| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. |
moreover, it lowered the expression of inflammation-related proteins, such as caspase-1, il-1β, and nlrp3 in microglia. |
2024-06-22 |
2024-06-25 |
rat |
| Ryan Gober, Julian Dallmeier, David Davis, Daniel Brzostowicki, Juan Pablo de Rivero Vaccari, Brianna Cyr, Ayled Barreda, Xiaoyan Sun, Sakir Humayun Gultekin, Susanna Garamszegi, William Scott, Regina Vontel. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. Journal of neuropathology and experimental neurology. 2024-06-21. PMID:38904417. |
to assess changes in the cell populations that express key inflammasome proteins, we performed ihc analyses of apoptosis-associated speck-like protein containing a card (asc), nod-like receptor protein 3 (nlrp3), and interleukin (il)-18 to determine if these proteins are expressed in microglia, astrocytes, oligodendrocytes, or neurons. |
2024-06-21 |
2024-06-23 |
Not clear |
| Ryan Gober, Julian Dallmeier, David Davis, Daniel Brzostowicki, Juan Pablo de Rivero Vaccari, Brianna Cyr, Ayled Barreda, Xiaoyan Sun, Sakir Humayun Gultekin, Susanna Garamszegi, William Scott, Regina Vontel. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. Journal of neuropathology and experimental neurology. 2024-06-21. PMID:38904417. |
increased numbers of microglia were present in the sfc of scz brains and exhibited higher inflammasome protein expression of asc, nlrp3, and il-18 compared to nps. |
2024-06-21 |
2024-06-23 |
Not clear |
| Jia-Rui Zhang, Shi-Yu Shen, Meng-Ying Zhai, Zu-Qi Shen, Wei Li, Ling-Feng Liang, Shu-Yuan Yin, Qiu-Qin Han, Bing Li, Yu-Qiu Zhang, Jin Y. Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress. Nature communications. vol 15. issue 1. 2024-06-18. PMID:38890305. |
extracellular atp (eatp) signaling through the p2x7 receptor pathway is widely believed to trigger nlrp3 inflammasome assembly in microglia, potentially contributing to depression. |
2024-06-18 |
2024-06-21 |
mouse |
| Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tan. Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-11. PMID:38860393. |
pde4 inhibitors play a role in depression; autism spectrum and huntington's disease by inhibiting the advanced glycation end product receptor (rage), tlr4 and nlrp3 pathways in the hippocampus, reducing the activation of microglia and the production of interleukin-1β, down-regulating hmgb1/rage signaling pathway and inhibiting inflammatory factors and increase the nociception threshold. |
2024-06-11 |
2024-06-14 |
Not clear |
| Shuai Feng, Juanji Li, Tingting Liu, Shiqi Huang, Xiangliang Chen, Shen Liu, Junshan Zhou, Hongdong Zhao, Ye Hon. Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819062. |
low-density lipoprotein receptor, a classic cholesterol regulatory receptor, has been found to inhibit nlr family pyrin domain containing protein 3 (nlrp3) inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with alzheimer's disease. |
2024-06-06 |
2024-06-08 |
mouse |
| Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang, Fanying Jiang, Yanan Guo, Mengqing Xian. CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis. Journal of neuroinflammation. vol 21. issue 1. 2024-05-28. PMID:38802924. |
accordingly, overexpression of ccr5, a ccl5 receptor, in mesenchymal stem cells (mscs) enhances their homing capacity and improves their immunomodulatory outcomes in preventing eau, by reducing infiltrating t cells and activated microglia and suppressing nlrp3 inflammasome activation. |
2024-05-28 |
2024-06-03 |
mouse |
| Federica Mannino, Valentina Urzì Brancati, Rita Lauro, Igor Pirrotta, Michelangelo Rottura, Natasha Irrera, Gian Maria Cavallini, Giovanni Pallio, Eloisa Gitto, Sara Mant. Levosimendan and Dobutamin Attenuate LPS-Induced Inflammation in Microglia by Inhibiting the NF-κB Pathway and NLRP3 Inflammasome Activation via Nrf2/HO-1 Signalling. Biomedicines. vol 12. issue 5. 2024-05-25. PMID:38790971. |
levosimendan and dobutamin attenuate lps-induced inflammation in microglia by inhibiting the nf-κb pathway and nlrp3 inflammasome activation via nrf2/ho-1 signalling. |
2024-05-25 |
2024-05-27 |
human |
| Blake W Dieckmann, Marcell E Paguaga, Gary W McCollum, John S Penn, Md Imam Uddi. Role of NLRP3 Inflammasomes in Monocyte and Microglial Recruitments in Choroidal Neovascularization. ImmunoHorizons. vol 8. issue 5. 2024-05-22. PMID:38775688. |
inhibition of nlrp3 inflammasomes, using mcc950, caused an increased ccr2rfp-positive macrophages, cx3cr1gfp-positive microglia, and other cells, resulting in an increase in total lesion size. |
2024-05-22 |
2024-05-27 |
mouse |
| Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong L. RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson's disease by suppressing NLRP3 inflammasome activation. Experimental cell research. vol 439. issue 1. 2024-05-22. PMID:38744409. |
in vivo experiments confirmed that rnd3 overexpression could modulate microglia phenotype and ameliorate mptp-induced neuroinflammation through inhibiting activation of the nlrp3 inflammasome in substantia nigra pars compacta (snpc). |
2024-05-22 |
2024-05-27 |
mouse |
| Ting-Bin Chen, Cheng-Chia Yang, I-Ju Tsai, Hao-Wen Yang, Yung-Chu Hsu, Ching-Mao Chang, Chun-Pai Yan. Neuroimmunological effects of omega-3 fatty acids on migraine: a review. Frontiers in neurology. vol 15. 2024-05-21. PMID:38770523. |
this interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (cgrp), pituitary adenylate cyclase activating polypeptide (pacap) and/or cortical spreading depression (csd) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (nlrp3) inflammasome formation, activated microglia, and reactive astrocytes. |
2024-05-21 |
2024-05-27 |
Not clear |
| Fernanda da Silva Rodrigues, William Robert Newton, Isadora D'Ávila Tassinari, Felipe Henrique da Cunha Xavier, Adél Marx, Luciano Stürmer de Fraga, Karen Wright, Renata Padilha Guedes, Victorio Bambini-J. Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ. Neurochemistry international. 2024-05-18. PMID:38761855. |
cannabidiol prevents lps-induced inflammation by inhibiting the nlrp3 inflammasome and inos activity in bv2 microglia cells via cb2 receptors and pparγ. |
2024-05-18 |
2024-05-27 |
Not clear |
| Yuan Zhao, Wenzhe Sun, Qinlin Fan, Yanjie Huang, Yufan Ma, Shuang Zhang, Changxiong Gong, Bingqiao Wang, Wanyun Zhang, Qingwu Yang, Sen Li. Exploring the potential molecular intersection of stroke and major depression disorder. Biochemical and biophysical research communications. vol 720. 2024-05-17. PMID:38759300. |
single-cell sequencing analysis indicated that mlkl and nlrp3 are mainly influential on endothelial cells and microglia, suggesting that the impairment of these two cell types may be a factor in the relationship between stroke and major depression. |
2024-05-17 |
2024-05-27 |
mouse |
| Chunyang Kang, Qiuling Sang, Dingxi Liu, Libo Wang, Jia Li, Xiaoyang Li. Polyphyllin I alleviates neuroinflammation after cerebral ischemia-reperfusion injury via facilitating autophagy-mediated M2 microglial polarization. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-05-15. PMID:38745316. |
furthermore, ppi facilitated autophagy-mediated ros clearance to inhibit nlrp3 inflammasome activation in microglia, and nlrp3 inflammasome reactivation by nigericin abolished the effect of ppi on m2 microglia polarization. |
2024-05-15 |
2024-05-27 |
mouse |
| Guoqiang Du, Zixi Yang, Yin Wen, Xusheng Li, Wenhong Zhong, Zhuo Li, Shiying Zhang, Ensi Luo, Hongguang Ding, Weifeng L. Heat stress induces IL-1β and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke. Neuroreport. 2024-04-30. PMID:38687900. |
we found that heat stress attack induced excessive ros in microglia and subsequently activated nlrp3 inflammasome in both mice and bv2 cells. |
2024-04-30 |
2024-05-03 |
mouse |
| Guoqiang Du, Zixi Yang, Yin Wen, Xusheng Li, Wenhong Zhong, Zhuo Li, Shiying Zhang, Ensi Luo, Hongguang Ding, Weifeng L. Heat stress induces IL-1β and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke. Neuroreport. 2024-04-30. PMID:38687900. |
these results suggest that heat stress attack caused neuroinflammation via excessive ros activating the nlrp3 inflammasome in microglia cells. |
2024-04-30 |
2024-05-03 |
mouse |
| Bridget K Greuel, Dylan E Da Silva, Victoria N Robert-Gostlin, Andis Klegeri. Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia. Brain sciences. vol 14. issue 4. 2024-04-27. PMID:38671980. |
we hypothesized that some of the beneficial effects of oridonin and shikonin on microglia are independent of their suppression of nlrp3 inflammasomes. |
2024-04-27 |
2024-04-29 |
human |
| Dae Won Kim, Tae-Kyeong Lee, Ji Hyeon Ahn, Se-Ran Yang, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kang, Joon Ha Par. Porphyran Attenuates Neuronal Loss in the Hippocampal CA1 Subregion Induced by Ischemia and Reperfusion in Gerbils by Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation. Marine drugs. vol 22. issue 4. 2024-04-26. PMID:38667787. |
overall, our findings suggest that porphyran exerts neuroprotective effects against brain ir injury, potentially by reducing the reaction (activation) and proliferation of microglia and reducing nlrp3 inflammasome-mediated neuroinflammation. |
2024-04-26 |
2024-04-28 |
Not clear |
| Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward Jenkins, Frederik H Lassen, Sam J Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou, Fangyuan Cao, Xiaonan Zheng, Ricardo A Fernandes, Tao Dong, Edward W Tate, Elena Di Daniel, Benedikt M Kessle. Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia. Cell reports. vol 43. issue 5. 2024-04-26. PMID:38669140. |
uch-l1 chemical inhibition with small molecules interfered with nlrp3 puncta formation and asc oligomerization, leading to altered il-1β cleavage and secretion, particularly in microglia cells, which exhibited elevated uch-l1 expression as compared to monocytes/macrophages. |
2024-04-26 |
2024-04-29 |
human |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
we also observe abnormal activation of microglia characterized by enhanced release of the nlrp3 inflammasome, casepase-1 and pro-inflammatory cytokines il-1β, in the hippocampus of mice and bv2 cells. |
2024-04-24 |
2024-04-28 |
mouse |