| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Bender, Rachel-Maria Schwarzkopf, Anja McMillan, Kim J Krishnan, Gabriele Rieder, Manuela Neumann, Matthias Elstner, Douglas M Turnbull, Thomas Klopstoc. Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions. Journal of neurology. vol 255. issue 8. 2009-04-14. PMID:18604467. |
this data shows that there is a specific susceptibility of dopaminergic sn neurons to accumulate substantial amounts of mtdna deletions, regardless of the underlying clinical phenotype. |
2009-04-14 |
2023-08-12 |
human |
| Salma Bukhatwa, Mahmoud M Iravani, Bai-Yun Zeng, Jonathan D Cooper, Sarah Rose, Peter Jenne. An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19187437. |
to provide a method of marking sn neurones independent of protein expression, fluorogold (fg) was stereotaxically injected bilaterally into the striatum of male wistar rats to retrogradely label nigral dopaminergic neurons. |
2009-04-13 |
2023-08-12 |
rat |
| Chee Yeun Chung, James B Koprich, Hasan Siddiqi, Ole Isacso. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295143. |
recombinant adeno-associated virus 2-mediated delivery of mutant (a53t) human alpha-synuclein into the substantia nigra (sn) under a neuron-specific synapsin promoter resulted in protracted neurodegeneration with significant dopaminergic (da) neuron loss by 17 weeks. |
2009-04-13 |
2023-08-12 |
human |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) are collectively implicated in motor- and reward-related behaviors. |
2009-04-10 |
2023-08-12 |
rat |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
however, dopaminergic sn and vta neurons differ on several functional levels, and dopaminergic sn neurons themselves vary in their intrinsic electrical properties, neurochemical characteristics and connections. |
2009-04-10 |
2023-08-12 |
rat |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
this heterogeneity is not only important for normal function; calbindin (cb) expression by some dopaminergic sn neurons has been linked with their increased survival in parkinson's disease. |
2009-04-10 |
2023-08-12 |
rat |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
to test whether the activity of cb-negative and cb-positive dopaminergic sn neurons differs during distinct spontaneous and driven brain states, we recorded single units in anesthetized rats before, during and after aversive somatosensory stimuli. |
2009-04-10 |
2023-08-12 |
rat |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
during spontaneous cortical activation, dopaminergic sn neurons fired in a more regular manner, with fewer bursts, but did not change their firing rate. |
2009-04-10 |
2023-08-12 |
rat |
| Matthew T C Brown, Pablo Henny, J Paul Bolam, Peter J Magil. Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 9. 2009-04-10. PMID:19261887. |
furthermore, the firing of dopaminergic sn neurons is brain state-dependent, and, unlike dopaminergic vta neurons, they are not commonly recruited or inhibited by aversive stimuli. |
2009-04-10 |
2023-08-12 |
rat |
| Qian Wang, Huan Zheng, Zuo-feng Zhang, Yu-xin Zhan. [Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 28. issue 9. 2009-04-06. PMID:18819875. |
to investigate the role of p38 signaling pathway in modulating the expression of cyclooxygenase-2 (cox-2) in the substantia nigra (sn) of mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced parkinson disease (pd), and explore the possible mechanism of the dopaminergic (da) neuron death in pd and the effects of ginsenoside rg1 on the p38 signaling pathway and da neurons. |
2009-04-06 |
2023-08-12 |
mouse |
| Jiro Fukae, Shigeto Sato, Kahori Shiba, Ken-ichi Sato, Hideo Mori, Philip A Sharp, Yoshikuni Mizuno, Nobutaka Hattor. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. FEBS letters. vol 583. issue 3. 2009-02-16. PMID:19146857. |
accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (sn) of arpd. |
2009-02-16 |
2023-08-12 |
Not clear |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
monoamine concentrations and dopaminergic nerve terminals in the striatum and the number of dopaminergic neurons in the substantia nigra (sn) were assessed. |
2009-01-26 |
2023-08-12 |
mouse |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
the expression of mac-1 increased 1 day after mdma treatment and glial fibrillary acidic protein increased 3 days post-treatment in the striatum and sn but not in the nac, in strict anatomical correlation with dopaminergic damage. |
2009-01-15 |
2023-08-12 |
mouse |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
these data provide the first evidence that mdma causes persistent loss of dopaminergic cell bodies in the sn. |
2009-01-15 |
2023-08-12 |
mouse |
| Songhee Jeon, Youn Jung Kim, Seung-Tae Kim, Woongjoon Moon, Younbyoung Chae, Minjeong Kang, Mi-Young Chung, Hyangsook Lee, Mi-Sook Hong, Joo-Ho Chung, Tong H Joh, Hyejung Lee, Hi-Joon Par. Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model. Proteomics. vol 8. issue 22. 2009-01-13. PMID:18942673. |
acupuncture is frequently used as an alternative therapy for parkinson's disease (pd), and it attenuates dopaminergic (da) neurodegeneration in the substantia nigra (sn) in pd animal models. |
2009-01-13 |
2023-08-12 |
mouse |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
dopaminergic cell death in the substantia nigra (sn) is central to parkinson's disease (pd), but the neurodegenerative mechanisms have not been completely elucidated. |
2009-01-07 |
2023-08-12 |
mouse |
| Julio Salazar, Natalia Mena, Stephane Hunot, Annick Prigent, Daniel Alvarez-Fischer, Miguel Arredondo, Charles Duyckaerts, Veronique Sazdovitch, Lin Zhao, Laura M Garrick, Marco T Nuñez, Michael D Garrick, Rita Raisman-Vozari, Etienne C Hirsc. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19011085. |
iron accumulation in dopaminergic and glial cells in the sn of pd patients may contribute to the generation of oxidative stress, protein aggregation, and neuronal death. |
2009-01-07 |
2023-08-12 |
mouse |
| Lars M Ittner, Thomas Fath, Yazi D Ke, Mian Bi, Janet van Eersel, Kong M Li, Peter Gunning, Jürgen Göt. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 41. 2008-11-24. PMID:18832465. |
the early-onset symptoms in the k3 mice are mechanistically related to selectively impaired anterograde axonal transport of distinct cargos, which precedes the loss of dopaminergic sn neurons that occurs in aged mice. |
2008-11-24 |
2023-08-12 |
mouse |
| Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. The effect of glucocorticoids on bradykinesia induced by immobilization stress. Hormones and behavior. vol 54. issue 1. 2008-11-18. PMID:18342862. |
it was also recently reported that imo damages dopaminergic (da) neurons in the substantia nigra (sn), which is known to cause symptoms similar to parkinson's disease (pd). |
2008-11-18 |
2023-08-12 |
mouse |
| Emilce Carrasco, Peter Werner, Diana Caspe. Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597941. |
dopaminergic neurons in the substantia nigra (sn) selectively die in parkinson's disease (pd), but it is unclear how and why this occurs. |
2008-11-05 |
2023-08-12 |
human |