| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Ben-Shachar, M B Youdi. Iron, melanin and dopamine interaction: relevance to Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 1. 1993-01-21. PMID:8416600. |
in the absence of an identified exogenous or endogenous neurotoxin in idiopathic parkinson's disease, iron-melanin interaction in the sn may serve as a candidate for the oxygen-radical induced neurodegeneration of the melanin containing dopaminergic neurons. |
1993-01-21 |
2023-08-12 |
rat |
| I D Smith, A A Grac. Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity. Synapse (New York, N.Y.). vol 12. issue 4. 1993-01-19. PMID:1465742. |
the influence of subthalamic nucleus (stn) afferents on dopaminergic (da) neurons of the rat substantia nigra (sn) was investigated. |
1993-01-19 |
2023-08-11 |
rat |
| T Shirao, M J Evinger, L Iacovitti, D J Rei. Lesions of nigrostriatal pathway reduce expression of tyrosine hydroxylase gene in residual dopaminergic neurons of substantia nigra. Neuroscience letters. vol 141. issue 2. 1992-12-11. PMID:1359468. |
in situ hybridization analyses also demonstrated the reduction of th mrna concentration in surviving dopaminergic neurons in the ipsilateral sn. |
1992-12-11 |
2023-08-11 |
rat |
| M P Carrera, R Mattioli, C Toma. Preoperative operant circling training facilitates recovery following unilateral substantia nigra lesion in rats. Behavioral and neural biology. vol 58. issue 1. 1992-11-04. PMID:1417669. |
this study was undertaken to examine (1) whether pre- and/or postoperative training, using water reinforcement, to turn in circles (rotation) affects the behavioral symptoms induced by unilateral 6-hydroxydopamine (6-ohda)-induced da denervation of the rat substantia nigra (sn); (2) whether there was any influence of this training on the temporal pattern of recovery; and (3) whether the rotational training influences turning induced by systemic injection of dopaminergic drugs. |
1992-11-04 |
2023-08-11 |
rat |
| D Ben-Shachar, G Eshel, P Riederer, M B Youdi. Role of iron and iron chelation in dopaminergic-induced neurodegeneration: implication for Parkinson's disease. Annals of neurology. vol 32 Suppl. 1992-09-18. PMID:1510367. |
recent studies in parkinson's disease suggest that the degeneration of the nigrostriatal melanin-containing dopaminergic neurons results from toxic effects of free radicals, which are generated during dopamine metabolism in the substantia nigra (sn). |
1992-09-18 |
2023-08-11 |
rat |
| G J Sengstock, C W Olanow, A J Dunn, G W Arendas. Iron induces degeneration of nigrostriatal neurons. Brain research bulletin. vol 28. issue 4. 1992-08-05. PMID:1617450. |
to test whether excess iron in the sn could cause a pd-like loss of dopaminergic neurons, various concentrations of iron were infused unilaterally within the sn of adult male rats. |
1992-08-05 |
2023-08-11 |
rat |
| V Leviel, B Guibert, J Mallet, N Faucon-Bigue. Induction of tyrosine hydroxylase in the rat substantia nigra by local injection of forskolin. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1686787. |
in addition, the decrease of the ratio between dopamine and its first metabolite in the cn and the sn suggested a decreased activity of the dopaminergic nigral cells. |
1992-04-15 |
2023-08-11 |
rat |
| V Leviel, B Guibert, J Mallet, N Faucon-Bigue. Induction of tyrosine hydroxylase in the rat substantia nigra by local injection of forskolin. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1686787. |
these results confirm that, in vivo, th induction is camp-dependent and demonstrate that the th-gene activity is not strictly coupled to the activity of dopaminergic cells in the sn. |
1992-04-15 |
2023-08-11 |
rat |
| M E Old. Enhanced dopamine metabolism in accumbens leads to motor activity and concurrently to increased output from nondopamine neurons in ventral tegmental area and substantia nigra. Physiology & behavior. vol 51. issue 1. 1992-03-23. PMID:1311110. |
the present study represents an attempt to determine the contribution of nucleus accumbens (acc) dopaminergic activity to these effects, and to ascertain whether the effects in vta differ from those seen in sn when dopaminergic activity is enhanced locally in acc. |
1992-03-23 |
2023-08-11 |
rat |
| M Mavridis, F C Colpaert, M J Milla. Differential modulation of (+)-amphetamine-induced rotation in unilateral substantia nigra-lesioned rats by alpha 1 as compared to alpha 2 agonists and antagonists. Brain research. vol 562. issue 2. 1992-03-03. PMID:1685341. |
in rats sustaining unilateral 6-hydroxy-dopamine lesions of the substantia nigra (sn), the indirect dopaminergic agonist, (+)-amphetamine (amph), dose-dependently induced robust, ipsilateral rotation: this could be dose-dependently abolished by the dopamine (d2/d1) antagonist, haloperidol. |
1992-03-03 |
2023-08-11 |
rat |
| H Nissbrandt, G Engberg, E Pilebla. The effects of GBR 12909, a dopamine re-uptake inhibitor, on monoaminergic neurotransmission in rat striatum, limbic forebrain, cortical hemispheres and substantia nigra. Naunyn-Schmiedeberg's archives of pharmacology. vol 344. issue 1. 1992-03-02. PMID:1663587. |
furthermore, gbr 12909 did not significantly affect the firing rate of dopaminergic neurons in the sn or that of noradrenergic neurons in the lc. |
1992-03-02 |
2023-08-11 |
rat |
| K R Melia, K Rasmussen, R Z Terwilliger, J W Haycock, E J Nestler, R S Duma. Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments. Journal of neurochemistry. vol 58. issue 2. 1992-02-13. PMID:1345939. |
chronic (5 days) cold exposure significantly increased levels of th immunoreactivity in the lc, as previously reported, but not in substantia nigra (sn) or ventral tegmentum (vt), two dopaminergic nuclei studied for comparison. |
1992-02-13 |
2023-08-11 |
rat |
| G Pezzoli, A Zecchinelli, S Ricciardi, R E Burke, S Fahn, G Scarlato, A Carenz. Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats. Movement disorders : official journal of the Movement Disorder Society. vol 6. issue 4. 1992-02-05. PMID:1684638. |
we assessed the effect of a 35-day delayed intracerebroventricular (icv) infusion of epidermal growth factor (egf) on the survival and function of the substantia nigra (sn) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. |
1992-02-05 |
2023-08-11 |
rat |
| A Elverfors, H Nissbrand. Reserpine-insensitive dopamine release in the substantia nigra? Brain research. vol 557. issue 1-2. 1992-01-22. PMID:1720998. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic pathway, but also from the dendrites in the substantia nigra (sn). |
1992-01-22 |
2023-08-11 |
Not clear |
| Y Ichitani, H Okamura, Y Matsumoto, I Nagatsu, Y Ibat. Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum. Brain research. vol 549. issue 2. 1991-10-04. PMID:1679369. |
the results showed a retrograde cytotoxic effect of 6-ohda from the striatal terminals to their dopaminergic neuronal perikarya in the sn, and suggest the possibility that the striatum may be a primary locus in the degeneration process in parkinson's disease. |
1991-10-04 |
2023-08-11 |
rat |
| G S Robertson, A Fine, H A Robertso. Dopaminergic grafts in the striatum reduce D1 but not D2 receptor-mediated rotation in 6-OHDA-lesioned rats. Brain research. vol 539. issue 2. 1991-07-31. PMID:1675908. |
fetal dopaminergic grafts in the ipsilateral substantia nigra (sn) did not augment the decreases in turning produced by concomitant ipsilateral dopaminergic grafts in the striatum in response to skf 38393. |
1991-07-31 |
2023-08-11 |
rat |
| G S Robertson, A Fine, H A Robertso. Dopaminergic grafts in the striatum reduce D1 but not D2 receptor-mediated rotation in 6-OHDA-lesioned rats. Brain research. vol 539. issue 2. 1991-07-31. PMID:1675908. |
dopaminergic grafts in the sn increased, while dopaminergic grafts in the striatum or in striatum and sn decreased, the facilitatory effect of d-amphetamine on rotation elicited by subsequent injection of dopamine agonists. |
1991-07-31 |
2023-08-11 |
rat |
| M Gupta, M H Stoler, L H Fossom, A W Tan. Tyrosine hydroxylase mRNA in the dopaminergic neurons of young adult and aged mice by in situ hybridization. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:1982959. |
tyrosine hydroxylase (th) mrna in the dopaminergic neurons of the substantia nigra (sn) and the ventral tegmental area (vta) in young adult and aged mice was detected and quantitated using in situ hybridization. |
1991-07-19 |
2023-08-11 |
mouse |
| M Gupta, M H Stoler, L H Fossom, A W Tan. Tyrosine hydroxylase mRNA in the dopaminergic neurons of young adult and aged mice by in situ hybridization. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:1982959. |
using 3h-labeled antisense rna complementary to th mrna, these studies demonstrate the presence of th mrna in dopaminergic neurons of the sn and the vta. |
1991-07-19 |
2023-08-11 |
mouse |
| M Gupta, M H Stoler, L H Fossom, A W Tan. Tyrosine hydroxylase mRNA in the dopaminergic neurons of young adult and aged mice by in situ hybridization. Neuroscience letters. vol 119. issue 1. 1991-07-19. PMID:1982959. |
quantitative analysis of the number of silver grains present over the dopaminergic neurons of the sn and vta revealed no statistically significant difference between the two age groups. |
1991-07-19 |
2023-08-11 |
mouse |