| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Wu, H L Wan. CCK-8-evoked cationic currents in substantia nigra dopaminergic neurons are mediated by InsP3-induced Ca2+ release. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7526297. |
our recent study demonstrated that by activating cck-a receptors, cck-8 excites substantia nigra (sn) dopaminergic (da) neurons via increasing a non-selective cationic conductance. |
1994-12-29 |
2023-08-12 |
Not clear |
| J Thomas, J Wang, H Takubo, J Sheng, S de Jesus, K S Bankiewic. A 6-hydroxydopamine-induced selective parkinsonian rat model: further biochemical and behavioral characterization. Experimental neurology. vol 126. issue 2. 1994-11-17. PMID:7925817. |
the main focus of the present study was to define the rotational response of 6-hydroxydopamine-lesioned rats to dopaminergic agonists to separate the partially lesioned rats from those having complete substantia nigra (sn) and ventral tegmental area (vta) lesions. |
1994-11-17 |
2023-08-12 |
rat |
| E K O'Malley, B A Sieber, R S Morrison, I B Black, C F Dreyfu. Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basic fibroblast growth factor. Brain research. vol 647. issue 1. 1994-09-26. PMID:8069707. |
our studies have been directed to the identification of local, naturally-occurring molecules that support substantia nigra (sn) dopaminergic (da) neuron survival. |
1994-09-26 |
2023-08-12 |
Not clear |
| Q P Ma, Y Zhou, J S Ha. Electroacupuncture accelerated the expression of c-Fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat. The International journal of neuroscience. vol 70. issue 3-4. 1994-09-20. PMID:8063541. |
electroacupuncture stimulation significantly increased the number of fos-positive dopaminergic neurons in the ventral tegmental area (vta), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (sn). |
1994-09-20 |
2023-08-12 |
rat |
| D M Bronstein, H Ye, K R Pennypacker, P M Hudson, J S Hon. Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat. Brain research. Molecular brain research. vol 23. issue 3. 1994-09-12. PMID:7914658. |
d1 dopamine (da) receptor agonists induce the expression of the opioid peptide dynorphin (dyn) in the striatum, an effect accentuated several fold by removing the dopaminergic innervation to the striatum (e.g., by lesioning the da cell bodies in the substantia nigra [sn]). |
1994-09-12 |
2023-08-12 |
rat |
| T Wu, H L Wan. CCK-8 excites substantia nigra dopaminergic neurons by increasing a cationic conductance. Neuroscience letters. vol 170. issue 2. 1994-09-12. PMID:8058194. |
using the whole-cell patch-clamp technique, we investigated electrophysiological effects of cholecystokinin on acutely isolated dopaminergic (da) neurons of rat substantia nigra (sn). |
1994-09-12 |
2023-08-12 |
rat |
| F Zhang, G Dryhurs. Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease. Journal of medicinal chemistry. vol 37. issue 8. 1994-05-24. PMID:7909337. |
this hypothesis proposes that in response to some form of chronic brain insult, the activity of gamma-glutamyltranspeptidase is upregulated leading to an increased rate of translocation of glutathione (gsh) into the cytoplasm of dopaminergic cell bodies in the substantia nigra (sn) para compacta. |
1994-05-24 |
2023-08-12 |
mouse |
| F Zhang, G Dryhurs. Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease. Journal of medicinal chemistry. vol 37. issue 8. 1994-05-24. PMID:7909337. |
the results of this in vitro study predict that such an elevated translocation of gsh into heavily pigmented dopaminergic neurons would cause a diversion of the neuromelanin pathway with consequent depigmentation of these cells and formation of 8, all of which occur in the parkinsonian sn. |
1994-05-24 |
2023-08-12 |
mouse |
| F Zhang, G Dryhurs. Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease. Journal of medicinal chemistry. vol 37. issue 8. 1994-05-24. PMID:7909337. |
the further very facile oxidation of 8 which must occur under intraneuronal conditions where 1 is autoxidized, i.e., in neuromelanin-pigmented cells, would lead to dihydrobenzothiazine 11 and its cysteinyl conjugates which could be the endotoxins responsible for the selective degeneration of dopaminergic sn neurons in pd. |
1994-05-24 |
2023-08-12 |
mouse |
| N Todo, T Momiyama, T Amano, Y Kohno, M Sas. Excitation by talipexole, a dopamine D2 agonist, of caudate nucleus neurons activated by nigral stimulation. Life sciences. vol 54. issue 14. 1994-04-26. PMID:7908115. |
these findings suggest that talipexole activates cn neurons receiving a dopaminergic input from sn via d2 receptors, as does quinpirole. |
1994-04-26 |
2023-08-12 |
Not clear |
| G Engberg, H Nissbrand. gamma-Hydroxybutyric acid (GHBA) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating GABAB-receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 5. 1994-03-28. PMID:8114948. |
in the present study the actions of gamma-hydroxybutyric acid (ghba) on dopaminergic neurons in the rat substantia nigra (sn) were pharmacologically analysed utilising extracellular single unit recording techniques. |
1994-03-28 |
2023-08-12 |
rat |
| H Takashima, B R Walker, H E Cannon-Spoor, W J Free. Kainic acid lesions increase reafferentation of the striatum by substantia nigra grafts. Brain research. vol 621. issue 1. 1993-12-09. PMID:8221075. |
these data suggest that striatal injury promotes the growth of dopaminergic neurites from sn grafts. |
1993-12-09 |
2023-08-12 |
rat |
| M Santiago, A Machado, J Can. In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen. British journal of pharmacology. vol 109. issue 3. 1993-09-28. PMID:7689406. |
the results suggest that gabab receptors modulate the release of dopamine in the sn and pfc, but do not affect the striatal release of dopamine, which indicates that the role of gaba receptor activation is different in the dopaminergic terminals of the st and pfc. |
1993-09-28 |
2023-08-12 |
rat |
| A Macaya, R E Burk. Effect of striatal lesion with quinolinate on the development of substantia nigra dopaminergic neurons: a quantitative morphological analysis. Developmental neuroscience. vol 14. issue 5-6. 1993-07-30. PMID:1363970. |
we conclude that the adult number of sn dopaminergic neurons depends on developmental support by the striatum. |
1993-07-30 |
2023-08-11 |
rat |
| P Schmitt, J Pequignot, C Garcia, J F Pujol, J M Pequigno. Regional specificity of the long-term regulation of tyrosine hydroxylase in some catecholaminergic rat brainstem areas. I. Influence of long-term hypoxia. Brain research. vol 611. issue 1. 1993-07-29. PMID:8100175. |
th protein quantity was also measured in a dopaminergic structure, the substantia nigra (sn). |
1993-07-29 |
2023-08-12 |
rat |
| Y S Zhu, S B Jones, R E Burke, S O Franklin, C E Inturris. Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions. Life sciences. vol 52. issue 19. 1993-06-01. PMID:8097862. |
expression of the striatal proenkephalin gene is modulated by dopaminergic input from the substantia nigra (sn). |
1993-06-01 |
2023-08-12 |
rat |
| A Elverfors, J Jonason, G Jonason, G Leonsson, H Nissbrand. Determination of release of endogenous dopamine from superfused substantia nigra slices. Journal of neuroscience methods. vol 45. issue 3. 1993-04-09. PMID:1363484. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic neuronal pathway but also from cell bodies and dendrites in the substantia nigra (sn). |
1993-04-09 |
2023-08-11 |
Not clear |
| I Tooyama, T Kawamata, D Walker, T Yamada, K Hanai, H Kimura, M Iwane, K Igarashi, E G McGeer, P L McGee. Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease. Neurology. vol 43. issue 2. 1993-03-23. PMID:8437705. |
these results suggest a profound depletion of bfgf in surviving dopaminergic neurons of the sn in pd, and this depletion may be related to the disease process. |
1993-03-23 |
2023-08-12 |
Not clear |
| C Nitsch, G Wolfrum, F Schaefer, A L Scotti, J Unge. Opposite effects of intranigral ibotenic acid and 6-hydroxydopamine on motor behavior and on striatal neuropeptide Y neurons. Brain research bulletin. vol 30. issue 1-2. 1993-02-12. PMID:8420631. |
in the present investigation, the effects of an interruption of the striato-nigro-thalamic loop by ibotenic acid (ibo)-induced lesions of total substantia nigra (sn) on circling behavior and on striatal neuropeptide y (npy) neurons were compared with those after the selective destruction of the dopaminergic nigrostriatal projection with 6-hydroxydopamine (6-ohda). |
1993-02-12 |
2023-08-12 |
rat |
| D Ben-Shachar, M B Youdi. Iron, melanin and dopamine interaction: relevance to Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 1. 1993-01-21. PMID:8416600. |
interaction between iron and melanin may provide a reasonable explanation for the vulnerability of the melanin containing dopaminergic neurons in the substantia nigra (sn) to neurodegeneration in parkinson's disease (pd). |
1993-01-21 |
2023-08-12 |
rat |