| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gail Chapman, Blaine L Beaman, David A Loeffler, Dianne M Camp, Edward F Domino, Dennis W Dickson, William G Ellis, Ibsen Chen, Susan E Bachus, Peter A LeWit. In situ hybridization for detection of nocardial 16S rRNA: reactivity within intracellular inclusions in experimentally infected cynomolgus monkeys--and in Lewy body-containing human brain specimens. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769363. |
our previous studies found that experimental infection of balb/c mice with the gram-positive bacterium nocardia asteroides induced a parkinsonian-type syndrome with levodopa-responsive movement abnormalities, loss of nigrostriatal dopaminergic neurons, depletion of striatal dopamine, and intraneuronal inclusions in the substantia nigra (sn) with an appearance similar to lewy bodies. |
2004-04-02 |
2023-08-12 |
mouse |
| Yi He, Patricia S Thong, Timothy Lee, S K Leong, Bo Y Mao, Fang Dong, Frank Wat. Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys. Free radical biology & medicine. vol 35. issue 5. 2004-04-01. PMID:12927603. |
using nuclear microscopy, iron histochemistry, tunel method for apoptosis detection, and tyrosine hydroxylase (th) immunohistochemistry, the present study investigated possible changes in iron contents in the sn and correlations of dopaminergic cell death progression with the process of iron accumulation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(mptp)-induced parkinsonian monkey from 1 d to 18 months after mptp administration. |
2004-04-01 |
2023-08-12 |
monkey |
| Yi He, Patricia S Thong, Timothy Lee, S K Leong, Bo Y Mao, Fang Dong, Frank Wat. Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys. Free radical biology & medicine. vol 35. issue 5. 2004-04-01. PMID:12927603. |
however, iron content was significantly increased in the ipsilateral sn from 4.5 months to 18 months after mptp injection, and the iron increase was significantly correlated to the extent of dopaminergic cell death. |
2004-04-01 |
2023-08-12 |
monkey |
| Yi He, Patricia S Thong, Timothy Lee, S K Leong, Bo Y Mao, Fang Dong, Frank Wat. Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys. Free radical biology & medicine. vol 35. issue 5. 2004-04-01. PMID:12927603. |
these results suggest that dopaminergic cell death induced by mptp administration might lead to iron accumulation in the monkey sn, and increased iron might contribute to the progression of nigral degeneration. |
2004-04-01 |
2023-08-12 |
monkey |
| Shin-ichi Iwata, Masahiro Nomoto, Hirofumi Morioka, Atsuro Miyat. Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse (New York, N.Y.). vol 51. issue 4. 2004-03-24. PMID:14696015. |
in this model, mice are intrastriatally injected with 6-hydroxydopamine (6-ohda) and dopaminergic neurons in the substantia nigra (sn) gradually die by retrograde degeneration. |
2004-03-24 |
2023-08-12 |
mouse |
| Marta Barrachina, Isabel Domínguez, Santiago Ambrosio, Julio Secades, Rafael Lozano, Isidro Ferre. Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells. Journal of the neurological sciences. vol 215. issue 1-2. 2004-01-20. PMID:14568136. |
finally, citicoline significantly attenuates substantia nigra (sn) dopaminergic cell dropout and tyrosine hydroxylase immunoreactivity in the ipsilateral striatum in rats injected intrastriatally with 6-hydroxydopamine (6-ohda). |
2004-01-20 |
2023-08-12 |
human |
| Sang-H Choi, Da Y Lee, Jae K Ryu, Jean Kim, Eun H Joe, Byung K Ji. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572441. |
one week after intranigral injection of thrombin resulted in a dose-dependent loss of dopaminergic neurons (20-78%) in the rat substantia nigra (sn), as evidenced by tyrosine hydroxylase (th) immunohistochemistry. |
2004-01-06 |
2023-08-12 |
rat |
| Sang-H Choi, Da Y Lee, Jae K Ryu, Jean Kim, Eun H Joe, Byung K Ji. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572441. |
this cell death was accompanied by localization of terminal deoxynucleotidyl transferase-mediated fluorecein utp nick end labeling (tunel) staining within dopaminergic neurons, activation of caspase-3 and attenuation of dopaminergic neuronal cell death in the sn by the caspase inhibitor (zvad-fmk), indicative of apoptosis. |
2004-01-06 |
2023-08-12 |
rat |
| Sang-H Choi, Da Y Lee, Jae K Ryu, Jean Kim, Eun H Joe, Byung K Ji. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572441. |
furthermore, western blot analyses and double-immunofluorescent staining showed activation of c-jun n-terminal kinase (jnk) and p53, and a localization of p53 in the dopaminergic neurons in the sn after thrombin, respectively. |
2004-01-06 |
2023-08-12 |
rat |
| Manfred Gerlach, Kay L Double, Dorit Ben-Shachar, Luigi Zecca, Moussa B H Youdim, Peter Riedere. Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotoxicity research. vol 5. issue 1-2. 2003-11-21. PMID:12832223. |
neuromelanin (nm) is a granular, dark brown pigment produced in some but not all of the dopaminergic neurons of the human substantia nigra (sn). |
2003-11-21 |
2023-08-12 |
human |
| Manfred Gerlach, Kay L Double, Dorit Ben-Shachar, Luigi Zecca, Moussa B H Youdim, Peter Riedere. Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotoxicity research. vol 5. issue 1-2. 2003-11-21. PMID:12832223. |
in parkinson's disease (pd) the pigmented dopaminergic neurons of the sn degenerate, suggesting that this process is related to the presence of nm. |
2003-11-21 |
2023-08-12 |
human |
| Manuel Rodríguez, Ernesto Pereda, Julián González, Patricio Abdala, Jose A Obes. How is firing activity of substantia nigra cells regulated? Relevance of pattern-code in the basal ganglia. Synapse (New York, N.Y.). vol 49. issue 4. 2003-11-10. PMID:12827640. |
these findings indicate two types of nonrenewal firing pattern codes specifically present in sn dopaminergic and gabaergic neurons. |
2003-11-10 |
2023-08-12 |
rat |
| Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development. Journal of chemical neuroanatomy. vol 26. issue 1. 2003-11-06. PMID:12954528. |
we have used highly sensitive in situ hybridization to determine opioid receptor and peptide expression in embryonic and postnatal rat striatum, to follow the compartmentalization into patch and matrix structures, and have examined their developmental expression in the dopaminergic cell group of the substantia nigra (sn). |
2003-11-06 |
2023-08-12 |
rat |
| Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development. Journal of chemical neuroanatomy. vol 26. issue 1. 2003-11-06. PMID:12954528. |
the major findings of the study are: (1) striatal patches were first delineated by prodynorphin mrna followed by mu opioid receptor mrna expression at embryonic days 19 and 21, respectively; (2) in neonates, prodynorphin, mu and kappa opioid receptor mrnas were transiently co-distributed within patches; (3) prodynorphin mrna was co-expressed with mu but not kappa, receptor mrna in neonatal patch neurons; (4) in the sn, kappa receptor and prodynorphin mrnas were detected as early as embryonic days 15 and 19, respectively; (5) kappa receptor, but not prodynorphin, mrna was expressed in dopaminergic neurons in the sn. |
2003-11-06 |
2023-08-12 |
rat |
| Benoît Melchior, Véronique Nerrière-Daguin, David A Laplaud, Séverine Rémy, Sandrine Wiertlewski, Isabelle Neveu, Philippe Naveilhan, Susan O Meakin, Philippe Brache. Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. Experimental neurology. vol 183. issue 2. 2003-10-31. PMID:14552878. |
unilateral injection of this raav into the substantia nigra (sn) resulted in a protracted expression of trka (or c-myc) immunoreactivity in numerous cell bodies, including tyrosine-hydroxylase (th)-positive dopaminergic neurons. |
2003-10-31 |
2023-08-12 |
human |
| Benoît Melchior, Véronique Nerrière-Daguin, David A Laplaud, Séverine Rémy, Sandrine Wiertlewski, Isabelle Neveu, Philippe Naveilhan, Susan O Meakin, Philippe Brache. Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. Experimental neurology. vol 183. issue 2. 2003-10-31. PMID:14552878. |
ngf treatment, in contrast to treatment with vehicle, significantly enhanced the number of dopaminergic neurons counted in the lesioned sn. |
2003-10-31 |
2023-08-12 |
human |
| Kay L Double, Manfred Gerlach, Volker Schünemann, Alfred X Trautwein, Luigi Zecca, Mario Gallorini, Moussa B H Youdim, Peter Riederer, Dorit Ben-Shacha. Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochemical pharmacology. vol 66. issue 3. 2003-09-12. PMID:12907248. |
the vulnerability of the dopaminergic neurons of the substantia nigra (sn) in parkinson's disease has been related to the presence of the pigment neuromelanin (nm) in these neurons. |
2003-09-12 |
2023-08-12 |
human |
| Kay L Double, Manfred Gerlach, Volker Schünemann, Alfred X Trautwein, Luigi Zecca, Mario Gallorini, Moussa B H Youdim, Peter Riederer, Dorit Ben-Shacha. Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochemical pharmacology. vol 66. issue 3. 2003-09-12. PMID:12907248. |
these findings are consistent with the hypothesis that nm may act as an endogenous iron-binding molecule in dopaminergic neurons of the sn in the human brain. |
2003-09-12 |
2023-08-12 |
human |
| Sang-H Choi, Eun H Joe, Seung U Kim, Byung K Ji. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843292. |
the present study examined whether thrombin-induced microglial activation could contribute to death of dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2003-08-14 |
2023-08-12 |
rat |
| Sang-H Choi, Eun H Joe, Seung U Kim, Byung K Ji. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843292. |
seven days after thrombin injection into the sn, tyrosine hydroxylase immunohistochemistry showed a significant loss of nigral dopaminergic neurons. |
2003-08-14 |
2023-08-12 |
rat |