| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Xin Chen, Zhenhua Guo, Qianyue Jin, Songlin Qiao, Rui Li, Xuewu Li, Ruiguang Deng, Wen-Hai Feng, Gai-Ping Zhan. Porcine reproductive and respiratory syndrome virus induces interleukin-1β through MyD88/ERK/AP-1 and NLRP3 inflammasome in microglia. Veterinary microbiology. vol 227. 2019-01-31. PMID:30473357. |
moreover, nod-like receptor protein 3 (nlrp3) inflammasome is activated by prrsv in microglia, which is required for il-1β secretion. |
2019-01-31 |
2023-08-13 |
Not clear |
| Sofie Voet, Conor Mc Guire, Nora Hagemeyer, Arne Martens, Anna Schroeder, Peter Wieghofer, Carmen Daems, Ori Staszewski, Lieselotte Vande Walle, Marta Joana Costa Jordao, Mozes Sze, Hanna-Kaisa Vikkula, Delphine Demeestere, Griet Van Imschoot, Charlotte L Scott, Esther Hoste, Amanda Gonçalves, Martin Guilliams, Saskia Lippens, Claude Libert, Roos E Vandenbroucke, Ki-Wook Kim, Steffen Jung, Zsuzsanna Callaerts-Vegh, Patrick Callaerts, Joris de Wit, Mohamed Lamkanfi, Marco Prinz, Geert van Lo. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29789522. |
microglia a20 deficiency also exacerbates multiple sclerosis (ms)-like disease, due to hyperactivation of the nlrp3 inflammasome leading to enhanced interleukin-1β secretion and cns inflammation. |
2018-12-11 |
2023-08-13 |
mouse |
| Tianshu Wu, Xue Liang, Keyu He, Tingting Wei, Yan Wang, Jie Lu, Ying Yao, Ting Zhang, Yuying Xue, Meng Tan. MPA-modified CdTe quantum dots increased interleukin-1beta secretion through MyD88-dependent Toll-like receptor pathway and NLRP3 inflammasome activation in microglia. Toxicology in vitro : an international journal published in association with BIBRA. vol 52. 2018-11-26. PMID:29852215. |
mpa-modified cdte quantum dots increased interleukin-1beta secretion through myd88-dependent toll-like receptor pathway and nlrp3 inflammasome activation in microglia. |
2018-11-26 |
2023-08-13 |
rat |
| Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Anna Piotrowska, Bogusława Budziszewska, Marta Kubera, Katarzyna Popiołek-Barczyk, Władysław Lasoń, Joanna Mika, Agnieszka Basta-Kai. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures. International journal of molecular sciences. vol 19. issue 7. 2018-11-05. PMID:29976873. |
targeting the nlrp3 inflammasome-related pathways via tianeptine treatment-suppressed microglia polarization to the m1 phenotype in lipopolysaccharide-stimulated cultures. |
2018-11-05 |
2023-08-13 |
Not clear |
| Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Anna Piotrowska, Bogusława Budziszewska, Marta Kubera, Katarzyna Popiołek-Barczyk, Władysław Lasoń, Joanna Mika, Agnieszka Basta-Kai. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures. International journal of molecular sciences. vol 19. issue 7. 2018-11-05. PMID:29976873. |
moreover, we found that m1 microglia suppression may be related to the nlrp3 inflammasome and tlr4 signaling. |
2018-11-05 |
2023-08-13 |
Not clear |
| Yan Tan, Si-Wei Tan, Bo-Ya Fan, Lei Li, Yuan-Guo Zho. Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells. Iranian journal of immunology : IJI. vol 15. issue 2. 2018-10-18. PMID:29947341. |
although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and nlrp3 in microglia remains poorly understood. |
2018-10-18 |
2023-08-13 |
Not clear |
| Xue Teng, Weiwei Chen, Zhihan Liu, Tao Feng, Hui Li, Sheng Ding, Yonggang Chen, Ying Zhang, Xianping Tang, Deqin Gen. NLRP3 Inflammasome Is Involved in Q-VD-OPH Induced Necroptosis Following Cerebral Ischemia-Reperfusion Injury. Neurochemical research. vol 43. issue 6. 2018-10-15. PMID:29802529. |
we also demonstrated that nlrp3 was not only expressed in microglia and vascular endothelial cell, but also in neurons when necroptosis is induced with q-vd-oph. |
2018-10-15 |
2023-08-13 |
rat |
| Ming-Yii Huang, Chia-En Tu, Shu-Chi Wang, Yung-Li Hung, Chia-Cheng Su, Shih-Hua Fang, Chi-Shuo Chen, Po-Len Liu, Wei-Chung Cheng, Yu-Wei Huang, Chia-Yang L. Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia. BMC complementary and alternative medicine. vol 18. issue 1. 2018-10-01. PMID:30107806. |
corylin inhibits lps-induced inflammatory response and attenuates the activation of nlrp3 inflammasome in microglia. |
2018-10-01 |
2023-08-13 |
Not clear |
| Hua Bai, Bo Yang, Wenfeng Yu, Yan Xiao, Dejun Yu, Qifang Zhan. Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome. Experimental cell research. vol 362. issue 1. 2018-09-07. PMID:29196167. |
oxidative stress-mediated activation of nlrp3 inflammasome in microglia is critical in the development of neurodegerative diseases such as alzheimer's disease (ad), parkinson disease (pd). |
2018-09-07 |
2023-08-13 |
Not clear |
| C Dempsey, A Rubio Araiz, K J Bryson, O Finucane, C Larkin, E L Mills, A A B Robertson, M A Cooper, L A J O'Neill, M A Lync. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:28003153. |
here, we examined the effect of the small molecule inhibitor of the nlrp3 inflammasome, mcc950, on microglia in vitro and in vivo. |
2018-08-10 |
2023-08-13 |
mouse |
| Zheng Fan, Zhigang Liang, Hui Yang, Yuting Pan, Yan Zheng, Xiaomin Wan. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. Journal of neuroinflammation. vol 14. issue 1. 2018-07-27. PMID:29262843. |
tenuigenin protects dopaminergic neurons from inflammation via suppressing nlrp3 inflammasome activation in microglia. |
2018-07-27 |
2023-08-13 |
Not clear |
| Roya Aryanpour, Parichehr Pasbakhsh, Kazem Zibara, Zeinab Namjoo, Fatemeh Beigi Boroujeni, Saeed Shahbeigi, Iraj Ragerdi Kashani, Cordian Beyer, Adib Zendehde. Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model. International immunopharmacology. vol 51. 2018-05-10. PMID:28830026. |
progesterone therapy induces an m1 to m2 switch in microglia phenotype and suppresses nlrp3 inflammasome in a cuprizone-induced demyelination mouse model. |
2018-05-10 |
2023-08-13 |
mouse |
| M E Brocca, L Pietranera, M Meyer, A Lima, P Roig, E R de Kloet, A F De Nicol. Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats. Journal of neuroendocrinology. vol 29. issue 7. 2018-04-23. PMID:28523794. |
we also measured serum-glucocorticoid-activated kinase 1 (sgk1 mrna), the number and phenotype of iba1+ microglia, as well as mrna expression levels of the pro-inflammatory factors cyclo-oxygenase 2 (cox2), nlrp3 inflammasome and tumour necrosis factor α (tnfα). |
2018-04-23 |
2023-08-13 |
rat |
| Diya Wang, Jianbin Zhang, Wenkai Jiang, Zipeng Cao, Fang Zhao, Tongjian Cai, Michael Aschner, Wenjing Lu. The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability. Autophagy. vol 13. issue 5. 2018-03-29. PMID:28318352. |
nlrp3 (nlr family, pyrin domain containing 3)- casp1 (caspase 1) inflammasome-mediated neuroinflammation in microglia has specific relevance to neurological diseases. |
2018-03-29 |
2023-08-13 |
mouse |
| Manmeet K Mamik, Elizabeth Hui, William G Branton, Brienne A McKenzie, Jesse Chisholm, Eric A Cohen, Christopher Powe. HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 2. 2018-03-02. PMID:27726055. |
hiv-1 viral protein r activates nlrp3 inflammasome in microglia: implications for hiv-1 associated neuroinflammation. |
2018-03-02 |
2023-08-13 |
mouse |
| Matthew G Frank, Michael D Weber, Laura K Fonken, Sarah A Hershman, Linda R Watkins, Steven F Maie. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26482581. |
we found that ds-hmgb1 increased expression of nf-κbiα mrna and nlrp3 mrna in isolated microglia, and potentiated the microglial pro-inflammatory response (tnfα mrna, il-1β mrna and il-1β protein) to lps. |
2017-12-29 |
2023-08-13 |
Not clear |
| Hong-Mei Wang, Ting Zhang, Jian-Kang Huang, Jing-Yan Xiang, Jing-Jiong Chen, Jian-Liang Fu, Yu-Wu Zha. Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 43. issue 3. 2017-12-26. PMID:28977782. |
edaravone attenuates the proinflammatory response in amyloid-β-treated microglia by inhibiting nlrp3 inflammasome-mediated il-1β secretion. |
2017-12-26 |
2023-08-13 |
mouse |
| Adib Zendedel, Sonja Johann, Soraya Mehrabi, Mohammad-Taghi Joghataei, Gholamreza Hassanzadeh, Markus Kipp, Cordian Beye. Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25972240. |
immunofluorescence double-labeling demonstrated that microglia and neurons are major sources of the asc and nlrp3 respectivley. |
2017-12-25 |
2023-08-13 |
rat |
| Hannah Scheiblich, Anna Schlütter, Douglas T Golenbock, Eicke Latz, Pilar Martinez-Martinez, Michael T Henek. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28940479. |
activation of the nlrp3 inflammasome in microglia: the role of ceramide. |
2017-12-07 |
2023-08-13 |
Not clear |
| Hannah Scheiblich, Anna Schlütter, Douglas T Golenbock, Eicke Latz, Pilar Martinez-Martinez, Michael T Henek. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28940479. |
growing evidence suggests that ceramide plays a critical role in nlrp3 inflammasome assembly, however, the relationship between ceramide and inflammasome activation in microglia remains unknown. |
2017-12-07 |
2023-08-13 |
Not clear |