| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilkcan Ercan, Serap Cilaker Micili, Sila Soy, Defne Engur, Kemal Ugur Tufekci, Abdullah Kumral, Sermin Gen. Bilirubin induces microglial NLRP3 inflammasome activation in vitro and in vivo. Molecular and cellular neurosciences. 2023-03-25. PMID:36965549. |
following injection of bilirubin into the cisterna magna of a neonatal mouse, activation of the nlrp3 inflammasome and microglia were determined by double staining with iba1-nlrp3 and iba1-caspase-1. |
2023-03-25 |
2023-08-14 |
mouse |
| Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Che. Exercise suppresses neuroinflammation for alleviating Alzheimer's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-03-20. PMID:36935511. |
herein, based on animal experiments and a few clinical trials, neuroinflammation in ad is characterized by long-term activation of pro-inflammatory microglia and the nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasomes. |
2023-03-20 |
2023-08-14 |
Not clear |
| Zhongyan Wu, Fan Mei, Yangyang Gan, Anhang Liu, Jiapan Hu, Yan Jin, Yuxin Yi. FAM69C functions as a kinase for eIF2α and promotes stress granule assembly. EMBO reports. 2023-03-17. PMID:36929224. |
defective stress granule assembly in microglia correlates with the formation of asc specks and nlrp3 inflammasome activation, whereas induction of stress granule precludes inflammasome formation. |
2023-03-17 |
2023-08-14 |
mouse |
| Possemato Elena, La Barbera Livia, Nobili Annalisa, Krashia Paraskevi, D'Amelio Marcell. The role of dopamine in NLRP3 inflammasome inhibition: implications for neurodegenerative diseases. Ageing research reviews. 2023-03-09. PMID:36893920. |
the neurotransmitter dopamine (da) is one of the players that negatively modulate nlrp3 inflammasome activation through da receptors expressed in both microglia and astrocytes. |
2023-03-09 |
2023-08-14 |
Not clear |
| Jinqing Lai, Genwang Chen, Zhe Wu, Shaoyang Yu, Rongfu Huang, Yile Zeng, Weibin Lin, Chunmei Fan, Xiangrong Che. PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following experimental subarachnoid hemorrhage. Frontiers in immunology. vol 14. 2023-03-06. PMID:36875102. |
concomitant with phlda1 activation, nod-like receptor pyrin domain-containing protein 3 (nlrp3) inflammasome expression in microglia was also evidently enhanced after sah. |
2023-03-06 |
2023-08-14 |
mouse |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
compared with the model control group, the erjing pill groups enhanced the new object recognition index of rats, decreased the deposition of aβ_(1-42) and the expression of p-tau~(404) positive protein in the hippocampus, inhibited the activation of microglia in the dentate gyrus, reduced the levels of inflammatory factors il-1β, tnf-α, and il-6 in the hippocampus, and down-regulated the expression levels of tlr4, p-nf-κb p65/nf-κb p65, p-iκbα/iκbα, and nlrp3 proteins in the hippocampus. |
2023-03-05 |
2023-08-14 |
rat |
| Muthukumar Kannan, Seema Singh, Divya T Chemparathy, Abiola A Oladapo, Dinesh Y Gawande, Shashank M Dravid, Shilpa Buch, Susmita Si. HIV-1 Tat induced microglial EVs leads to neuronal synaptodendritic injury: microglia-neuron cross-talk in NeuroHIV. Extracellular vesicles and circulating nucleic acids. vol 3. issue 2. 2023-02-22. PMID:36812097. |
we hypothesized that hiv-1 tat mediated microglia evs carrying significant levels of nlrp3 contribute to the synaptodendritic injury, thereby affecting the maturation of neurons. |
2023-02-22 |
2023-08-14 |
Not clear |
| Charlotte Braatz, Max P Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M McManus, Michael T Henek. NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. Journal of neurochemistry. 2023-02-17. PMID:36799439. |
nlrp3 mrna degradation was achieved at 72 hours of aso treatment in primary murine microglia. |
2023-02-17 |
2023-08-14 |
human |
| Charlotte Braatz, Max P Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Róisín M McManus, Michael T Henek. NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. Journal of neurochemistry. 2023-02-17. PMID:36799439. |
together nlrp3-directed asos can suppress nlrp3 inflammasome activity and subsequent release of il-1β in primary murine microglia and thp-1 cells. |
2023-02-17 |
2023-08-14 |
human |
| Pin-Yu Chen, Jiin-Cherng Yen, Tzu-Ting Liu, Szu-Ting Chen, Shuu-Jiun Wang, Shih-Pin Che. Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation. Brain : a journal of neurology. 2023-02-16. PMID:36795624. |
the sd-evoked nlrp3 inflammasome activation was observed exclusively in neurons but not microglia or astrocytes. |
2023-02-16 |
2023-08-14 |
Not clear |
| Pin-Yu Chen, Jiin-Cherng Yen, Tzu-Ting Liu, Szu-Ting Chen, Shuu-Jiun Wang, Shih-Pin Che. Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation. Brain : a journal of neurology. 2023-02-16. PMID:36795624. |
moreover, multiple sds induced microglial activation subsequent to neuronal nlrp3 inflammasome activation, which in turn orchestrated with neurons to mediate cortical neuroinflammation, as demonstrated by decreased neuronal inflammation after pharmacological inhibition of microglia activation or blockade of the tlr2/4 receptors. |
2023-02-16 |
2023-08-14 |
Not clear |
| Xintong Zheng, Mingwei Wang, Shuting Liu, Haiqiao Chen, Yifei Li, Fa Yuan, Ludong Yang, Suo Qiu, Hongwei Wang, Zhi Xie, Mengqing Xian. A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Cell death & disease. vol 14. issue 2. 2023-02-15. PMID:36792584. |
its deficiency in mice protected retinal ganglion cells from retinal ir injury by attenuating the activation of microglia and the nlrp3 inflammasome pathway. |
2023-02-15 |
2023-08-14 |
mouse |
| Jiande Li, Hongxuan Wang, Dandan Liu, Xiangpen Li, Lei He, Jingrui Pan, Qingyu Shen, Ying Pen. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in the microglia of the prefrontal cortex in mice. Brain, behavior, and immunity. 2023-02-08. PMID:36754245. |
cb2r activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing nlrp3 inflammasome activation in the microglia of the prefrontal cortex in mice. |
2023-02-08 |
2023-08-14 |
mouse |
| Jiande Li, Hongxuan Wang, Dandan Liu, Xiangpen Li, Lei He, Jingrui Pan, Qingyu Shen, Ying Pen. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in the microglia of the prefrontal cortex in mice. Brain, behavior, and immunity. 2023-02-08. PMID:36754245. |
alcohol exposure increases nlrp3 inflammasome expression, increasing cytokine secretion by activated microglia. |
2023-02-08 |
2023-08-14 |
mouse |
| Jianqiang Wei, Jing Yin, Ying Cui, Kaijie Wang, Mingyan Hong, Jianzhong Cu. FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF-κB pathway. Experimental animals. 2023-02-05. PMID:36740252. |
fermt1 knockdown reduced microglia activity, inhibited nlr family pyrin domain containing 3 (nlrp3) inflammasome activity and decreased the expression of inflammatory factors including interleukin-1β (il-1β) and interleukin 18 (il-18) in the peri-hematoma tissues. |
2023-02-05 |
2023-08-14 |
rat |
| Jianqiang Wei, Jing Yin, Ying Cui, Kaijie Wang, Mingyan Hong, Jianzhong Cu. FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF-κB pathway. Experimental animals. 2023-02-05. PMID:36740252. |
bv2 microglial cells were transfected with fermt1 sirna and incubated with 60 μm hemin for 24 h. activation of nlrp3 inflammasome induced by hemin were reduced in microglia when fermt1 was knocked down, leading to decreased production of inflammatory factors il-1β and il-18. |
2023-02-05 |
2023-08-14 |
rat |
| Dan Gao, Ceng-Ceng Zheng, Jin-Ping Hao, Cui-Cui Yang, Chao-Ying H. Icariin Ameliorates Behavioral Deficits and Neuropathology in a Mouse Model of Multiple Sclerosis. Brain research. 2023-02-02. PMID:36731819. |
meanwhile, it was observed that the activation of microglia in cerebral cortex and hippocampus were inhibited followed by the neuroinflammatory cytokines downregulation such as il-1β, il-6 and tnf-α after ica treatment, which was probably attributable to the suppression of microglial nlrp3 inflammasome activation. |
2023-02-02 |
2023-08-14 |
mouse |
| Jingrui Pan, Jialing Peng, Xiangpen Li, Hongxuan Wang, Xiaoming Rong, Ying Pen. Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6. Molecular neurobiology. 2023-01-30. PMID:36717480. |
in addition, ruptured lysosomes engulfing asc specks which were possibly secreted from microglia triggered the enhanced nlrp3 expression. |
2023-01-30 |
2023-08-14 |
rat |
| Jingrui Pan, Jialing Peng, Xiangpen Li, Hongxuan Wang, Xiaoming Rong, Ying Pen. Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6. Molecular neurobiology. 2023-01-30. PMID:36717480. |
neuronal and endothelial nlrp3 inflammasomes were activated by microglia in cerebral ischemia and reperfusion injury mainly via il-1β/il-1r1/traf6 signaling, which might be therapeutically targetable. |
2023-01-30 |
2023-08-14 |
rat |
| Zhiyou Yang, Junxin Liu, Shuai Wei, Jiahang Deng, Xinyue Feng, Shucheng Liu, Mingxin Li. A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer's disease. Frontiers in pharmacology. vol 13. 2023-01-26. PMID:36699095. |
in response to a wide range of stimuli like aβ, nlrp3 assembles apoptosis-associated speck-like protein (asc) and procaspase-1 into an inflammasome complex to induce the caspase-1 mediated secretion of interleukin (il)-1β/il-18 in m1 polarized microglia, triggering the pathophysiological changes and cognitive decline of ad. |
2023-01-26 |
2023-08-14 |
Not clear |