| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Tam, D P Barry, L Beaman, B L Beama. Neuroinvasive Nocardia asteroides GUH-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. Experimental neurology. vol 177. issue 2. 2002-11-26. PMID:12429191. |
following infection with guh-2, dopaminergic apoptotic cells were identified in the sn of animals by in situ end labeling, which detects dna fragmentation, combined with fluorescent immunolabeling of tyrosine hydroxylase-positive cells. |
2002-11-26 |
2023-08-12 |
Not clear |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
the gamma-aminobutyric acid a (gaba(a)) receptor subunit expression of the dopaminergic cells of the substantia nigra (sn) was investigated in the present study. |
2002-11-15 |
2023-08-12 |
human |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
especially the dopaminergic cells, located in the pars compacta of sn (snc), are of great neurologic interest, because the functional deficit and depletion of these cells are the correlate of parkinson's disease. |
2002-11-15 |
2023-08-12 |
human |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
we used a combination of in situ hybridization histochemistry (ish) and immunohistochemistry (ihc) on sections of human postmortem mesencephalon to investigate the expression of gaba(a) receptor subunit messenger rnas (mrnas) and of the receptor protein in dopaminergic sn cells. |
2002-11-15 |
2023-08-12 |
human |
| Srinivas Bharath, Michael Hsu, Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Glutathione, iron and Parkinson's disease. Biochemical pharmacology. vol 64. issue 5-6. 2002-10-17. PMID:12213603. |
parkinson's disease (pd) is a progressive neurodegenerative disease involving neurodegeneration of dopaminergic neurons of the substantia nigra (sn), a part of the midbrain. |
2002-10-17 |
2023-08-12 |
Not clear |
| Srinivas Bharath, Michael Hsu, Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Glutathione, iron and Parkinson's disease. Biochemical pharmacology. vol 64. issue 5-6. 2002-10-17. PMID:12213603. |
oxidative damage via gsh depletion might also accelerate the build-up of defective proteins leading to cell death of sn dopaminergic neurons by impairing the ubiquitin-proteasome pathway of protein degradation. |
2002-10-17 |
2023-08-12 |
Not clear |
| Yi He, Wei-Dong Le, Stanley H Appe. Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra. Experimental neurology. vol 176. issue 2. 2002-10-17. PMID:12359173. |
immunoglobulin g (igg) from patients with pd can induce injury of dopaminergic neurons following stereotaxic injection into rat substantia nigra (sn). |
2002-10-17 |
2023-08-12 |
human |
| Alison L McCormack, Mona Thiruchelvam, Amy B Manning-Bog, Christine Thiffault, J William Langston, Deborah A Cory-Slechta, Donato A Di Mont. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiology of disease. vol 10. issue 2. 2002-09-06. PMID:12127150. |
repeated intraperitoneal paraquat injections killed dopaminergic neurons in the substantia nigra (sn) pars compacta, as assessed by stereological counting of tyrosine hydroxylase (th)-immunoreactive and nissl-stained neurons. |
2002-09-06 |
2023-08-12 |
mouse |
| D Chichung Lie, Gustavo Dziewczapolski, Andrew R Willhoite, Brian K Kaspar, Clifford W Shults, Fred H Gag. The adult substantia nigra contains progenitor cells with neurogenic potential. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151543. |
in parkinson's disease, progressive loss of dopaminergic neurons in the substantia nigra pars compacta (sn) leads to debilitating motor dysfunction. |
2002-09-03 |
2023-08-12 |
Not clear |
| D Chichung Lie, Gustavo Dziewczapolski, Andrew R Willhoite, Brian K Kaspar, Clifford W Shults, Fred H Gag. The adult substantia nigra contains progenitor cells with neurogenic potential. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151543. |
one current therapy aims at exogenous cellular replacement of dopaminergic function by transplanting fetal midbrain cells into the striatum, the main projection area of the sn. |
2002-09-03 |
2023-08-12 |
Not clear |
| Guangyu Gu, Patricio E Reyes, Gregory T Golden, Randall L Woltjer, Christine Hulette, Thomas J Montine, Jing Zhan. Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders. Journal of neuropathology and experimental neurology. vol 61. issue 7. 2002-08-07. PMID:12125742. |
inhibition of mitochondrial respiratory chain function may contribute to dopaminergic neurodegeneration in the substantia nigra (sn) of patients with parkinson disease (pd). |
2002-08-07 |
2023-08-12 |
Not clear |
| Joana Gomes-da-Silva, Alberto Pérez-Rosado, Rosario de Miguel, Javier Fernández-Ruiz, M Carolina Silva, M Amélia Tavare. Prenatal exposure to methamphetamine in the rat: ontogeny of tyrosine hydroxylase mRNA expression in mesencephalic dopaminergic neurons. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105086. |
in the rat, prolonged neonatal meth exposure altered several dopaminergic markers (th activity and gene expression) in substantia nigra pars compacta (sn) and in caudate-putamen (th activity) when animals matured. |
2002-08-02 |
2023-08-12 |
rat |
| Joana Gomes-da-Silva, Alberto Pérez-Rosado, Rosario de Miguel, Javier Fernández-Ruiz, M Carolina Silva, M Amélia Tavare. Prenatal exposure to methamphetamine in the rat: ontogeny of tyrosine hydroxylase mRNA expression in mesencephalic dopaminergic neurons. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105086. |
the present study was designed to address this issue by analyzing th gene expression, measured by in situ hybridization in sn and ventral tegmental area (vta), dopaminergic areas that are well characterized as target areas for meth, and in rats prenatally exposed to this psychostimulant. |
2002-08-02 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Krister S Eriksson, Helmut L Haas, Ritchie E Brow. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regulatory peptides. vol 104. issue 1-3. 2002-05-21. PMID:11830281. |
here we have investigated the effect of orexins on the firing of dopaminergic and gabaergic neurons of the substantia nigra (sn) in brain slices. |
2002-05-21 |
2023-08-12 |
rat |
| José L Venero, El-Hadi Absi, Josefina Cano, Alberto Machad. Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus. Journal of pineal research. vol 32. issue 1. 2002-05-20. PMID:11841594. |
in the ventral mesencephalon, melatonin treatment significantly induced th mrna levels in individual dopaminergic neurons in sn and vta. |
2002-05-20 |
2023-08-12 |
rat |
| Jae K Ryu, Won H Shin, Jean Kim, Eun H Joe, Yong B Lee, Kyung G Cho, Young J Oh, Seung U Kim, Byung K Ji. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. vol 38. issue 1. 2002-05-10. PMID:11921200. |
the present study examines the in vivo neurotoxic effects of gt1b on dopaminergic neurons in the substantia nigra (sn) of sprague-dawley rats. |
2002-05-10 |
2023-08-12 |
rat |
| Jae K Ryu, Won H Shin, Jean Kim, Eun H Joe, Yong B Lee, Kyung G Cho, Young J Oh, Seung U Kim, Byung K Ji. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. vol 38. issue 1. 2002-05-10. PMID:11921200. |
seven days after gt1b injection into the sn, immunocytochemical staining of sn tissue revealed death of nigral neurons, including dopaminergic neurons. |
2002-05-10 |
2023-08-12 |
rat |
| Jae K Ryu, Won H Shin, Jean Kim, Eun H Joe, Yong B Lee, Kyung G Cho, Young J Oh, Seung U Kim, Byung K Ji. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. vol 38. issue 1. 2002-05-10. PMID:11921200. |
gt1b-induced loss of dopaminergic neurons in the sn was partially inhibited by n(g)-nitro-l-arginine methyl ester hydrochloride, an nos inhibitor. |
2002-05-10 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Helmut L Haas, Ritchie E Brow. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro. Neuroscience letters. vol 320. issue 3. 2002-04-25. PMID:11852180. |
we have investigated the effect of histamine (ha) on spontaneous firing of dopaminergic (da) and gabaergic neurons in the substantia nigra (sn) and the ventral tegmental area (vta) of the rat in vitro. |
2002-04-25 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Helmut L Haas, Ritchie E Brow. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro. Neuroscience letters. vol 320. issue 3. 2002-04-25. PMID:11852180. |
our results suggest that histamine does not directly inhibit dopaminergic neurons in sn and vta, but rather that this inhibition is mediated through histamine-induced excitation of gabaergic neurons. |
2002-04-25 |
2023-08-12 |
rat |