| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A McRitchie, H Cartwright, S M Pond, C J van der Schyf, N Castagnoli, D G van der Nest, G M Hallida. The midbrain dopaminergic cell groups in the baboon Papio ursinus. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078618. |
the major difference between the organization of human and baboon midbrain dopaminergic neurons is the anteroposterior extent of the dense cell clusters within the sn pars compacta. |
1999-05-06 |
2023-08-12 |
human |
| M Blu. A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196526. |
here i investigated whether a null mutation in the tgf-alpha gene affects the normal development or survival of dopaminergic neurons in either the substantial nigra (sn) or the ventral tegmental area (vta). |
1999-04-28 |
2023-08-12 |
mouse |
| M Blu. A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196526. |
the sn of tgf-alpha knockout mice contained 50% fewer dopaminergic neurons than the control sn, but vta neuron number was unchanged. |
1999-04-28 |
2023-08-12 |
mouse |
| M Blu. A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196526. |
newborn mice showed a similar decrease in the number of sn dopaminergic neurons, suggesting that tgf-alpha is unlikely to regulate developmental neuron death. |
1999-04-28 |
2023-08-12 |
mouse |
| M Blu. A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra. Nature neuroscience. vol 1. issue 5. 1999-04-28. PMID:10196526. |
these studies indicate that tgf-alpha is required for the normal proliferation or differentiation of a select population of dopaminergic neurons within the sn. |
1999-04-28 |
2023-08-12 |
mouse |
| B Liss, R Bruns, J Roepe. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. The EMBO journal. vol 18. issue 4. 1999-04-26. PMID:10022826. |
in contrast to gabaergic neurons, single dopaminergic sn neurons displayed alternative co-expression of either sur1, sur2b or both sur isoforms with kir6.2. |
1999-04-26 |
2023-08-12 |
mouse |
| B Liss, R Bruns, J Roepe. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. The EMBO journal. vol 18. issue 4. 1999-04-26. PMID:10022826. |
dopaminergic sn neurons expressed alternative k-atp channel species distinguished by significant differences in sulfonylurea affinity and metabolic sensitivity. |
1999-04-26 |
2023-08-12 |
mouse |
| B Liss, R Bruns, J Roepe. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. The EMBO journal. vol 18. issue 4. 1999-04-26. PMID:10022826. |
in single dopaminergic sn neurons, co-expression of sur1 + kir6.2, but not of sur2b + kir6.2, correlated with functional k-atp channels highly sensitive to metabolic inhibition. |
1999-04-26 |
2023-08-12 |
mouse |
| B Liss, R Bruns, J Roepe. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. The EMBO journal. vol 18. issue 4. 1999-04-26. PMID:10022826. |
in contrast to wild-type, surviving dopaminergic sn neurons of homozygous weaver mouse exclusively expressed sur1 + kir6.2 during the active period of dopaminergic neurodegeneration. |
1999-04-26 |
2023-08-12 |
mouse |
| A Inanobe, Y Yoshimoto, Y Horio, K I Morishige, H Hibino, S Matsumoto, Y Tokunaga, T Maeda, Y Hata, Y Takai, Y Kurach. Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 3. 1999-02-25. PMID:9920664. |
this study reveals that the kir3.2 splicing variants play distinct roles in the control of function and localization of some of the kg channels in dopaminergic neurons of sn. |
1999-02-25 |
2023-08-12 |
Not clear |
| J H Son, H S Chun, T H Joh, S Cho, B Conti, J W Le. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 1. 1999-02-05. PMID:9870933. |
the major pathological lesion of parkinson's disease (pd) is the selective cell death of dopaminergic (da) neurons in substantia nigra (sn). |
1999-02-05 |
2023-08-12 |
mouse |
| D L Choi-Lundberg, Q Lin, T Schallert, D Crippens, B L Davidson, Y N Chang, Y L Chiang, J Qian, L Bardwaj, M C Boh. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878166. |
previously, we observed that an adenoviral (ad) vector encoding human glial cell line-derived neurotrophic factor (gdnf), injected near the rat substantia nigra (sn), protects sn dopaminergic (da) neuronal soma from 6-hydroxydopamine (6-ohda)-induced degeneration. |
1999-02-04 |
2023-08-12 |
human |
| K J Elliott, J M Jones, A I Sacaan, G K Lloyd, J Corey-Naev. 6-hydroxydopamine lesion of rat nigrostriatal dopaminergic neurons differentially affects nicotinic acetylcholine receptor subunit mRNA expression. Journal of molecular neuroscience : MN. vol 10. issue 3. 1998-12-08. PMID:9770646. |
nicotinic acetylcholine receptor (nachr) subunit mrna expression in the rat substantia nigra (sn) was assayed by semiquantitative rt-pcr following 6-hydroxydopamine (6-ohda) lesion of nigrostriatal dopaminergic neurons. |
1998-12-08 |
2023-08-12 |
rat |
| K J Elliott, J M Jones, A I Sacaan, G K Lloyd, J Corey-Naev. 6-hydroxydopamine lesion of rat nigrostriatal dopaminergic neurons differentially affects nicotinic acetylcholine receptor subunit mRNA expression. Journal of molecular neuroscience : MN. vol 10. issue 3. 1998-12-08. PMID:9770646. |
the results suggest that alpha 5, alpha 6, and beta 3 subunit-encoding mrnas are expressed at substantially higher levels in dopaminergic than in nondopaminergic cell bodies in the sn. |
1998-12-08 |
2023-08-12 |
rat |
| Y S Kim, W S Joo, B K Jin, Y H Cho, H H Baik, C W Par. Melatonin protects 6-OHDA-induced neuronal death of nigrostriatal dopaminergic system. Neuroreport. vol 9. issue 10. 1998-10-14. PMID:9694233. |
melatonin treatment also resulted in the survival of dopaminergic neurons in sn and th-immuoreactive terminals in the dorsolateral striatum. |
1998-10-14 |
2023-08-12 |
rat |
| D G Walker, K Terai, A Matsuo, T G Beach, E G McGeer, P L McGee. Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases. Brain research. vol 794. issue 2. 1998-08-27. PMID:9622624. |
the use of neurotrophic growth factors as a means of preventing loss of the dopaminergic (da) neurons in the substantia nigra (sn) is becoming an accepted treatment strategy for parkinson's disease (pd). |
1998-08-27 |
2023-08-12 |
human |
| D G Walker, T G Beach, R Xu, J Lile, K D Beck, E G McGeer, P L McGee. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593897. |
in this study, tissue sections of human substantia nigra (sn) from normal and pd cases were examined to determine the pattern of ret expression in this region, and whether there was continued ret expression in surviving dopaminergic neurons in pd cases. |
1998-07-20 |
2023-08-12 |
human |
| D G Walker, T G Beach, R Xu, J Lile, K D Beck, E G McGeer, P L McGee. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593897. |
using a polyclonal antibody to the amino terminal of ret, immunoreactivity was localized in the sn to dopaminergic neurons. |
1998-07-20 |
2023-08-12 |
human |
| S M Johnson, P T Bywoo. Excitatory amino acid-induced degeneration of dendrites of catecholamine neurons in rat substantia nigra. Experimental neurology. vol 151. issue 2. 1998-07-09. PMID:9628758. |
dopaminergic sn neurons were labeled using antibody to tyrosine hydroxylase (th) coupled to diaminobenzidine. |
1998-07-09 |
2023-08-12 |
rat |
| N S Kolomeets, N A Uranov. [Synaptic contacts in schizophrenia: study with immunocytochemical identification of dopaminergic neurons]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 97. issue 12. 1998-06-09. PMID:9591064. |
the ultrastructure of synaptic contacts located on dopaminergic (tyrosine hydroxylase immunopositive--tp) neurons was investigated in substantia nigra (sn) of postmortem brains in 4 schizophrenic patients compared to 3 mentally healthy control cases. |
1998-06-09 |
2023-08-12 |
Not clear |