| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
parkinson's disease (pd) is characterised by the loss of dopaminergic neurones in the substantia nigra (sn) but the pathogenic mechanism remains unknown. |
2007-01-23 |
2023-08-12 |
human |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
both opn mrna and protein were present in the normal marmoset sn, and opn protein was localised to nigral neurones although these were not dopaminergic cells and it was not present in glial cells. |
2007-01-23 |
2023-08-12 |
human |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
in contrast, opn protein was found in dopaminergic neurones in the normal human sn but again not in glial cells with some accumulation in the extracellular matrix. |
2007-01-23 |
2023-08-12 |
human |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
in the sn in pd, opn protein expression was decreased in the remaining dopaminergic neurones and it was present in activated microglia but not in astrocytes. |
2007-01-23 |
2023-08-12 |
human |
| Joanna Iczkiewicz, Michael J Jackson, Lance A Smith, Sarah Rose, Peter Jenne. Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease. Brain research. vol 1118. issue 1. 2007-01-23. PMID:16962083. |
the presence of opn in the normal human and non-human primate sn coupled to its decreased expression following nigral cell degeneration suggests that it may play an important role in dopaminergic neurone survival. |
2007-01-23 |
2023-08-12 |
human |
| Xiaoyang Shan, Liying Chi, Michael Bishop, Chun Luo, Lindsey Lien, Zheng Zhang, Rugao Li. Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice. Stem cells (Dayton, Ohio). vol 24. issue 5. 2007-01-18. PMID:16424396. |
research reports on de novo neurogenesis, particularly dopaminergic (da) neurogenesis in the adult mammalian substantia nigra (sn), remain very controversial. |
2007-01-18 |
2023-08-12 |
mouse |
| Supriti Samantaray, Swapan K Ray, Syed F Ali, Naren L Bani. Calpain activation in apoptosis of motoneurons in cell culture models of experimental parkinsonism. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105932. |
parkinson's disease (pd) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (sn). |
2007-01-10 |
2023-08-12 |
Not clear |
| Hong Jiang, Zhuo Luan, Jun Wang, Junxia Xi. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochemistry international. vol 49. issue 6. 2006-12-12. PMID:16806586. |
the aim of the present study was to investigate whether the iron chelator desferal prevents the degeneration of dopaminergic neurons in the substantia nigra (sn) induced by iron-overload in rats. |
2006-12-12 |
2023-08-12 |
rat |
| Hong Jiang, Zhuo Luan, Jun Wang, Junxia Xi. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochemistry international. vol 49. issue 6. 2006-12-12. PMID:16806586. |
using fast cyclic voltammetry, tyrosine hydroxylase (th) immunohistochemistry, perls' iron staining, and high-performance liquid chromatography-electrochemical detection, we measured the degeneration of dopaminergic neurons and increased iron content in the sn of rats overloaded with iron dextran and assessed the effects of treatment with desferal. |
2006-12-12 |
2023-08-12 |
rat |
| Rachel L Nosheny, Alessia Bachis, Sadia A Aden, Maria A De Bernardi, Italo Mocchett. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. Journal of neurobiology. vol 66. issue 12. 2006-12-11. PMID:16967504. |
because glial cell line-derived neurotrophic factor (gdnf) and bdnf are neurotrophic factors crucial for the survival of dopaminergic neurons of the sn, we investigated whether gp120 reduces gdnf and bdnf levels concomitantly to induce apoptosis. |
2006-12-11 |
2023-08-12 |
human |
| M Rosario Luquin, Laura Saldise, Javier Guillén, Silvia Belzunegui, Waldy San Sebastián, Amaya Izal, Pablo Garrido, Marianne Vázque. Does increased excitatory drive from the subthalamic nucleus contribute to dopaminergic neuronal death in Parkinson's disease? Experimental neurology. vol 201. issue 2. 2006-12-05. PMID:16806173. |
these data indicate that the surgical removal of the excitatory drive from the stn to sn neurons does not protect dopaminergic neurons against a chronic and extended toxic effect of mptp and do not support the assumption that stn blockade might delay the progression of pd. |
2006-12-05 |
2023-08-12 |
Not clear |
| Zhiming Zhang, Anders H Andersen, Yi Ai, Aaron Loveland, Peter A Hardy, Greg A Gerhardt, Don M Gas. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. NeuroImage. vol 33. issue 2. 2006-11-21. PMID:16949305. |
the primary findings were (1) the putamen and substantia nigra (sn) but not the caudate nucleus displayed significant bold responses to these dopaminergic drugs; (2) a significant relationship was found between amphetamine-evoked activation and the number of surviving dopamine neurons in the sn, which was also correlated with bradykinesia; and (3) inverse relationships were seen in response to apomorphine and amphetamine stimulation between the mptp-lesioned and unlesioned putamen and sn. |
2006-11-21 |
2023-08-12 |
monkey |
| Carina Cintia Ferrari, María Clara Pott Godoy, Rodolfo Tarelli, Mariela Chertoff, Amaicha Mara Depino, Fernando Juan Pitoss. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiology of disease. vol 24. issue 1. 2006-11-07. PMID:16901708. |
the chronic expression of il-1beta for 60 days induced dopaminergic cell death in the sn and unilateral akinesia starting only at 21 days post-injection. |
2006-11-07 |
2023-08-12 |
rat |
| Carina Cintia Ferrari, María Clara Pott Godoy, Rodolfo Tarelli, Mariela Chertoff, Amaicha Mara Depino, Fernando Juan Pitoss. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiology of disease. vol 24. issue 1. 2006-11-07. PMID:16901708. |
the chronic expression of a single proinflammatory cytokine as il-1beta in the sn elicited most of the characteristics of pd, including progressive dopaminergic cell death, akinesia and glial activation. |
2006-11-07 |
2023-08-12 |
rat |
| Alessandro Martorana, Carmela Giampà, Zena DeMarch, Maria Teresa Viscomi, Stefano Patassini, Giuseppe Sancesario, Giorgio Bernardi, Francesca R Fusc. Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930403. |
the expression, at mrna level, of several trpcs has been demonstrated recently in dopaminergic neurons of the substantia nigra (sn). |
2006-11-01 |
2023-08-12 |
rat |
| L Zecca, F A Zucca, A Albertini, E Rizzio, R G Fariell. A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease. Neurology. vol 67. issue 7 Suppl 2. 2006-10-30. PMID:17030740. |
in many parkinsonian syndromes, neuromelanin (nm)-containing dopaminergic neurons of the substantia nigra (sn) are selectively targeted by the noxius pathogens. |
2006-10-30 |
2023-08-12 |
human |
| M J Zigmon. Triggering endogenous neuroprotective mechanisms in Parkinson's disease: studies with a cellular model. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017565. |
we have now shown that gdnf can also protect against the effects of 6-hydroxydopamine (6-ohda) in a dopaminergic cell line and in cultures of primary da neurons prepared from rat substantia nigra (sn). |
2006-10-24 |
2023-08-12 |
rat |
| Aristea S Galanopoulo. Sex- and cell-type-specific patterns of GABAA receptor and estradiol-mediated signaling in the immature rat substantia nigra. The European journal of neuroscience. vol 23. issue 9. 2006-10-06. PMID:16706849. |
in females, 17beta-estradiol did not influence phosphocreb expression in prv-ir snr cells, but increased it in the dopaminergic sn neurons. |
2006-10-06 |
2023-08-12 |
rat |
| Tae-Beom Ahn, Beom S Jeo. Protective role of heat shock and heat shock protein 70 in lactacystin-induced cell death both in the rat substantia nigra and PC12 cells. Brain research. vol 1087. issue 1. 2006-08-25. PMID:16626658. |
immunohistochemical studies showed the death of dopaminergic neurons and activated microglia in the sn. |
2006-08-25 |
2023-08-12 |
rat |
| Tae-Beom Ahn, Beom S Jeo. Protective role of heat shock and heat shock protein 70 in lactacystin-induced cell death both in the rat substantia nigra and PC12 cells. Brain research. vol 1087. issue 1. 2006-08-25. PMID:16626658. |
lactacystin with prior wbh increased the expression of hsp70 more than did lactacystin alone and decreased lactacystin-induced dopaminergic neuronal death in the sn. |
2006-08-25 |
2023-08-12 |
rat |