Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619672. |
we further assessed the roles of the mesostriatal dopaminergic system and found that local perfusion of quinpirole and 7-oh-dpat into the substantia nigra (sn) significantly aggravated cataplexy, while perfusion of a d2/d3 antagonist significantly reduced cataplexy. |
2000-01-19 |
2023-08-12 |
Not clear |
K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619672. |
although autoregulation of the vta and sn dopaminergic neurons are involved in the regulation of cataplexy, both structures have distinct roles for the regulation of sleep. |
2000-01-19 |
2023-08-12 |
Not clear |
E M Nikulina, R P Hammer, K A Miczek, R M Krea. Social defeat stress increases expression of mu-opioid receptor mRNA in rat ventral tegmental area. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549815. |
because opioids mediate significant regulatory activities of brain dopamine neurons, dopaminergic loci in the ventral tegmental area (vta) and substantia nigra (sn) were selected for analysis. |
2000-01-04 |
2023-08-12 |
rat |
K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep [corrected]. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549832. |
we further assessed the roles of the mesostriatal dopaminergic system and found that local perfusion of quinpirole and 7-oh-dpat into the substantia nigra (sn) significantly aggravated cataplexy, while perfusion of a d2/d3 antagonist significantly reduced cataplexy. |
2000-01-04 |
2023-08-12 |
Not clear |
K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep [corrected]. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549832. |
although autoregulation of the vta and sn dopaminergic neurons are involved in the regulation of cataplexy, both structures have distinct roles for the regulation of sleep. |
2000-01-04 |
2023-08-12 |
Not clear |
B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
in contrast to gabaergic sn neurons, which were unaffected in homozygous weaver mice (wv/wv), dopaminergic sn neurons possessed a dramatically altered phenotype with a depolarized membrane potential and complete loss of spontaneous pacemaker activity. |
1999-10-28 |
2023-08-12 |
mouse |
B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
the gain-of-function phenotype was mediated by a large, nonselective membrane conductance exclusively present in (wv/wv) dopaminergic sn neurons. |
1999-10-28 |
2023-08-12 |
mouse |
B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
single-cell girk1-4 expression profiling suggested that homomeric girk2 channels were present in most dopaminergic sn neurons, whereas girk2 was always coexpressed with other girk family members in gabaergic sn neurons. |
1999-10-28 |
2023-08-12 |
mouse |
B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
we also show that in contrast to wild-type neurons, all (wv/wv) dopaminergic sn neurons expressed calbindin, a calcium-binding protein that marks dopaminergic sn neurons resistant to neurodegeneration. |
1999-10-28 |
2023-08-12 |
mouse |
B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
the identification of two ion channels that in concert determine the weaver phenotype of surviving calbindin-positive dopaminergic sn neurons will help to understand the molecular mechanisms of selective neurodegeneration of dopaminergic sn neurons in the weaver mouse and might be important in parkinson's disease. |
1999-10-28 |
2023-08-12 |
mouse |
J Han, F C Cheng, Z Yang, G Dryhurs. Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501216. |
in this investigation, microdialysis has been used to study the effects of 1-methyl-4-phenylpyridinium (mpp+), an inhibitor of mitochondrial complex i and alpha-ketoglutarate dehydrogenase and the active metabolite of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), on extracellular concentrations of glutathione (gsh) and cysteine (cysh) in the rat striatum and substantia nigra (sn). |
1999-10-14 |
2023-08-12 |
human |
K A Jellinge. Post mortem studies in Parkinson's disease--is it possible to detect brain areas for specific symptoms? Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370901. |
reduced dopaminergic input causes overactivity of the gaba ergic inhibitory striatal neurons projecting via the "indirect loop" to sn zona reticulata (snzr) and medial pallidum (gpi) leading to inhibition of the glutamatergic thalamo-cortical motor loop and reduced cortical activation. |
1999-08-02 |
2023-08-12 |
Not clear |
W Duan, M P Mattso. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398297. |
parkinson's disease (pd) is an age-related disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and corresponding motor deficits. |
1999-07-28 |
2023-08-12 |
mouse |
W Duan, M P Mattso. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398297. |
we report that dr in adult mice results in resistance of dopaminergic neurons in the sn to the toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
1999-07-28 |
2023-08-12 |
mouse |
W Duan, M P Mattso. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398297. |
mice receiving 2-dg exhibited reduced damage to dopaminergic neurons in the sn and improved behavioral outcome following mptp treatment. |
1999-07-28 |
2023-08-12 |
mouse |
E Charpantier, P Barnéoud, P Moser, F Besnard, F Sgar. Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804323. |
using the reverse transcriptase-polymerase chain reaction we have analyzed the mrna for nachr subunits expressed in the substantia nigra (sn) and ventral tegmental area (vta) following unilateral 6-hydroxydopamine lesion of the dopaminergic system. |
1999-06-07 |
2023-08-12 |
rat |
E Charpantier, P Barnéoud, P Moser, F Besnard, F Sgar. Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804323. |
in contrast to the unlesioned hemisphere, no signal was found in the lesioned hemisphere for alpha3, alpha5, alpha6 and beta4 subunits in the sn nor for alpha2, alpha3, alpha5, alpha6, alpha7 and beta4 subunits in the vta, indicating the expression of these subunits in dopaminergic neurons. |
1999-06-07 |
2023-08-12 |
rat |
J Zhang, G Perry, M A Smith, D Robertson, S J Olson, D G Graham, T J Montin. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. The American journal of pathology. vol 154. issue 5. 1999-06-03. PMID:10329595. |
oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (sn) of patients with parkinson's disease (pd). |
1999-06-03 |
2023-08-12 |
Not clear |
M Yamada, T Oligino, M Mata, J R Goss, J C Glorioso, D J Fin. Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 7. 1999-05-12. PMID:10097166. |
6-hydroxydopamine (6-ohda) is widely used to selectively lesion dopaminergic neurons of the substantia nigra (sn) in the creation of animal models of parkinson's disease. |
1999-05-12 |
2023-08-12 |
rat |
M Yamada, T Oligino, M Mata, J R Goss, J C Glorioso, D J Fin. Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 7. 1999-05-12. PMID:10097166. |
to test the hypothesis that apoptotic pathways are involved in the death of dopaminergic neurons of the sn caused by 6-ohda, we created a replication-defective genomic herpes simplex virus-based vector containing the coding sequence for the antiapoptotic peptide bcl-2 under the transcriptional control of the simian cytomegalovirus immediate early promoter. |
1999-05-12 |
2023-08-12 |
rat |