| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jih Ing Chuang, Shur Tzu Che. Differential expression of Bcl-2 and APP immunoreactivity after intrastriatal injection of MPP+ in the rat. Neurochemistry international. vol 40. issue 2. 2002-02-26. PMID:11738483. |
however, an up-regulation of bcl-2 expression, but not app, appears in dopaminergic neurons in the ipsilateral sn pars compacta where there was retrograde degeneration. |
2002-02-26 |
2023-08-12 |
rat |
| Henrike Neuhoff, Axel Neu, Birgit Liss, Jochen Roepe. I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11850457. |
dopaminergic (da) midbrain neurons in the substantia nigra (sn) and ventral tegmental area (vta) are involved in various brain functions such as voluntary movement and reward and are targets in disorders such as parkinson's disease and schizophrenia. |
2002-02-26 |
2023-08-12 |
mouse |
| B Liss, O Franz, S Sewing, R Bruns, H Neuhoff, J Roepe. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. The EMBO journal. vol 20. issue 20. 2001-12-05. PMID:11598014. |
the activity of dopaminergic (da) substantia nigra (sn) neurons is essential for voluntary movement control. |
2001-12-05 |
2023-08-12 |
Not clear |
| T R Werkman, C G Kruse, H Nievelstein, S K Long, W J Wadma. In vitro modulation of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area by antipsychotic drugs. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378163. |
the difference in firing rates of sn and vta dopamine neurons could have consequences for the effectiveness of dopaminergic drugs acting at the d2-like dopamine (auto)receptor on these neurons. |
2001-08-09 |
2023-08-12 |
rat |
| H Nissbrandt, F Bergquist, J Jonason, G Engber. Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway? Synapse (New York, N.Y.). vol 40. issue 4. 2001-07-26. PMID:11309845. |
the results show that cyp 2e1 activity affects dopaminergic neurotransmission in the sn, possibly by participating in da metabolism. |
2001-07-26 |
2023-08-12 |
rat |
| F Yantiri, A Gasparyan, J K Anderse. Glutamyl cysteine synthetase catalytic and regulatory subunits localize to dopaminergic nigral neurons as well as to astrocytes. Journal of neuroscience research. vol 64. issue 2. 2001-07-12. PMID:11288148. |
we report that the catalytic and regulatory subunit proteins of glutamyl cysteine synthetase (gcs), the primary enzyme involved in gsh synthesis, are present not only in astrocytes but also in dopaminergic neurons of the sn. |
2001-07-12 |
2023-08-12 |
Not clear |
| S Dallvechia-Adams, Y Smith, M J Kuha. CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat. The Journal of comparative neurology. vol 434. issue 1. 2001-06-28. PMID:11329127. |
they were particularly abundant in the dorsomedial sn where they overlapped with non-dopaminergic substantia nigra pars reticulata (snr) neurons and proximal dendrites of dopaminergic substantia nigra pars compacta (snc) neurons. |
2001-06-28 |
2023-08-12 |
rat |
| K Mukhida, K A Baker, D Sadi, I Mende. Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331381. |
the aim of this study was to investigate a multitarget neural transplantation strategy for pd by assessing whether simultaneous dopaminergic transplants in the st, sn, and stn induce functional recovery in hemiparkinsonian rats. |
2001-06-21 |
2023-08-12 |
rat |
| K Mukhida, K A Baker, D Sadi, I Mende. Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331381. |
at 8 weeks after transplantation, simultaneous dopaminergic transplants in the st, sn, and stn induced significant improvement in rotational behavior and stepping test scores. |
2001-06-21 |
2023-08-12 |
rat |
| K Mukhida, K A Baker, D Sadi, I Mende. Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331381. |
these results suggest that restoration of dopaminergic activity to multiple basal ganglia targets, such as the st and sn, or the st and stn, promotes a more complete functional recovery of complex sensorimotor behaviors. |
2001-06-21 |
2023-08-12 |
rat |
| B Connor, D A Kozlowski, J R Unnerstall, J D Elsworth, J L Tillerson, T Schallert, M C Boh. Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration. Experimental neurology. vol 169. issue 1. 2001-06-07. PMID:11312561. |
previously, we observed that injection of an adenoviral (ad) vector expressing glial cell line-derived neurotrophic factor (gdnf) into the striatum, but not the substantia nigra (sn), prior to a partial 6-ohda lesion protects dopaminergic (da) neuronal function and prevents the development of behavioral impairment in the aged rat. |
2001-06-07 |
2023-08-12 |
rat |
| G P Demyanenko, Y Shibata, P F Manes. Altered distribution of dopaminergic neurons in the brain of L1 null mice. Brain research. Developmental brain research. vol 126. issue 1. 2001-05-17. PMID:11172883. |
there was no evidence of dopaminergic cell loss in the mutant sn. |
2001-05-17 |
2023-08-12 |
mouse |
| M R Palmer, A C Granholm, C G van Horne, K E Giardina, R K Freund, J W Moorhead, G A Gerhard. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain research. vol 890. issue 1. 2001-04-26. PMID:11164771. |
this finding suggests that trophic influences of transplanted fetal striatal tissue can stimulate the re-expression of dopaminergic phenotype in sn neurons following a 6-ohda lesion. |
2001-04-26 |
2023-08-12 |
rat |
| M R Palmer, A C Granholm, C G van Horne, K E Giardina, R K Freund, J W Moorhead, G A Gerhard. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain research. vol 890. issue 1. 2001-04-26. PMID:11164771. |
our data support the hypothesis that a dopaminergic re-innervation of the sn and surrounding tissue by a single solid tissue graft is sufficient to improve motor asymmetry in unilateral 6-ohda-lesioned rats. |
2001-04-26 |
2023-08-12 |
rat |
| K L Double, M Gerlach, M B Youdim, P Riedere. Impaired iron homeostasis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205155. |
such a iron source is neuromelanin (nm), a dark-coloured pigment found in the dopaminergic neurons of the human sn. |
2001-04-12 |
2023-08-12 |
human |
| R Klink, A de Kerchove d'Exaerde, M Zoli, J P Changeu. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 5. 2001-04-05. PMID:11222635. |
nicotinic acetylcholine receptors (nachrs) on dopaminergic (da) and gabaergic (gaba) projection neurons of the substantia nigra (sn) and ventral tegmental area (vta) are characterized by single-cell rt-pcr and patch-clamp recordings in slices of rat and wild-type, beta2-/-, alpha4-/-, and alpha7-/- mice. |
2001-04-05 |
2023-08-12 |
mouse |
| P M Kid. Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 6. 2001-03-01. PMID:11134975. |
parkinson's disease (pd) is the most common movement pathology, severely afflicting dopaminergic neurons within the substantia nigra (sn) along with non-dopaminergic, extra-nigral projection bundles that control circuits for sensory, associative, premotor, and motor pathways. |
2001-03-01 |
2023-08-12 |
Not clear |
| P M Kid. Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 6. 2001-03-01. PMID:11134975. |
these pro-oxidative factors combine within the sn dopaminergic neurons to create extreme vulnerability to oxidative challenge. |
2001-03-01 |
2023-08-12 |
Not clear |
| D A Kozlowski, B Connor, J L Tillerson, T Schallert, M C Boh. Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031079. |
the effects of delivering gdnf via an adenoviral vector (adgdnf) 1 week after lesioning dopaminergic neurons in the rat substantia nigra (sn) with 6-hydroxydopamine (6-ohda) were examined. |
2000-12-07 |
2023-08-12 |
rat |
| D A Kozlowski, B Connor, J L Tillerson, T Schallert, M C Boh. Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031079. |
rats were unilaterally lesioned by injection of 6-ohda into the striatum, resulting in progressive degeneration of dopaminergic neurons in the sn. |
2000-12-07 |
2023-08-12 |
rat |