| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masanori Yamada, Yoshikuni Mizuno, Hideki Mochizuk. Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease. Human gene therapy. vol 16. issue 2. 2005-06-28. PMID:15761265. |
therefore, in the present study, the effect of parkin was examined by co-infection of raav-parkin with raav-alpha-synuclein into dopaminergic neurons in sn. |
2005-06-28 |
2023-08-12 |
rat |
| A J Herrera, M Tomás-Camardiel, J L Venero, J Cano, A Machad. Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599609. |
the specific degeneration of dopaminergic neurons in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd). |
2005-06-07 |
2023-08-12 |
Not clear |
| A J Herrera, M Tomás-Camardiel, J L Venero, J Cano, A Machad. Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599609. |
this single injection produced the induction of inflammatory process with the activation of microglia along with the specific degeneration of dopaminergic neurons in the sn without affecting neither other neurotransmitter systems nor other structures of the cns. |
2005-06-07 |
2023-08-12 |
Not clear |
| A J Herrera, M Tomás-Camardiel, J L Venero, J Cano, A Machad. Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599609. |
we also discuss other inductors of inflammatory process in relationship to the dopaminergic degeneration in the sn. |
2005-06-07 |
2023-08-12 |
Not clear |
| R M Miller, L L Chen, G L Kiser, T L Giesler, T M Kaysser-Kranich, C Palaniappan, H J Federof. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of aging. vol 26. issue 5. 2005-05-09. PMID:15708451. |
the gradual loss of striatal dopamine and dopaminergic neurons residing in the substantia nigra (sn) causes parkinsonism characterized by slow, halting movements, rigidity, and resting tremor when neuronal loss exceeds a threshold of approximately 80%. |
2005-05-09 |
2023-08-12 |
mouse |
| Michael Hsu, Bharath Srinivas, Jyothi Kumar, Rajagopalan Subramanian, Julie Anderse. Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715660. |
an early biochemical change in the parkinsonian substantia nigra (sn) is reduction in total glutathione (gsh + gssg) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex i activity, dopamine loss, and cell death. |
2005-04-28 |
2023-08-12 |
Not clear |
| Heidi Fedorow, Russell Pickford, James M Hook, Kay L Double, Glenda M Halliday, Manfred Gerlach, Peter Riederer, Brett Garne. Dolichol is the major lipid component of human substantia nigra neuromelanin. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686500. |
neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (sn). |
2005-03-21 |
2023-08-12 |
human |
| Gonzalo Bustos, Jorge Abarca, Jorge Campusano, Victor Bustos, Viviana Noriega, Esteban Aliag. Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain. Brain research. Brain research reviews. vol 47. issue 1-3. 2005-03-15. PMID:15572168. |
dopaminergic nigrostriatal neurons may be considered as bipolar functional entities since they are endowed with the ability to synthesize, store and release the transmitter dopamine (da) at the somatodendritic level in the substantia nigra (sn). |
2005-03-15 |
2023-08-12 |
Not clear |
| Karen Müller Smith, Lorri Bauer, Mariellen Fischer, Russell Barkley, Bradford A Navi. Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635701. |
nr4a2, or nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (vta) and the substantia nigra (sn). |
2005-03-14 |
2023-08-12 |
human |
| Y Shimizu, S Sugama, L A Degiorgio, B P Cho, T H Jo. Cell-type specific signal transduction and gene regulation via mitogen-activated protein kinase pathway in catecholaminergic neurons by restraint stress. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541904. |
the stimuli, such as stress or reserpine administration, significantly increased the th gene in noradrenergic neurons in the locus ceruleus (lc), but not in dopaminergic neurons in the substantia nigra (sn). |
2005-03-07 |
2023-08-12 |
Not clear |
| Iwona Kurkowska-Jastrzebska, Tomasz Litwin, Ilona Joniec, Agnieszka Ciesielska, Adam Przybyłkowski, Andrzej Członkowski, Anna Członkowsk. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. International immunopharmacology. vol 4. issue 10-11. 2005-02-23. PMID:15313429. |
we observed the same protection in both situations: less dopamine depletion and less decrease in the number of dopaminergic cells in the substantia nigra (sn). |
2005-02-23 |
2023-08-12 |
mouse |
| Renee M Miller, Linda M Callahan, Cindy Casaceli, Linlin Chen, Gretchen L Kiser, Buena Chui, Tamma M Kaysser-Kranich, Timothy J Sendera, Chockalingam Palaniappan, Howard J Federof. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 34. 2005-01-26. PMID:15329391. |
parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons of the substantia nigra (sn). |
2005-01-26 |
2023-08-12 |
mouse |
| Renee M Miller, Linda M Callahan, Cindy Casaceli, Linlin Chen, Gretchen L Kiser, Buena Chui, Tamma M Kaysser-Kranich, Timothy J Sendera, Chockalingam Palaniappan, Howard J Federof. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 34. 2005-01-26. PMID:15329391. |
although the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) model of oxidative sn injury is frequently used to study degeneration of dopaminergic neurons in mice and non-human primates, an understanding of the temporal sequence of molecular events from inhibition of mitochondrial complex 1 to neuronal cell death is limited. |
2005-01-26 |
2023-08-12 |
mouse |
| G Garcia, P Tagliaferro, A Ferri, A M Evangelista de Duffard, R Duffard, A Brusc. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. vol 25. issue 6. 2005-01-14. PMID:15474613. |
dopaminergic neurons from the midbrain nuclei substantia nigra (sn; a9) and ventral tegmental area (vta; a10) were investigated by tyrosine hydroxylase (th) immunostaining in neonate rat brains exposed to 2,4-dichlorophenoxyacetic acid (2,4-d) through lactation. |
2005-01-14 |
2023-08-12 |
rat |
| Hiroyuki Arai, Tsuyoshi Furuya, Toru Yasuda, Masayuki Miura, Yoshikuni Mizuno, Hideki Mochizuk. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. The Journal of biological chemistry. vol 279. issue 49. 2005-01-11. PMID:15383538. |
the endotoxin lipopolysaccharide (lps), a component of the gram-negative bacterial cell wall, selectively induces degeneration of substantia nigral (sn) dopaminergic neurons via activation of microglial cells in rats and mice. |
2005-01-11 |
2023-08-12 |
mouse |
| Hiroyuki Arai, Tsuyoshi Furuya, Toru Yasuda, Masayuki Miura, Yoshikuni Mizuno, Hideki Mochizuk. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. The Journal of biological chemistry. vol 279. issue 49. 2005-01-11. PMID:15383538. |
we examined the mechanism of lps neurotoxicity on sn dopaminergic neurons in c57bl/6 mice and caspase-11 knockout mice. |
2005-01-11 |
2023-08-12 |
mouse |
| Hiroyuki Arai, Tsuyoshi Furuya, Toru Yasuda, Masayuki Miura, Yoshikuni Mizuno, Hideki Mochizuk. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. The Journal of biological chemistry. vol 279. issue 49. 2005-01-11. PMID:15383538. |
immunohistochemistry, western blotting analysis, enzyme-linked immunosorbent assay, and reverse transcriptase-pcr were performed to evaluate damage of sn dopaminergic neurons and activation of microglial cells. |
2005-01-11 |
2023-08-12 |
mouse |
| Vandana Zaman, Matthew E Nelson, Greg A Gerhardt, Baerbel Rohre. Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530873. |
these data suggest that elevated neurotransmitter and neurotrophic factor levels might be a compensatory mechanism following dopaminergic cell loss in the sn. |
2004-12-29 |
2023-08-12 |
mouse |
| Gang Li, Shenggang Sun, Xuebing Cao, Jiangxin Zhong, E'tang Ton. LPS-induced degeneration of dopaminergic neurons of substantia nigra in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 1. 2004-12-10. PMID:15165124. |
in order to investigate the neurotoxicity of lipopolysaccharide (lps) on the dopaminergic neurons of substantia nigra and the pathogenesis of parkinson disease, lps was stereotaxically infused into substantia nigra (sn). |
2004-12-10 |
2023-08-12 |
rat |
| Gang Li, Shenggang Sun, Xuebing Cao, Jiangxin Zhong, E'tang Ton. LPS-induced degeneration of dopaminergic neurons of substantia nigra in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 1. 2004-12-10. PMID:15165124. |
at different dosages and different time points with 5 microg lps, the damage of the dopaminergic neurons in sn was observed by using tyrosine-hydroxylase (th) immunohistochemical staining. |
2004-12-10 |
2023-08-12 |
rat |