| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang-H Choi, Eun H Joe, Seung U Kim, Byung K Ji. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843292. |
the thrombin-induced loss of sn dopaminergic neurons was partially inhibited by ng-nitro-l-arginine methyl ester hydrochloride, an nos inhibitor, and by dup-697, a cox-2 inhibitor. |
2003-08-14 |
2023-08-12 |
rat |
| Sang-H Choi, Eun H Joe, Seung U Kim, Byung K Ji. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843292. |
inhibition of erk1/2 and p38 mapk reduced inos and cox-2 mrna expression and rescued dopaminergic neurons in the sn. |
2003-08-14 |
2023-08-12 |
rat |
| Shuei Sugama, Lichuan Yang, Byung Pil Cho, Lorraine A DeGiorgio, Stefan Lorenzl, David S Albers, M Flint Beal, Bruce T Volpe, Tong H Jo. Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain research. vol 964. issue 2. 2003-06-18. PMID:12576189. |
the double immunohistochemistry further demonstrated that the activated microglia surrounded dopaminergic neurons in older mice at 7 days, which was sharply in contrast to the young mice which were devoid of massive microglial activation in the sn later than 3 days after mptp treatment. |
2003-06-18 |
2023-08-12 |
mouse |
| Manuel Rodríguez Díaz, Pedro Barroso-Chinea, Abraham Acevedo, Tomás González-Hernánde. Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 3. 2003-06-17. PMID:12621628. |
in this work, different electrophysiological and neurochemical parameters were studied in gabaergic cells of the sn after unilateral nigrostriatal dopaminergic lesion using 6-hydroxydopamine injection in rats. |
2003-06-17 |
2023-08-12 |
rat |
| Manuel Rodríguez Díaz, Pedro Barroso-Chinea, Abraham Acevedo, Tomás González-Hernánde. Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 3. 2003-06-17. PMID:12621628. |
our data showed that 1) the sn under normal conditions contains different subsets of gabaergic cells according to their firing pattern and glutamic acid decarboxylase mrna levels, and 2) the response of these gabaergic cell subgroups was different after the ipsi- and contralateral dopaminergic cell degeneration. |
2003-06-17 |
2023-08-12 |
rat |
| Joshua P Fessel, Christine Hulette, Suzanne Powell, L Jackson Roberts, Jing Zhan. Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. Journal of neurochemistry. vol 85. issue 3. 2003-06-17. PMID:12694390. |
this preferential increase in isofs in the sn of patients with pd or dlb not only indicates a unique mode of oxidant injury in these two diseases but also suggests different underlying mechanisms of dopaminergic neurodegeneration in pd and dlb from those of msa. |
2003-06-17 |
2023-08-12 |
Not clear |
| Xi-Bin Liang, Xian-Yu Liu, Feng-Qiao Li, Yong Luo, Jun Lu, Wang-Ming Zhang, Xiao-Min Wang, Ji-Sheng Ha. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480178. |
the results show a marked decrease of dopaminergic neurons on the lesioned side of the substantia nigra (sn) comparing with the unlesioned side. |
2003-06-16 |
2023-08-12 |
rat |
| Xi-Bin Liang, Xian-Yu Liu, Feng-Qiao Li, Yong Luo, Jun Lu, Wang-Ming Zhang, Xiao-Min Wang, Ji-Sheng Ha. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480178. |
our results suggest that long-term high-frequency ea is effective in halting the degeneration of dopaminergic neurons in the sn and up-regulating the levels of bdnf mrna in the subfields of the ventral midbrain. |
2003-06-16 |
2023-08-12 |
rat |
| Nirit Lev, Eldad Melamed, Daniel Offe. Apoptosis and Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 2. 2003-05-29. PMID:12657363. |
it is caused by the selective loss of the dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2003-05-29 |
2023-08-12 |
human |
| Toyoko Arimoto, Guoying Bin. Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiology of disease. vol 12. issue 1. 2003-05-09. PMID:12609487. |
the present study was designed to examine whether expression of inos was involved in lps-induced neurodegeneration in rat substantia nigra (sn) and to study the role of no in the loss of the sn dopaminergic neurons. |
2003-05-09 |
2023-08-12 |
rat |
| Toyoko Arimoto, Guoying Bin. Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiology of disease. vol 12. issue 1. 2003-05-09. PMID:12609487. |
these results demonstrate that lps induces the expression of inos in activated microglia in the sn, and that no and/or its metabolites may play a crucial role in inflammation-mediated degeneration of dopaminergic neurons. |
2003-05-09 |
2023-08-12 |
rat |
| J M Henderson, S Watson, G M Halliday, T Heinemann, M Gerlac. Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat. Behavioural brain research. vol 139. issue 1-2. 2003-05-02. PMID:12642181. |
we analysed the relationships between several deficits induced by unilateral 6-ohda lesions and striatal neurochemistry, as well as neuronal loss in the dopaminergic substantia nigra (sn). |
2003-05-02 |
2023-08-12 |
rat |
| Hi-Joon Park, Sabina Lim, Wan-Seok Joo, Chang-Shik Yin, Hyang-Sook Lee, Hye-Jung Lee, Jung Chul Seo, Kanghyun Leem, Yang-Sun Son, Youn-Jung Kim, Chang-Ju Kim, Yong-Sik Kim, Joo-Ho Chun. Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model. Experimental neurology. vol 180. issue 1. 2003-04-17. PMID:12668152. |
however, acupunctural treatment resulted in the enhanced survival of dopaminergic neurons in the sn (21.4% loss) and their terminals in the dorsolateral striatum. |
2003-04-17 |
2023-08-12 |
rat |
| Scott A Lyness, Chris Zarow, Helena C Chu. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493547. |
cell counts in the cholinergic nucleus basalis (nb), noradrenergic locus coeruleus (lc), dopaminergic substantia nigra (sn), and the serotonergic dorsal raphe nucleus (drn) were assessed from primary-level reports in patients with alzheimer disease (ad) and in controls. |
2003-03-26 |
2023-08-12 |
Not clear |
| Eloisa Carreño-Müller, Antonio J Herrera, Rocio M de Pablos, Mayka Tomás-Camardiel, José L Venero, Josefina Cano, Alberto Machad. Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603843. |
moreover, selective damage to dopaminergic neurones was produced after thrombin injection, evidenced by loss of tyrosine hydroxylase immunostaining and tyrosine hydroxylase mrna-expressing cell bodies, and the unaltered transcription of glutamic acid decarboxylase mrna in the sn and striatum. |
2003-03-19 |
2023-08-12 |
Not clear |
| L Cathala, A Guyon, D Eugene, D Paupardin-Tritsc. Alpha2-adrenoceptor activation increases a cationic conductance and spontaneous GABAergic synaptic activity in dopaminergic neurones of the rat substantia nigra. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453479. |
noradrenaline (na) plays an important role in compensating for the loss in dopaminergic (da) function following lesions of the da neurones of the substantia nigra (sn). |
2003-03-12 |
2023-08-12 |
rat |
| A Nicotra, S Parve. Apoptotic molecules and MPTP-induced cell death. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200191. |
mptp administered in vivo to mice causes selective loss of dopaminergic neurons in the substantia nigra (sn), as in this disease. |
2002-12-19 |
2023-08-12 |
mouse |
| K L Double, D Ben-Shachar, M B H Youdim, L Zecca, P Riederer, M Gerlac. Influence of neuromelanin on oxidative pathways within the human substantia nigra. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200193. |
neuromelanin (nm) is a dark-coloured pigment produced in the dopaminergic neurons of the human substantia nigra (sn). |
2002-12-19 |
2023-08-12 |
human |
| S Bharat, B C Cochran, M Hsu, J Liu, B N Ames, J K Anderse. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology. vol 23. issue 4-5. 2002-12-16. PMID:12428720. |
oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2002-12-16 |
2023-08-12 |
Not clear |
| S Tam, D P Barry, L Beaman, B L Beama. Neuroinvasive Nocardia asteroides GUH-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. Experimental neurology. vol 177. issue 2. 2002-11-26. PMID:12429191. |
n. asteroides strain guh-2 invades the brains of experimentally infected animals and selectively affects dopaminergic neurons of the substantia nigra (sn), causing an l-dopa-responsive movement disorder resembling parkinsonism. |
2002-11-26 |
2023-08-12 |
Not clear |