| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Pakkenberg, B B Andersen, R S Burns, B Pakkenber. A stereological study of substantia nigra in young and old rhesus monkeys. Brain research. vol 693. issue 1-2. 1996-07-31. PMID:8653409. |
instead of estimating the total number of pigmented and non-pigmented cells, only sn neurons positive for th using immunohistochemical techniques might be used an indicator of the total number of dopaminergic neurons in sn in monkeys. |
1996-07-31 |
2023-08-12 |
monkey |
| X L Chen, F J Roisen, M Gupt. The effect of prior in vitro exposure of donor cells to trophic factors in neurotransplantation. Experimental neurology. vol 138. issue 1. 1996-04-11. PMID:8593897. |
transplantation of ngf-naive pc12 cells leads to a significant increase in the number of dopaminergic neurons in the host substantia nigra (sn) compared to mptp-treated animals. |
1996-04-11 |
2023-08-12 |
mouse |
| X L Chen, F J Roisen, M Gupt. The effect of prior in vitro exposure of donor cells to trophic factors in neurotransplantation. Experimental neurology. vol 138. issue 1. 1996-04-11. PMID:8593897. |
following mptp treatment and pc12 cell transplantation, injection of cya did not affect the dopaminergic neurons in the host sn. |
1996-04-11 |
2023-08-12 |
mouse |
| H Okamura, C Yokoyama, Y Ibat. Lateromedial gradient of the susceptibility of midbrain dopaminergic neurons to neonatal 6-hydroxydopamine toxicity. Experimental neurology. vol 136. issue 2. 1996-01-17. PMID:7498403. |
in all cases of intracisternal 6-ohda treatment, a9 dopaminergic neurons in the substantia nigra (sn) were much more vulnerable to death than more medially located a10 dopaminergic neurons. |
1996-01-17 |
2023-08-12 |
Not clear |
| A Jaffer, G D van der Spuy, V A Russell, M Mintz, J J Taljaar. Activation of the subthalamic nucleus and pedunculopontine tegmentum: does it affect dopamine levels in the substantia nigra, nucleus accumbens and striatum? Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 2. 1995-11-28. PMID:7583677. |
this study investigated whether death of substantia nigra (sn) dopaminergic neurons could be caused by the hyperactivity of afferent pathways resulting in the release of a toxic dose of excitatory amino acids in the sn. |
1995-11-28 |
2023-08-12 |
rat |
| S A Oakman, P L Faris, P E Kerr, C Cozzari, B K Hartma. Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 9. 1995-10-12. PMID:7666171. |
these findings support the concept that this cholinergic group is functionally organized in a manner which selectively innervates motor (sn) and limbic (vta) dopaminergic nuclei. |
1995-10-12 |
2023-08-12 |
rat |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
expression of mrnas encoding the dopamine transporter (dat) and tyrosine hydroxylase (th) in dopaminergic neurons of the substantia nigra (sn) was examined in young and aged fischer 344 rats by in situ hybridization. |
1995-08-18 |
2023-08-12 |
rat |
| D L Rosin, K Melia, A M Knorr, E J Nestler, R H Roth, R S Duma. Chronic imipramine administration alters the activity and phosphorylation state of tyrosine hydroxylase in dopaminergic regions of rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 12. issue 2. 1995-07-20. PMID:7779239. |
chronic administration of imipramine (18 days) decreased levels of th enzyme activity in ventral tegmental area (vta) and substantia nigra (sn), dopaminergic cell body regions, as well as in caudate-putamen (cp), nucleus accumbens (acb), prefrontal cortex (pfc), and olfactory tubercle (ot), dopaminergic terminal fields. |
1995-07-20 |
2023-08-12 |
rat |
| G Nikkhah, M G Cunningham, M A Cenci, R D McKay, A Björklun. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 1. 1995-06-20. PMID:7538563. |
the results demonstrate that homotopically placed dopaminergic neurons survive and integrate well into the previously 6-ohda-lesioned neonatal sn region. |
1995-06-20 |
2023-08-12 |
rat |
| T Wu, H L Wan. Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. Neuroscience letters. vol 184. issue 2. 1995-05-23. PMID:7724045. |
whole-cell voltage-clamp recordings were used to investigate the molecular transduction mechanism by which neurotensin decreases the inwardly rectifying potassium conductance of dopaminergic (da) neurons acutely isolated from the rat substantia nigra (sn). |
1995-05-23 |
2023-08-12 |
rat |
| F Vaglini, F Fascetti, F Fornai, R Maggio, G U Corsin. (+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704605. |
the number of th+ neurons in the substantia nigra (sn) of (+)mk-801-pretreated mice was not significantly different from that of control animals, indicating that this treatment specifically antagonized the extensive ddc-induced lesion of dopaminergic cell bodies in this brain area. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
the observation that parkinson's disease (pd) is associated with locus coeruleus (lc) noradrenergic neuronal degeneration suggests that the lc noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (sn) dopaminergic neurons in parkinson's disease. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
a significant loss of dopaminergic cells was only found in the sn on the side of the lc lesions. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
these results suggest that the lc may have protective effects on sn dopaminergic neurons. |
1995-05-10 |
2023-08-12 |
mouse |
| A Gasbarri, C Verney, R Innocenzi, E Campana, C Pacitt. Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704620. |
the quantitative evaluation of retrogradely labeled and th-ir stained cells showed that both vta and sn projections towards the hf are partially (15-18%) dopaminergic. |
1995-05-10 |
2023-08-12 |
rat |
| W D Le, J Engelhardt, W J Xie, L Schneider, R G Smith, S H Appe. Experimental autoimmune nigral damage in guinea pigs. Journal of neuroimmunology. vol 57. issue 1-2. 1995-05-09. PMID:7706439. |
the eand model suggests that degeneration of dopaminergic neurons in sn can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in parkinson's disease. |
1995-05-09 |
2023-08-12 |
Not clear |
| C G Charlton, J Mac. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888091. |
the major symptoms of parkinson's disease (pd) are tremors, hypokinesia, rigidity, and abnormal posture, caused by degeneration of dopamine (da) neurons in the substantia nigra (sn) and deficiency of da in the neostriatal dopaminergic terminals. |
1995-04-18 |
2023-08-12 |
rat |
| Y Ichitani, H Okamura, D Nakahara, I Nagatsu, Y Ibat. Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injection in the rat nigrostriatal dopamine neuron system: evidence for cell death in the substantia nigra. Experimental neurology. vol 130. issue 2. 1995-03-27. PMID:7867756. |
the results showed that degeneration of the dopaminergic terminals in the striatum may lead to cell death of the parent cell bodies in the sn and suggest that the striatum may be the initial site in which the neurodegeneration occurs in parkinson's disease. |
1995-03-27 |
2023-08-12 |
rat |
| G J Sengstock, C W Olanow, A J Dunn, S Barone, G W Arendas. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7529713. |
we recently reported that intranigral fe infusion into the rat substantia nigra (sn) induces dose-dependent sn neurodegeneration and associated reductions in striatal dopaminergic (da) markers. |
1995-02-14 |
2023-08-12 |
rat |
| M B Youdim, L Lavi. Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7527888. |
in the absence of identification of either an endogenously or an exogenously derived dopaminergic neurotoxin, the most valid hypothesis currently envisaged for etiopathology of parkinson's disease (pd) is selective oxidative stress (os) in substantia nigra (sn). |
1995-01-18 |
2023-08-12 |
Not clear |