| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Weise, Reinhard Lorenz, Mira Schliesser, Andreas Schirbel, Karlheinz Reiners, Joseph Classe. Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 11. 2010-01-15. PMID:19514075. |
we sought to clarify the relationship between sonographic abnormalities of sn and dysfunction of striatal dopaminergic neurotransmission. |
2010-01-15 |
2023-08-12 |
Not clear |
| Jun Jia, ZuoLi Sun, Bo Li, YanLi Pan, HaoMin Wang, Xuan Wang, Fen Yu, LiMin Liu, LiJuan Zhang, XiaoMin Wan. Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19549545. |
tyrosine hydroxylase immunohistochemical staining revealed that ea at 100 hz protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn). |
2010-01-12 |
2023-08-12 |
rat |
| Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease. Brain research. vol 1297. 2010-01-08. PMID:19699718. |
while ferritin elevation within dopaminergic (da) neurons of the substantia nigra (sn) is protective against neurodegeneration elicited by two toxin models of parkinson's disease (pd), mptp and paraquat, in young animals, its prolonged elevation results in a selective age-related neurodegeneration. |
2010-01-08 |
2023-08-12 |
mouse |
| Andrea Tarozzi, Fabiana Morroni, Adriana Merlicco, Silvana Hrelia, Cristina Angeloni, Giorgio Cantelli-Forti, Patrizia Hreli. Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. Journal of neurochemistry. vol 111. issue 5. 2009-12-11. PMID:19780897. |
the total gsh depletion observed in the substantia nigra (sn) appears to be responsible for subsequent oxidative stress (os), mitochondrial dysfunction, and dopaminergic cell loss in patients with parkinson's disease. |
2009-12-11 |
2023-08-12 |
Not clear |
| Andrea Tarozzi, Fabiana Morroni, Adriana Merlicco, Silvana Hrelia, Cristina Angeloni, Giorgio Cantelli-Forti, Patrizia Hreli. Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. Journal of neurochemistry. vol 111. issue 5. 2009-12-11. PMID:19780897. |
a strategy to prevent the os of dopaminergic cells in the sn may be the use of chemopreventive agents as inducers of endogenous gsh, antioxidant and phase 2 enzymes. |
2009-12-11 |
2023-08-12 |
Not clear |
| Marta Biagioli, Milena Pinto, Daniela Cesselli, Marta Zaninello, Dejan Lazarevic, Paola Roncaglia, Roberto Simone, Christina Vlachouli, Charles Plessy, Nicolas Bertin, Antonio Beltrami, Kazuto Kobayashi, Vittorio Gallo, Claudio Santoro, Isidro Ferrer, Stefano Rivella, Carlo Alberto Beltrami, Piero Carninci, Elio Raviola, Stefano Gustincic. Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 36. 2009-12-07. PMID:19717439. |
the mesencephalic dopaminergic (mda) cell system is composed of two major groups of projecting cells in the substantia nigra (sn) (a9 neurons) and the ventral tegmental area (vta) (a10 cells). |
2009-12-07 |
2023-08-12 |
mouse |
| Baohua Cheng, Xinxin Yang, Liangxiang An, Bo Gao, Xia Liu, Shuwei Li. Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease. Brain research. vol 1286. 2009-10-20. PMID:19559687. |
in our present work, we examined whether kd protected dopaminergic neurons of substantia nigra (sn) against 6-hydroxydopamine (6-ohda) neurotoxicity in a rat model of parkinson's disease (pd) using nissl staining and tyrosine hydroxylase (th) immunohistochemistry. |
2009-10-20 |
2023-08-12 |
rat |
| Anna L Bartels, Klaus L Leender. Parkinson's disease: the syndrome, the pathogenesis and pathophysiology. Cortex; a journal devoted to the study of the nervous system and behavior. vol 45. issue 8. 2009-09-22. PMID:19095226. |
an important pathophysiological feature in pd is the loss of part of the dopaminergic neurons in the substantia nigra (sn) resulting in a specific dysorganisation of the complicated basal ganglia (bg) circuits. |
2009-09-22 |
2023-08-12 |
Not clear |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
intrastriatally injected manf protected nigrostriatal dopaminergic nerves from 6-ohda-induced degeneration as evaluated by counting tyrosine hydroxylase (th)-positive cell bodies in the substantia nigra (sn) and th-positive fibers in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A S Reyes, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes. Neurobiology of disease. vol 34. issue 3. 2009-08-17. PMID:19327399. |
dopaminergic sn neurons (expressing tyrosine hydroxylase, th, in the sn and dopamine transporter, dat, in the cp) were mostly affected: intra-cp gp120 caused approximately 50% dat+ sn neuron loss. |
2009-08-17 |
2023-08-12 |
rat |
| Jean-Pierre Louboutin, Lokesh Agrawal, Beverly A S Reyes, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes. Neurobiology of disease. vol 34. issue 3. 2009-08-17. PMID:19327399. |
thus, sn dopaminergic neurons are highly sensitive to hiv-1 gp120-induced neurotoxicity, and antioxidant gene delivery, even at a distance, is protective. |
2009-08-17 |
2023-08-12 |
rat |
| Jason B Tatom, David B Wang, Robert D Dayton, Omar Skalli, Michael L Hutton, Dennis W Dickson, Ronald L Klei. Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 4. 2009-08-05. PMID:19223871. |
tdp-43 gene transfer caused loss of dopaminergic neurons in the sn and their axons in the striatum. |
2009-08-05 |
2023-08-12 |
human |
| Ruth F Villarán, Rocío M de Pablos, Sandro Argüelles, Ana M Espinosa-Oliva, Mayka Tomás-Camardiel, Antonio J Herrera, Josefina Cano, Alberto Machad. The intranigral injection of tissue plasminogen activator induced blood-brain barrier disruption, inflammatory process and degeneration of the dopaminergic system of the rat. Neurotoxicology. vol 30. issue 3. 2009-08-04. PMID:19442825. |
we have observed that tpa injection in the sn leads to the degeneration of the dopaminergic neurons in a dose-dependent manner, without affecting the gabaergic neurons. |
2009-08-04 |
2023-08-12 |
rat |
| H Jourdi, L Hamo, T Oka, A Seegan, M Baudr. BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices. Neuropharmacology. vol 56. issue 5. 2009-07-02. PMID:19371576. |
neurotoxicity is involved in various neurodegenerative diseases including parkinson's disease (pd), which affects mesencephalic dopaminergic neurons of the substantia nigra (sn). |
2009-07-02 |
2023-08-12 |
Not clear |
| D E Vaillancourt, M B Spraker, J Prodoehl, I Abraham, D M Corcos, X J Zhou, C L Comella, D M Littl. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology. vol 72. issue 16. 2009-06-22. PMID:19129507. |
in the midbrain of patients with parkinson disease (pd), there is a selective loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (sn). |
2009-06-22 |
2023-08-12 |
mouse |
| You-Joung Kim, Hyun-Jung Park, Gwang Lee, Oh Young Bang, Young Hwan Ahn, Eunhye Joe, Hyun Ok Kim, Phil Hyu Le. Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action. Glia. vol 57. issue 1. 2009-05-26. PMID:18661552. |
parkinson's disease (pd) is a common, progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2009-05-26 |
2023-08-12 |
human |
| Eugene V Mosharov, Kristin E Larsen, Ellen Kanter, Kester A Phillips, Krystal Wilson, Yvonne Schmitz, David E Krantz, Kazuto Kobayashi, Robert H Edwards, David Sulze. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. vol 62. issue 2. 2009-05-20. PMID:19409267. |
parkinson's disease (pd) is a synucleinopathy characterized by a preferential loss of dopaminergic neurons in the substantia nigra (sn), whereas neurons of the ventral tegmental area (vta) are spared. |
2009-05-20 |
2023-08-12 |
Not clear |
| Shin-Ichi Kyuho. Preventive effects of genistein on motor dysfunction following 6-hydroxydopamine injection in ovariectomized rats. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18952148. |
because they have been reported to possess neuroprotective effects on dopaminergic neurons in the substantia nigra (sn), isoflavones appear particularly promising for post-menopausal women at risk for pd. |
2009-04-16 |
2023-08-12 |
rat |
| Andreas Bender, Rachel-Maria Schwarzkopf, Anja McMillan, Kim J Krishnan, Gabriele Rieder, Manuela Neumann, Matthias Elstner, Douglas M Turnbull, Thomas Klopstoc. Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions. Journal of neurology. vol 255. issue 8. 2009-04-14. PMID:18604467. |
by employing quantitative single cell techniques, we were recently able to show significantly high levels of mtdna deletions in dopaminergic substantia nigra (sn) neurons from pd patients and age-matched controls. |
2009-04-14 |
2023-08-12 |
human |
| Andreas Bender, Rachel-Maria Schwarzkopf, Anja McMillan, Kim J Krishnan, Gabriele Rieder, Manuela Neumann, Matthias Elstner, Douglas M Turnbull, Thomas Klopstoc. Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions. Journal of neurology. vol 255. issue 8. 2009-04-14. PMID:18604467. |
there were no significant differences between patients and controls in either region but in both groups the deletion load was markedly higher in dopaminergic sn neurons than in putamen or frontal cortex (p < 0.01; anova). |
2009-04-14 |
2023-08-12 |
human |