| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guanghong Shen, Chengjian Lou, Qunfeng Li, Bingxin Zhao, Yuhuan Luo, Fei Wu, Dian Jiao, Marong Fang, Yu Gen. Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway. Anatomical record (Hoboken, N.J. : 2007). 2023-07-21. PMID:37475155. |
the expression of the nuclear factor kappa-b (nf-κb)/ the nod-like receptor protein (nlrp3) inflammasome signal pathway and microglia polarization were detected by immunofluorescence and western blotting. |
2023-07-21 |
2023-08-14 |
rat |
| Guanghong Shen, Chengjian Lou, Qunfeng Li, Bingxin Zhao, Yuhuan Luo, Fei Wu, Dian Jiao, Marong Fang, Yu Gen. Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway. Anatomical record (Hoboken, N.J. : 2007). 2023-07-21. PMID:37475155. |
in conclusion, this study indicates that c.eda alleviates i/r injury by blocking the activation of the nlrp3 inflammasome and regulating the polarization of m1/m2 microglia via the nf-κb signal pathway. |
2023-07-21 |
2023-08-14 |
rat |
| Yu-Jie Mou, Ya-Ting Ma, Xin Yuan, Miao Wang, Yang Liu, Chong-Shuang Pei, Chun-Feng Liu, Xiao-Ou Hou, Lifang H. Cystathionine β-synthase (CBS) suppresses NLRP3 inflammasome activation via redox regulation in microglia. Antioxidants & redox signaling. 2023-07-19. PMID:37464816. |
cystathionine β-synthase (cbs) suppresses nlrp3 inflammasome activation via redox regulation in microglia. |
2023-07-19 |
2023-08-14 |
mouse |
| Wei Sun, Qingpeng Wang, Ruiyan Zhang, Ning Zhan. Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation. Food & function. 2023-07-19. PMID:37466915. |
in addition, kd inhibits nlrp3 activation in the microglia, as revealed by the significantly decreased co-expression of nlrp3 |
2023-07-19 |
2023-08-14 |
mouse |
| Yehonatan Weinberger, Ivan Budnik, Yael Nisgav, Dahlia Palevski, Gil Ben-David, José A Fernández, Shany Nivinsky Margalit, Sarina Levy-Mendelovich, Gili Kenet, Dov Weinberger, John H Griffin, Tami Livna. 3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445820. |
the impact of 3k3a-apc treatment on myeloid and microglia cell activation and recruitment and on nlrp3 inflammasome, il-1β, and vegf levels was assessed using cryosection, retinal flat-mount immunohistochemistry and vascular imaging. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yehonatan Weinberger, Ivan Budnik, Yael Nisgav, Dahlia Palevski, Gil Ben-David, José A Fernández, Shany Nivinsky Margalit, Sarina Levy-Mendelovich, Gili Kenet, Dov Weinberger, John H Griffin, Tami Livna. 3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445820. |
our results demonstrated that 3k3a-apc treatment significantly reduced the accumulation and activation of myeloid cells and microglia in the cnv area and decreased the nlrp3 and il-1β levels at the cnv site and the surrounding retina. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yousef Mohamadi, Maryam Borhani-Haghigh. TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model. Journal of chemical neuroanatomy. 2023-07-02. PMID:37394105. |
tgn020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and nlrp3 inflammasome in a cuprizone mouse model. |
2023-07-02 |
2023-08-14 |
mouse |
| Yousef Mohamadi, Maryam Borhani-Haghigh. TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model. Journal of chemical neuroanatomy. 2023-07-02. PMID:37394105. |
astrogliosis, m1-m2 microglia polarization, nlrp3 inflammasome activation, and demyelination were investigated in the corpus callosum by immunohistochemistry, real-time pcr, western blot, and luxol fast blue staining. |
2023-07-02 |
2023-08-14 |
mouse |
| Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui H. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371502. |
microglia nlrp3 inflammasome and neuroimmune signaling in substance use disorders. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui H. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371502. |
among the family of inflammasomes, nod-, lrr-, and pyrin-domain-containing protein 3 (nlrp3) serves the primary research target due to its abundant expression in microglia. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui H. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371502. |
nlrp3 has the capability of integrating multiple external and internal inputs and coordinately determining the intensity of microglia activation under various pathological conditions. |
2023-06-28 |
2023-08-14 |
Not clear |
| Panmei Liu, Yu Zhang, Xinxin Li, Minyu M. DEAD-box helicase 54 regulates microglial inflammatory response in rats with chronic constriction injuries through NF-κB/NLRP3 signaling axis. Journal of neurophysiology. 2023-06-28. PMID:37377223. |
results the expressions of il-1β, tnfα and il-6 were up-regulated, and those of ddx54, myd88, nf-κb and nlrp3 were up-regulated in microglia and hmc3 cells after lps induction. |
2023-06-28 |
2023-08-14 |
rat |
| Panmei Liu, Yu Zhang, Xinxin Li, Minyu M. DEAD-box helicase 54 regulates microglial inflammatory response in rats with chronic constriction injuries through NF-κB/NLRP3 signaling axis. Journal of neurophysiology. 2023-06-28. PMID:37377223. |
ddx54 knockdown in microglia and hmc3 cells inhibited il-1β, tnfα and il-6 expressions, and down-regulated the protein levels of myd88, p-p65 and nlrp3. |
2023-06-28 |
2023-08-14 |
rat |
| Xudong Huang, Xiao Chen, Qi Li, Bai-He Ni, Weiguo Wan. Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-κB/NLRP3 signalling. Toxicon : official journal of the International Society on Toxinology. 2023-06-22. PMID:37348819. |
loganin promoted animal motor recovery after sci at the behavioural level, and it inhibited m1 differentiation of microglia and reduced nod-like receptor thermal protein domain associated protein 3 (nlrp3)-mediated inflammatory responses at the tissue level. |
2023-06-22 |
2023-08-14 |
rat |
| Dan Gao, Jin-Ping Hao, Bo-Ya Li, Ceng-Ceng Zheng, Bei-Bei Miao, Li Zhang, Ya-Li Li, Lin Li, Xing-Jie Li, Lan Zhan. Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING. European journal of pharmacology. 2023-06-16. PMID:37328043. |
meanwhile, it was observed that the expressions of serum inflammatory cytokines and the activation of microglia in cerebral cortex and hippocampus were suppressed after tsg treatment, which was probably attributable to the decrease of cyclic gmp-amp synthase (cgas) and stimulator of interferon genes (sting) triggered immune response and nlrp3 inflammasome activation. |
2023-06-16 |
2023-08-14 |
mouse |
| Zhihong Zhuo, Yao Wang, Huimin Kong, Tianjiao F. GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures. International immunopharmacology. vol 121. 2023-06-09. PMID:37295029. |
results showed that gklf enhanced ka-induced neuronal loss, pro-inflammatory cytokine secretion, activation of nod-like receptor protein-3 (nlrp3) inflammasomes and microglia, and txnip expression in the hippocampus. |
2023-06-09 |
2023-08-14 |
Not clear |
| Zhihong Zhuo, Yao Wang, Huimin Kong, Tianjiao F. GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures. International immunopharmacology. vol 121. 2023-06-09. PMID:37295029. |
gklf inhibition showed negative effects on lps-induced microglia activation, as evidenced by reduced pro-inflammatory cytokine secretion and activation of nlrp3 inflammasomes. |
2023-06-09 |
2023-08-14 |
Not clear |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
further analysis showed that vav1 was almost exclusively localized to microglia and that vav1 downregulation inhibited microglial activation and the nod-like receptor pyrin 3 (nlrp3) inflammasome in the ischemic penumbra, as well as the expression of inflammatory factors. |
2023-06-07 |
2023-08-14 |
rat |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
taken together, these findings show that silencing vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/reperfusion through inhibiting the activation of microglia and nlrp3 inflammasome. |
2023-06-07 |
2023-08-14 |
rat |
| Ngoc Minh Hong Hoang, Wonhee Jo, Min-Sun Ki. Protective effect of Prolactin releasing peptide against 1,2-diacetylbenzene -induced neuroinflammation. Neuropeptides. vol 100. 2023-06-03. PMID:37269608. |
we observed that prrp modulated nadph oxidase - regulated nlrp3 inflammasome and prl signaling pathways differently between physical and toxic conditions in microglia. |
2023-06-03 |
2023-08-14 |
Not clear |