| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hebatallah M Saad, Esraa Atef, Abeer E Elsaye. New Insights on the Potential Role of Pyroptosis in Parkinson's Neuropathology and Therapeutic Targeting of NLRP3 Inflammasome with Recent Advances in Nanoparticle-Based miRNA Therapeutics. Molecular neurobiology. 2025-03-18. PMID:40100493. |
microglia possess an inflammatory complex pathway termed the nucleotide-binding oligomerization domain-, leucine-rich repeat, and pyrin domain-containing 3 (nlrp3) inflammasome. |
2025-03-18 |
2025-03-21 |
mouse |
| Kai-Long He, Xian Yu, Lei Xia, Yan-Dong Xie, En-Bo Qi, Liang Wan, Xu-Ming Hua, Chao-Hui Jin. A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies. Frontiers in immunology. vol 16. 2025-03-14. PMID:40083546. |
targeting nlrp3 inflammasomes in microglia or astrocytes may provide an effective approach to mitigate neuroinflammation following ich. |
2025-03-14 |
2025-03-16 |
Not clear |
| Xuheng Tang, Lin Huang, Weiquan Ma, Mingxin Huang, Zhenhua Zeng, Yiqin Yu, Na Qin, Fei Zhou, Fen Li, Shenhai Gong, Hong Yan. Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 140. 2025-03-09. PMID:40058316. |
intestinal 8 gingerol attenuates tbi-induced neuroinflammation by inhibiting microglia nlrp3 inflammasome activation in a pink1/parkin-dependent manner. |
2025-03-09 |
2025-03-12 |
Not clear |
| Xiaolin Pang, Zhun Wang, Mengxue Zhang, Jinpeng Dong, Zhonglan Dong, Yiqing Yi. SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer's Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia. Neuromolecular medicine. vol 27. issue 1. 2025-03-07. PMID:40055261. |
app-ps1 mice with grik1 knockdown were constructed using adeno-associated virus, and the effects of grik1 knockdown on the nlrp3 inflammasome activation in microglia of brain tissues of app-ps1 mice were analyzed. |
2025-03-07 |
2025-03-12 |
mouse |
| Xiaolin Pang, Zhun Wang, Mengxue Zhang, Jinpeng Dong, Zhonglan Dong, Yiqing Yi. SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer's Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia. Neuromolecular medicine. vol 27. issue 1. 2025-03-07. PMID:40055261. |
overall, our results revealed that sp3-induced grik1 transcription potentiates nlrp3 inflammasome activation in microglia, leading to cognitive dysfunction in ad. |
2025-03-07 |
2025-03-12 |
mouse |
| Zhifei Cheng, Wei Shao, Chaoqi Wei, Yaru Zhang, Ru Xiao, Shuai Zhang, Jingyi Zhang, Yunfei She, Chenglin Pan, Qi Liu, Qi Wan. Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury. ACS nano. 2025-03-06. PMID:40047143. |
excessive generation of reactive oxygen species (ros) by overactivated microglia is considered to serve as the signal molecule that triggers nlrp3 inflammasome-mediated pyroptosis. |
2025-03-06 |
2025-03-08 |
rat |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
studies utilizing rodent models of neurodegenerative disease reveal heightened activation of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) and nod like receptor 3 (nlrp3) mediate microglia activation and associated neuronal injury. |
2025-03-04 |
2025-03-07 |
mouse |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
in primary microglia, ethanol-induced expression of reactivity markers and nlrp3 inflammasome activation were more pronounced in microglia from aged mice compared to young. |
2025-03-04 |
2025-03-07 |
mouse |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
using a nlrp3-specific inhibitor (olt1177) and a novel brain-penetrant nanoligomer that inhibits nf-κb and nlrp3 translation (sb_ni_112), we find ethanol-induced microglial reactivity can be attenuated by olt1177 and sb_ni_112 in microglia from aged mice. |
2025-03-04 |
2025-03-07 |
mouse |
| Juhee Shin, Junhua Wu, Hyewon Park, Song I Kim, Nara Shin, Hyo Jung Shin, Guang Ren, Jeong-A Kim, Patrick T J Hwang, Ho-Wook Jun, Sun Yeul Lee, Sangkyu Lee, Hyeong-Geug Kim, Dong Woon Ki. Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2025-02-19. PMID:39971256. |
our findings reveal that microglia pyroptosis plays a key role in neuropathic pain and suggest nlrp3 sirna nanoparticles as a promising therapeutic avenue for pain management. |
2025-02-19 |
2025-02-23 |
Not clear |
| Akihiko Miura, Takehiko Yamanashi, Naofumi Kajitani, Saki Fukuda, Kyohei Tsunetomi, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Shenghong Pu, Yumeto Nakada, Yukihiko Shirayama, Ken Watanabe, Koichi Kaneko, Masaaki Iwat. Medium-Chain Triglyceride Administration Induces Antidepressant Effects in Animal Models by Increasing Beta-Hydroxybutyrate Levels. Yonago acta medica. vol 68. issue 1. 2025-02-19. PMID:39968118. |
our prior research found that stress activates microglia in the brain to produce il-1β via the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (nlrp3) inflammasome. |
2025-02-19 |
2025-02-23 |
Not clear |
| Michael Aschner, Anatoly V Skalny, Airton C Martins, Yousef Tizabi, Irina P Zaitseva, Abel Santamaria, Rongzhu Lu, Yordanka Y Gluhcheva, Alexey A Tinko. The role of NLRP3 inflammasome activation in proinflammatory and cytotoxic effects of metal nanoparticles. Archives of toxicology. 2025-02-17. PMID:39960653. |
titanium, zinc, silver, aluminum, iron, cobalt, nickel, vanadium, and tungsten nanoparticles, as well as metal-based quantum dots have all been shown to induce nlrp3 inflammasome activation in vitro in macrophages and monocytes, dendritic cells, keratinocytes, hepatocytes, enterocytes, microglia, astrocytes, lung epithelial cells, endotheliocytes, as well as certain types of cancer cells. |
2025-02-17 |
2025-02-23 |
Not clear |
| Oluwatomi Akinduro, Sanjay Kumar, Yuechuan Chen, Barbara Thomas, Quamarul Hassan, Brian Sim. Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia. Journal of neuroinflammation. vol 22. issue 1. 2025-02-15. PMID:39955566. |
the synthesis of the proinflammatory proteins cd40 and nlrp3 depends on the canonical nf-κb cascade as the genes encoding cd40 and nlrp3 are transcribed by the phosphorylated nf-κb p50/p65 heterodimer in lps-induced microglia. |
2025-02-15 |
2025-02-18 |
human |
| Oluwatomi Akinduro, Sanjay Kumar, Yuechuan Chen, Barbara Thomas, Quamarul Hassan, Brian Sim. Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia. Journal of neuroinflammation. vol 22. issue 1. 2025-02-15. PMID:39955566. |
activated microglia may cause brain-associated injuries or disorders; therefore, we hypothesize that human breast milk-derived exosomes (hbme) attenuate lps-induced activation of cd40 and nlrp3 by decreasing p38 mapk and nf-κb p50/p65 activation/phosphorylation downstream of tlr4 in murine microglia (bv2). |
2025-02-15 |
2025-02-18 |
human |
| Oluwatomi Akinduro, Sanjay Kumar, Yuechuan Chen, Barbara Thomas, Quamarul Hassan, Brian Sim. Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia. Journal of neuroinflammation. vol 22. issue 1. 2025-02-15. PMID:39955566. |
analysis of microglia exposed to lps and hbme indicated that hbme modulated the expression of signaling molecules in the canonical nf-κb pathway, including myd88, iκbα, p38 mapk, nf-κb p65, and their products cd40, nlrp3, and cytokines il-1β and il-10. |
2025-02-15 |
2025-02-18 |
human |
| Shunfeng Liu, Zegang M. The role of cannabinoid-mediated signaling pathways and mechanisms in brain disorders. Cellular signalling. 2025-02-14. PMID:39952540. |
therefore, this article primarily focuses on microglia to summarize the inflammatory pathways mediated by cannabinoids in the cns, including nuclear factor-κb (nf-κb), nod-like receptor protein 3 (nlrp3) inflammasome, mitogen-activated protein kinase (mapk), protein kinase b (akt), and camp-dependent protein kinase (pka) signaling pathways. |
2025-02-14 |
2025-02-18 |
Not clear |
| Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huan. Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2. Neurobiology of disease. 2025-02-08. PMID:39921112. |
microglia trpc1 sumoylation drives neuroinflammation after stroke by modulating nlrp3 activity via increasing trpc1 interaction with arrb2. |
2025-02-08 |
2025-02-11 |
mouse |
| Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huan. ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation. Acta neuropathologica communications. vol 13. issue 1. 2025-01-28. PMID:39871308. |
ros-regulated sur1-trpm4 drives persistent activation of nlrp3 inflammasome in microglia after whole-brain radiation. |
2025-01-28 |
2025-01-30 |
mouse |
| Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huan. ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation. Acta neuropathologica communications. vol 13. issue 1. 2025-01-28. PMID:39871308. |
the activation of nlrp3 inflammasome within microglia after brain radiation is involved in the progression of ribi by mediating inflammatory responses. |
2025-01-28 |
2025-01-30 |
mouse |
| Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huan. ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation. Acta neuropathologica communications. vol 13. issue 1. 2025-01-28. PMID:39871308. |
here, we found that whole-brain radiation induced up-regulation and assembly of sur1-trpm4, which further activated the nlrp3 inflammasome in microglia and caused persistent neuroinflammation in mice. |
2025-01-28 |
2025-01-30 |
mouse |