| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Kozlowski, B Connor, J L Tillerson, T Schallert, M C Boh. Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031079. |
adgdnf injection in the sn rescued dopaminergic neurons in the sn and increased the number of dopaminergic neurons that maintained a connection to the striatum, compared to rats injected with adlacz. |
2000-12-07 |
2023-08-12 |
rat |
| B Liu, J W Jiang, B C Wilson, L Du, S N Yang, J Y Wang, G C Wu, X D Cao, J S Hon. Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991969. |
in this study, injection of lps into the rat sn led to the activation of microglia and degeneration of dopaminergic neurons: microglial activation was observed as early as 6 h and loss of dopaminergic neurons was detected 3 days after the lps injection. |
2000-11-03 |
2023-08-12 |
rat |
| B Liu, J W Jiang, B C Wilson, L Du, S N Yang, J Y Wang, G C Wu, X D Cao, J S Hon. Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991969. |
furthermore, the lps-induced loss of dopaminergic neurons in the sn was time- and lps concentration-dependent. |
2000-11-03 |
2023-08-12 |
rat |
| B Liu, J W Jiang, B C Wilson, L Du, S N Yang, J Y Wang, G C Wu, X D Cao, J S Hon. Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991969. |
systemic infusion of either (-)-naloxone or (+)-naloxone inhibited the lps-induced activation of microglia and significantly reduced the lps-induced loss of dopaminergic neurons in the sn. |
2000-11-03 |
2023-08-12 |
rat |
| B Liu, J W Jiang, B C Wilson, L Du, S N Yang, J Y Wang, G C Wu, X D Cao, J S Hon. Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991969. |
in addition, the inflammation-mediated degeneration of dopaminergic neurons in the rat sn resulting from the targeted injection of lps may serve as a useful model to gain further insights into the pathogenesis of parkinson's disease. |
2000-11-03 |
2023-08-12 |
rat |
| P A Starr, T Subramanian, R A Bakay, T Wichman. Electrophysiological localization of the substantia nigra in the parkinsonian nonhuman primate. Journal of neurosurgery. vol 93. issue 4. 2000-10-16. PMID:11014554. |
therefore, precise surgical approaches to the dopaminergic cell-containing region of the sn are required to avoid damage to nearby structures such as the corticospinal tract and subthalamic nucleus. |
2000-10-16 |
2023-08-12 |
monkey |
| A J Herrera, A Castaño, J L Venero, J Cano, A Machad. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964613. |
moreover, only the dopaminergic neurons of the sn were affected, with no detectable damage to either the gabaergic or the serotoninergic neurons. |
2000-10-11 |
2023-08-12 |
rat |
| A J Herrera, A Castaño, J L Venero, J Cano, A Machad. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964613. |
therefore, we suggest that the injection of a single dose of lps within the sn is an interesting model for studying the selective effects of inflammatory reaction on dopaminergic system and also potentially useful for studying pd. |
2000-10-11 |
2023-08-12 |
rat |
| I Suárez, G Bodega, J A Ramos, J J Fernández-Ruiz, B Fernánde. Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra. Developmental neuroscience. vol 22. issue 4. 2000-10-11. PMID:10965147. |
the responses of neurons and astroglial cells to pre- and perinatal exposure to delta(9)-tetrahydrocannabinol (delta(9)-thc) were evaluated in the substantia nigra (sn) of male and female rats, at three postnatal ages (pd21, pd30 and pd70), by immunohistochemical detection of tyrosine hydroxylase (th) in dopaminergic neurons and of glial fibrillary acidic protein (gfap) in astrocytes. |
2000-10-11 |
2023-08-12 |
rat |
| G Mateu, A Privat, J Thibault, J Vigno. Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 6. 2000-09-28. PMID:10884605. |
glutamate toxicity was compared in substantia nigra (sn)/striatum (str) and sn/cerebellum (crb) co-cultures on both the entire neuronal population (neuron specific enolase (nse) immunopositive cells) and dopaminergic neurons (tyrosine hydroxylase (th) immunopositive cells). |
2000-09-28 |
2023-08-12 |
Not clear |
| N Jha, O Jurma, G Lalli, Y Liu, E H Pettus, J T Greenamyre, R M Liu, H J Forman, J K Anderse. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10846169. |
oxidative stress appears to play an important role in degeneration of dopaminergic neurons of the substantia nigra (sn) associated with parkinson's disease (pd). |
2000-09-25 |
2023-08-12 |
Not clear |
| N Jha, O Jurma, G Lalli, Y Liu, E H Pettus, J T Greenamyre, R M Liu, H J Forman, J K Anderse. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10846169. |
these results suggest that the early observed gsh losses in the sn may be directly responsible for the noted decreases in complex i activity and the subsequent mitochondrial dysfunction, which ultimately leads to dopaminergic cell death associated with pd. |
2000-09-25 |
2023-08-12 |
Not clear |
| J Chung, S Chang, Y Kim, H Shi. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neuroscience letters. vol 286. issue 3. 2000-07-12. PMID:10832015. |
we, therefore, examined the effect of zn(2+) on the intrinsic electrical properties of dopaminergic sn neurons, using a whole-cell recording method. |
2000-07-12 |
2023-08-12 |
rat |
| J Chung, S Chang, Y Kim, H Shi. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neuroscience letters. vol 286. issue 3. 2000-07-12. PMID:10832015. |
zn(2+) hyperpolarized dopaminergic sn neurons at resting state. |
2000-07-12 |
2023-08-12 |
rat |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
the substantia nigra (sn) is a midbrain center composed of dopaminergic (da-) and gamma aminobutyric acid (gaba)ergic (gaba-) neurons. |
2000-06-23 |
2023-08-12 |
rat |
| H Kim, W Jhoo, E Shin, G Bin. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799693. |
the present study was designed to understand the role of an antioxidant, selenium (se) on methamphetamine (ma)-induced dopaminergic cell damage in the substantia nigra (sn). |
2000-06-21 |
2023-08-12 |
mouse |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
the pathologic hallmark of parkinson's disease is the dopaminergic cell death in the substantia nigra (sn). |
2000-04-25 |
2023-08-12 |
rat |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
the results suggest that dopaminergic cells in sn undergo apoptosis in the rat model of parkinson's disease. |
2000-04-25 |
2023-08-12 |
rat |
| A M Lin, T Y Luh, C K Chou, L T H. The antioxidative effect of carboxyfullerenes (C3/D3) on iron-induced oxidative injury in CNS. Annals of the New York Academy of Sciences. vol 890. 2000-03-15. PMID:10668440. |
in urethane-anesthetized rats, intranigral infusion of iron degenerated the nigrostriatal dopaminergic system, including as elevation in lipid peroxidation in the infused substantia nigra (sn) and reductions in k(+)-evoked dopamine overflow and dopamine content in the ipsilateral striatum 7 days after the infusion. |
2000-03-15 |
2023-08-12 |
rat |
| B Connor, D A Kozlowski, T Schallert, J L Tillerson, B L Davidson, M C Boh. Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat. Gene therapy. vol 6. issue 12. 2000-02-24. PMID:10637445. |
injection of an adenoviral (ad) vector encoding human glial cell line-derived neurotrophic factor (gdnf) protects dopaminergic (da) neurons in the substantia nigra (sn) of young rats. |
2000-02-24 |
2023-08-12 |
human |