned sn(c) recovered substantially in a time-dependent manner. |
2006-07-25 |
2023-08-12 |
rat |
| Jörg Spiegel, Dirk Hellwig, Marc-Oliver Möllers, Stefanie Behnke, Wolfgang Jost, Klaus Fassbender, Samuel Samnick, Ulrich Dillmann, Georg Becker, Carl-Martin Kirsc. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease. Brain : a journal of neurology. vol 129. issue Pt 5. 2006-05-31. PMID:16513685. |
but so far it is unknown whether the extent of sn hyperechogenicity represents a correlate for the degeneration of presynaptic dopaminergic neurons in pd. |
2006-05-31 |
2023-08-12 |
Not clear |
| Jörg Spiegel, Dirk Hellwig, Marc-Oliver Möllers, Stefanie Behnke, Wolfgang Jost, Klaus Fassbender, Samuel Samnick, Ulrich Dillmann, Georg Becker, Carl-Martin Kirsc. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease. Brain : a journal of neurology. vol 129. issue Pt 5. 2006-05-31. PMID:16513685. |
our data show that the extent of sn hyperechogenicity does not correlate with the degeneration of presynaptic dopaminergic nerve terminals. |
2006-05-31 |
2023-08-12 |
Not clear |
| Jörg Spiegel, Dirk Hellwig, Marc-Oliver Möllers, Stefanie Behnke, Wolfgang Jost, Klaus Fassbender, Samuel Samnick, Ulrich Dillmann, Georg Becker, Carl-Martin Kirsc. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease. Brain : a journal of neurology. vol 129. issue Pt 5. 2006-05-31. PMID:16513685. |
obviously sn hyperechogenicity and degeneration of presynaptic dopaminergic nerve terminals exist independently from each other and may be based on different pathomechanisms. |
2006-05-31 |
2023-08-12 |
Not clear |
| S Zechel, J Jarosik, I Kiprianova, A Schober, K Unsicker, O von Bohlen und Halbac. FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice. The European journal of neuroscience. vol 23. issue 6. 2006-05-30. PMID:16553632. |
to address the putative physiological relevance of endogenous fgf-2 for midbrain dopaminergic neurons, we have analysed densities of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and th-positive fibers in the striatum and amygdala of adult fgf-2-deficient mice. |
2006-05-30 |
2023-08-12 |
mouse |
| Martine Barkats, Philippe Horellou, Philippe Colin, Stéphanie Millecamps, Nicole Faucon-Biguet, Jacques Malle. 1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16353238. |
strong transgene expression was detected in the sn dopaminergic neurons, a consequence of retrograde axonal transport of the adenoviral particles. |
2006-05-25 |
2023-08-12 |
human |
| Sung Tae Kim, Ji Hyun Choi, Donghou Kim, Onyou Hwan. Increases in TH immunoreactivity, neuromelanin and degeneration in the substantia nigra of middle aged mice. Neuroscience letters. vol 396. issue 3. 2006-05-25. PMID:16377085. |
the dopaminergic (dargic) neurons in the substantia nigra (sn) are particularly vulnerable to oxidative stress and during aging. |
2006-05-25 |
2023-08-12 |
mouse |
| Gülin Oz, Melissa Terpstra, Ivan Tkác, Pratibha Aia, Jodi Lowary, Paul J Tuite, Rolf Gruette. Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla: detection of high GABA concentrations. Magnetic resonance in medicine. vol 55. issue 2. 2006-05-11. PMID:16408282. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra (sn), the cause of which is unknown. |
2006-05-11 |
2023-08-12 |
human |
| A Guyon, D Skrzydelsi, C Rovère, W Rostène, S Mélik Parsadaniantz, J L Naho. Stromal cell-derived factor-1alpha modulation of the excitability of rat substantia nigra dopaminergic neurones: presynaptic mechanisms. Journal of neurochemistry. vol 96. issue 6. 2006-05-10. PMID:16476083. |
in rat substantia nigra (sn), chemokine (cxc motif) receptor 4 (cxcr4) for the chemokine stromal cell-derived factor (sdf)-1alpha is expressed on dopaminergic (da) neurones, but also on non-da cells, suggesting presynaptic actions. |
2006-05-10 |
2023-08-12 |
rat |
| H Arai, T Furuya, Y Mizuno, H Mochizuk. Inflammation and infection in Parkinson's disease. Histology and histopathology. vol 21. issue 6. 2006-05-04. PMID:16528677. |
the hallmark of parkinson's disease (pd) is a specific degeneration of dopaminergic neurons in the substantia nigra (sn). |
2006-05-04 |
2023-08-12 |
Not clear |
| Kelly J Conn, Wenwu Gao, Ann McKee, Michael S Lan, M David Ullman, Patricia B Eisenhauer, Richard E Fine, John M Well. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353226. |
pathological hallmarks of the disease include the loss of dopaminergic neurons from the substantia nigra (sn) and the presence of lewy bodies (lbs) (alpha-synuclein and ubiquitin-positive, eosinophilic, cytoplasmic inclusions) in many of the surviving neurons. |
2006-03-23 |
2023-08-12 |
human |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
dopamine (da) has been postulated to play a role in the loss of dopaminergic substantia nigra (sn) neurons in parkinson's disease because of its propensity to oxidize and form quinones and other reactive oxygen species that can alter cellular function. |
2006-03-13 |
2023-08-12 |
mouse |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
to test the contribution of da to sn impairment in vivo, we used da-deficient mice, which lack the enzyme tyrosine hydroxylase in dopaminergic cells, and mice pharmacologically depleted of da by alpha-methyl-p-tyrosine pretreatment. |
2006-03-13 |
2023-08-12 |
mouse |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
in contrast to in vitro results, genetic or pharmacologic da depletion did not attenuate loss of dopaminergic neurons in the sn or dopaminergic neuron terminals in the striatum. |
2006-03-13 |
2023-08-12 |
mouse |
| Ennio Esposit. Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475959. |
among the multiple classes of 5-ht receptors described in the central nervous system, much attention has been devoted to the role of 5-ht2 receptor family in the control of central dopaminergic activity, because of the moderate to dense localization of both transcript and protein for 5-ht2a and 5-ht2c receptors in the substantia nigra (sn) and ventral tegmental area (vta), as well as their terminal regions. |
2006-03-10 |
2023-08-12 |
human |
| Akifumi Kamata, Yusuke Takeuchi, Kohji Fukunag. Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16277604. |
an immunohistochemical study also confirmed the preferential localization of gamma and delta isoforms in sn dopaminergic neurons. |
2006-02-14 |
2023-08-12 |
rat |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |