| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
we found that ripostc suppressed the activation of nlrp3 inflammasome to reduce the maturation of gsdmd, leading to decreased pyroptosis in microglia after ais. |
2023-12-01 |
2023-12-07 |
mouse |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
we found that ripostc suppressed the activation of nlrp3 inflammasome to reduce the maturation of gsdmd, leading to decreased pyroptosis in microglia after ais. |
2023-11-29 |
2023-12-07 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
[eriodictyol improves cognitive function in 5×fad mice of alzheimer's disease by inhibiting the microglia nlrp3 inflammasome signaling pathway]. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
objective to investigate the therapeutic effects of eriodictyol on transgenic mice with five familial alzheimer's disease (5×fad) and the modulation of nod-like receptor-pyrin domain containing 3 (nlrp3) inflammasome in microglia. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
results compared with the wt group and the eriodictyol-treated wt group, cognitive function was significantly impaired in the ad group mice, and the expression of nlrp3, caspase-1, il-18, asc, il-1β and iba1 were increased in microglia of mouse brain tissue. |
2023-11-19 |
2023-11-20 |
mouse |
| Na Li, Mengdi Li, Minfang Guo, Tao Meng, Bingtao Mu, Jingwen Yu, Jiwei Wang, Lijuan Song, Cungen Ma, Jiezhong We. [Eriodictyol improves cognitive function in 5×FAD mice of Alzheimer's disease by inhibiting the microglia NLRP3 inflammasome signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980548. |
conclusion eriodictyol may improve cognitive function in animal models of ad by inhibiting the activation of the nlrp3 signaling pathway in microglia. |
2023-11-19 |
2023-11-20 |
mouse |
| Jing Wang, Qiao-Min Ru, Xiao-Hui Yu, Changlong Wang, Kai Li, Chao-Zhen-Yi Han, Na Li, Jing Zhao, John N Wood, Xin Liu, Rui Wang, Yuan Wan. Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity. European journal of pharmacology. 2023-11-11. PMID:37951488. |
the nlr family pyrin domain containing 3 (nlrp3) related signaling pathway may be involved in the interaction between mel-0614 and microglia. |
2023-11-11 |
2023-11-20 |
mouse |
| Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kai. Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures. Cells. vol 12. issue 21. 2023-11-10. PMID:37947648. |
microglia depletion attenuates the pro-resolving activity of the formyl peptide receptor 2 agonist ams21 related to inhibition of inflammasome nlrp3 signalling pathway: a study of organotypic hippocampal cultures. |
2023-11-10 |
2023-11-20 |
Not clear |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
after trem2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, nlrp3 inflammasome, il-1β, gsdmd, and gsdmd-n was increased. |
2023-11-02 |
2023-11-08 |
mouse |
| Ru-Huei Fu, Hui-Jye Chen, Syuan-Yu Hon. Glycine-Alanine Dipeptide Repeat Protein from C9-ALS Interacts with Sulfide Quinone Oxidoreductase (SQOR) to Induce the Activity of the NLRP3 Inflammasome in HMC3 Microglia: Irisflorentin Reverses This Interaction. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891975. |
glycine-alanine dipeptide repeat protein from c9-als interacts with sulfide quinone oxidoreductase (sqor) to induce the activity of the nlrp3 inflammasome in hmc3 microglia: irisflorentin reverses this interaction. |
2023-10-30 |
2023-11-08 |
Not clear |
| Leilei Yang, Peng Lu, Xiangyu Qi, Qian Yang, Luna Liu, Tao Dou, Qingbo Guan, Chunxiao Y. Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice. iScience. vol 26. issue 10. 2023-10-20. PMID:37860765. |
further mechanistic analysis revealed that metformin inhibited the expression and activation of sting and nlrp3 in microglia. |
2023-10-20 |
2023-11-08 |
mouse |
| Hui He, Xiaofang Xie, Xixi Kang, Jinqiang Zhang, Lu Wang, Nan Hu, Lei Xie, Cheng Peng, Zili Yo. Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress. European journal of pharmacology. 2023-10-20. PMID:37863415. |
grg1 exert antidepressant effects by preventing stress from activating the nlrp3 inflammasome in microglia, promoting a proneurogenic phenotype and allowing adult hippocampal neurogenesis. |
2023-10-20 |
2023-11-08 |
mouse |
| Qianhui Huang, Pei Yang, Yang Liu, Jianhua Ding, Ming Lu, Gang H. The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-18. PMID:37852103. |
it has been reported that abnormal aggregation of α-syn can induce the activation of nlrp3 inflammasome in microglia, increase the production of il-1β, and aggravate neuroinflammation. |
2023-10-18 |
2023-11-08 |
Not clear |
| Suzanne M Green-Fulgham, Jayson B Ball, Andrew J Kwilasz, Michael E Harland, Matthew Frank, Joseph Dragavon, Peter M Grace, Linda R Watkin. Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats. Brain, behavior, and immunity. 2023-10-14. PMID:37838078. |
we have discovered that intrathecal il-1 receptor antagonist reverses established pain in both sexes, and increased gene expression of inflammasome nlrp3 is specific to microglia and astrocytes rather than neurons, while il-1beta is specific to microglia in both sexes. |
2023-10-14 |
2023-11-08 |
human |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
mitophagy-dependent mitochondrial ros mediates 2,5-hexanedione-induced nlrp3 inflammasome activation in bv2 microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
here, we investigated whether mitochondrial reactive oxygen species (mtros) was involved in hd-elicited nlrp3 inflammasome activation in microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
furthermore, inhibition of mitophagy by 3-methyladenine (3-ma) greatly reduced production of mtros, expression of mitochondrial fission-related proteins, dynamin-related protein 1 (drp1) and fission protein 1 (fis1) and activation of nlrp3 inflammasome in hd-intoxicated microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Wenqiong Wang, Rui Chang, Yan Wang, Liyan Hou, Qingshan Wan. Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia. Neurotoxicology. 2023-09-18. PMID:37722613. |
blocking mitochondrial fission by mdivi-1 also prevented hd-induced mtros production and nlrp3 inflammasome activation in microglia. |
2023-09-18 |
2023-10-07 |
Not clear |
| Feng Zhang, Ruo-Lin Cao, Peng Liu, Tian-Yan Chi, Xue-Fei Ji, Zhong-Hui Zheng, Guo-Liang Chen, Li-Bo Zo. The bexarotene derivative OAB-14 ameliorates cognitive decline in APP/PS1 transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-γ pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-11. PMID:37696142. |
simultaneously, oab-14 dramatically inhibited the activation of microglia in the cerebral cortex and hippocampus of ad mice and dose-dependently downregulated the expression of nuclear factor kappa b (nf-κb) and nod-like receptor protein 3 (nlrp3) in the cerebral cortex. |
2023-09-11 |
2023-10-07 |
mouse |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
we found that hpc decreased nlrp3 inflammasome in microglia and inhibited m1 polarization of microglia in ca1 after tgci. |
2023-09-08 |
2023-10-07 |
rat |