| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazumasa Wakamatsu, Hitomi Tanaka, Keisuke Tabuchi, Makoto Ojika, Fabio A Zucca, Luigi Zecca, Shosuke It. Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin. Molecules (Basel, Switzerland). vol 19. issue 6. 2015-01-09. PMID:24936706. |
neuromelanin (nm) is produced in dopaminergic neurons of the substantia nigra (sn) and in noradrenergic neurons of the locus coeruleus (lc). |
2015-01-09 |
2023-08-13 |
Not clear |
| Da-Wei Li, Zhi-Qiang Liu, Wei Chen, Min Yao, Guang-Ren L. Association of glycogen synthase kinase-3β with Parkinson's disease (review). Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24681994. |
the present review focuses on the involvement of this protein in parkinson's disease (pd), a common neurodegenerative disorder characterized by the gradually progressive and selective loss of dopaminergic neurons, and by intracellular inclusions known as lewy bodies (lbs) expressed in surviving neurons of the substantia nigra (sn). |
2015-01-05 |
2023-08-12 |
Not clear |
| Marta R S Carmo, Ana Paula F Menezes, Ana Carla L Nunes, Anna Pliássova, Anabela P Rolo, Carlos M Palmeira, Rodrigo A Cunha, Paula M Canas, Geanne M Andrad. The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis. Neuropharmacology. vol 81. 2014-12-15. PMID:24508709. |
parkinson's disease (pd) involves an initial loss of striatal dopaminergic terminals evolving into a degeneration of dopaminergic neurons in the substantia nigra (sn), which can be modeled by 6-hydroxydopamine (6-ohda) administration. |
2014-12-15 |
2023-08-12 |
rat |
| Eun Jeong Sohn, Min Jea Shin, Dae Won Kim, Eun Hee Ahn, Hyo Sang Jo, Duk-Soo Kim, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson's disease model. Molecules and cells. vol 37. issue 3. 2014-12-12. PMID:24625574. |
in this study, we investigate whether tat-sag, fused with a tat domain, could protect sh-sy5y neuroblastoma cells against 1-methyl-4-phenylpyridinium (mpp(+)) and dopaminergic (da) neurons in the substantia nigra (sn) against 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (mptp) toxicity. |
2014-12-12 |
2023-08-12 |
mouse |
| Carmen Noelker, Lydie Morel, Anke Osterloh, Daniel Alvarez-Fischer, Thomas Lescot, Minka Breloer, Maike Gold, Wolfgang H Oertel, Carmen Henze, Patrick P Michel, Richard C Dodel, Lixia Lu, Etienne C Hirsch, Stéphane Hunot, Andreas Hartman. Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease. Journal of neuroinflammation. vol 11. 2014-12-01. PMID:24886419. |
increasing evidence suggests that inflammation associated with microglial cell activation in the substantia nigra (sn) of patients with parkinson disease (pd) is not only a consequence of neuronal degeneration, but may actively sustain dopaminergic (da) cell loss over time. |
2014-12-01 |
2023-08-13 |
Not clear |
| Tiago Martins Rodrigues, André Jerónimo-Santos, Tiago Fleming Outeiro, Ana Maria Sebastião, Maria José Diógene. Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease. Drugs & aging. vol 31. issue 4. 2014-11-13. PMID:24610720. |
parkinson's disease (pd) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2014-11-13 |
2023-08-12 |
human |
| M J Tobia, R Guo, U Schwarze, W Boehmer, J Gläscher, B Finckh, A Marschner, C Büchel, K Obermayer, T Somme. Neural systems for choice and valuation with counterfactual learning signals. NeuroImage. vol 89. 2014-10-29. PMID:24321554. |
the depletion procedure revealed significantly different neural responses to expected value in the vmpfc, caudate, and dopaminergic midbrain in the vicinity of the substantia nigra (sn). |
2014-10-29 |
2023-08-12 |
human |
| Virginie Licker, Natacha Turck, Enikö Kövari, Karim Burkhardt, Mélanie Côte, Maria Surini-Demiri, Johannes A Lobrinus, Jean-Charles Sanchez, Pierre R Burkhar. Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis. Proteomics. vol 14. issue 6. 2014-10-27. PMID:24449343. |
sn exhibits a progressive loss of dopaminergic neurons responsible for the major cardinal motor symptoms, along with the occurrence of lewy bodies in the surviving neurons. |
2014-10-27 |
2023-08-12 |
human |
| Mayur S Parmar, Juliann D Jaumotte, Stephanie L Wyrostek, Michael J Zigmond, Jane E Cavanaug. Role of ERK1, 2, and 5 in dopamine neuron survival during aging. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24411019. |
these data suggest that erk5 is essential for the basal survival of sn and vta dopaminergic neurons. |
2014-09-29 |
2023-08-12 |
Not clear |
| Mayur S Parmar, Juliann D Jaumotte, Stephanie L Wyrostek, Michael J Zigmond, Jane E Cavanaug. Role of ERK1, 2, and 5 in dopamine neuron survival during aging. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24411019. |
this is the first study to examine erk1, 2, and 5 expression and activation in the sn, str, and vta during aging, and the relative roles of erk1, 2, and 5 in basal survival of sn and vta dopaminergic neurons. |
2014-09-29 |
2023-08-12 |
Not clear |
| Yuan-Yi Ma, Shu-Zhen Kong, Li-Jiang Yang, Jin-Lan Meng, Le-Chun Lv, Min H. [Sexual dimorphisms of dopaminergic neurons in rat substantia nigra]. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 6. 2014-09-26. PMID:18157467. |
parkinson's disease (pd), caused by the mesencephalic substantia nigra (sn) dopaminergic neuronal loss, displays sexual difference, i.e., the incidence is higher and the symptoms are more intense in males than that in females. |
2014-09-26 |
2023-08-12 |
rat |
| Yuan-Yi Ma, Shu-Zhen Kong, Li-Jiang Yang, Jin-Lan Meng, Le-Chun Lv, Min H. [Sexual dimorphisms of dopaminergic neurons in rat substantia nigra]. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 6. 2014-09-26. PMID:18157467. |
there was no significant difference in the t/c ratio of p50 and the number of th(+) cells in the sn between ovx- e(2) and f-int groups 15-20 d after estrogen replacement, suggesting that estrogen can promote the survival and functional recovery of dopaminergic neurons in the sn. |
2014-09-26 |
2023-08-12 |
rat |
| Yuan-Yi Ma, Shu-Zhen Kong, Li-Jiang Yang, Jin-Lan Meng, Le-Chun Lv, Min H. [Sexual dimorphisms of dopaminergic neurons in rat substantia nigra]. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 6. 2014-09-26. PMID:18157467. |
the results suggest that there exist sex-specific differences in the dopaminergic neurons in the sn structurally and functionally. |
2014-09-26 |
2023-08-12 |
rat |
| Mario Riverol, Cristina Ordóñez, María Collantes, Carla DiCaudo, Iván Peñuelas, Javier Arbizu, Irene Marcilla, María R Luqui. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076099. |
the levels of several striatal dopaminergic markers and the number of surviving dopaminergic neurons in the substantia nigra (sn) were also assessed. |
2014-09-03 |
2023-08-12 |
monkey |
| Mario Riverol, Cristina Ordóñez, María Collantes, Carla DiCaudo, Iván Peñuelas, Javier Arbizu, Irene Marcilla, María R Luqui. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076099. |
in group ii (18)f-dopa pet studies performed at 3 and 6months after interrupting levodopa showed a significantly increased ki in the anterior putamen as compared to group i. levodopa and placebo treated animals exhibited a similar number of surviving dopaminergic cells in the sn. |
2014-09-03 |
2023-08-12 |
monkey |
| J A Teske, C J Billington, C M Kot. Mechanisms underlying obesity resistance associated with high spontaneous physical activity. Neuroscience. vol 256. 2014-08-27. PMID:24161277. |
these data suggest oxa-stimulated spa is not secondary to enhanced arousal, propensity for spa parallels inclination to run and that orexin action on dopaminergic neurons in sn may participate in the mediation of spa and running wheel activity. |
2014-08-27 |
2023-08-12 |
rat |
| Eun Hee Ahn, Dae Won Kim, Min Jea Shin, Young Nam Kim, Hye Ri Kim, Su Jung Woo, So Mi Kim, Duk-Soo Kim, Joon Kim, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. Free radical biology & medicine. vol 55. 2014-08-20. PMID:23178948. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a gradual loss of dopaminergic (da) neurons in the substantia nigra (sn) of the brain. |
2014-08-20 |
2023-08-12 |
mouse |
| Wenjiao Tai, Xuan Ye, Xiuqi Bao, Baozhong Zhao, Xiaoliang Wang, Dan Zhan. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. vol 75. 2014-08-19. PMID:23916477. |
flz treatment significantly improved the motor dysfunction of pd model rats induced by intra-nigral injection of lps and this beneficial effect of flz attributed to the inhibition of microglial over-activation and the protection on dopaminergic neurons in the substantia nigra (sn). |
2014-08-19 |
2023-08-12 |
rat |
| Michaeline L Hebron, Irina Lonskaya, Charbel E-H Mouss. Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance. Autophagy. vol 9. issue 8. 2014-08-13. PMID:23787811. |
parkinson disease (pd) is a movement disorder characterized by death of dopaminergic substantia nigra (sn) neurons and brain accumulation of snca. |
2014-08-13 |
2023-08-12 |
mouse |
| Christopher A Bates, Wei Zhen. Brain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease. Fluids and barriers of the CNS. vol 11. 2014-08-05. PMID:25093076. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the accumulation of α-synuclein (a-syn) into lewy body inclusions and the loss of dopaminergic neurons in the substantia nigra (sn). |
2014-08-05 |
2023-08-13 |
Not clear |