| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yousef Mohamadi, Maryam Borhani-Haghigh. TGN020 application against aquaporin 4 improved multiple sclerosis by inhibiting astrocytes, microglia, and NLRP3 inflammasome in a cuprizone mouse model. Journal of chemical neuroanatomy. 2023-07-02. PMID:37394105. |
astrogliosis, m1-m2 microglia polarization, nlrp3 inflammasome activation, and demyelination were investigated in the corpus callosum by immunohistochemistry, real-time pcr, western blot, and luxol fast blue staining. |
2023-07-02 |
2023-08-14 |
mouse |
| Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui H. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371502. |
microglia nlrp3 inflammasome and neuroimmune signaling in substance use disorders. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui H. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371502. |
among the family of inflammasomes, nod-, lrr-, and pyrin-domain-containing protein 3 (nlrp3) serves the primary research target due to its abundant expression in microglia. |
2023-06-28 |
2023-08-14 |
Not clear |
| Ming-Lei Guo, Soheil Kazemi Roodsari, Yan Cheng, Rachael Elizabeth Dempsey, Wenhui H. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371502. |
nlrp3 has the capability of integrating multiple external and internal inputs and coordinately determining the intensity of microglia activation under various pathological conditions. |
2023-06-28 |
2023-08-14 |
Not clear |
| Panmei Liu, Yu Zhang, Xinxin Li, Minyu M. DEAD-box helicase 54 regulates microglial inflammatory response in rats with chronic constriction injuries through NF-κB/NLRP3 signaling axis. Journal of neurophysiology. 2023-06-28. PMID:37377223. |
results the expressions of il-1β, tnfα and il-6 were up-regulated, and those of ddx54, myd88, nf-κb and nlrp3 were up-regulated in microglia and hmc3 cells after lps induction. |
2023-06-28 |
2023-08-14 |
rat |
| Panmei Liu, Yu Zhang, Xinxin Li, Minyu M. DEAD-box helicase 54 regulates microglial inflammatory response in rats with chronic constriction injuries through NF-κB/NLRP3 signaling axis. Journal of neurophysiology. 2023-06-28. PMID:37377223. |
ddx54 knockdown in microglia and hmc3 cells inhibited il-1β, tnfα and il-6 expressions, and down-regulated the protein levels of myd88, p-p65 and nlrp3. |
2023-06-28 |
2023-08-14 |
rat |
| Xudong Huang, Xiao Chen, Qi Li, Bai-He Ni, Weiguo Wan. Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-κB/NLRP3 signalling. Toxicon : official journal of the International Society on Toxinology. 2023-06-22. PMID:37348819. |
loganin promoted animal motor recovery after sci at the behavioural level, and it inhibited m1 differentiation of microglia and reduced nod-like receptor thermal protein domain associated protein 3 (nlrp3)-mediated inflammatory responses at the tissue level. |
2023-06-22 |
2023-08-14 |
rat |
| Dan Gao, Jin-Ping Hao, Bo-Ya Li, Ceng-Ceng Zheng, Bei-Bei Miao, Li Zhang, Ya-Li Li, Lin Li, Xing-Jie Li, Lan Zhan. Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING. European journal of pharmacology. 2023-06-16. PMID:37328043. |
meanwhile, it was observed that the expressions of serum inflammatory cytokines and the activation of microglia in cerebral cortex and hippocampus were suppressed after tsg treatment, which was probably attributable to the decrease of cyclic gmp-amp synthase (cgas) and stimulator of interferon genes (sting) triggered immune response and nlrp3 inflammasome activation. |
2023-06-16 |
2023-08-14 |
mouse |
| Zhihong Zhuo, Yao Wang, Huimin Kong, Tianjiao F. GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures. International immunopharmacology. vol 121. 2023-06-09. PMID:37295029. |
results showed that gklf enhanced ka-induced neuronal loss, pro-inflammatory cytokine secretion, activation of nod-like receptor protein-3 (nlrp3) inflammasomes and microglia, and txnip expression in the hippocampus. |
2023-06-09 |
2023-08-14 |
Not clear |
| Zhihong Zhuo, Yao Wang, Huimin Kong, Tianjiao F. GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures. International immunopharmacology. vol 121. 2023-06-09. PMID:37295029. |
gklf inhibition showed negative effects on lps-induced microglia activation, as evidenced by reduced pro-inflammatory cytokine secretion and activation of nlrp3 inflammasomes. |
2023-06-09 |
2023-08-14 |
Not clear |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
further analysis showed that vav1 was almost exclusively localized to microglia and that vav1 downregulation inhibited microglial activation and the nod-like receptor pyrin 3 (nlrp3) inflammasome in the ischemic penumbra, as well as the expression of inflammatory factors. |
2023-06-07 |
2023-08-14 |
rat |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
taken together, these findings show that silencing vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/reperfusion through inhibiting the activation of microglia and nlrp3 inflammasome. |
2023-06-07 |
2023-08-14 |
rat |
| Ngoc Minh Hong Hoang, Wonhee Jo, Min-Sun Ki. Protective effect of Prolactin releasing peptide against 1,2-diacetylbenzene -induced neuroinflammation. Neuropeptides. vol 100. 2023-06-03. PMID:37269608. |
we observed that prrp modulated nadph oxidase - regulated nlrp3 inflammasome and prl signaling pathways differently between physical and toxic conditions in microglia. |
2023-06-03 |
2023-08-14 |
Not clear |
| Edward Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok-Soo Son, Michael Aschner, Eunsook Le. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. The Journal of biological chemistry. 2023-06-03. PMID:37269951. |
rab10 played a critical role in lrrk2-mediated mn toxicity by dysregulating the autophagy-lysosome pathway, and nlrp3 inflammasome in microglia. |
2023-06-03 |
2023-08-14 |
mouse |
| Cheng-Qiang Wang, Zou Su, Chun-Guang Dai, Jia-Le Song, Bo Qia. Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis. Ecotoxicology and environmental safety. vol 259. 2023-05-24. PMID:37224780. |
meanwhile, bde47 exposure reduced protein levels of tyrosine hydroxylase (th) and dopamine transporter (dat), activated astrocytes and microglia cells, and increased protein levels of nlrp3, il-6, il-1β, and tnf-α in the brain of mice. |
2023-05-24 |
2023-08-14 |
mouse |
| Seema Singh, Annadurai Thangaraj, Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buc. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-06. PMID:37148425. |
role of dysregulated autophagy in hiv tat, cocaine, and cart mediated nlrp3 activation in microglia. |
2023-05-06 |
2023-08-14 |
mouse |
| Seema Singh, Annadurai Thangaraj, Ernest T Chivero, Ming-Lei Guo, Palsamy Periyasamy, Shilpa Buc. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-06. PMID:37148425. |
our findings also demonstrated activation of the nlrp3 signaling in microglia exposed to these agents. |
2023-05-06 |
2023-08-14 |
mouse |
| Weam W Ibrahim, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Saye. NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy/D-galactose Alzheimer's disease rat model. International immunopharmacology. vol 119. 2023-05-03. PMID:37137264. |
this study investigated the neuroprotective potential of sco in ad animal model focusing on determining its effect on m1/m2 microglia polarization and exploring the plausible mechanism involved via investigating its modulatory role on tlr4/myd88/nf-κb and nlrp3 inflammasome. |
2023-05-03 |
2023-08-14 |
rat |
| Jung Lo, Hsin-En Wu, Ching-Chih Liu, Kun-Che Chang, Po-Yen Lee, Po-Len Liu, Shu-Pin Huang, Pei-Chang Wu, Tzu-Chieh Lin, Yu-Hung Lai, Yo-Chen Chang, Yuan-Ru Chen, Sheng-I Lee, Yu-Kai Huang, Shu-Chi Wang, Chia-Yang L. Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108458. |
nordalbergin exerts anti-neuroinflammatory effects by attenuating mapk signaling pathway, nlrp3 inflammasome activation and ros production in lps-stimulated bv2 microglia. |
2023-04-28 |
2023-08-14 |
Not clear |
| Xingru Chen, Xiaolan Zhou, Xiaoqing Cheng, Liting Lin, Qi Wang, Ruoting Zhan, Qingguang Wu, Sijun Li. Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. Molecules (Basel, Switzerland). vol 28. issue 8. 2023-04-28. PMID:37110714. |
we further studied the mechanism of fa's regulation of lps-induced bv2 neuroinflammation and found that fa can significantly reduce the expression of mtor in bv2 microglia induced by lps, and significantly increase the expression of ampk, indicating that fa may have an anti-inflammatory effect by activating the ampk/mtor signaling pathway to regulate the release of inflammatory mediators (such as nlrp3, caspase-1 p20 and il-1β). |
2023-04-28 |
2023-08-14 |
Not clear |