All Relations between nlrp3 and microglial cell

Publication Sentence Publish Date Extraction Date Species
Cira Dansokho, Michael Thomas Henek. Neuroinflammatory responses in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 5. 2019-11-04. PMID:29273951. this review discusses recent knowledge on microglia responses toward amyloid and tau pathology in ad, focusing on the role of toll-like receptors and nod-like receptor protein 3 (nlrp3) inflammasome activation in microglial cells. 2019-11-04 2023-08-13 mouse
Xiaolong Yao, Qian Jiang, Wei Ding, Pengjie Yue, Junwen Wang, Kai Zhao, Huaqiu Zhan. Interleukin 4 inhibits high mobility group box-1 protein-mediated NLRP3 inflammasome formation by activating peroxisome proliferator-activated receptor-γ in astrocytes. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-28. PMID:30606476. high mobility group box-1 protein (hmgb-1) is one of the most important damps and has been previously shown to promote the formation of the nod-like receptor with pyrin domain containing-3 (nlrp3) inflammasome in microglia. 2019-10-28 2023-08-13 Not clear
Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Ya. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 22. issue 3. 2019-10-18. PMID:31056470. dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting nlrp3. 2019-10-18 2023-08-13 Not clear
Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Ya. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 22. issue 3. 2019-10-18. PMID:31056470. to investigate whether dexmedetomidine (dex) can reduce the production of inflammatory factor il-1β by inhibiting the activation of nlrp3 inflammasome in hippocampal microglia, thereby alleviating the inflammatory response of the central nervous system induced by surgical injury. 2019-10-18 2023-08-13 Not clear
Jie Feng, Jing-Xue Wang, Ye-Hong Du, Ying Liu, Wei Zhang, Jing-Fei Chen, Yuan-Jie Liu, Min Zheng, Ke-Jian Wang, Gui-Qiong H. Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice. CNS neuroscience & therapeutics. vol 24. issue 12. 2019-10-14. PMID:29869390. in addition, chronic activation of nlrp3 inflammasomes triggered by amyloid β peptide (aβ) in microglia contributes to persistent neuroinflammation. 2019-10-14 2023-08-13 mouse
Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill, Anumantha G Kanthasamy, Kate Schroder, Matthew A Cooper, Trent M Woodruf. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science translational medicine. vol 10. issue 465. 2019-10-11. PMID:30381407. nlrp3 activation by fibrillar α-synuclein in mouse microglia resulted in a delayed but robust activation of the nlrp3 inflammasome leading to extracellular interleukin-1β and asc release in the absence of pyroptosis. 2019-10-11 2023-08-13 mouse
Fangzhou Li, Takashi Ayaki, Takakuni Maki, Nobukatsu Sawamoto, Ryosuke Takahash. NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy. Journal of neuropathology and experimental neurology. vol 77. issue 11. 2019-10-07. PMID:30295793. we demonstrated that the density of microglia expressing nlrp3 inflammasome-related proteins was increased in the putamina of msa cases and was significantly related to the deposition of phosphorylated α-synuclein-positive glial cytoplasmic inclusions, tyrosine hydroxylase-positive fiber loss, and gliosis of glial fibrillary acidic protein-positive astrocytes. 2019-10-07 2023-08-13 Not clear
Enquan Xu, Jianuo Liu, Han Liu, Xiaobei Wang, Huangui Xion. Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1β Production in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 2. 2019-10-02. PMID:29492824. it is our hypothesis that meth activates nlrp3 inflammasome in microglia and promotes the processing and release of interleukin (il)-1β, resulting in neurotoxic activity. 2019-10-02 2023-08-13 human
Sherif Rashad, Kuniyasu Niizuma, Mika Sato-Maeda, Miki Fujimura, Ahmed Mansour, Hidenori Endo, Shuntaro Ikawa, Teiji Tominag. Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis. Brain research. vol 1699. 2019-09-30. PMID:29981290. our data showed the intense activation of immune cells, particularly the microglia, along with the increase in macrophage activity and nlrp3 inflammasome activation that is indicated by nlrp3, il-1β, and il-18 gene and caspase-1 upregulation and cleavage as well as pyroptotic cell death. 2019-09-30 2023-08-13 Not clear
Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J Kaiser, Masanori A Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W Abbott, Fu-Dong Shi, Richard M Ransohoff, Xiaoxia L. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. The Journal of clinical investigation. vol 128. issue 12. 2019-09-16. PMID:30372424. this study reports a mechanistic insight into noncanonical nlrp3 inflammasome activation in microglia for the effector stage of eae. 2019-09-16 2023-08-13 Not clear
Xin Xu, Dongpei Yin, Honglei Ren, Weiwei Gao, Fei Li, Dongdong Sun, Yingang Wu, Shuai Zhou, Li Lyu, Mengchen Yang, Jianhua Xiong, Lulu Han, Rongcai Jiang, Jianning Zhan. Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859317. we found that nlrp3 inflammasome expression was significantly increased in the peri-contusional cortex and that microglia were the primary source of this expression. 2019-09-06 2023-08-13 mouse
Runxiao Lv, Lili Du, Xueyong Liu, Fenghua Zhou, Zhiqiang Zhang, Lixin Zhan. Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway. International immunopharmacology. vol 70. 2019-08-27. PMID:30785088. above all, our data indicated that polydatin possessed neuroprotective effects in sci rats, possibly by suppressing inos expression and nlrp3 inflammasome activation in microglia. 2019-08-27 2023-08-13 rat
Michael T Heneka, Róisín M McManus, Eicke Lat. Inflammasome signalling in brain function and neurodegenerative disease. Nature reviews. Neuroscience. vol 19. issue 10. 2019-08-22. PMID:30206330. in microglia, the nlrp3 (nod-, lrr- and pyrin domain-containing 3) inflammasome becomes activated when these cells sense proteins such as misfolded or aggregated amyloid-β, α-synuclein and prion protein or superoxide dismutase, atp and members of the complement pathway. 2019-08-22 2023-08-13 Not clear
Wei He, Ting Long, Qi Pan, Shanshan Zhang, Yixin Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zho. Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model. Journal of neuroinflammation. vol 16. issue 1. 2019-08-12. PMID:30971286. the nod-like receptor protein 3 (nlrp3) inflammasome may regulate the inflammatory process of microglia in several neurological diseases, but its role in cm is largely unknown. 2019-08-12 2023-08-13 Not clear
Francis J Herman, Giulio Maria Pasinett. Principles of inflammasome priming and inhibition: Implications for psychiatric disorders. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:29902514. a recent focus on why primed microglia cells are susceptible to environmental insults has been the nlrp3 inflammasome. 2019-07-31 2023-08-13 Not clear
Francis J Herman, Giulio Maria Pasinett. Principles of inflammasome priming and inhibition: Implications for psychiatric disorders. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:29902514. the activation of nlrp3 inflammasome in microglia results in the cleavage of zymogen inflammatory interleukins into functional forms that elicit a number of consequential effects in the local neuronal environment. 2019-07-31 2023-08-13 Not clear
Lang Zhang, Rahul Previn, Liang Lu, Ri-Fang Liao, Yi Jin, Ri-Kang Wan. Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway. Brain research bulletin. vol 142. 2019-07-30. PMID:30179677. the effect was found to be due to inhibition of nlrp3 inflammasome and nf-κb and its promoted m1 to m2 phenotypic conversion of microglia. 2019-07-30 2023-08-13 mouse
Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A Specto. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. vol 67. issue 5. 2019-07-29. PMID:30582668. human immunodeficiency virus type-1 single-stranded rna activates the nlrp3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. 2019-07-29 2023-08-13 human
Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A Specto. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. vol 67. issue 5. 2019-07-29. PMID:30582668. our findings show that exposure of human primary microglia to ssrna40 activates the nlr family pyrin domain containing 3 (nlrp3) inflammasome. 2019-07-29 2023-08-13 human
Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A Specto. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. vol 67. issue 5. 2019-07-29. PMID:30582668. treatment with ssrna40 resulted in a blockade of autophagy/mitophagy mediated negative regulation of nlrp3 inflammasome activity with the release of inflammatory cytokines, caspase-1 activation, and pyroptotic microglial cell death. 2019-07-29 2023-08-13 human