| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Wang, Yongmin Chen, Jing Lu, Qinqin Xiao, Ge Li, Rong Wang, Rong Chen, Da-Qi Zhan. Forsythoside B Ameliorates Neuroinflammation via Inhibiting NLRP3 Inflammasome of Glial Cells in Experimental Autoimmune Encephalomyelitis Mice. Brain research bulletin. 2024-12-27. PMID:39730017. |
further experiments confirmed that fts·b inhibited the formation of nlrp3 inflammasome in microglia and astrocytes, thereby suppressing neuroinflammation and gsdmd-mediated pyroptosis. |
2024-12-27 |
2024-12-30 |
mouse |
| Zhi-Wei Xu, Xiao-Jie Zhou, Jun-Hao Huang, Li-Ting Ji, Chang-Yu L. [Essential oil of Acori Tatarinowii Rhizoma inhibits pyroptosis of microglia by regulating NLRP3 inflammasomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 18. 2024-12-19. PMID:39701681. |
[essential oil of acori tatarinowii rhizoma inhibits pyroptosis of microglia by regulating nlrp3 inflammasomes]. |
2024-12-19 |
2024-12-22 |
Not clear |
| Zhi-Wei Xu, Xiao-Jie Zhou, Jun-Hao Huang, Li-Ting Ji, Chang-Yu L. [Essential oil of Acori Tatarinowii Rhizoma inhibits pyroptosis of microglia by regulating NLRP3 inflammasomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 18. 2024-12-19. PMID:39701681. |
the results indicated that the essential oil of acori tatarinowii rhizoma inhibited the nlrp3 inflammasome-mediated pyroptosis of microglia. |
2024-12-19 |
2024-12-22 |
Not clear |
| Yanning Li, Yi Zhang, Dandan Lin, Xiaoliang Fu, Chenchen Jin. Demyelination of the amygdala mediates psychological stress-induced emotional disorders partially contributed by activation of P2X7R/NLRP3 cascade. Brain, behavior, and immunity. 2024-12-17. PMID:39689840. |
in the amygdala, psychological stress was also noted to activate microglia and increase the levels of nod-like receptor protein 3 (nlrp3) and the proinflammatory cytokines interleukin 1β and tumor necrosis factor α, as indicated by elisa and western blot analyses. |
2024-12-17 |
2024-12-21 |
mouse |
| Wenping Lin, Ziming Cai, Jinzhu Liang, Ping Miao, Ye Ruan, Pian Li, Shuhui Lin, He Tian, Qinghe Yu, Xu H. Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia. Drug development research. vol 85. issue 8. 2024-12-11. PMID:39660541. |
the adeno-associated virus (aav) was used to induce ho-1 overexpression to observe the effects of ho-1 overexpression on microglia survival, morphological changes, microglia activation, inflammatory cytokines secretion, mitochondrial dynamics, and nucleotide-binding oligomerization domain-like receptor protein (nlrp3) inflammatory complex and nuclear factor-κb (nf-κb) signaling pathways. |
2024-12-11 |
2024-12-13 |
rat |
| Wenping Lin, Ziming Cai, Jinzhu Liang, Ping Miao, Ye Ruan, Pian Li, Shuhui Lin, He Tian, Qinghe Yu, Xu H. Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia. Drug development research. vol 85. issue 8. 2024-12-11. PMID:39660541. |
overexpressed ho-1 inhibited microglia m1-type polarization, downregulated the nf-κb signaling pathway, inhibited nlrp3 inflammatory complex activation, and reduced the secretion of inflammatory factors. |
2024-12-11 |
2024-12-13 |
rat |
| Ming-Chen Yu, Xiao-Lin Li, Ming-Liang Ning, Zhen-Zhong Yan, Wan-Tao Y. USP22 Inhibits Microglial M1 Polarization by Regulating the PU.1/NLRP3 Inflammasome Pathway. Brain research bulletin. 2024-12-04. PMID:39631712. |
this study aimed to investigate the effect of ubiquitin-specific peptidase 22 (usp22) on the inflammatory response mediated by bv-2 mouse microglia and explore the role of the pu box binding protein 1 (pu.1)/nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasome in the usp22-induced polarization of bv-2 cells. |
2024-12-04 |
2024-12-07 |
mouse |
| Qun Cai, Liyuan Shen, Xiaoqun Zhang, Zhijun Zhang, Ting Wan. The IRE1-XBP1 Axis Regulates NLRP3 Inflammasome-Mediated Microglia Activation in Hypoxic Ischemic Encephalopathy. Critical reviews in immunology. vol 45. issue 1. 2024-11-29. PMID:39612277. |
the ire1-xbp1 axis regulates nlrp3 inflammasome-mediated microglia activation in hypoxic ischemic encephalopathy. |
2024-11-29 |
2024-12-02 |
rat |
| Qun Cai, Liyuan Shen, Xiaoqun Zhang, Zhijun Zhang, Ting Wan. The IRE1-XBP1 Axis Regulates NLRP3 Inflammasome-Mediated Microglia Activation in Hypoxic Ischemic Encephalopathy. Critical reviews in immunology. vol 45. issue 1. 2024-11-29. PMID:39612277. |
4μ8С treatment inhibited nlrp3 inflammasome activation-mediated microglia activation and inflammatory response. |
2024-11-29 |
2024-12-02 |
rat |
| Qun Cai, Liyuan Shen, Xiaoqun Zhang, Zhijun Zhang, Ting Wan. The IRE1-XBP1 Axis Regulates NLRP3 Inflammasome-Mediated Microglia Activation in Hypoxic Ischemic Encephalopathy. Critical reviews in immunology. vol 45. issue 1. 2024-11-29. PMID:39612277. |
in conclusion, 4μ8С suppressed microglia and nlrp3 inflammasome activation by inactivating ire1/xbp1 axis during hie development, which revealed ire1α inhibition as a novel mechanism for neuron protection. |
2024-11-29 |
2024-12-02 |
rat |
| Yan Shi, Yufeng Yang, Juntong Liu, Jinling Zhen. Avicularin Treatment Ameliorates Ischemic Stroke Damage by Regulating Microglia Polarization and its Exosomes via the NLRP3 Pathway. Journal of integrative neuroscience. vol 23. issue 11. 2024-11-29. PMID:39613475. |
avicularin treatment ameliorates ischemic stroke damage by regulating microglia polarization and its exosomes via the nlrp3 pathway. |
2024-11-29 |
2024-12-02 |
Not clear |
| Wei Zhang, Yubao Lu, Ruoqi Shen, Yingjie Wu, Chenrui Liu, Xingxing Fang, Liangming Zhang, Bin Liu, Limin Ron. Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury. Neural regeneration research. vol 20. issue 10. 2024-11-29. PMID:39610106. |
collectively, these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by nlrp3, thereby exerting neuroprotective effects. |
2024-11-29 |
2024-12-01 |
mouse |
| Kosma Sakrajda, Wojciech Langwiński, Zuzanna Stachowiak, Kamil Ziarniak, Beata Narożna, Aleksandra Szczepankiewic. Immunomodulatory effect of lithium treatment on in vitro model of neuroinflammation. Neuropharmacology. 2024-11-25. PMID:39586495. |
we aimed to investigate whether lithium treatment and pretreatment of microglia modify the expression of genes associated with nlrp3 inflammasome. |
2024-11-25 |
2024-11-28 |
human |
| Kosma Sakrajda, Wojciech Langwiński, Zuzanna Stachowiak, Kamil Ziarniak, Beata Narożna, Aleksandra Szczepankiewic. Immunomodulatory effect of lithium treatment on in vitro model of neuroinflammation. Neuropharmacology. 2024-11-25. PMID:39586495. |
to assess the influence on microglia responding to innate-immune cytokines, we analyzed the expression of genes involved in innate-immune and inflammasome (tspo, tlr4, nfkb1, casp1, casp4, nlrp3, il-1β, il-6), caspase activity, extracellular il-1β concentration, phospho-gsk-3β(ser9) expression and lactate concentration. |
2024-11-25 |
2024-11-28 |
human |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy. Aging cell. 2024-11-21. PMID:39571180. |
residual microglia following short-term plx5622 treatment in 5xfad mice exhibit diminished nlrp3 inflammasome and mtor signaling, and enhanced autophagy. |
2024-11-21 |
2024-11-24 |
mouse |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy. Aging cell. 2024-11-21. PMID:39571180. |
the leftover microglia displayed a noninflammatory phenotype with reduced nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome complexes. |
2024-11-21 |
2024-11-24 |
mouse |
| Hongguang Ding, Shiying Zhang, Zhuo Li, Juhao Zeng, Hongke Zen. Hypercapnia promotes NLRP3 inflammasome activation in microglia by activating P2X7R after lipopolysaccharide-induced activation of the TLR4/NF-κB signaling pathway. Cytokine. vol 185. 2024-11-16. PMID:39549469. |
hypercapnia promotes nlrp3 inflammasome activation in microglia by activating p2x7r after lipopolysaccharide-induced activation of the tlr4/nf-κb signaling pathway. |
2024-11-16 |
2024-11-20 |
Not clear |
| b' Andrea Calderone, Desir\\xc3\\xa8e Latella, Davide Cardile, Antonio Gangemi, Francesco Corallo, Carmela Rifici, Angelo Quartarone, Rocco Salvatore Calabr\\xc3\\xb. The Role of Neuroinflammation in Shaping Neuroplasticity and Recovery Outcomes Following Traumatic Brain Injury: A Systematic Review. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519259.' |
additionally, insights from animal studies reveal how neuroinflammation affects recovery, emphasizing targets such as nod-like receptor family pyrin domain-containing 3 (nlrp3) and microglia for enhancing therapeutic interventions. |
2024-11-09 |
2024-11-17 |
Not clear |
| Leelavathi N Madhu, Maheedhar Kodali, Raghavendra Upadhya, Shama Rao, Yogish Somayaji, Sahithi Attaluri, Bing Shuai, Maha Kirmani, Shreyan Gupta, Nathaniel Maness, Xiaolan Rao, James J Cai, Ashok K Shett. Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer's disease. Journal of extracellular vesicles. vol 13. issue 11. 2024-11-05. PMID:39499013. |
multiple genes linked to disease-associated microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3)-inflammasome and interferon-1 (ifn-1) signalling displayed reduced expression in microglia. |
2024-11-05 |
2024-11-08 |
mouse |
| Pan Su, Liming Liu, Yuhang Gong, Shuaijun Peng, Xiangli Yan, Ming Bai, Erping Xu, Yucheng L. Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling. International immunopharmacology. vol 143. issue Pt 3. 2024-11-04. PMID:39492132. |
kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing nlrp3 via tilting the balance of pparγ and stat1 signaling. |
2024-11-04 |
2024-11-06 |
Not clear |