| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta), and noradrenergic neurons in the lc were determined. |
2012-11-07 |
2023-08-12 |
mouse |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
the loss of lc neurons did not affect the number of dopaminergic neurons in the sn and vta compared to control; however, lc 6ohda significantly reduced striatal dopamine (da; 29% reduced) but not norepinephrine (ne) concentration. |
2012-11-07 |
2023-08-12 |
mouse |
| Keiji Mori, Yoko S Kaneko, Akira Nakashima, Hiroshi Nagasaki, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ot. Subventricular zone under the neuroinflammatory stress and Parkinson's disease. Cellular and molecular neurobiology. vol 32. issue 5. 2012-10-17. PMID:22189676. |
this review summarizes the effects of neuroinflammatory stress on the subventricular zone (svz), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with parkinson's disease (pd), because the svz is under the control of dopaminergic afferents from the substantia nigra (sn). |
2012-10-17 |
2023-08-12 |
Not clear |
| P Szot, L Knight, A Franklin, C Sikkema, S Foster, C W Wilkinson, S S White, M A Raskin. Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling. Neuroscience. vol 216. 2012-10-17. PMID:22542679. |
direct administration of 6ohda into the lc results in the specific reduction of noradrenergic neurons in the lc (as measured by electrophysiology, immunoreactivity and in situ hybridization), the lateral tegmental neurons and dopaminergic neurons in the substantia nigra (sn) and ventral tegmental region were unaffected. |
2012-10-17 |
2023-08-12 |
mouse |
| Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizab. Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease. Neurotoxicity research. vol 22. issue 2. 2012-10-10. PMID:22528249. |
parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (sn). |
2012-10-10 |
2023-08-12 |
Not clear |
| Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizab. Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease. Neurotoxicity research. vol 22. issue 2. 2012-10-10. PMID:22528249. |
aminochrome, the precursor of neuromelanin is an endogenous substance capable of inducing selective neurotoxicity to dopaminergic neurons in sn. |
2012-10-10 |
2023-08-12 |
Not clear |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| Hong Yuan, Li-Wu Liang, Zheng-Jing Chen, Hui-Ru Ji, Mei-Kang Wang, Hai-Ying Zhang, Cao Li, Jian-Yang X. R-apomorphine protects against 6-hydroxydopamine-induced nigrostriatal damage in rat. Neuroscience bulletin. vol 22. issue 6. 2012-10-02. PMID:17690718. |
objective the aim of the present study was not only to assess the retrograde degenerative changes in the dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) after injection of 6-hydroxydopamine (6-ohda) into the striatum, but also to use this 6-ohda model of parkinson's disease to explore the possible neuroprotective effect of r-apomorphine (r-apo). |
2012-10-02 |
2023-08-12 |
rat |
| Henriqueta D Cardoso, Priscila P Passos, Claudia J Lagranha, Anete C Ferraz, Eraldo F Santos Júnior, Rafael S Oliveira, Pablo E L Oliveira, Rita de C F Santos, David F Santana, Juliana M C Borba, Ana P Rocha-de-Melo, Rubem C A Guedes, Daniela M A F Navarro, Geanne K N Santos, Roseane Borner, Cristovam W Picanço-Diniz, Eduardo I Beltrão, Janilson F Silva, Marcelo C A Rodrigues, Belmira L S Andrade da Cost. Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids. Frontiers in human neuroscience. vol 6. 2012-10-02. PMID:22969716. |
in our previous study on rat brains, we observed that a two-generation efa dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (sn) rostro-dorso-medial. |
2012-10-02 |
2023-08-12 |
rat |
| Henriqueta D Cardoso, Priscila P Passos, Claudia J Lagranha, Anete C Ferraz, Eraldo F Santos Júnior, Rafael S Oliveira, Pablo E L Oliveira, Rita de C F Santos, David F Santana, Juliana M C Borba, Ana P Rocha-de-Melo, Rubem C A Guedes, Daniela M A F Navarro, Geanne K N Santos, Roseane Borner, Cristovam W Picanço-Diniz, Eduardo I Beltrão, Janilson F Silva, Marcelo C A Rodrigues, Belmira L S Andrade da Cost. Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids. Frontiers in human neuroscience. vol 6. 2012-10-02. PMID:22969716. |
in ef2 young animals, degeneration in dopaminergic and non-dopaminergic neurons and a significant increase in lp (p < 0.01) and decrease in the cat activity (p < 0.001) were detected in the sn, while no inter-group difference was found for these parameters in the cs. |
2012-10-02 |
2023-08-12 |
rat |
| Alexandra Dumitriu, Jeanne C Latourelle, Tiffany C Hadzi, Nathan Pankratz, Dan Garza, John P Miller, Jeffery M Vance, Tatiana Foroud, Thomas G Beach, Richard H Myer. Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation. PLoS genetics. vol 8. issue 6. 2012-09-27. PMID:22761592. |
while the degeneration of dopaminergic neurons in pd mainly takes place in the substantia nigra pars compacta (sn) region, other brain areas, including the prefrontal cortex, develop lewy bodies, the neuropathological hallmark of pd. |
2012-09-27 |
2023-08-12 |
human |
| Jie Li, Junfeng Yang, Peng Zhao, Shen Li, Renyun Zhang, Xiaobin Zhang, Dan Liu, Benshu Zhan. Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 6. 2012-09-20. PMID:22200858. |
the key pathological feature of parkinson's disease (pd) is selective degeneration of the neuromelanin (nm)-pigmented dopaminergic neurons in the substantia nigra (sn). |
2012-09-20 |
2023-08-12 |
human |
| Ma Carmen Hernández-Romero, M José Delgado-Cortés, Manuel Sarmiento, Rocío M de Pablos, Ana María Espinosa-Oliva, Sandro Argüelles, Manuel J Bández, Ruth F Villarán, Raquel Mauriño, Marti Santiago, José L Venero, Antonio J Herrera, Josefina Cano, Alberto Machad. Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22330755. |
overall, the treatment with carrageenan increased the effect of the intranigral injection of lps on the loss of dopaminergic neurons in the sn along with all the other parameters studied, including: serum levels of the inflammatory markers tnf-α, il-1β, il-6 and c-reactive protein; activation of microglia, expression of proinflammatory cytokines, the adhesion molecule icam and the enzyme inos, loss of astrocytes and damage to the blood brain barrier (bbb). |
2012-09-18 |
2023-08-12 |
rat |
| Xianzhi Zeng, Huijuan Shen, Junpeng Zhao, Qing Cai, Congrong Wang, Qunyuan X. Long-term changes in morphology, D2R expression and targets of regenerated dopaminergic terminals in the striatum after a partial lesion in the substantia nigra in the rat. Brain research. vol 1450. 2012-09-14. PMID:22424788. |
the dopaminergic fibers were almost completely lost in the dorsal part of the striatum 2weeks after the lesion, but returned to normal by 16weeks with an equal degree of dopaminergic neuron lesions in the sn at both time points. |
2012-09-14 |
2023-08-12 |
rat |
| A Machado, A J Herrera, J L Venero, M Santiago, R M de Pablos, R F Villarán, A M Espinosa-Oliva, S Argüelles, M Sarmiento, M J Delgado-Cortés, R Mauriño, J Can. Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN neurology. vol 2011. 2012-08-23. PMID:22389821. |
we injected 2 μg of the potent proinflammatory compound lipopolysaccharide (lps) in different areas of the cns, finding that sn displayed the highest inflammatory response and that dopaminergic (body) neurons showed a special and specific sensitivity to this process with the induction of selective dopaminergic degeneration. |
2012-08-23 |
2023-08-12 |
Not clear |
| C Venkateshappa, G Harish, Rajeswara Babu Mythri, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21971758. |
parkinson's disease (pd) is characterized by selective degeneration and loss of dopaminergic neurons in the substantia nigra (sn) of the ventral mid brain leading to dopamine depletion in the striatum. |
2012-08-13 |
2023-08-12 |
human |
| C A Brown, M C Campbell, M Karimi, S D Tabbal, S K Loftin, L L Tian, S M Moerlein, J S Perlmutte. Dopamine pathway loss in nucleus accumbens and ventral tegmental area predicts apathetic behavior in MPTP-lesioned monkeys. Experimental neurology. vol 236. issue 1. 2012-08-07. PMID:22579525. |
dopaminergic cell loss in vta provided significant predictive power for apathy scores after controlling for the influence of cell loss in sn. |
2012-08-07 |
2023-08-12 |
monkey |
| Hany E S Marei, Asma Althani, Nahla Afifi, Fabrizio Michetti, Mario Pescatori, Roberto Pallini, Patricia Casalbore, Carlo Cenciarelli, Philip Schwartz, Abd-Elmaksoud Ahme. Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra. PloS one. vol 6. issue 12. 2012-07-20. PMID:22163301. |
we used agilent's and illumina whole human genome oligonucleotide microarray to compare the genomic profiles of human embryonic nsc at a single time point in culture, and a multicellular tissue from postmortem adult substantia nigra (sn) which are rich in dopaminergic (da) neurons. |
2012-07-20 |
2023-08-12 |
human |
| Patricia Mathieu, Valeria Roca, Cecilia Gamba, Ana Del Pozo, Fernando Pitoss. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease. Journal of neuroimmunology. vol 246. issue 1-2. 2012-06-19. PMID:22458982. |
rats receiving hmscs in the sn displayed significant preservation in the number of dopaminergic neurons in the sn at 21 days after lesion and an improved performance in behavioral tests compared to control rats. |
2012-06-19 |
2023-08-12 |
human |
| L MacGillivray, K B Reynolds, M Sickand, P I Rosebush, M F Mazure. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584867. |
we studied the time course of changes in dopaminergic neurons in the substantia nigra (sn) after initiation of two different sert inhibitors, citalopram and fluoxetine. |
2012-06-18 |
2023-08-12 |
rat |