Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
N S Kolomeets, N A Uranov. [Synaptic contacts in schizophrenia: study with immunocytochemical identification of dopaminergic neurons]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 97. issue 12. 1998-06-09. PMID:9591064. |
the altered presynaptic terminals were preferentially located on distal (small and middle diameter) tp dendrites in pars compacta of sn, where practically all dendrites revealed belonged to dopaminergic neurons and formed asymmetric contacts with short active zones in most cases. |
1998-06-09 |
2023-08-12 |
Not clear |
Y He, T Lee, S K Leon. Effect of 6-OHDA injection on the AMPA glutamate receptor subunits in the substantia nigra of Sprague-Dawley rats. Neuroscience letters. vol 241. issue 1. 1998-04-28. PMID:9502201. |
parkinson's disease (pd) is characterized by the destruction of dopaminergic cells in the substantia nigra (sn). |
1998-04-28 |
2023-08-12 |
rat |
T J Counihan, G B Landwehrmeyer, D G Standaert, C M Kosinski, C R Scherzer, L P Daggett, G Veliçelebi, A B Young, J B Penne. Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: mesencephalic dopaminergic neurons. The Journal of comparative neurology. vol 390. issue 1. 1998-03-03. PMID:9456178. |
these results demonstrate that nrs are expressed to a significant degree in dopaminergic neurons of the sn and that their distribution does not correlate with the characteristic pattern of neuronal degeneration in pd. |
1998-03-03 |
2023-08-12 |
human |
A H Rajput, M e Fenton, S Birdi, R Macaula. Is levodopa toxic to human substantia nigra? Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 5. 1997-11-07. PMID:9380042. |
levodopa (ld) is the most effective drug for symptomatic control of parkinson's disease, but has been suspected to be toxic to substantia nigra (sn) dopaminergic neurons. |
1997-11-07 |
2023-08-12 |
human |
A Rohlfs, G Nikkhah, C Rosenthal, C Rundfeldt, A Brandis, M Samii, W Lösche. Hemispheric asymmetries in spontaneous firing characteristics of substantia nigra pars reticulata neurons following a unilateral 6-hydroxydopamine lesion of the rat nigrostriatal pathway. Brain research. vol 761. issue 2. 1997-09-24. PMID:9252038. |
single unit activity of substantia nigra pars reticulata (snr) neurons was recorded bilaterally in rats subjected to unilateral 6-hydroxydopamine lesions of the ascending mesostriatal dopaminergic pathway, resulting in an almost complete loss of dopaminergic neurons in the ipsilateral sn pars compacta. |
1997-09-24 |
2023-08-12 |
rat |
C Henchcliffe, R E Burk. Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra. Neuroscience letters. vol 230. issue 1. 1997-09-24. PMID:9259459. |
we reported previously that striatal excitotoxic lesion with quinolinic acid of rat pups during the first 2 weeks of postnatal life results in loss of dopaminergic neurons of the substantia nigra (sn) due to induced apoptosis. |
1997-09-24 |
2023-08-12 |
rat |
J Balthazart, P Absi. Identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the Japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry. The Journal of comparative neurology. vol 382. issue 3. 1997-07-30. PMID:9183702. |
in these last two regions, many retrogradely labeled cells were located in dopaminergic areas such as the retroruberal field (rrf), substantia nigra (sn), and area ventralis of tsai (avt) but also in noradrenergic cell groups such as the locus ceruleus and subceruleus. |
1997-07-30 |
2023-08-12 |
Not clear |
X M Shen, B Xia, M Z Wrona, G Dryhurs. Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease. Chemical research in toxicology. vol 9. issue 7. 1997-02-20. PMID:8902266. |
a very early event in the pathogenesis of idiopathic parkinson's disease (pd) has been proposed to be an elevated translocation of l-cysteine (cysh) and/or glutathione (gsh) into pigmented dopaminergic cell bodies in the substantia nigra (sn) in which cytoplasmic dopamine (da) is normally autoxidized to da-o-quinone as the first step in a reaction leading to black neuromelanin polymer. |
1997-02-20 |
2023-08-12 |
mouse |
J L Tseng, E E Baetge, A D Zurn, P Aebische. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987758. |
parkinson's disease (pd) is characterized by the progressive loss of the substantia nigra (sn) dopaminergic neurons projecting to the striatum. |
1997-02-04 |
2023-08-12 |
rat |
J L Tseng, E E Baetge, A D Zurn, P Aebische. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987758. |
improvement of rotational behavior in the absence of dopaminergic striatal reinnervation may reflect neuronal plasticity in the sn, as suggested by the dendritic sprouting observed in animals receiving gdnf. |
1997-02-04 |
2023-08-12 |
rat |
J L Tseng, E E Baetge, A D Zurn, P Aebische. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987758. |
these results illustrate that the continuous release of low levels of gdnf close to the sn is capable of protecting the nigral dopaminergic neurons from an axotomy-induced lesion and significantly improving pharmacological rotational behavior by a mechanism other than dopaminergic striatal reinnervation. |
1997-02-04 |
2023-08-12 |
rat |
M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
midbrain dopaminergic neurons are known to release dopamine from somata and/or dendrites located in the substantia nigra (sn) and the ventral tegmental area (vta). |
1996-12-13 |
2023-08-12 |
rat |
M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
in the present study, we used dual-labeling electron microscopic immunocytochemistry to localize the vesicular monoamine transporter-2 (vmat2), a novel marker for sites of intracellular monoamine storage, within identified dopaminergic (tyrosine hydroxylase-containing) neurons in the rat sn and vta. |
1996-12-13 |
2023-08-12 |
rat |
M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
dopaminergic dendrites in the vta contained a significantly higher number of immunogold particles for vmat2 per unit than those in the sn. |
1996-12-13 |
2023-08-12 |
rat |
M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
in addition, they provide new evidence that dopaminergic dendrites in the vta may have greater potential for reserpine-sensitive storage and release of dopamine than those in the sn. |
1996-12-13 |
2023-08-12 |
rat |
D G Schaar, M R Varia, S Elkabes, L Ramakrishnan, C F Dreyfus, I B Blac. The identification of a novel cDNA preferentially expressed in the olfactory-limbic system of the adult rat. Brain research. vol 721. issue 1-2. 1996-11-27. PMID:8793103. |
our previous studies indicated that local substantia nigra (sn) type 1 astrocytes elaborate an array of trophic molecules which support the survival of sn dopaminergic neurons. |
1996-11-27 |
2023-08-12 |
rat |
X M Shen, G Dryhurs. Further insights into the influence of L-cysteine on the oxidation chemistry of dopamine: reaction pathways of potential relevance to Parkinson's disease. Chemical research in toxicology. vol 9. issue 4. 1996-11-19. PMID:8831820. |
the initial step in the genesis of neuromelanin, a black polymeric pigment normally found in the cytoplasm of dopaminergic cell bodies in the substantia nigra (sn), is the autoxidation of dopamine (da) to da-o-quinone (1). |
1996-11-19 |
2023-08-12 |
mouse |
X M Shen, G Dryhurs. Further insights into the influence of L-cysteine on the oxidation chemistry of dopamine: reaction pathways of potential relevance to Parkinson's disease. Chemical research in toxicology. vol 9. issue 4. 1996-11-19. PMID:8831820. |
these and related results provide support for the hypothesis that the massive, irreversible loss of glutathione (gsh), increased 5-s-cys-da/da concentration ratio, and depigmentation of dopaminergic neurons in the sn that all occur in parkinson's disease (pd) might be caused by the gamma-glutamyl transpeptidase-mediated translocation of cysh (and/or gsh) into these cells. |
1996-11-19 |
2023-08-12 |
mouse |
E Kienzl, L Puchinger, K Jellinger, W Linert, H Stachelberger, R F Jameso. The role of transition metals in the pathogenesis of Parkinson's disease. Journal of the neurological sciences. vol 134 Suppl. 1996-10-24. PMID:8847547. |
the mechanisms that lead to degeneration of melanized dopaminergic neurons in the brain stem, and particularly in the substantia nigra (sn) in patients with parkinson's disease (pd) are still unknown. |
1996-10-24 |
2023-08-12 |
Not clear |
S Fenu, A Carta, M Morell. Intranigral injections of glutamate antagonists modulate dopamine D1-mediated turning behavior and striatal c-fos expression. Journal of neural transmission. Supplementum. vol 45. 1996-10-23. PMID:8748612. |
the contribution of the substantia nigra (sn) in the positive interaction between dopamine d1 receptor agonists and glutamate antagonists was studied in rats with a unilateral 6-hydroxydopamine (6-ohda) lesion of dopaminergic nigro-striatal pathway. |
1996-10-23 |
2023-08-12 |
rat |