| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelvin C Luk, Vladimir V Rymar, Pepijn van den Munckhof, Stefan Nicolau, Claude Steriade, Panojot Bifsha, Jacques Drouin, Abbas F Sadiko. The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23331067. |
cell-mapping studies in wild-type mice revealed that pitx3 is primarily expressed in the ventral sn, a region particularly susceptible to mptp and other dopaminergic neurotoxins. |
2013-08-06 |
2023-08-12 |
mouse |
| Joanne Clark, Jessica M Silvaggi, Tomas Kiselak, Kangni Zheng, Elizabeth L Clore, Ying Dai, Caroline E Bass, David K Simo. Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PloS one. vol 7. issue 11. 2013-07-24. PMID:23145024. |
overexpression of pgc-1α in the sn induced expression of target genes, but unexpectedly it also greatly reduced the expression of tyrosine hydroxylase (th) and other markers of the dopaminergic phenotype with resultant severe loss of striatal dopamine. |
2013-07-24 |
2023-08-12 |
mouse |
| Joanne Clark, Jessica M Silvaggi, Tomas Kiselak, Kangni Zheng, Elizabeth L Clore, Ying Dai, Caroline E Bass, David K Simo. Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PloS one. vol 7. issue 11. 2013-07-24. PMID:23145024. |
pgc-1α overexpression alone, in the absence of mptp treatment, did not lead to cell loss in the sn or to loss of dopaminergic terminals. |
2013-07-24 |
2023-08-12 |
mouse |
| Kiyoka Kinugawa, Yann Monnet, Lixia Lu, Amaury J Bekaert, Clotilde Théry, Ziad Mallat, Etienne C Hirsch, Stéphane Huno. MFGE8 does not orchestrate clearance of apoptotic neurons in a mouse model of Parkinson's disease. Neurobiology of disease. vol 51. 2013-07-24. PMID:23194669. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by a loss of dopaminergic neurons (dn) in the substantia nigra (sn). |
2013-07-24 |
2023-08-12 |
mouse |
| Makoto Tanaka, Eriko Yamaguchi, Mami Takahashi, Kana Hashimura, Takao Shibata, Wataru Nakamura, Takahiro J Nakamur. Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neuroscience research. vol 74. issue 3-4. 2013-07-22. PMID:23044185. |
in this study, we examined the effects of dopaminergic neuronal loss in the substantia nigra (sn) on circadian rhythms of mice to assess whether age-related degeneration of the dopamine system influences circadian rhythm. |
2013-07-22 |
2023-08-12 |
mouse |
| Makoto Tanaka, Eriko Yamaguchi, Mami Takahashi, Kana Hashimura, Takao Shibata, Wataru Nakamura, Takahiro J Nakamur. Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neuroscience research. vol 74. issue 3-4. 2013-07-22. PMID:23044185. |
young male c57bl/6j mice were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), a compound that selectively destroys dopaminergic neurons in the sn, and their wheel-running activities were recorded. |
2013-07-22 |
2023-08-12 |
mouse |
| Makoto Tanaka, Eriko Yamaguchi, Mami Takahashi, Kana Hashimura, Takao Shibata, Wataru Nakamura, Takahiro J Nakamur. Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice. Neuroscience research. vol 74. issue 3-4. 2013-07-22. PMID:23044185. |
we observed that mptp-treated mice lost 43% of their dopaminergic neurons in the sn (on average) and demonstrated longer period of wheel-running activity rhythm in constant darkness compared with control mice. |
2013-07-22 |
2023-08-12 |
mouse |
| Candan Depboylu, Matthias Höllerhage, Stefan Schnurrbusch, Patrik Brundin, Wolfgang H Oertel, André Schrattenholz, Günter U Höglinge. Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease. Neuroscience letters. vol 531. issue 2. 2013-07-22. PMID:23123776. |
in substantia nigra (sn), neuregulin-1-β1 phosphorylated erbb4 and protected dopaminergic neurons in a toxin-based mouse model of parkinson disease (pd). |
2013-07-22 |
2023-08-12 |
mouse |
| Candan Depboylu, Matthias Höllerhage, Stefan Schnurrbusch, Patrik Brundin, Wolfgang H Oertel, André Schrattenholz, Günter U Höglinge. Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease. Neuroscience letters. vol 531. issue 2. 2013-07-22. PMID:23123776. |
in control individuals, 85.0±5.0% of dopaminergic neurons, containing cytoplasmic neuromelanin, expressed erbb4 in the sn. |
2013-07-22 |
2023-08-12 |
mouse |
| Candan Depboylu, Matthias Höllerhage, Stefan Schnurrbusch, Patrik Brundin, Wolfgang H Oertel, André Schrattenholz, Günter U Höglinge. Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease. Neuroscience letters. vol 531. issue 2. 2013-07-22. PMID:23123776. |
thus, dopaminergic neurons in sn might be susceptible to neuregulin-1 treatment in pd. |
2013-07-22 |
2023-08-12 |
mouse |
| O M Littrell, J L Fuqua, A D Richardson, J Turchan-Cholewo, E R Hascup, P Huettl, F Pomerleau, L H Bradley, D M Gash, G A Gerhard. A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function. Neuropeptides. vol 47. issue 1. 2013-07-16. PMID:22981157. |
a major consequence of parkinson's disease (pd) involves the loss of dopaminergic neurons in the substantia nigra (sn) and a subsequent loss of dopamine (da) in the striatum. |
2013-07-16 |
2023-08-12 |
rat |
| Adriane Gröger, Benjamin Bender, Isabel Wurster, Grzegorz Lukasz Chadzynski, Uwe Klose, Daniela Ber. Differentiation between idiopathic and atypical parkinsonian syndromes using three-dimensional magnetic resonance spectroscopic imaging. Journal of neurology, neurosurgery, and psychiatry. vol 84. issue 6. 2013-07-12. PMID:23334525. |
degeneration of dopaminergic neurons in the substantia nigra (sn) pars compacta is the primary cause of idiopathic parkinson's disease (ipd). |
2013-07-12 |
2023-08-12 |
Not clear |
| Hugo González, Francisco Contreras, Carolina Prado, Daniela Elgueta, Dafne Franz, Sebastián Bernales, Rodrigo Pachec. Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 10. 2013-07-02. PMID:23589621. |
in this study, we examined the role of d3r expressed on cd4(+) t cells in neurodegeneration of dopaminergic neurons in the sn using a mouse model of pd. |
2013-07-02 |
2023-08-12 |
mouse |
| Alison I Bernstein, Karen L O'Malle. MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death. Toxicology letters. vol 219. issue 2. 2013-06-14. PMID:23500530. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) and depletion of striatal dopamine (da), leading to a range of motor symptoms, including resting tremor, rigidity, bradykinesia and postural abnormalities. |
2013-06-14 |
2023-08-12 |
mouse |
| Francisco Pan-Montojo, Richard H W Fun. Implications of Parkinson's disease pathophysiology for the development of cell replacement strategies and drug discovery in neurodegenerative diseases. CNS & neurological disorders drug targets. vol 11. issue 7. 2013-06-13. PMID:23131153. |
parkinson's disease (pd) is a progressive neurodegenerative disorder traditionally characterized by the loss of dopaminergic neurons in the substantia nigra (sn) at the midbrain. |
2013-06-13 |
2023-08-12 |
Not clear |
| Shelby K Suckow, Emily L Deichsel, Susan L Ingram, Michael M Morgan, Sue A Aiche. Columnar distribution of catecholaminergic neurons in the ventrolateral periaqueductal gray and their relationship to efferent pathways. Synapse (New York, N.Y.). vol 67. issue 2. 2013-05-29. PMID:23152302. |
sn and vta contain dopaminergic neurons that are critical for the maintenance of positive reinforcement. |
2013-05-29 |
2023-08-12 |
Not clear |
| Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Masato Koike, Naoko Kuzumaki, Hideki Hayakawa, Tomoko Nihira, Tetsuro Kobayashi, Manabu Ohyama, Shigeto Sato, Masashi Takanashi, Manabu Funayama, Akiyoshi Hirayama, Tomoyoshi Soga, Takako Hishiki, Makoto Suematsu, Takuya Yagi, Daisuke Ito, Arifumi Kosakai, Kozo Hayashi, Masanobu Shouji, Atsushi Nakanishi, Norihiro Suzuki, Yoshikuni Mizuno, Noboru Mizushima, Masayuki Amagai, Yasuo Uchiyama, Hideki Mochizuki, Nobutaka Hattori, Hideyuki Okan. Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Molecular brain. vol 5. 2013-05-15. PMID:23039195. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-05-15 |
2023-08-12 |
mouse |
| Kim M Gerecke, Yun Jiao, Viswajeeth Pagala, Richard J Smeyn. Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912838. |
exercise has been demonstrated to potently protect substantia nigra pars compacta (sn) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity. |
2013-05-01 |
2023-08-12 |
mouse |
| Lanying Song, Yuxi Shan, K C Kent Lloyd, Gino A Cortopass. Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Human molecular genetics. vol 21. issue 23. 2013-04-12. PMID:22949510. |
parkinson's disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2013-04-12 |
2023-08-12 |
mouse |
| Terina N Martinez, Xi Chen, Sibali Bandyopadhyay, Alfred H Merrill, Malú G Tanse. Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons. Molecular neurodegeneration. vol 7. 2013-04-09. PMID:22973882. |
dopaminergic (da) neurons in the ventral midbrain selectively degenerate in parkinson's disease (pd) in part because their oxidative environment in the substantia nigra (sn) may render them vulnerable to neuroinflammatory stimuli. |
2013-04-09 |
2023-08-12 |
rat |