| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Emmanuel Díaz-Martínez, Elisa Tamariz, N Fabián Díaz, Claudia M García-Peña, Alfredo Varela-Echavarría, Iván Velasc. Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 8. 2014-03-06. PMID:23732989. |
one strategy to promote axonal growth of dopaminergic neurons from the substantia nigra (sn) to the striatum is degradation of inhibitory components such as chondroitin sulphate proteoglycans (cspg). |
2014-03-06 |
2023-08-12 |
rat |
| Zhengwei Cai, Lir-Wan Fan, Asuka Kaizaki, Lu-Tai Tien, Tangeng Ma, Yi Pang, Shuying Lin, Rick C S Lin, Kimberly L Simpso. Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life. Developmental neuroscience. vol 35. issue 2-3. 2014-03-05. PMID:23446007. |
neonatal lps exposure resulted in suppression of tyrosine hydroxylase (th) expression, but not actual death of dopaminergic neurons in the sn, as indicated by the reduced number of th+ cells and unchanged total number of neurons (neun+) in the sn. |
2014-03-05 |
2023-08-12 |
rat |
| Zhengwei Cai, Lir-Wan Fan, Asuka Kaizaki, Lu-Tai Tien, Tangeng Ma, Yi Pang, Shuying Lin, Rick C S Lin, Kimberly L Simpso. Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life. Developmental neuroscience. vol 35. issue 2-3. 2014-03-05. PMID:23446007. |
a small dose of rotenone at p70 induced loss of dopaminergic neurons, as indicated by reduced numbers of both th+ and neun+ cells in the sn, and parkinson's disease (pd)-like motor impairment in p98 rats that had experienced neonatal lps exposure, but not in those without the lps exposure. |
2014-03-05 |
2023-08-12 |
rat |
| Zhengwei Cai, Lir-Wan Fan, Asuka Kaizaki, Lu-Tai Tien, Tangeng Ma, Yi Pang, Shuying Lin, Rick C S Lin, Kimberly L Simpso. Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life. Developmental neuroscience. vol 35. issue 2-3. 2014-03-05. PMID:23446007. |
these results indicate that although neonatal systemic lps exposure may not necessarily lead to death of dopaminergic neurons in the sn, such an exposure could cause persistent functional alterations in the dopaminergic system and indirectly predispose the nigrostriatal system in the adult brain to be damaged by environmental toxins at an ordinarily nontoxic or subtoxic dose and develop pd-like pathological features and motor dysfunction. |
2014-03-05 |
2023-08-12 |
rat |
| Kiyoka Kinugawa, Yann Monnet, Catherine Béchade, Daniel Alvarez-Fischer, Etienne C Hirsch, Alain Bessis, Stéphane Huno. DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson's disease. Journal of neuroinflammation. vol 10. 2014-03-03. PMID:23844828. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons (dn) in the substantia nigra (sn). |
2014-03-03 |
2023-08-12 |
mouse |
| Maik M A Worlitzer, Thomas Viel, Andreas H Jacobs, Jens C Schwambor. The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation. The European journal of neuroscience. vol 38. issue 5. 2014-02-26. PMID:23734736. |
parkinson's disease is characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn). |
2014-02-26 |
2023-08-12 |
mouse |
| Sara Ailane, Philip Long, Peter Jenner, Sarah Ros. Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra. The European journal of neuroscience. vol 38. issue 3. 2014-02-19. PMID:23692556. |
the multifunctional protein osteopontin (opn) is expressed in the substantia nigra (sn) and protects nigral dopaminergic neurones against toxic insult in animal models of parkinson's disease, although the mechanisms involved are uncertain. |
2014-02-19 |
2023-08-12 |
rat |
| Andreia Neves Carvalho, Carla Marques, Elsa Rodrigues, Colin J Henderson, C Roland Wolf, Paulo Pereira, Maria João Gam. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice. Molecular neurobiology. vol 47. issue 2. 2014-02-13. PMID:23129554. |
parkinson's disease (pd) is neuropathologically characterized by selective death of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracytoplasmic inclusions of aggregated proteins. |
2014-02-13 |
2023-08-12 |
mouse |
| E Hensleigh, L M Pritchar. Glucocorticoid receptor expression and sub-cellular localization in dopamine neurons of the rat midbrain. Neuroscience letters. vol 556. 2014-02-10. PMID:24121048. |
glucocorticoid receptors were observed in dopaminergic neurons in both the substantia nigra (sn) and ventral tegmental area (vta). |
2014-02-10 |
2023-08-12 |
rat |
| Michaeline L Hebron, Irina Lonskaya, Charbel E-H Mouss. Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models. Human molecular genetics. vol 22. issue 16. 2014-02-06. PMID:23666528. |
parkinson's disease is a movement disorder characterized by death of dopaminergic substantia nigra (sn) neurons and brain accumulation of α-synuclein. |
2014-02-06 |
2023-08-12 |
mouse |
| Rong Li, Tao Liang, Lingyuan Xu, Ni Zheng, Kefeng Zhang, Xiaoqun Dua. Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. Brain research. vol 1523. 2014-02-04. PMID:23747813. |
pathological examination showed that dopaminergic neuronal degeneration in the sn was attenuated by pr treatment. |
2014-02-04 |
2023-08-12 |
rat |
| Hueng-Chuen Fan, Shyi-Jou Chen, Horng-Jyh Harn, Shinn-Zong Li. Parkinson's disease: from genetics to treatments. Cell transplantation. vol 22. issue 4. 2014-01-23. PMID:23127617. |
the hallmark pathological features of pd are loss of dopaminergic neurons in the substantia nigra (sn) and the presence of neuronal intracellular lewy body (lb) inclusions. |
2014-01-23 |
2023-08-12 |
Not clear |
| Ilse S Pienaar, Wilma van de Ber. A non-cholinergic neuronal loss in the pedunculopontine nucleus of toxin-evoked parkinsonian rats. Experimental neurology. vol 248. 2013-11-27. PMID:23769975. |
since a noted demise of dopaminergic neurons residing in the sn was confirmed in the 6-ohda-lesioned rats, the current study suggests that a "dying-back" mechanism may underlie the cell death affecting non-cholinergic ppn neurons. |
2013-11-27 |
2023-08-12 |
human |
| J A Priebe, P Rieckmann, S Lautenbache. [Central pain processing and Parkinson's disease. Epidemiology, physiology, and experimental results issuing pain processing]. Schmerz (Berlin, Germany). vol 26. issue 6. 2013-11-19. PMID:23052966. |
parkinson's disease (pd) is caused by degeneration of the dopaminergic neurons in the substantia nigra (sn) and a resulting dysfunction of the nigrostriatal pathways including the basal ganglia. |
2013-11-19 |
2023-08-12 |
Not clear |
| Patrick P Michel, Damien Toulorge, Serge Guerreiro, Etienne C Hirsc. Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23699175. |
parkinson disease (pd) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2013-11-12 |
2023-08-12 |
Not clear |
| Liya Qin, Yuxin Liu, Jau-Shyong Hong, Fulton T Crew. NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia. vol 61. issue 6. 2013-10-29. PMID:23536230. |
parkinson's disease is characterized by a progressive degeneration of substantia nigra (sn) dopaminergic neurons with age. |
2013-10-29 |
2023-08-12 |
mouse |
| Joanna A Korecka, Ruben Eggers, Dick F Swaab, Koen Bossers, Joost Verhaage. Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment. Restorative neurology and neuroscience. vol 31. issue 2. 2013-09-20. PMID:23271419. |
parkinson's disease (pd) is a movement disorder mainly characterized by progressive neurodegeneration of dopaminergic (daergic) neurons in the substantia nigra (sn). |
2013-09-20 |
2023-08-12 |
Not clear |
| Lingling Lu, Chunyan Zhang, Qing Cai, Qiang Lu, Chunli Duan, Yuangang Zhu, Hui Yan. Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats. Acta biochimica et biophysica Sinica. vol 45. issue 3. 2013-09-12. PMID:23291291. |
furthermore, over-expression of α-syn in rat brain partly mimics the neuropathological and behavioral features of pd by triggering the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-09-12 |
2023-08-12 |
rat |
| Stefano Delli Pizzi, Cosmo Rossi, Vincenzo Di Matteo, Ennio Esposito, Simone Guarnieri, Maria Addolorata Mariggiò, Raffaella Franciotti, Massimo Caulo, Astrid Thomas, Marco Onofrj, Armando Tartaro, Laura Bonann. Morphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS study. PloS one. vol 8. issue 2. 2013-08-15. PMID:23431380. |
systemic administration of a synthetic proteasome inhibitor (psi) in rats has been described as able to provide a model of parkinson's disease (pd), characterized by behavioral and biochemical modifications, including loss of dopaminergic neurons in the substantia nigra (sn), as assessed by post-mortem studies. |
2013-08-15 |
2023-08-12 |
rat |
| Lu-Tai Tien, Asuka Kaizaki, Yi Pang, Zhengwei Cai, Abhay J Bhatt, Lir-Wan Fa. Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology. vol 308. 2013-08-13. PMID:23567316. |
our previous studies show that perinatal lipopolysaccharide (lps) exposure enhances adult susceptibility to rotenone-induced injury to the dopaminergic system in the substantia nigra (sn) of the adult rat brain. |
2013-08-13 |
2023-08-12 |
rat |