| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Cao, Lanqin Li, Runge Zhang, Zhou Shu, Yaxin Zhang, Weiguang Sun, Yonghui Zhang, Zhengxi H. Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition. Natural products and bioprospecting. vol 14. issue 1. 2024-02-26. PMID:38407685. |
our results provide a new understanding of how lc inhibits the nlrp3 inflammasome in microglia, providing neuroprotection. |
2024-02-26 |
2024-02-28 |
Not clear |
| Jinsong Xue, Keju Tao, Weijia Wang, Xiaofei Wan. What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson's Disease? International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338925. |
additionally, we describe the potential anti-inflammatory therapies, including nod-like receptor pyrin domain containing protein 3 (nlrp3) inflammasome inhibition, nuclear factor κb (nf-κb) inhibition, microglia inhibition, astrocyte inhibition, nicotinamide adenine dinucleotide phosphate (nadph) oxidase inhibition, the peroxisome proliferator-activated receptor γ (pparγ) agonist, targeting the mitogen-activated protein kinase (mapk) pathway, targeting the adenosine monophosphate-activated protein kinase (ampk)-dependent pathway, targeting α-synuclein, targeting mirna, acupuncture, and exercise. |
2024-02-10 |
2024-02-12 |
Not clear |
| Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Emma V Jones, Eve Corrie, Rebecca L Kelly, Mairi Challinor, Sally Freeman, Richard A Bryce, Catherine B Lawrence, David Brough, Paul R Kashe. Brazilin is a natural product inhibitor of the NLRP3 inflammasome. iScience. vol 27. issue 2. 2024-02-08. PMID:38327788. |
here we have identified that the natural product brazilin effectively inhibits both priming and activation of the nlrp3 inflammasome in cultured murine macrophages, a human ipsc microglial cell line and in a mouse model of acute peritoneal inflammation. |
2024-02-08 |
2024-02-10 |
mouse |
| Longfei Du, Xuyuan Fan, Yi Yang, Shusheng Wu, Yuan Li. Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation. Molecular neurobiology. 2024-02-08. PMID:38329680. |
the current study indicated that quercetin mitigated depressive-like behavior and by targeting hsp90 to inhibit nlrp3 inflammasome activation in microglia and depressive mice model, meanwhile ameliorated cognitive impairment in depression. |
2024-02-08 |
2024-02-10 |
mouse |
| Changcun Qi, Yuandong Yan, Qi Cao, Lingyun Zou, Shanshan Li, Qiuyu Yang, Qing Deng, Bailin Wu, Bo Son. Elucidating the mechanisms underlying astrocyte-microglia crosstalk in hippocampal neuroinflammation induced by acute diquat exposure. Environmental science and pollution research international. 2024-02-02. PMID:38305974. |
dq exposure to the co-cultured cells induced an increase in atp secretion from c6 astrocytes as well as a significant increase of p2x4, nlrp3, il-1β, and il-18 expression in bv-2 microglia. |
2024-02-02 |
2024-02-04 |
rat |
| Changcun Qi, Yuandong Yan, Qi Cao, Lingyun Zou, Shanshan Li, Qiuyu Yang, Qing Deng, Bailin Wu, Bo Son. Elucidating the mechanisms underlying astrocyte-microglia crosstalk in hippocampal neuroinflammation induced by acute diquat exposure. Environmental science and pollution research international. 2024-02-02. PMID:38305974. |
in contrast, pretreatment of c6 astrocytes with apyrase (an atp hydrolase) resulted in a significant decrease of p2x4, nlrp3, il-1β, and il-18 expression in bv-2 microglia. |
2024-02-02 |
2024-02-04 |
rat |
| Changcun Qi, Yuandong Yan, Qi Cao, Lingyun Zou, Shanshan Li, Qiuyu Yang, Qing Deng, Bailin Wu, Bo Son. Elucidating the mechanisms underlying astrocyte-microglia crosstalk in hippocampal neuroinflammation induced by acute diquat exposure. Environmental science and pollution research international. 2024-02-02. PMID:38305974. |
furthermore, inhibition of p2x4 expression in bv-2 microglia by transfection with si-p2x4 effectively reversed the increase of nlrp3, il-1β, and il-18 in bv-2 microglia induced by dq when co-cultured with c6 astrocytes. |
2024-02-02 |
2024-02-04 |
rat |
| Daniela M Magalhães, Myrthe Mampay, Ana M Sebastião, Graham K Sheridan, Cláudia A Valent. Age-related impact of social isolation in mice: Young vs middle-aged. Neurochemistry international. 2024-01-24. PMID:38266657. |
increased iba-1 expression and nlrp3 priming were both observed in the hippocampus of socially isolated middle-aged mice, suggesting a role for microglia and nlrp3 pathway in the detrimental effects of social isolation on cognition and behaviour. |
2024-01-24 |
2024-01-27 |
mouse |
| Qiuqin Han, Wenhui Li, Peiqing Chen, Lijuan Wang, Xiwen Bao, Renyan Huang, Guobin Liu, Xiaorong Che. Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227513. |
the modulation of nlrp3 inflammasomes in microglia holds promise for the management of depression. |
2024-01-16 |
2024-01-18 |
Not clear |
| Guido S Alvarez Quintero, Analia Lima, Paulina Roig, Maria Meyer, E Ron de Kloet, Alejandro F De Nicola, Laura I Gara. effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis. The Journal of steroid biochemistry and molecular biology. 2024-01-14. PMID:38219844. |
the mr blocker (a) significantly decreased the inflammatory parameters tlr4, myd88, il-1β, and inos mrnas; (b) attenuated hmgb1, nlrp3, tgf-β mrnas, microglia, and aquaporin4 immunoreaction without modifying gfap. |
2024-01-14 |
2024-01-17 |
mouse |
| Yiwei Feng, Lishan Lin, Tengteng Wu, Yukun Feng, Fengyin Liang, Ge Li, Yongchao Li, Yalun Guan, Shuhua Liu, Yu Zhang, Guangqing Xu, Zhong Pe. Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity. Cell death & disease. vol 15. issue 1. 2024-01-12. PMID:38216560. |
furthermore, the knockout of nlrp3 in microglia alleviated the trained immunity and reduced the harmful effects of microinfarcts on recurrent stroke. |
2024-01-12 |
2024-01-15 |
Not clear |
| Debashis Dutta, Jianuo Liu, Enquan Xu, Huangui Xion. Methamphetamine enhancement of HIV-1 gp120-mediated NLRP3 inflammasome activation and resultant proinflammatory responses in rat microglial cultures. Research square. 2024-01-03. PMID:38168345. |
results meth enhanced gp120-induced microglia activation revealed by immunostaining and iba-1 expression, and potentiated gp120-mediated nlrp3 expression, il-1β processing and release assayed by immunoblot and elisa. |
2024-01-03 |
2024-01-06 |
human |
| Debashis Dutta, Jianuo Liu, Enquan Xu, Huangui Xion. Methamphetamine enhancement of HIV-1 gp120-mediated NLRP3 inflammasome activation and resultant proinflammatory responses in rat microglial cultures. Research square. 2024-01-03. PMID:38168345. |
meth also augmented the co-localization of nlrp3 and caspase-1, increased the numbers of nlrp3 puncta and ros production, elevated levels of inos expression and no production, and enhanced levels of cleaved gasdermind (gsdmd-n, an executor of pyroptosis) in gp120-primed microglia. |
2024-01-03 |
2024-01-06 |
human |
| Debashis Dutta, Jianuo Liu, Enquan Xu, Huangui Xion. Methamphetamine enhancement of HIV-1 gp120-mediated NLRP3 inflammasome activation and resultant proinflammatory responses in rat microglial cultures. Research square. 2024-01-03. PMID:38168345. |
the meth-associated effects were attenuated or blocked by mcc950, an nlrp3 inhibitor, or mito-tempo, a mitochondrial superoxide scavenger, indicating the involvement of mitochondria in meth enhancement of nlrp3 inflammasome activation in gp120-primed microglia. |
2024-01-03 |
2024-01-06 |
human |
| Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuj. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Experimental neurology. 2023-12-31. PMID:38160982. |
moreover, nlrp3 staining was observed in the neurons and microglia, and cleaved gsdmd staining in neurons in the hippocampus of dss-treated mice. |
2023-12-31 |
2024-01-05 |
mouse |
| Paige E Anton, Lauren N Rutt, Michael L Kaufman, Nicolas Busquet, Elizabeth J Kovacs, Rebecca L McCulloug. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain, behavior, and immunity. 2023-12-27. PMID:38151165. |
binge ethanol exposure also increased measures of senescence, the nod like receptor pyrin domain containing 3 (nlrp3) inflammasome, and microglia reactivity in the brains of aged mice compared to young. |
2023-12-27 |
2023-12-30 |
mouse |
| Mohammadjavad Khoshnavay Foumani, Keyvan Amirshahrokhi, Zeinab Namjoo, Ali Niapou. Carvedilol attenuates inflammatory reactions of lipopolysaccharide-stimulated BV2 cells and modulates M1/M2 polarization of microglia via regulating NLRP3, Notch, and PPAR-γ signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-22. PMID:38133658. |
carvedilol attenuates inflammatory reactions of lipopolysaccharide-stimulated bv2 cells and modulates m1/m2 polarization of microglia via regulating nlrp3, notch, and ppar-γ signaling pathways. |
2023-12-22 |
2023-12-24 |
Not clear |
| Fudong Li, Xiaofei Sun, Kaiqiang Sun, Fanqi Kong, Xin Jiang, Qingjie Kon. Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway. Neural regeneration research. vol 19. issue 8. 2023-12-16. PMID:38103247. |
furthermore, lupenone decreased nlrp3 inflammasome activation, nlrp3-induced microglial cell polarization, and microglia pyroptosis by inhibiting the nuclear factor kappa b pathway. |
2023-12-16 |
2023-12-19 |
mouse |
| Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Sha. Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2023-12-13. PMID:38092305. |
specifically, diosmin treatment significantly suppressed the secretion of pro-inflammatory cytokines (tnf-α, il-6 and il-1β), reduced the activation of microglia, and inhibited the expression of nlrp3 inflammasome and its downstream effector caspase-1 in both pfc of mice and bv2 microglial cells exposed to lps. |
2023-12-13 |
2023-12-17 |
mouse |
| Hongxia Che, Xiyu Wang, Shusen He, Xiufang Dong, Liangtao Lv, Wancui Xie, Hongyan L. Orally administered selenium-containing α-D-1,6-glucan and α-D-1,6-glucan relief early cognitive deficit in APP/PS1 mice. International journal of biological macromolecules. 2023-12-04. PMID:38048923. |
the results of the morris water maze and open-field test revealed that se-cpa exerted more significant effects than cpa in improving cognitive function and depressive-like behavior by attenuating the oxidative stress, decreasing serum lps level, downregulating the inflammation of astrocytes and microglia through inhibiting the activation of nlrp3 inflammasome, mitigating neuronal cells loss and improving synaptic plasticity. |
2023-12-04 |
2023-12-10 |
mouse |